Negative regulation of TCF-dependent signaling by WNT ligand antagonists

No Pathway Network information available for Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Pathways in the Negative regulation of TCF-dependent signaling by WNT ligand antagonists SuperPath

#	Name	Source	Genes
1	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	Reactome	DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LRP5 LRP6 SFRP1 SFRP2 SOST WIF1 WNT3A WNT4 WNT5A WNT9A (see all 15) (see less)
2	Signaling by LRP5 mutants	Reactome	DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LRP5 (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	2
2	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	2
3	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	2
4	LRP5	LDL Receptor Related Protein 5	Protein Coding	2
5	KREMEN2	Kringle Containing Transmembrane Protein 2	Protein Coding	2
6	KREMEN1	Kringle Containing Transmembrane Protein 1	Protein Coding	2
7	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
8	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
9	SOST	Sclerostin	Protein Coding	1
10	WNT4	Wnt Family Member 4	Protein Coding	1
11	SFRP1	Secreted Frizzled Related Protein 1	Protein Coding	1
12	SFRP2	Secreted Frizzled Related Protein 2	Protein Coding	1
13	WNT5A	Wnt Family Member 5A	Protein Coding	1
14	WNT9A	Wnt Family Member 9A	Protein Coding	1
15	WNT3A	Wnt Family Member 3A	Protein Coding	1

Disorders associated with Negative regulation of TCF-dependent signaling by WNT ligand antagonists SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Direct
2	Parathyroid carcinoma	Direct
3	Van buchem disease	Enrichment	LRP5, SOST	5.94
4	Osteoporosis, juvenile	Enrichment	DKK1, WNT3A	5.47
5	Polycystic liver disease	Enrichment	LRP5, LRP6	3.81
6	Autosomal dominant polycystic liver disease	Enrichment	LRP5, LRP6	3.81
7	Chiari malformation type i	Enrichment	DKK1	2.96
8	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.96
9	Craniodiaphyseal dysplasia, autosomal dominant	Enrichment	SOST	2.96
10	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.96
11	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.96
12	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.96
13	Sclerosteosis 1	Enrichment	SOST	2.96
14	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.96
15	Tooth agenesis, selective, 7	Enrichment	LRP6	2.96
16	Ectodermal dysplasia 13, hair/tooth type	Enrichment	KREMEN1	2.96
17	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.96
18	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.96
19	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.96
20	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.96
21	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.96
22	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.96
23	Craniodiaphyseal dysplasia	Enrichment	SOST	2.66
24	Sclerosteosis	Enrichment	SOST	2.66
25	Osteosclerosis	Enrichment	LRP5	2.66
26	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	2.48
27	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	2.48
28	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	2.35
29	Orofacial cleft	Enrichment	LRP6	2.35
30	Retinopathy of prematurity	Enrichment	LRP5	2.35
31	Autosomal dominant robinow syndrome	Enrichment	WNT5A	2.35
32	Vitreoretinopathy	Enrichment	LRP5	2.35
33	Orofacial clefting syndrome	Enrichment	LRP6	2.35
34	Exudative vitreoretinopathy 1	Enrichment	LRP5	2.26
35	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	2.26
36	Autosomal recessive robinow syndrome	Enrichment	WNT5A	2.18
37	Exudative vitreoretinopathy	Enrichment	LRP5	2.05
38	Osteoporosis	Enrichment	LRP5	1.81
39	Tooth agenesis	Enrichment	LRP6	1.62
40	Brittle bone disorder	Enrichment	LRP5	1.60
41	Hereditary retinal dystrophy	Enrichment	LRP5	0.56
42	Fundus dystrophy	Enrichment	LRP5	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Pathway Network for Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Member Pathways for Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Pathways in the Negative regulation of TCF-dependent signaling by WNT ligand antagonists SuperPath

Associated Genes for Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Associated Disorders for Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Disorders associated with Negative regulation of TCF-dependent signaling by WNT ligand antagonists SuperPath

STRING Interaction Network for Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Sources for Negative regulation of TCF-dependent signaling by WNT ligand antagonists