MTOR signalling

Pathway network for the MTOR signalling SuperPath

Sources:

Reactome
WikiPathways

Pathways in the MTOR signalling SuperPath

#	Name	Source	Genes
1	MTOR signalling	Reactome	AKT1 AKT1S1 AKT2 CAB39 CAB39L EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FKBP1A LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MLST8 MTOR PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK11 STRADA STRADB TSC1 TSC2 YWHAB (see all 41) (see less)
2	Target of rapamycin signaling	WikiPathways	AKT1 AKT1S1 CDC42 DDIT4 DDIT4L EIF4EBP1 FKBP1A HMGCR IDI1 MAPKAP1 MLST8 MTOR PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKCA PRR5 PRR5L RAC1 RHEB RICTOR RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD TSC1 TSC2 ULK1 ULK2 ULK3 (see all 36) (see less)
3	Energy dependent regulation of mTOR by LKB1-AMPK	Reactome	CAB39 CAB39L LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MLST8 MTOR PPM1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RHEB RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 STK11 STRADA STRADB TSC1 TSC2 (see all 29) (see less)
4	mTORC1-mediated signalling	Reactome	AKT1S1 EEF2K EIF4B EIF4E EIF4EBP1 EIF4G1 FKBP1A LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MLST8 MTOR RHEB RPS6 RPS6KB1 RPTOR RRAGA RRAGB RRAGC RRAGD SLC38A9 YWHAB (see all 24) (see less)
5	Inhibition of TSC complex formation by PKB	Reactome	AKT2 TSC1 TSC2

Gene overlap in member pathways for MTOR signalling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RRAGB	Ras Related GTP Binding B	Protein Coding	4
2	RRAGA	Ras Related GTP Binding A	Protein Coding	4
3	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	4
4	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	4
5	RRAGD	Ras Related GTP Binding D	Protein Coding	4
6	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	4
7	RRAGC	Ras Related GTP Binding C	Protein Coding	4
8	MLST8	MTOR Associated Protein MLST8	Protein Coding	4
9	TSC1	TSC Complex Subunit 1	Protein Coding	4
10	TSC2	TSC Complex Subunit 2	Protein Coding	4
11	LAMTOR5	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5	Protein Coding	3
12	SLC38A9	Solute Carrier Family 38 Member 9	Protein Coding	3
13	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	3
14	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	3
15	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	3
16	LAMTOR4	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4	Protein Coding	3
17	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	3
18	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	3
19	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	3
20	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	3
21	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	3
22	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	3
23	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	3
24	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	3
25	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	3
26	AKT1S1	AKT1 Substrate 1	Protein Coding	3
27	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	3
28	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	2
29	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	2
30	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	2
31	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
32	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
33	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	2
34	CAB39	Calcium Binding Protein 39	Protein Coding	2
35	PPM1A	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A	Protein Coding	2
36	STRADB	STE20 Related Adaptor Beta	Protein Coding	2
37	RPS6	Ribosomal Protein S6	Protein Coding	2
38	STK11	Serine/Threonine Kinase 11	Protein Coding	2
39	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
40	CAB39L	Calcium Binding Protein 39 Like	Protein Coding	2
41	STRADA	STE20 Related Adaptor Alpha	Protein Coding	2
42	CDC42	Cell Division Cycle 42	Protein Coding	1
43	ULK2	Unc-51 Like Autophagy Activating Kinase 2	Protein Coding	1
44	RAC1	Rac Family Small GTPase 1	Protein Coding	1
45	PRKCA	Protein Kinase C Alpha	Protein Coding	1
46	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
47	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
48	DDIT4L	DNA Damage Inducible Transcript 4 Like	Protein Coding	1
49	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
50	PRR5L	Proline Rich 5 Like	Protein Coding	1
51	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
52	PRR5	Proline Rich 5	Protein Coding	1
53	IDI1	Isopentenyl-Diphosphate Delta Isomerase 1	Protein Coding	1
54	ULK3	Unc-51 Like Kinase 3	Protein Coding	1
55	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1

Disorders associated with MTOR signalling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	10.55
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	10.55
3	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	7.49
4	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	7.01
5	Hamartoma	Enrichment	TSC1, TSC2	7.01
6	Tuberous sclerosis	Enrichment	TSC1, TSC2	6.71
7	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	5.93
8	Hemimegalencephaly	Enrichment	MTOR, RHEB	4.52
9	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	3.66
10	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	3.66
11	Inherited cancer-predisposing syndrome	Enrichment	TSC1, TSC2	3.55
12	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	3.18
13	Tuberous sclerosis 2	Enrichment	TSC2	3.18
14	Xanthinuria, type ii	Enrichment	TSC2	3.18
15	Keratoconus	Enrichment	TSC1	2.88
16	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	2.81
17	Polycystic kidney disease 1	Enrichment	TSC2	2.81
18	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	2.75
19	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	2.75
20	Autism 19	Enrichment	EIF4E	2.75
21	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	2.75
22	Tubular renal disease-cardiomyopathy syndrome	Enrichment	RRAGD	2.75
23	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.67
24	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.67
25	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.67
26	Intestinal polyposis syndrome	Enrichment	STK11	2.67
27	Proteus syndrome	Enrichment	AKT1	2.58
28	Cowden syndrome 6	Enrichment	AKT1	2.58
29	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.58
30	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.58
31	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.58
32	Nocarh syndrome	Enrichment	CDC42	2.58
33	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.58
34	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	2.48
35	Kidney disease	Enrichment	TSC1	2.48
36	Hypomagnesemia 7, renal, with or without dilated cardiomyopathy	Enrichment	RRAGD	2.45
37	Cebalid syndrome	Enrichment	MTOR	2.45
38	Smith-kingsmore syndrome	Enrichment	MTOR	2.45
39	Long-olsen-distelmaier syndrome	Enrichment	RRAGC	2.45
40	Peutz-jeghers syndrome	Enrichment	STK11	2.37
41	Polyhydramnios, megalencephaly, and symptomatic epilepsy	Enrichment	STRADA	2.37
42	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.28
43	Immune system disease	Enrichment	CDC42	2.28
44	Testicular germ cell cancer	Enrichment	STK11	2.19
45	Testicular cancer	Enrichment	STK11	2.19
46	Apc-associated polyposis conditions	Enrichment	STK11	2.19
47	Bladder cancer	Enrichment	TSC1	2.19
48	Type 2 diabetes mellitus	Enrichment	AKT2	2.03
49	West syndrome	Enrichment	TSC2	2.01
50	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.98
51	Familial adenomatous polyposis 1	Enrichment	STK11	1.97
52	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.97
53	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.91
54	Overgrowth syndrome	Enrichment	MTOR	1.91
55	Testicular germ cell tumor	Enrichment	STK11	1.89
56	Breast adenocarcinoma	Enrichment	AKT1	1.80
57	Melanoma	Enrichment	STK11	1.67
58	Ovarian cancer	Enrichment	TSC2	1.65
59	Congenital nervous system abnormality	Enrichment	TSC2	1.63
60	Nervous system disease	Enrichment	TSC2	1.63
61	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.63
62	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.63
63	Cowden syndrome	Enrichment	AKT1	1.63
64	Autism spectrum disorder	Enrichment	TSC2	1.62
65	Lip and oral cavity carcinoma	Enrichment	STK11	1.60
66	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.58
67	Rare genetic intellectual disability	Enrichment	MTOR	1.58
68	Meningioma	Enrichment	AKT1	1.50
69	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.47
70	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.45
71	Parkinson disease, late-onset	Enrichment	EIF4G1	1.38
72	Pancreatic cancer	Enrichment	STK11	1.28
73	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.17
74	Benign epilepsy with centrotemporal spikes	Enrichment	STRADA	1.08
75	Centralopathic epilepsy	Enrichment	STRADA	1.06
76	Gastric cancer	Enrichment	STK11	1.06
77	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.06
78	Hereditary breast carcinoma	Enrichment	AKT1	0.96
79	Primary ovarian insufficiency	Enrichment	RICTOR	0.84
80	Breast cancer	Enrichment	AKT1	0.74
81	Colorectal cancer	Enrichment	AKT1	0.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for MTOR signalling

Pathway network for the MTOR signalling SuperPath

Member Pathways for MTOR signalling

Pathways in the MTOR signalling SuperPath

Gene overlap in member pathways for MTOR signalling SuperPath

Associated Genes for MTOR signalling

Associated Disorders for MTOR signalling

Disorders associated with MTOR signalling SuperPath

STRING Interaction Network for MTOR signalling

Sources for MTOR signalling