NAD metabolism

Pathway network for the NAD metabolism SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways
PubChem

Pathways in the NAD metabolism SuperPath

#	Name	Source	Genes
1	NAD metabolism	GeneGo (Thomson Reuters)	AFMID ALPG ALPI ALPL ALPP AOX1 ART1 ART3 ART4 ART5 BST1 CD38 CYB5R3 CYP2D6 ENPP1 ENPP2 ENPP3 HAAO IDO1 KMO KYNU NADK NADSYN1 NAMPT NMNAT1 NMNAT2 NMNAT3 NMRK1 NMRK2 NNMT NNT NT5C NT5C1A NT5C1B NT5C2 NT5C3A NT5E NT5M NUDT12 PARP1 PARP2 PARP3 PARP4 PNP QPRT SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 TDO2 TNKS TNKS2 (see all 55) (see less)
2	NAD+ biosynthetic pathways	WikiPathways	ACMSD BST1 CD38 IDO1 NADSYN1 NAMPT NAPRT NMNAT1 PARP1 PARP2 PARP4 QPRT SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 TDO2 TNKS TNKS2 (see all 22) (see less)
3	NAD+ metabolism	WikiPathways	CD38 NADK NAMPT NMNAT1 NMNAT2 NMNAT3 NRK NT5E PARP1 SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 (see all 16) (see less)
4	NAD salvage	PubChem	NAMPT NMNAT1 NMNAT2 NMNAT3
5	NAD salvage pathway IV (from nicotinamide riboside)	PubChem	NMNAT1 NMNAT2 NMNAT3
6	NAD phosphorylation and transhydrogenation	PubChem	NADK NNT

Gene overlap in member pathways for NAD metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NMNAT1	Nicotinamide Nucleotide Adenylyltransferase 1	Protein Coding	5
2	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	4
3	NMNAT2	Nicotinamide Nucleotide Adenylyltransferase 2	Protein Coding	4
4	NMNAT3	Nicotinamide Nucleotide Adenylyltransferase 3	Protein Coding	4
5	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	3
6	CD38	CD38 Molecule	Protein Coding	3
7	SIRT2	Sirtuin 2	Protein Coding	3
8	SIRT5	Sirtuin 5	Protein Coding	3
9	SIRT4	Sirtuin 4	Protein Coding	3
10	SIRT3	Sirtuin 3	Protein Coding	3
11	SIRT1	Sirtuin 1	Protein Coding	3
12	SIRT7	Sirtuin 7	Protein Coding	3
13	SIRT6	Sirtuin 6	Protein Coding	3
14	NADK	NAD Kinase	Protein Coding	3
15	PARP4	Poly(ADP-Ribose) Polymerase Family Member 4	Protein Coding	2
16	BST1	Bone Marrow Stromal Cell Antigen 1	Protein Coding	2
17	IDO1	Indoleamine 2,3-Dioxygenase 1	Protein Coding	2
18	NT5E	5''-Nucleotidase Ecto	Protein Coding	2
19	TDO2	Tryptophan 2,3-Dioxygenase	Protein Coding	2
20	TNKS	Tankyrase	Protein Coding	2
21	PARP2	Poly(ADP-Ribose) Polymerase 2	Protein Coding	2
22	QPRT	Quinolinate Phosphoribosyltransferase	Protein Coding	2
23	NNT	Nicotinamide Nucleotide Transhydrogenase	Protein Coding	2
24	NADSYN1	NAD Synthetase 1	Protein Coding	2
25	TNKS2	Tankyrase 2	Protein Coding	2
26	ALPI	Alkaline Phosphatase, Intestinal	Protein Coding	1
27	ALPL	Alkaline Phosphatase, Biomineralization Associated	Protein Coding	1
28	ALPP	Alkaline Phosphatase, Placental	Protein Coding	1
29	ALPG	Alkaline Phosphatase, Germ Cell	Protein Coding	1
30	AOX1	Aldehyde Oxidase 1	Protein Coding	1
31	ART1	ADP-Ribosyltransferase 1	Protein Coding	1
32	ART3	ADP-Ribosyltransferase 3 (Inactive)	Protein Coding	1
33	ART4	ADP-Ribosyltransferase 4 (Inactive) (Dombrock Blood Group)	Protein Coding	1
34	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1
35	CYB5R3	Cytochrome B5 Reductase 3	Protein Coding	1
36	NNMT	Nicotinamide N-Methyltransferase	Protein Coding	1
37	PNP	Purine Nucleoside Phosphorylase	Protein Coding	1
38	ENPP1	Ectonucleotide Pyrophosphatase/Phosphodiesterase 1	Protein Coding	1
39	ENPP2	Ectonucleotide Pyrophosphatase/Phosphodiesterase 2	Protein Coding	1
40	ENPP3	Ectonucleotide Pyrophosphatase/Phosphodiesterase 3	Protein Coding	1
41	KMO	Kynurenine 3-Monooxygenase	Protein Coding	1
42	KYNU	Kynureninase	Protein Coding	1
43	PARP3	Poly(ADP-Ribose) Polymerase Family Member 3	Protein Coding	1
44	NT5C2	5''-Nucleotidase, Cytosolic II	Protein Coding	1
45	HAAO	3-Hydroxyanthranilate 3,4-Dioxygenase	Protein Coding	1
46	NMRK2	Nicotinamide Riboside Kinase 2	Protein Coding	1
47	NT5C	5'', 3''-Nucleotidase, Cytosolic	Protein Coding	1
48	NT5C3A	5''-Nucleotidase, Cytosolic IIIA	Protein Coding	1
49	NMRK1	Nicotinamide Riboside Kinase 1	Protein Coding	1
50	NT5M	5'',3''-Nucleotidase, Mitochondrial	Protein Coding	1
51	NUDT12	Nudix Hydrolase 12	Protein Coding	1
52	NT5C1A	5''-Nucleotidase, Cytosolic IA	Protein Coding	1
53	NT5C1B	5''-Nucleotidase, Cytosolic IB	Protein Coding	1
54	ART5	ADP-Ribosyltransferase 5	Protein Coding	1
55	AFMID	Arylformamidase	Protein Coding	1
56	ACMSD	Aminocarboxymuconate Semialdehyde Decarboxylase	Protein Coding	1
57	NAPRT	Nicotinate Phosphoribosyltransferase	Protein Coding	1
58	NRK	Nik Related Kinase	Protein Coding	1

Disorders associated with NAD metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital nad deficiency disorder	Enrichment	HAAO, KYNU, NADSYN1	6.60
2	Glucocorticoid deficiency 4 with or without mineralocorticoid deficiency	Enrichment	NNT	3.83
3	Spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis	Enrichment	NMNAT1	3.66
4	Leber congenital amaurosis 9	Enrichment	NMNAT1	3.35
5	Familial glucocorticoid deficiency	Enrichment	NNT	3.13
6	Calcification of joints and arteries	Enrichment	NT5E	2.93
7	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.93
8	Diarrhea	Enrichment	NMNAT1	2.88
9	Hypertryptophanemia	Enrichment	TDO2	2.79
10	Vertebral, cardiac, renal, and limb defects syndrome 3	Enrichment	NADSYN1	2.79
11	Renu syndrome	Enrichment	SIRT4	2.45
12	Anemia, congenital, nonspherocytic hemolytic, 8	Enrichment	NT5C3A	2.39
13	Hypophosphatasia, adult	Enrichment	ALPL	2.39
14	Blood group, dombrock system	Enrichment	ART4	2.39
15	Hydroxykynureninuria	Enrichment	KYNU	2.39
16	Hypophosphatasia, childhood	Enrichment	ALPL	2.39
17	Arterial calcification, generalized, of infancy, 1	Enrichment	ENPP1	2.39
18	Vertebral, cardiac, renal, and limb defects syndrome 2	Enrichment	KYNU	2.39
19	Ossification of the posterior longitudinal ligament of spine	Enrichment	ENPP1	2.39
20	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.39
21	Hypophosphatemic rickets, autosomal recessive, 2	Enrichment	ENPP1	2.39
22	Cole disease	Enrichment	ENPP1	2.39
23	Purine nucleoside phosphorylase deficiency	Enrichment	PNP	2.39
24	Prenatal benign hypophosphatasia	Enrichment	ALPL	2.39
25	Hypopigmentation-punctate palmoplantar keratoderma syndrome	Enrichment	ENPP1	2.39
26	Alpi-related inflammatory bowel disease	Enrichment	ALPI	2.39
27	Cone dystrophy	Enrichment	NMNAT1	2.28
28	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	CYB5R3	2.09
29	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ALPL	2.09
30	Vertebral, cardiac, renal, and limb defects syndrome 1	Enrichment	HAAO	2.09
31	Autosomal recessive hypophosphatemic rickets	Enrichment	ENPP1	2.09
32	Catel-manzke syndrome	Enrichment	KYNU	2.09
33	Spastic paraplegia 45, autosomal recessive	Enrichment	NT5C2	2.09
34	Hypophosphatasia	Enrichment	ALPL	2.09
35	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ALPL	2.09
36	Dystonia 28, childhood-onset	Enrichment	ENPP1	2.09
37	Arterial calcification of infancy	Enrichment	ENPP1	2.09
38	Hereditary methemoglobinemia	Enrichment	CYB5R3	2.09
39	Hypophosphatasia, infantile	Enrichment	ALPL	1.92
40	Cone-rod dystrophy 2	Enrichment	NMNAT1	1.82
41	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	CYB5R3	1.79
42	Congenital myopathy 1a	Enrichment	CYB5R3	1.79
43	Leber plus disease	Enrichment	NMNAT1	1.68
44	Pseudoxanthoma elasticum	Enrichment	ENPP1	1.62
45	Hypophosphatemic rickets	Enrichment	ENPP1	1.55
46	Hereditary retinal dystrophy	Enrichment	NMNAT1	1.20
47	Fundus dystrophy	Enrichment	NMNAT1	1.20
48	Primary ovarian insufficiency	Enrichment	SIRT6	1.17
49	Brittle bone disorder	Enrichment	ALPL	1.05
50	Severe combined immunodeficiency	Enrichment	PNP	0.90
51	Type 2 diabetes mellitus	Enrichment	ENPP1	0.80
52	Body mass index quantitative trait locus 11	Enrichment	ENPP1	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for NAD metabolism

Pathway network for the NAD metabolism SuperPath

Member Pathways for NAD metabolism

Pathways in the NAD metabolism SuperPath

Gene overlap in member pathways for NAD metabolism SuperPath

Associated Genes for NAD metabolism

Associated Disorders for NAD metabolism

Disorders associated with NAD metabolism SuperPath

STRING Interaction Network for NAD metabolism

Sources for NAD metabolism