N-glycan antennae elongation in the medial/trans-Golgi
Pathway network for the N-glycan antennae elongation in the medial/trans-Golgi SuperPath
Sources:
- Reactome
- PubChem
Pathways in the N-glycan antennae elongation in the medial/trans-Golgi SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | N-glycan antennae elongation in the medial/trans-Golgi | Reactome | |
| 2 | N-Glycan antennae elongation | Reactome | |
| 3 | complex N-linked glycan biosynthesis (vertebrates) | PubChem | |
| 4 | Reactions specific to the complex N-glycan synthesis pathway | Reactome | |
| 5 | Defective MGAT2 causes CDG-2a | Reactome | |
| 6 | Reactions specific to the hybrid N-glycan synthesis pathway | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | MGAT2 | Alpha-1,6-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase | Protein Coding | 4 |
| 2 | MGAT4B | Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase B | Protein Coding | 3 |
| 3 | MGAT4A | Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A | Protein Coding | 3 |
| 4 | FUT8 | Fucosyltransferase 8 | Protein Coding | 3 |
| 5 | MGAT4C | MGAT4 Family Member C | Protein Coding | 3 |
| 6 | B4GALT1 | Beta-1,4-Galactosyltransferase 1 | Protein Coding | 3 |
| 7 | MAN2A2 | Mannosidase Alpha Class 2A Member 2 | Protein Coding | 3 |
| 8 | MAN2A1 | Mannosidase Alpha Class 2A Member 1 | Protein Coding | 3 |
| 9 | MGAT3 | Beta-1,4-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase | Protein Coding | 3 |
| 10 | MGAT5 | Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase | Protein Coding | 3 |
| 11 | ST6GAL1 | ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1 | Protein Coding | 3 |
| 12 | CGA | Glycoprotein Hormones, Alpha Polypeptide | Protein Coding | 2 |
| 13 | FUCA1 | Alpha-L-Fucosidase 1 | Protein Coding | 2 |
| 14 | FUT3 | Fucosyltransferase 3 (Lewis Blood Group) | Protein Coding | 2 |
| 15 | ST8SIA6 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 6 | Protein Coding | 2 |
| 16 | LHB | Luteinizing Hormone Subunit Beta | Protein Coding | 2 |
| 17 | ST8SIA3 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 3 | Protein Coding | 2 |
| 18 | CHST8 | Carbohydrate Sulfotransferase 8 | Protein Coding | 2 |
| 19 | ST3GAL4 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 | Protein Coding | 2 |
| 20 | ST8SIA2 | ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2 | Protein Coding | 2 |
| 21 | B4GALT4 | Beta-1,4-Galactosyltransferase 4 | Protein Coding | 2 |
| 22 | B4GALT3 | Beta-1,4-Galactosyltransferase 3 | Protein Coding | 2 |
| 23 | B4GALT2 | Beta-1,4-Galactosyltransferase 2 | Protein Coding | 2 |
| 24 | B4GALT6 | Beta-1,4-Galactosyltransferase 6 | Protein Coding | 2 |
| 25 | B4GALT5 | Beta-1,4-Galactosyltransferase 5 | Protein Coding | 2 |
| 26 | CHST10 | Carbohydrate Sulfotransferase 10 | Protein Coding | 2 |
| 27 | MGAT5B | Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase B | Protein Coding | 1 |
| 28 | MGAT1 | Alpha-1,3-Mannosyl-Glycoprotein 2-Beta-N-Acetylglucosaminyltransferase | Protein Coding | 1 |
| 29 | ST3GAL3 | ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 | Protein Coding | 1 |
Disorders associated with N-glycan antennae elongation in the medial/trans-Golgi SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Immunodeficiency 47 | Direct | ||
| 2 | Congenital disorder of glycosylation, type iia | Enrichment | MGAT2 | 3.13 |
| 3 | Hypogonadotropic hypogonadism 23 with or without anosmia | Enrichment | LHB | 3.13 |
| 4 | Blood group, lewis system | Enrichment | FUT3 | 3.13 |
| 5 | Congenital disorder of glycosylation, type iid | Enrichment | B4GALT1 | 2.99 |
| 6 | Intellectual developmental disorder, autosomal recessive 12 | Enrichment | ST3GAL3 | 2.99 |
| 7 | Combined low ldl and fibrinogen | Enrichment | B4GALT1 | 2.99 |
| 8 | St3gal3-cdg | Enrichment | ST3GAL3 | 2.99 |
| 9 | Congenital disorder of glycosylation with defective fucosylation 1 | Enrichment | FUT8 | 2.83 |
| 10 | Developmental and epileptic encephalopathy 15 | Enrichment | ST3GAL3 | 2.69 |
| 11 | Fucosidosis | Enrichment | FUCA1 | 2.53 |
| 12 | Peeling skin syndrome 3 | Enrichment | CHST8 | 2.53 |
| 13 | Variegate porphyria | Enrichment | B4GALT3 | 2.26 |
| 14 | Developmental and epileptic encephalopathy | Enrichment | ST3GAL3 | 1.44 |
| 15 | Congenital nervous system abnormality | Enrichment | FUCA1 | 1.12 |
| 16 | Nervous system disease | Enrichment | FUCA1 | 1.12 |
