N-cadherin signaling events

No Pathway Network information available for N-cadherin signaling events

Pathways in the N-cadherin signaling events SuperPath

#	Name	Source	Genes
1	N-cadherin signaling events	PubChem	AXIN1 CAMK2G CDH2 CNR1 CTNNA1 CTNNB1 CTNND1 CTTN DAGLA DCTN1 FER FGFR1 GAP43 GJA1 GRIA2 GSN KIF5B LRP5 MAPK8 MAPRE1 MYL2 PIK3CA PIK3R1 PIP5K1C PLCG1 PTPN1 PTPN11 RAC1 RHOA ROCK1 (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DAGLA	Diacylglycerol Lipase Alpha	Protein Coding	1
2	FER	FER Tyrosine Kinase	Protein Coding	1
3	MYL2	Myosin Light Chain 2	Protein Coding	1
4	CDH2	Cadherin 2	Protein Coding	1
5	KIF5B	Kinesin Family Member 5B	Protein Coding	1
6	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
7	DCTN1	Dynactin Subunit 1	Protein Coding	1
8	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
9	CTTN	Cortactin	Protein Coding	1
10	AXIN1	Axin 1	Protein Coding	1
11	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
12	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
13	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
14	GSN	Gelsolin	Protein Coding	1
15	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
16	CTNND1	Catenin Delta 1	Protein Coding	1
17	CTNNB1	Catenin Beta 1	Protein Coding	1
18	CTNNA1	Catenin Alpha 1	Protein Coding	1
19	GAP43	Growth Associated Protein 43	Protein Coding	1
20	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
21	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
22	RHOA	Ras Homolog Family Member A	Protein Coding	1
23	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	1
24	RAC1	Rac Family Small GTPase 1	Protein Coding	1
25	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
26	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
27	CNR1	Cannabinoid Receptor 1	Protein Coding	1
28	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
29	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
30	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with N-cadherin signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1, PIK3CA	6.09
2	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	5.33
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.85
4	Hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1, PIK3CA	4.84
5	Colorectal cancer	Enrichment	CTNNA1, CTNNB1, PIK3CA, PIK3R1	4.42
6	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, LRP5	4.33
7	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.15
8	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA	4.01
9	Hypertrophic cardiomyopathy	Enrichment	KIF5B, MYL2, PTPN11	3.95
10	Exudative vitreoretinopathy	Enrichment	CTNNB1, LRP5	3.88
11	Polycystic liver disease	Enrichment	CTNNB1, LRP5	3.20
12	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5	3.20
13	Bladder cancer	Enrichment	CTNNB1, PIK3CA	2.73
14	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.66
15	Macrodactyly	Enrichment	PIK3CA	2.66
16	Osteoglophonic dysplasia	Enrichment	FGFR1	2.66
17	Metachondromatosis	Enrichment	PTPN11	2.66
18	Perry syndrome	Enrichment	DCTN1	2.66
19	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.66
20	Trigonocephaly 1	Enrichment	FGFR1	2.66
21	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.66
22	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.66
23	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.66
24	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.66
25	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.66
26	Oculodentodigital dysplasia	Enrichment	GJA1	2.66
27	Amyloidosis, finnish type	Enrichment	GSN	2.66
28	Leopard syndrome 1	Enrichment	PTPN11	2.66
29	Cowden syndrome 5	Enrichment	PIK3CA	2.66
30	Caudal duplication anomaly	Enrichment	AXIN1	2.66
31	Neuroocular syndrome 2, paroxysmal type	Enrichment	DAGLA	2.66
32	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.66
33	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.66
34	Short syndrome	Enrichment	PIK3R1	2.66
35	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.66
36	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.66
37	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.66
38	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.66
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.66
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.66
41	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.66
42	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	2.66
43	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.66
44	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.66
45	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.66
46	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.66
47	Hartsfield syndrome	Enrichment	FGFR1	2.66
48	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.66
49	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.66
50	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.66
51	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.66
