Nanoparticle triggered regulated necrosis

No Pathway Network information available for Nanoparticle triggered regulated necrosis

Pathways in the Nanoparticle triggered regulated necrosis SuperPath

#	Name	Source	Genes
1	Nanoparticle triggered regulated necrosis	WikiPathways	CASP8 FADD FTL MAPK8 PARP1 PLA2G4A RIPK1 RIPK3 TICAM1 TNF TNFRSF1A TRADD (see all 12) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FTL	Ferritin Light Chain	Protein Coding	1
2	TNF	Tumor Necrosis Factor	Protein Coding	1
3	FADD	Fas Associated Via Death Domain	Protein Coding	1
4	CASP8	Caspase 8	Protein Coding	1
5	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
6	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
7	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
8	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	1
9	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
10	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
11	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
12	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1

Disorders associated with Nanoparticle triggered regulated necrosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	3.05
2	Caspase 8 deficiency	Enrichment	CASP8	3.05
3	Neurodegeneration with brain iron accumulation 3	Enrichment	FTL	3.05
4	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	3.05
5	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	3.05
6	Multiple sclerosis 5	Enrichment	TNFRSF1A	3.05
7	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	3.05
8	L-ferritin deficiency	Enrichment	FTL	3.05
9	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	3.05
10	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	3.05
11	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	3.05
12	Genetic hyperferritinemia without iron overload	Enrichment	FTL	3.05
13	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	3.05
14	Hyperferritinemia with or without cataract	Enrichment	FTL	2.75
15	Immunodeficiency 127	Enrichment	TNF	2.75
16	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.75
17	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.75
18	Oculootodental syndrome	Enrichment	FADD	2.75
19	Psoriatic arthritis	Enrichment	TNF	2.58
20	Migraine without aura	Enrichment	TNF	2.58
21	Cerebral malaria	Enrichment	TNF	2.45
22	Vascular dementia	Enrichment	TNF	2.35
23	Herpes simplex virus encephalitis	Enrichment	TICAM1	2.35
24	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	2.28
25	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	2.28
26	Charge syndrome	Enrichment	TNFRSF1A	2.10
27	Adult hepatocellular carcinoma	Enrichment	CASP8	2.10
28	Immune deficiency disease	Enrichment	RIPK1	2.01
29	Asthma	Enrichment	TNF	2.01
30	Alzheimer's disease	Enrichment	TNF	1.94
31	Multiple sclerosis	Enrichment	TNFRSF1A	1.91
32	Behcet syndrome	Enrichment	TNFRSF1A	1.78
33	Hepatocellular carcinoma	Enrichment	CASP8	1.71
34	Malaria	Enrichment	TNF	1.70
35	Autoinflammatory disease	Enrichment	TNFRSF1A	1.68
36	Lung cancer	Enrichment	CASP8	1.55
37	Systemic lupus erythematosus	Enrichment	TNF	1.47
38	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	1.32
39	Breast cancer	Enrichment	CASP8	1.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nanoparticle triggered regulated necrosis

Pathway Network for Nanoparticle triggered regulated necrosis

Member Pathways for Nanoparticle triggered regulated necrosis

Pathways in the Nanoparticle triggered regulated necrosis SuperPath

Associated Genes for Nanoparticle triggered regulated necrosis

Associated Disorders for Nanoparticle triggered regulated necrosis

Disorders associated with Nanoparticle triggered regulated necrosis SuperPath

STRING Interaction Network for Nanoparticle triggered regulated necrosis

Sources for Nanoparticle triggered regulated necrosis