NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

No Pathway Network information available for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Pathways in the NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence SuperPath

#	Name	Source	Genes
1	NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence	WikiPathways	CCL27 GOT1 GOT2 HMGA1 IL1B IL6 MDH1 MDH2 NAMPT NMNAT2 PARP1 RELA SIRT1 SIRT2 SIRT3 SIRT5 TP53 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
2	TP53	Tumor Protein P53	Protein Coding	1
3	MDH2	Malate Dehydrogenase 2	Protein Coding	1
4	MDH1	Malate Dehydrogenase 1	Protein Coding	1
5	IL6	Interleukin 6	Protein Coding	1
6	IL1B	Interleukin 1 Beta	Protein Coding	1
7	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
8	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	1
9	SIRT1	Sirtuin 1	Protein Coding	1
10	SIRT3	Sirtuin 3	Protein Coding	1
11	SIRT2	Sirtuin 2	Protein Coding	1
12	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
13	CCL27	C-C Motif Chemokine Ligand 27	Protein Coding	1
14	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	1
15	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	1
16	SIRT5	Sirtuin 5	Protein Coding	1
17	NMNAT2	Nicotinamide Nucleotide Adenylyltransferase 2	Protein Coding	1

Disorders associated with NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 2 diabetes mellitus	Enrichment	HMGA1, IL6	2.91
2	Bone marrow failure syndrome 5	Enrichment	TP53	2.90
3	Papilloma of choroid plexus	Enrichment	TP53	2.90
4	Basal cell carcinoma 7	Enrichment	TP53	2.90
5	Anaplastic thyroid carcinoma	Enrichment	TP53	2.90
6	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	2.90
7	Ductal carcinoma in situ	Enrichment	TP53	2.90
8	Developmental and epileptic encephalopathy 51	Enrichment	MDH2	2.90
9	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.90
10	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.90
11	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.90
12	Choroid plexus cancer	Enrichment	TP53	2.90
13	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.90
14	Gastric cancer	Enrichment	IL1B, TP53	2.89
15	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.60
16	Cervical cancer	Enrichment	TP53	2.60
17	Lymphoma, hodgkin, classic	Enrichment	TP53	2.60
18	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.60
19	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.60
20	Developmental and epileptic encephalopathy 88	Enrichment	MDH1	2.60
21	Rela fusion-positive ependymoma	Enrichment	RELA	2.60
22	Congenital fibrosarcoma	Enrichment	TP53	2.60
23	Li-fraumeni syndrome 1	Enrichment	TP53	2.60
24	Sarcoma	Enrichment	TP53	2.60
25	Cervix carcinoma	Enrichment	TP53	2.60
26	Hodgkin's lymphoma	Enrichment	TP53	2.60
27	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.60
28	Osteogenic sarcoma	Enrichment	TP53	2.43
29	Nasopharyngeal carcinoma	Enrichment	TP53	2.43
30	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.43
31	Anaplastic astrocytoma	Enrichment	TP53	2.43
32	Squamous cell carcinoma	Enrichment	TP53	2.43
33	Adenocarcinoma	Enrichment	TP53	2.43
34	Bone osteosarcoma	Enrichment	TP53	2.43
35	Kaposi sarcoma	Enrichment	IL6	2.30
36	Small cell cancer of the lung	Enrichment	TP53	2.30
37	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.30
38	Lung sarcomatoid carcinoma	Enrichment	TP53	2.30
39	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.30
40	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.30
41	Rhabdomyosarcoma 2	Enrichment	TP53	2.20
42	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.20
43	Lymphoma	Enrichment	TP53	2.20
44	Acute megakaryocytic leukemia	Enrichment	TP53	2.20
45	Li-fraumeni syndrome	Enrichment	TP53	2.13
46	Type 1 diabetes mellitus	Enrichment	IL6	2.13
47	Adrenocortical carcinoma	Enrichment	TP53	2.13
48	Breast adenocarcinoma	Enrichment	TP53	2.13
49	Esophageal cancer	Enrichment	TP53	2.06
50	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.06
51	Essential thrombocythemia	Enrichment	TP53	2.06
52	Gallbladder cancer	Enrichment	TP53	2.06
53	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.06
54	Glioma susceptibility 1	Enrichment	TP53	2.00
55	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.00
56	Inflammatory bowel disease 1	Enrichment	IL6	1.95
57	Adult hepatocellular carcinoma	Enrichment	TP53	1.95
58	Primary hyperaldosteronism	Enrichment	TP53	1.95
59	Leukemia, chronic lymphocytic	Enrichment	TP53	1.90
60	Familial colorectal cancer	Enrichment	TP53	1.90
61	Myelodysplastic syndrome	Enrichment	TP53	1.86
62	Lip and oral cavity carcinoma	Enrichment	TP53	1.83
63	Lung cancer susceptibility 3	Enrichment	TP53	1.76
64	Rhabdomyosarcoma	Enrichment	TP53	1.70
65	Gliosarcoma	Enrichment	TP53	1.70
66	Giant cell glioblastoma	Enrichment	TP53	1.68
67	Arteriovenous malformations of the brain	Enrichment	IL6	1.63
68	Diffuse large b-cell lymphoma	Enrichment	TP53	1.63
69	Hepatoblastoma	Enrichment	TP53	1.58
70	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MDH2	1.58
71	Hepatocellular carcinoma	Enrichment	TP53	1.56
72	Diamond-blackfan anemia 1	Enrichment	TP53	1.55
73	Pancreatic cancer	Enrichment	TP53	1.51
74	Developmental and epileptic encephalopathy 1	Enrichment	MDH2	1.51
75	Bladder cancer	Enrichment	TP53	1.45
76	Prostate cancer	Enrichment	TP53	1.45
77	Developmental and epileptic encephalopathy	Enrichment	GOT2	1.35
78	Diamond-blackfan anemia	Enrichment	TP53	1.35
79	Leukemia, acute myeloid	Enrichment	TP53	1.31
80	West syndrome	Enrichment	MDH2	1.27
81	Hereditary breast carcinoma	Enrichment	TP53	1.27
82	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.18
83	Myeloma, multiple	Enrichment	TP53	1.17
84	Breast cancer	Enrichment	TP53	1.05
85	Colorectal cancer	Enrichment	TP53	0.98
86	Ovarian cancer	Enrichment	TP53	0.92
87	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Pathway Network for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Member Pathways for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Pathways in the NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence SuperPath

Associated Genes for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Associated Disorders for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Disorders associated with NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence SuperPath

STRING Interaction Network for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence

Sources for NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence