Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Pathway network for the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

Sources:

Reactome

Pathways in the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

#	Name	Source	Genes
1	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	Reactome	AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H B2M CD28 CD4 CD8B HLA-A LCK PACS1 (see all 21) (see less)
2	The role of Nef in HIV-1 replication and disease pathogenesis	Reactome	AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H B2M CD247 CD28 CD4 CD8B DOCK2 ELMO1 FYN HCK HLA-A LCK PACS1 PAK2 RAC1 (see all 28) (see less)
3	Nef mediated downregulation of MHC class I complex cell surface expression	Reactome	AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 B2M HLA-A PACS1 (see all 10) (see less)
4	Nef Mediated CD4 Down-regulation	Reactome	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ARF1 ATP6V1H CD4 LCK (see all 9) (see less)
5	Nef and signal transduction	Reactome	CD247 DOCK2 ELMO1 FYN HCK LCK PAK2 RAC1 (see all 8) (see less)
6	Nef Mediated CD8 Down-regulation	Reactome	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 ATP6V1H CD8B (see all 7) (see less)
7	Nef mediated downregulation of CD28 cell surface expression	Reactome	AP2M1 CD28
8	Blockage of phagosome acidification	Reactome	ATP6V1H

Gene overlap in member pathways for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	5
2	ATP6V1H	ATPase H+ Transporting V1 Subunit H	Protein Coding	5
3	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	4
4	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	4
5	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	4
6	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	4
7	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	4
8	AP1M2	Adaptor Related Protein Complex 1 Subunit Mu 2	Protein Coding	3
9	AP1S1	Adaptor Related Protein Complex 1 Subunit Sigma 1	Protein Coding	3
10	AP1S3	Adaptor Related Protein Complex 1 Subunit Sigma 3	Protein Coding	3
11	AP1B1	Adaptor Related Protein Complex 1 Subunit Beta 1	Protein Coding	3
12	AP1G1	Adaptor Related Protein Complex 1 Subunit Gamma 1	Protein Coding	3
13	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	3
14	ARF1	ARF GTPase 1	Protein Coding	3
15	PACS1	Phosphofurin Acidic Cluster Sorting Protein 1	Protein Coding	3
16	B2M	Beta-2-Microglobulin	Protein Coding	3
17	AP1S2	Adaptor Related Protein Complex 1 Subunit Sigma 2	Protein Coding	3
18	AP1M1	Adaptor Related Protein Complex 1 Subunit Mu 1	Protein Coding	3
19	CD4	CD4 Molecule	Protein Coding	3
20	CD8B	CD8 Subunit Beta	Protein Coding	3
21	CD28	CD28 Molecule	Protein Coding	3
22	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	2
23	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
24	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
25	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
26	RAC1	Rac Family Small GTPase 1	Protein Coding	2
27	CD247	CD247 Molecule	Protein Coding	2
28	ELMO1	Engulfment And Cell Motility 1	Protein Coding	2

Disorders associated with Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus infectious disease	Direct
2	Tuberculosis	Direct
3	Mednik syndrome	Enrichment	AP1B1, AP1S1	4.91
4	Keratitis-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	AP1B1	2.69
5	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.69
6	Immunodeficiency 43	Enrichment	B2M	2.69
7	Knobloch syndrome 2	Enrichment	PAK2	2.69
8	Okt4 epitope deficiency	Enrichment	CD4	2.69
9	Dialysis-related amyloidosis	Enrichment	B2M	2.69
10	Usmani-riazuddin syndrome, autosomal recessive	Enrichment	AP1G1	2.69
11	Immunodeficiency 25	Enrichment	CD247	2.69
12	Immunodeficiency 40	Enrichment	DOCK2	2.69
13	Birdshot chorioretinopathy	Enrichment	HLA-A	2.69
14	Psoriasis 15, pustular	Enrichment	AP1S3	2.69
15	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.69
16	Immunodeficiency 22	Enrichment	LCK	2.69
17	Usmani-riazuddin syndrome, autosomal dominant	Enrichment	AP1G1	2.69
18	Immunodeficiency 79	Enrichment	CD4	2.69
19	Amyloidosis, hereditary systemic 6	Enrichment	B2M	2.69
20	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.69
21	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.69
22	Severe combined immunodeficiency	Enrichment	CD247, LCK	2.68
23	Severe cutaneous adverse reaction	Enrichment	HLA-A	2.38
24	Schuurs-hoeijmakers syndrome	Enrichment	PACS1	2.38
25	Psoriasis 14, pustular	Enrichment	AP1S3	2.38
26	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.38
27	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.38
28	Pettigrew syndrome	Enrichment	AP1S2	2.38
29	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.38
30	Mycosis fungoides	Enrichment	CD28	2.21
31	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247	2.21
32	Saczary syndrome	Enrichment	CD28	2.21
33	Knobloch syndrome	Enrichment	PAK2	2.08
34	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M	2.08
35	Amyloidosis, hereditary systemic 2	Enrichment	B2M	1.99
36	Knobloch syndrome 1	Enrichment	PAK2	1.99
37	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.84
38	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.84
39	Lymphoma, non-hodgkin, familial	Enrichment	B2M	1.79
40	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.73
41	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.73
42	Periventricular nodular heterotopia	Enrichment	ARF1	1.54
43	Severe covid-19	Enrichment	HLA-A	1.23
44	Complex neurodevelopmental disorder	Enrichment	AP1G1	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Pathway Network for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Pathway network for the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

Member Pathways for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Pathways in the Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

Gene overlap in member pathways for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

Associated Genes for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Associated Disorders for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Disorders associated with Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters SuperPath

STRING Interaction Network for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Sources for Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters