Nectin adhesion pathway

No Pathway Network information available for Nectin adhesion pathway

Pathways in the Nectin adhesion pathway SuperPath

#	Name	Source	Genes
1	Nectin adhesion pathway	PubChem	AFDN CDC42 CDH1 CLDN1 CRK CTNNA1 CTNNB1 F11R FARP2 IQGAP1 ITGAV ITGB3 NECTIN1 NECTIN2 NECTIN3 PDGFB PDGFRB PIK3CA PIK3R1 PIP5K1C PTK2 PTPRM PVR RAC1 RAPGEF1 SRC TLN1 VAV2 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CLDN1	Claudin 1	Protein Coding	1
2	PTPRM	Protein Tyrosine Phosphatase Receptor Type M	Protein Coding	1
3	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
4	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
5	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
6	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
7	F11R	F11 Receptor	Protein Coding	1
8	NECTIN2	Nectin Cell Adhesion Molecule 2	Protein Coding	1
9	NECTIN3	Nectin Cell Adhesion Molecule 3	Protein Coding	1
10	PVR	PVR Cell Adhesion Molecule	Protein Coding	1
11	CTNNB1	Catenin Beta 1	Protein Coding	1
12	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	1
13	CTNNA1	Catenin Alpha 1	Protein Coding	1
14	CDH1	Cadherin 1	Protein Coding	1
15	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
16	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
17	CDC42	Cell Division Cycle 42	Protein Coding	1
18	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
19	FARP2	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2	Protein Coding	1
20	TLN1	Talin 1	Protein Coding	1
21	RAC1	Rac Family Small GTPase 1	Protein Coding	1
22	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
23	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
24	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
25	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
26	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
27	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
28	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Nectin adhesion pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	CDH1, CTNNA1, CTNNB1, PIK3CA, PIK3R1, SRC	7.71
2	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.91
3	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	4.61
4	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA	4.07
5	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	3.94
6	Adult hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.83
7	Meningioma	Enrichment	PDGFB, PIK3CA	3.57
8	Cleft lip/palate	Enrichment	CDH1, NECTIN1	3.43
9	Endometrial cancer	Enrichment	CDH1, PIK3CA	3.07
10	Hepatocellular carcinoma	Enrichment	CTNNB1, PIK3CA	3.03
11	Ovarian cancer	Enrichment	CDH1, CTNNB1, PIK3CA	2.94
12	Bladder cancer	Enrichment	CTNNB1, PIK3CA	2.79
13	Prostate cancer	Enrichment	CDH1, PIK3CA	2.79
14	Macrodactyly	Enrichment	PIK3CA	2.69
15	Cleft lip/palate-ectodermal dysplasia syndrome	Enrichment	NECTIN1	2.69
16	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.69
17	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.69
18	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.69
19	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.69
20	Cowden syndrome 5	Enrichment	PIK3CA	2.69
21	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.69
22	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.69
23	Short syndrome	Enrichment	PIK3R1	2.69
24	Orofacial cleft 7	Enrichment	NECTIN1	2.69
25	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.69
26	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.69
27	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.69
28	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.69
29	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.69
30	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.69
31	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.69
32	Thrombocytopenia 6	Enrichment	SRC	2.69
33	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.69
34	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.69
35	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.69
36	Adenoid ameloblastoma	Enrichment	CTNNB1	2.69
37	Hypospadias	Enrichment	PIK3CA	2.69
38	Breast lobular carcinoma	Enrichment	CDH1	2.69
39	Rare venous malformation	Enrichment	PIK3CA	2.69
40	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.69
41	Diaphragmatic eventration	Enrichment	PIK3CA	2.69
42	Capillary leak syndrome	Enrichment	TLN1	2.69
43	Nocarh syndrome	Enrichment	CDC42	2.69
44	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.69
45	Rare combined vascular malformation	Enrichment	PIK3CA	2.69
46	Cavernous lymphangioma	Enrichment	PIK3CA	2.69
47	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.69
48	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.69
49	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.69
50	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.69
51	Macrodactyly of toe	Enrichment	PIK3CA	2.69
52	Microcystic stromal tumor	Enrichment	CTNNB1	2.69
53	Gastric cancer	Enrichment	CDH1, PIK3CA	2.45
54	Hereditary breast carcinoma	Enrichment	CDH1, PIK3CA	2.43
55	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.38
56	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.38
57	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.38