52	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.66
53	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.66
54	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.66
55	Adenoid ameloblastoma	Enrichment	CTNNB1	2.66
56	Hypospadias	Enrichment	PIK3CA	2.66
57	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.66
58	Rare venous malformation	Enrichment	PIK3CA	2.66
59	Diaphragmatic eventration	Enrichment	PIK3CA	2.66
60	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.66
61	Rare combined vascular malformation	Enrichment	PIK3CA	2.66
62	Cavernous lymphangioma	Enrichment	PIK3CA	2.66
63	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.66
64	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.66
65	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.66
66	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.66
67	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.66
68	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.66
69	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.66
70	Macrodactyly of toe	Enrichment	PIK3CA	2.66
71	Microcystic stromal tumor	Enrichment	CTNNB1	2.66
72	Malignant astrocytoma	Enrichment	PTPN11	2.66
73	Blepharocheilodontic syndrome 1	Enrichment	CTNND1	2.35
74	Van buchem disease	Enrichment	LRP5	2.35
75	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.35
76	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.35
77	Keratosis, seborrheic	Enrichment	PIK3CA	2.35
78	Pfeiffer syndrome	Enrichment	FGFR1	2.35
79	Jackson-weiss syndrome	Enrichment	FGFR1	2.35
80	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.35
81	Hallermann-streiff syndrome	Enrichment	GJA1	2.35
82	Noonan syndrome 8	Enrichment	PIK3CA	2.35
83	Syndactyly, type iii	Enrichment	GJA1	2.35
84	Syndactyly, type v	Enrichment	GJA1	2.35
85	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.35
86	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.35
87	Werner syndrome	Enrichment	PTPN11	2.35
88	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.35
89	Craniometaphyseal dysplasia	Enrichment	GJA1	2.35
90	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.35
91	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.35
92	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.35
93	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.35
94	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	2.35
95	Teratoma	Enrichment	CTNNB1	2.35
96	Osteosclerosis	Enrichment	LRP5	2.35
97	Skeletal muscle disease	Enrichment	KIF5B	2.35
98	Desmoid disease, hereditary	Enrichment	CTNNB1	2.18
99	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.18
100	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.18
101	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	2.18
102	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.18
103	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.18
104	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.18
105	Anus, imperforate	Enrichment	CTNNB1	2.18
106	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.18
107	Desmoid tumor	Enrichment	CTNNB1	2.18
108	Immunodeficiency 14	Enrichment	PIK3R1	2.18
109	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.18
110	Tricuspid valve insufficiency	Enrichment	PTPN11	2.18
111	Keratoacanthoma	Enrichment	PIK3CA	2.18
112	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	2.05
113	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	2.05
114	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.05
115	Pilomatrixoma	Enrichment	CTNNB1	2.05
116	Alazami syndrome	Enrichment	CTNNB1	2.05
117	Retinopathy of prematurity	Enrichment	LRP5	2.05
118	Cerebrovascular disease	Enrichment	PIK3CA	2.05
119	Craniopharyngioma	Enrichment	CTNNB1	2.05
120	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.05
121	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.05
122	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.05
123	Vitreoretinopathy	Enrichment	LRP5	2.05
124	Capillary malformations, congenital	Enrichment	PIK3CA	1.96
125	Kearns-sayre syndrome	Enrichment	KIF5B	1.96
126	Lymphoma	Enrichment	PTPN11	1.96
127	Holoprosencephaly	Enrichment	FGFR1	1.96
128	Cleft upper lip	Enrichment	GJA1	1.96
129	Hemimegalencephaly	Enrichment	PIK3CA	1.96
130	Genetic motor neuron disease	Enrichment	DCTN1	1.96
131	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.96
132	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.88
133	Cowden syndrome 1	Enrichment	PIK3CA	1.88
134	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.88
135	Holoprosencephaly 1	Enrichment	FGFR1	1.88
136	Patent ductus arteriosus	Enrichment	PTPN11	1.88
137	Adrenocortical carcinoma	Enrichment	CTNNB1	1.88
138	Breast adenocarcinoma	Enrichment	PIK3CA	1.88
139	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.88
140	Cleft lip with or without cleft palate	Enrichment	CTNND1	1.88
141	Dilated cardiomyopathy	Enrichment	KIF5B, MYL2	1.87
