Negative regulation of FGFR3 signaling

Pathway network for the Negative regulation of FGFR3 signaling SuperPath

Sources:

Reactome

Pathways in the Negative regulation of FGFR3 signaling SuperPath

#	Name	Source	Genes
1	Negative regulation of FGFR3 signaling	Reactome	BRAF CBL FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 GRB2 MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC (see all 29) (see less)
2	Signaling by FGFR1	Reactome	ANOS1 BRAF CBL FGF1 FGF10 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FGFRL1 FLRT1 FLRT2 FLRT3 FRS2 FRS3 GAB1 GIPC1 GRB2 HRAS KL KRAS MAPK1 MAPK3 MKNK1 NRAS PIK3CA PIK3R1 PLCG1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SHC1 SOS1 SPRED1 SPRED2 SPRY2 SRC TGFBR3 UBA52 UBB UBC (see all 52) (see less)
3	Signaling by FGFR4	Reactome	BRAF CBL FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 FRS2 FRS3 GAB1 GRB2 HRAS KLB KRAS MAPK1 MAPK3 MKNK1 NRAS PIK3CA PIK3R1 PLCG1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SHC1 SOS1 SPRY2 SRC UBA52 UBB UBC (see all 41) (see less)
4	Signaling by FGFR3	Reactome	BRAF CBL FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF23 FGF4 FGF5 FGF8 FGF9 FGFR3 FRS2 FRS3 GAB1 GALNT3 GRB2 HRAS KRAS MAPK1 MAPK3 MKNK1 NRAS PIK3CA PIK3R1 PLCG1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SHC1 SOS1 SPRY2 SRC UBA52 UBB UBC (see all 40) (see less)
5	Negative regulation of FGFR2 signaling	Reactome	BRAF CBL FGF1 FGF10 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR2 FRS2 GRB2 MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC (see all 34) (see less)
6	Negative regulation of FGFR1 signaling	Reactome	ANOS1 BRAF CBL FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 FRS2 GRB2 KL MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC (see all 33) (see less)
7	Negative regulation of FGFR4 signaling	Reactome	BRAF CBL FGF1 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF23 FGF4 FGF6 FGF8 FGF9 FGFR4 FRS2 GRB2 KLB MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC (see all 31) (see less)
8	FGFR1 ligand binding and activation	Reactome	ANOS1 FGF1 FGF10 FGF17 FGF2 FGF20 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 GIPC1 KL TGFBR3 (see all 18) (see less)
9	Spry regulation of FGF signaling	Reactome	BRAF CBL GRB2 MAPK1 MAPK3 MKNK1 PPP2CA PPP2CB PPP2R1A PTPN11 RPS27A SPRY2 SRC UBA52 UBB UBC (see all 16) (see less)
10	FGFR1c ligand binding and activation	Reactome	ANOS1 FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 GIPC1 TGFBR3 (see all 14) (see less)
11	FGFRL1 modulation of FGFR1 signaling	Reactome	FGF10 FGF17 FGF18 FGF2 FGF22 FGF23 FGF3 FGF4 FGF5 FGF8 FGFRL1 SPRED1 SPRED2 (see all 13) (see less)
12	Signaling by activated point mutants of FGFR1	Reactome	FGF1 FGF17 FGF2 FGF20 FGF23 FGF4 FGF5 FGF6 FGF8 FGF9 FGFR1 (see all 11) (see less)
13	FGFR1b ligand binding and activation	Reactome	FGF1 FGF10 FGF2 FGF22 FGF3 FGFR1 GIPC1 TGFBR3 (see all 8) (see less)
14	TGFBR3 regulates FGF2 signaling	Reactome	FGF2 GIPC1 TGFBR3

Gene overlap in member pathways for Negative regulation of FGFR3 signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FGF2	Fibroblast Growth Factor 2	Protein Coding	13
2	FGF1	Fibroblast Growth Factor 1	Protein Coding	11
3	FGF4	Fibroblast Growth Factor 4	Protein Coding	11
4	FGF8	Fibroblast Growth Factor 8	Protein Coding	11
5	FGF23	Fibroblast Growth Factor 23	Protein Coding	11
6	FGF17	Fibroblast Growth Factor 17	Protein Coding	11
7	FGF9	Fibroblast Growth Factor 9	Protein Coding	10
8	FGF20	Fibroblast Growth Factor 20	Protein Coding	10
9	FGF5	Fibroblast Growth Factor 5	Protein Coding	9
10	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	8
11	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	8
12	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	8
13	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	8
14	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	8
15	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	8
16	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	8
17	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	8
18	RPS27A	Ribosomal Protein S27a	Protein Coding	8
19	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	8
20	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	8
21	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	8
22	UBB	Ubiquitin B	Protein Coding	8
23	UBC	Ubiquitin C	Protein Coding	8
24	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	8
25	CBL	Cbl Proto-Oncogene	Protein Coding	8
26	FGF6	Fibroblast Growth Factor 6	Protein Coding	8
27	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	7
28	FGF18	Fibroblast Growth Factor 18	Protein Coding	7
29	FGF3	Fibroblast Growth Factor 3	Protein Coding	6
30	FGF10	Fibroblast Growth Factor 10	Protein Coding	6
31	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	6
32	FGF22	Fibroblast Growth Factor 22	Protein Coding	6
33	FGF16	Fibroblast Growth Factor 16	Protein Coding	5
34	GIPC1	GIPC PDZ Domain Containing Family Member 1	Protein Coding	5
35	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	5
36	ANOS1	Anosmin 1	Protein Coding	4
37	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	3
38	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	3
39	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
40	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
41	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
42	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
43	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
44	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
45	SHC1	SHC Adaptor Protein 1	Protein Coding	3
46	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	3
47	KL	Klotho	Protein Coding	3
48	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	2
49	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	2
50	SPRED2	Sprouty Related EVH1 Domain Containing 2	Protein Coding	2
51	FGFRL1	Fibroblast Growth Factor Receptor Like 1	Protein Coding	2
52	KLB	Klotho Beta	Protein Coding	2
53	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	2
54	FGF19	Fibroblast Growth Factor 19	Protein Coding	2
55	FLRT3	Fibronectin Leucine Rich Transmembrane Protein 3	Protein Coding	1
56	FLRT2	Fibronectin Leucine Rich Transmembrane Protein 2	Protein Coding	1
57	FLRT1	Fibronectin Leucine Rich Transmembrane Protein 1	Protein Coding	1
58	GALNT3	Polypeptide N-Acetylgalactosaminyltransferase 3	Protein Coding	1
59	FGF7	Fibroblast Growth Factor 7	Protein Coding	1
60	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1

Disorders associated with Negative regulation of FGFR3 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bone development disease	Direct
2	Rasopathy	Enrichment	BRAF, CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	16.00
3	Noonan syndrome 1	Enrichment	BRAF, CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	11.81
4	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	11.69
5	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	10.77
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, PIK3CA	10.11
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	8.64
8	Kallmann syndrome	Enrichment	ANOS1, FGF17, FGF8, FGFR1	8.21
9	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, PTPN11	7.50
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.02
11	Colorectal cancer	Enrichment	BRAF, FGFR3, NRAS, PIK3CA, PIK3R1, SRC	6.73
12	Lung squamous cell carcinoma	Enrichment	FGFR3, KRAS, PIK3CA	6.33
13	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	6.15
14	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	6.08
15	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	6.08
16	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	6.08
17	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS	5.88
18	Bladder cancer	Enrichment	FGFR3, HRAS, KRAS, PIK3CA	5.84
19	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	5.84
20	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS	5.74
21	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23, KL	5.30
22	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	5.29
23	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	5.11
24	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11	5.11
25	Pulmonic stenosis	Enrichment	BRAF, SOS1	5.07
26	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	5.07
27	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.07
28	Holoprosencephaly	Enrichment	FGF8, FGFR1	5.01
29	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.84
30	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.84
31	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	4.83
32	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2	4.74
33	Lung cancer susceptibility 3	Enrichment	BRAF, FGF10, KRAS	4.73
34	Langerhans cell histiocytosis	Enrichment	BRAF, NRAS	4.60
35	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.60
36	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.60
37	Spermatocytoma	Enrichment	FGFR3, HRAS	4.60
38	Hypogonadotropic hypogonadism	Enrichment	ANOS1, FGFR1	4.45
39	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS	4.30
40	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS	4.30
41	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.30
42	Specific learning disability	Enrichment	MAPK1, PTPN11	4.15
43	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	ANOS1, FGFR1	4.05
44	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	4.00
45	Lung cancer	Enrichment	BRAF, KRAS, PIK3CA	3.95
46	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	3.93
47	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	3.93
48	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.90
49	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	3.82
50	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.75
51	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.75
52	Oculopharyngodistal myopathy 2	Enrichment	GIPC1	3.66
53	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8, KLB, PTPN11	3.56
54	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.52
55	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.42
56	Osteoglophonic dysplasia	Enrichment	FGFR1	3.23
57	Trigonocephaly 1	Enrichment	FGFR1	3.23
58	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	3.23
59	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	3.23
60	Hartsfield syndrome	Enrichment	FGFR1	3.23
61	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	3.23
62	Interstitial lung disease specific to childhood	Enrichment	FGF10	3.23
63	Myeloma, multiple	Enrichment	BRAF, FGFR3, KRAS	3.23
64	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.06
65	Legius syndrome	Enrichment	SPRED1	3.02
66	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	3.02
67	Noonan syndrome 14	Enrichment	SPRED2	3.02
68	Familial isolated trichomegaly	Enrichment	FGF5	3.02
69	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	3.02
70	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	3.02
71	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	3.02
72	Rhabdomyosarcoma	Enrichment	CBL, HRAS	3.00
73	Multiple synostoses syndrome 3	Enrichment	FGF9	2.99
74	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	2.99
75	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	2.96
76	Otodental dysplasia	Enrichment	FGF3	2.93
77	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.93
78	Pfeiffer syndrome	Enrichment	FGFR1	2.93
79	Jackson-weiss syndrome	Enrichment	FGFR1	2.93
80	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	2.93
81	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.93
82	Oculootodental syndrome	Enrichment	FGF3	2.93
83	Metachondromatosis	Enrichment	PTPN11	2.93
84	Noonan syndrome 7	Enrichment	BRAF	2.93
85	Leopard syndrome 3	Enrichment	BRAF	2.93
86	Leopard syndrome 1	Enrichment	PTPN11	2.93
87	Iga nephropathy 3	Enrichment	SPRY2	2.93
88	Noonan syndrome 13	Enrichment	MAPK1	2.93
89	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.93
90	Lymphangioma	Enrichment	BRAF	2.93
91	Phace association	Enrichment	BRAF	2.93
92	Thrombocytopenia 6	Enrichment	SRC	2.93
93	Syringocystadenoma papilliferum	Enrichment	BRAF	2.93
94	Ganglioglioma	Enrichment	BRAF	2.93
95	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.93
96	Phace syndrome	Enrichment	BRAF	2.93
97	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.93
98	Classic hairy cell leukemia	Enrichment	BRAF	2.93
99	Malignant astrocytoma	Enrichment	PTPN11	2.93
100	Tumoral calcinosis, hyperphosphatemic, familial, 3	Enrichment	KL	2.88
101	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	2.86
102	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.85
103	Thrombocytopenia	Enrichment	PTPN11, SRC	2.85
104	Oculopharyngodistal myopathy 1	Enrichment	GIPC1	2.81
105	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.75
106	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.75
107	Trichomegaly	Enrichment	FGF5	2.72
108	Hypochondroplasia	Enrichment	FGFR3	2.67
109	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.67
110	Muenke syndrome	Enrichment	FGFR3	2.67
111	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.67
112	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.67
113	Metacarpal 4-5 fusion	Enrichment	FGF16	2.67
114	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.67
115	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.67
116	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.67
117	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.67
118	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.67
119	Ovarian germ cell cancer	Enrichment	CBL	2.63
120	Werner syndrome	Enrichment	PTPN11	2.63
121	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.63
122	Malignant germ cell tumor of ovary	Enrichment	CBL	2.63
123	Submucosal cleft palate	Enrichment	UBB	2.63
124	Cleft hard palate	Enrichment	UBB	2.63
125	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.60
126	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.60
127	Apert syndrome	Enrichment	FGFR2	2.60
128	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.60
129	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.60
130	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.58
131	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	2.54
132	Primary hypereosinophilic syndrome	Enrichment	FGFR1	2.53
133	Macrodactyly	Enrichment	PIK3CA	2.53
134	Oculoectodermal syndrome	Enrichment	KRAS	2.53
135	Deafness, autosomal recessive 26	Enrichment	GAB1	2.53
136	Noonan syndrome 4	Enrichment	SOS1	2.53
137	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.53
138	Cowden syndrome 5	Enrichment	PIK3CA	2.53
139	Melanosis, neurocutaneous	Enrichment	NRAS	2.53
140	Noonan syndrome 6	Enrichment	NRAS	2.53
141	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.53
142	Short syndrome	Enrichment	PIK3R1	2.53
143	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.53
144	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.53
145	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.53
146	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.53
147	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.53
148	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.53
149	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.53
150	Hypospadias	Enrichment	PIK3CA	2.53
151	Congenital pulmonary airway malformation	Enrichment	KRAS	2.53
152	Rare venous malformation	Enrichment	PIK3CA	2.53
153	Diaphragmatic eventration	Enrichment	PIK3CA	2.53
154	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.53
155	Rare combined vascular malformation	Enrichment	PIK3CA	2.53
156	Cavernous lymphangioma	Enrichment	PIK3CA	2.53
157	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.53
158	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.53
159	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.53
160	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.53
161	Macrodactyly of toe	Enrichment	PIK3CA	2.53
162	Neurocutaneous melanocytosis	Enrichment	NRAS	2.53
163	Ataxia-telangiectasia	Enrichment	BRAF	2.45
164	Uvula, bifid	Enrichment	UBB	2.45
165	Cleft soft palate	Enrichment	UBB	2.45
166	Tethered spinal cord syndrome	Enrichment	BRAF	2.45
167	Tricuspid valve insufficiency	Enrichment	PTPN11	2.45
168	Multiple synostoses syndrome	Enrichment	FGF9	2.38
169	Cervical cancer	Enrichment	FGFR3	2.37
170	Cervix carcinoma	Enrichment	FGFR3	2.37
171	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.33
172	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.33
173	Craniopharyngioma	Enrichment	BRAF	2.33
174	Newborn respiratory distress syndrome	Enrichment	BRAF	2.33
175	Aural atresia, congenital	Enrichment	FGFR2	2.30
176	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.30
177	Split hand-foot malformation	Enrichment	FGFR2	2.30
178	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.30
179	Martsolf syndrome 1	Enrichment	ANOS1	2.29
180	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	ANOS1	2.29
181	Pseudovaginal perineoscrotal hypospadias	Enrichment	ANOS1	2.29
182	Orofacial cleft 1	Enrichment	FGF10	2.28
183	Lymphoma	Enrichment	PTPN11	2.23
184	Myeloproliferative neoplasm	Enrichment	CBL	2.23
185	Aggressive systemic mastocytosis	Enrichment	CBL	2.23
186	Fibromatosis, gingival, 1	Enrichment	SOS1	2.23
187	Costello syndrome	Enrichment	HRAS	2.23
188	Noonan syndrome 8	Enrichment	PIK3CA	2.23
189	Wooly hair nevus	Enrichment	HRAS	2.23
190	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.21
191	Crouzon syndrome	Enrichment	FGFR3	2.19
192	Achondroplasia	Enrichment	FGFR3	2.19
193	Larsen syndrome	Enrichment	FGFR3	2.19
194	Hamartoma	Enrichment	FGFR3	2.19
195	Testicular germ cell cancer	Enrichment	FGFR3	2.19
196	Testicular cancer	Enrichment	FGFR3	2.19
197	Hypophosphatemic rickets	Enrichment	FGF23	2.17
198	Septooptic dysplasia	Enrichment	FGFR1	2.15
199	Wilms tumor 5	Enrichment	BRAF	2.15
200	Patent ductus arteriosus	Enrichment	PTPN11	2.15
201	Gastric cancer	Enrichment	KRAS, PIK3CA	2.15
202	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.13
203	Spastic paraplegia, optic atrophy, and neuropathy	Enrichment	FLRT1	2.12
204	Hypogonadotropic hypogonadism 21 with or without anosmia	Enrichment	FLRT3	2.12
205	Myelofibrosis	Enrichment	SRC	2.08
206	Saethre-chotzen syndrome	Enrichment	FGFR3	2.07
207	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.07
208	Neurofibromatosis, type i	Enrichment	SPRED1	2.07
209	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.05
210	Nuchal bleb, familial	Enrichment	SOS1	2.05
211	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.05
212	Immunodeficiency 14	Enrichment	PIK3R1	2.05
213	Keratoacanthoma	Enrichment	PIK3CA	2.05
214	Microcephaly	Enrichment	MAPK1, PTPN11	2.05
215	Renal agenesis, bilateral	Enrichment	FGF20	2.03
216	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	2.03
217	Gliosarcoma	Enrichment	FGFR1	2.03
218	Giant cell glioblastoma	Enrichment	FGFR1	2.00
219	Glioma	Enrichment	FGFR2	2.00
220	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.98
221	Primary hyperaldosteronism	Enrichment	BRAF	1.98
222	Ventricular septal defect	Enrichment	BRAF	1.98
223	Hemifacial hyperplasia	Enrichment	FGFR3	1.97
224	Melanoma	Enrichment	BRAF	1.93
225	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.93
226	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.93
227	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.93
228	Cerebrovascular disease	Enrichment	PIK3CA	1.93
229	Pilocytic astrocytoma	Enrichment	KRAS	1.93
230	Epidermolytic nevus	Enrichment	HRAS	1.93
231	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.93
232	Gingival fibromatosis	Enrichment	SOS1	1.93
233	Testicular germ cell tumor	Enrichment	FGFR3	1.89
234	46,xy disorder of sex development	Enrichment	FGFR3	1.89
235	Pectus excavatum	Enrichment	PTPN11	1.89
236	Tooth agenesis	Enrichment	FGFR1	1.89
237	Epicanthus	Enrichment	PTPN11	1.85
238	Congenital long qt syndrome	Enrichment	PTPN11	1.85
239	Septopreoptic holoprosencephaly	Enrichment	FGF8	1.85
240	Male infertility with spermatogenesis disorder	Enrichment	SPRED1	1.85
241	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	1.85
242	Capillary malformations, congenital	Enrichment	PIK3CA	1.83
243	Hemimegalencephaly	Enrichment	PIK3CA	1.83
244	Split-hand/foot malformation 1	Enrichment	FGFR2	1.83
245	Alobar holoprosencephaly	Enrichment	FGF8	1.79
246	Osteoporosis	Enrichment	SRC	1.79
247	Wilms tumor 1	Enrichment	BRAF	1.76
248	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.76
249	Cowden syndrome 1	Enrichment	PIK3CA	1.76
250	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.76
251	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.70
252	Dandy-walker syndrome	Enrichment	BRAF	1.70
253	Overgrowth syndrome	Enrichment	PIK3R1	1.69
254	Heart, malformation of	Enrichment	MAPK1	1.68
255	Patent foramen ovale	Enrichment	PTPN11	1.68
256	Primary bone dysplasia	Enrichment	FGFR3	1.67
257	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.65
258	Osteochondrodysplasia	Enrichment	FGFR3	1.63
259	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.61
260	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.60
261	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.58
262	Cowden syndrome	Enrichment	PIK3CA	1.58
263	Scoliosis	Enrichment	PTPN11	1.55
264	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.54
265	Strabismus	Enrichment	PTPN11	1.50
266	Long qt syndrome 1	Enrichment	PTPN11	1.46
267	Meningioma	Enrichment	PIK3CA	1.46
268	Ovarian cancer	Enrichment	KRAS, PIK3CA	1.45
269	Hydrocephalus	Enrichment	FGFR2	1.43
270	Aortic valve disease 1	Enrichment	SOS1	1.42
271	Protein-deficiency anemia	Enrichment	NRAS	1.42
272	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.39
273	Craniosynostosis	Enrichment	FGFR3	1.38
274	Hepatoblastoma	Enrichment	FGFR3	1.36
275	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.30
276	Endometrial cancer	Enrichment	FGFR2	1.29
277	Hepatocellular carcinoma	Enrichment	PIK3CA	1.20
278	Connective tissue disease	Enrichment	FGFR3	1.18
279	Pancreatic cancer	Enrichment	KRAS	1.15
280	Prostate cancer	Enrichment	PIK3CA	1.09
281	Dilated cardiomyopathy	Enrichment	BRAF	1.04
282	Autism spectrum disorder	Enrichment	PTPN11	0.92
283	Hypertelorism	Enrichment	FGFR2	0.91
284	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.86
285	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.84
286	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.82
287	Congenital nervous system abnormality	Enrichment	FGFR3	0.69
288	Nervous system disease	Enrichment	FGFR3	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Negative regulation of FGFR3 signaling

Pathway Network for Negative regulation of FGFR3 signaling

Pathway network for the Negative regulation of FGFR3 signaling SuperPath

Member Pathways for Negative regulation of FGFR3 signaling

Pathways in the Negative regulation of FGFR3 signaling SuperPath

Gene overlap in member pathways for Negative regulation of FGFR3 signaling SuperPath

Associated Genes for Negative regulation of FGFR3 signaling

Associated Disorders for Negative regulation of FGFR3 signaling

Disorders associated with Negative regulation of FGFR3 signaling SuperPath

STRING Interaction Network for Negative regulation of FGFR3 signaling

Sources for Negative regulation of FGFR3 signaling