58	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.38
59	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.38
60	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1	2.38
61	Keratosis, seborrheic	Enrichment	PIK3CA	2.38
62	Noonan syndrome 8	Enrichment	PIK3CA	2.38
63	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.38
64	Infantile myofibromatosis	Enrichment	PDGFRB	2.38
65	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.38
66	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.38
67	Immune system disease	Enrichment	CDC42	2.38
68	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.38
69	Teratoma	Enrichment	CTNNB1	2.38
70	Thrombocytopenia	Enrichment	ITGB3, SRC	2.36
71	Desmoid disease, hereditary	Enrichment	CTNNB1	2.21
72	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.21
73	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.21
74	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.21
75	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.21
76	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.21
77	Anus, imperforate	Enrichment	CTNNB1	2.21
78	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.21
79	Desmoid tumor	Enrichment	CTNNB1	2.21
80	Immunodeficiency 14	Enrichment	PIK3R1	2.21
81	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.21
82	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.21
83	Keratoacanthoma	Enrichment	PIK3CA	2.21
84	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	2.08
85	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.08
86	Pilomatrixoma	Enrichment	CTNNB1	2.08
87	Alazami syndrome	Enrichment	CTNNB1	2.08
88	Cerebrovascular disease	Enrichment	PIK3CA	2.08
89	Craniopharyngioma	Enrichment	CTNNB1	2.08
90	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.08
91	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.08
92	Cleft lip and alveolus	Enrichment	NECTIN1	2.08
93	Capillary malformations, congenital	Enrichment	PIK3CA	1.99
94	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.99
95	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.99
96	Cleft upper lip	Enrichment	NECTIN1	1.99
97	Hemimegalencephaly	Enrichment	PIK3CA	1.99
98	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.99
99	Breast cancer	Enrichment	CDH1, PIK3CA	1.98
100	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.91
101	Cowden syndrome 1	Enrichment	PIK3CA	1.91
102	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.91
103	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.91
104	Adrenocortical carcinoma	Enrichment	CTNNB1	1.91
105	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.91
106	Breast adenocarcinoma	Enrichment	PIK3CA	1.91
107	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.91
108	Cleft lip with or without cleft palate	Enrichment	CDH1	1.91
109	Nevus, epidermal	Enrichment	PIK3CA	1.84
110	Myelofibrosis	Enrichment	SRC	1.84
111	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.84
112	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.84
113	Overgrowth syndrome	Enrichment	PIK3R1	1.84
114	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.79
115	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.73
116	Arteriovenous malformation	Enrichment	PIK3CA	1.73
117	Cowden syndrome	Enrichment	PIK3CA	1.73
118	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.69
119	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.69
120	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.69
121	Meningioma, familial	Enrichment	PDGFB	1.65
122	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.65
123	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.61
124	Osteoporosis	Enrichment	SRC	1.54
125	Medulloblastoma	Enrichment	CTNNB1	1.54
126	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CTNNA1	1.52
127	Hydrocephalus	Enrichment	PDGFRB	1.52
128	Lynch syndrome	Enrichment	PIK3CA	1.52
129	Dandy-walker syndrome	Enrichment	PDGFRB	1.46
130	Polycystic liver disease	Enrichment	CTNNB1	1.46
131	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.46
132	Craniosynostosis	Enrichment	CTNNA1	1.39
133	Hepatoblastoma	Enrichment	CTNNB1	1.37
134	Myocardial infarction	Enrichment	ITGB3	1.35
135	Severe covid-19	Enrichment	ITGAV	1.23
136	Lung cancer	Enrichment	PIK3CA	1.19
137	Cerebral palsy	Enrichment	PDGFRB	1.11
138	Hypertelorism	Enrichment	PIK3CA	0.99
139	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.97
140	Schizophrenia	Enrichment	PTPRM	0.94
141	Congenital nervous system abnormality	Enrichment	CTNNB1	0.70
142	Nervous system disease	Enrichment	CTNNB1	0.70
143	Microcephaly	Enrichment	CTNNB1	0.65
144	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.34
145	Fundus dystrophy	Enrichment	CTNNA1	0.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nectin adhesion pathway

Pathway Network for Nectin adhesion pathway

Member Pathways for Nectin adhesion pathway

Pathways in the Nectin adhesion pathway SuperPath

Associated Genes for Nectin adhesion pathway

Associated Disorders for Nectin adhesion pathway

Disorders associated with Nectin adhesion pathway SuperPath

STRING Interaction Network for Nectin adhesion pathway

Sources for Nectin adhesion pathway