142	Nevus, epidermal	Enrichment	PIK3CA	1.81
143	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.81
144	Noonan syndrome 3	Enrichment	PTPN11	1.81
145	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.81
146	Overgrowth syndrome	Enrichment	PIK3R1	1.81
147	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	1.81
148	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.76
149	Hypoplastic left heart syndrome	Enrichment	GJA1	1.76
150	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.70
151	Arteriovenous malformation	Enrichment	PIK3CA	1.70
152	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.70
153	Cowden syndrome	Enrichment	PIK3CA	1.70
154	Autosomal dominant cerebellar ataxia	Enrichment	DAGLA	1.70
155	Ovarian cancer	Enrichment	CTNNB1, PIK3CA	1.68
156	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	1.66
157	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.66
158	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.66
159	Pectus excavatum	Enrichment	PTPN11	1.62
160	Frontotemporal dementia 1	Enrichment	DCTN1	1.62
161	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.62
162	Specific learning disability	Enrichment	PTPN11	1.62
163	Epicanthus	Enrichment	PTPN11	1.58
164	Septooptic dysplasia	Enrichment	FGFR1	1.58
165	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.58
166	Meningioma	Enrichment	PIK3CA	1.58
167	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.58
168	Congenital long qt syndrome	Enrichment	PTPN11	1.58
169	Microcephaly	Enrichment	CTNNB1, PTPN11	1.52
170	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.52
171	Osteoporosis	Enrichment	LRP5	1.52
172	Medulloblastoma	Enrichment	CTNNB1	1.52
173	Heart disease	Enrichment	MYL2	1.52
174	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	1.52
175	Congenital myopathy 4a, autosomal dominant	Enrichment	MYL2	1.49
176	Corpus callosum, agenesis of	Enrichment	CDH2	1.49
177	Lynch syndrome	Enrichment	PIK3CA	1.49
178	Isolated corpus callosum agenesis	Enrichment	CDH2	1.49
179	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.49
180	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.49
181	Inherited cancer-predisposing syndrome	Enrichment	CTNNA1, PTPN11	1.47
182	Gliosarcoma	Enrichment	FGFR1	1.46
183	Microform holoprosencephaly	Enrichment	FGFR1	1.46
184	Lobar holoprosencephaly	Enrichment	FGFR1	1.46
185	Cardiomyopathy, dilated, 1e	Enrichment	MYL2	1.43
186	Giant cell glioblastoma	Enrichment	FGFR1	1.43
187	Patent foramen ovale	Enrichment	PTPN11	1.41
188	Semilobar holoprosencephaly	Enrichment	FGFR1	1.41
189	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.41
190	Arteriovenous malformations of the brain	Enrichment	CDH2	1.38
191	Craniosynostosis	Enrichment	CTNNA1	1.36
192	Endometrial cancer	Enrichment	PIK3CA	1.34
193	Hepatoblastoma	Enrichment	CTNNB1	1.34
194	Attention deficit-hyperactivity disorder	Enrichment	KIF5B	1.32
195	Tooth agenesis	Enrichment	FGFR1	1.32
196	Noonan syndrome 1	Enrichment	PTPN11	1.30
197	Brittle bone disorder	Enrichment	LRP5	1.30
198	Kallmann syndrome	Enrichment	FGFR1	1.30
199	Scoliosis	Enrichment	PTPN11	1.29
200	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.25
201	Rasopathy	Enrichment	PTPN11	1.25
202	Auditory neuropathy	Enrichment	CDH2	1.25
203	Strabismus	Enrichment	PTPN11	1.24
204	Prostate cancer	Enrichment	PIK3CA	1.21
205	Long qt syndrome 1	Enrichment	PTPN11	1.19
206	Non-immune hydrops fetalis	Enrichment	PTPN11	1.18
207	Lung cancer	Enrichment	PIK3CA	1.16
208	Familial hypertrophic cardiomyopathy	Enrichment	MYL2	1.15
209	Charcot-marie-tooth disease	Enrichment	DCTN1	1.06
210	Type 2 diabetes mellitus	Enrichment	PTPN1	1.05
211	Gastric cancer	Enrichment	PIK3CA	1.04
212	Hereditary breast carcinoma	Enrichment	PIK3CA	1.03
213	Thrombocytopenia	Enrichment	PTPN11	1.00
214	Hypertelorism	Enrichment	PIK3CA	0.96
215	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.94
216	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.93
217	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DCTN1	0.92
218	Hereditary retinal dystrophy	Enrichment	CTNNA1, LRP5	0.87
219	Fundus dystrophy	Enrichment	CTNNA1, LRP5	0.87
220	Autism	Enrichment	CAMK2G	0.83
221	Breast cancer	Enrichment	PIK3CA	0.81
222	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.75
223	Congenital nervous system abnormality	Enrichment	CTNNB1	0.68
224	Nervous system disease	Enrichment	CTNNB1	0.68
225	Autism spectrum disorder	Enrichment	PTPN11	0.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

N-cadherin signaling events

Pathway Network for N-cadherin signaling events

Member Pathways for N-cadherin signaling events

Pathways in the N-cadherin signaling events SuperPath

Associated Genes for N-cadherin signaling events

Associated Disorders for N-cadherin signaling events

Disorders associated with N-cadherin signaling events SuperPath

STRING Interaction Network for N-cadherin signaling events

Sources for N-cadherin signaling events