Neovascularisation processes

No Pathway Network information available for Neovascularisation processes

Pathways in the Neovascularisation processes SuperPath

#	Name	Source	Genes
1	Neovascularisation processes	WikiPathways	ACVRL1 AKT1 ANGPT1 CXCL12 CXCR4 DLL4 EPHB2 EPHB4 FLT4 HIF1A JAG1 KDR KIT KITLG MAPK1 MAPK3 MAPK8 MMP9 NFKB1 NFKB2 NOTCH3 PDGFB REL RELA RELB SMAD1 SMAD2 SMAD3 SMAD5 SMAD9 TGFB1 TGFB2 TGFB3 TGFBR1 (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
2	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
3	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
4	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
5	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
6	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	1
7	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
8	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
9	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
10	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
11	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
12	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
13	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
15	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
16	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
17	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
18	NOTCH3	Notch Receptor 3	Protein Coding	1
19	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
20	KITLG	KIT Ligand	Protein Coding	1
21	SMAD9	SMAD Family Member 9	Protein Coding	1
22	SMAD5	SMAD Family Member 5	Protein Coding	1
23	SMAD3	SMAD Family Member 3	Protein Coding	1
24	SMAD2	SMAD Family Member 2	Protein Coding	1
25	SMAD1	SMAD Family Member 1	Protein Coding	1
26	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
27	KDR	Kinase Insert Domain Receptor	Protein Coding	1
28	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
29	ANGPT1	Angiopoietin 1	Protein Coding	1
30	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
31	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
32	EPHB4	EPH Receptor B4	Protein Coding	1
33	EPHB2	EPH Receptor B2	Protein Coding	1
34	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1

Disorders associated with Neovascularisation processes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1	10.57
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1	7.13
3	Tetralogy of fallot	Enrichment	EPHB4, FLT4, JAG1, KDR	6.33
4	Lymphatic malformation 1	Enrichment	EPHB4, FLT4	5.21
5	Intracranial hypertension, idiopathic	Enrichment	EPHB4, FLT4	5.21
6	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	5.21
7	Hereditary lymphedema i	Enrichment	EPHB4, FLT4	5.21
8	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1	4.74
9	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.44
10	Testicular germ cell tumor	Enrichment	KIT, KITLG	4.04
11	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	4.04
12	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.90
13	Marfan syndrome	Enrichment	TGFB2, TGFBR1	3.57
14	Heritable pulmonary arterial hypertension	Enrichment	ACVRL1, SMAD9	3.48
15	Meningioma	Enrichment	AKT1, PDGFB	3.40
16	Heart, malformation of	Enrichment	JAG1, MAPK1	3.04
17	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2	2.99
18	Hydrops fetalis, nonimmune	Enrichment	EPHB4, FLT4	2.72
19	Lymphatic malformation 5	Enrichment	EPHB4	2.60
20	Proteus syndrome	Enrichment	AKT1	2.60
21	Telangiectasia, hereditary hemorrhagic, type 2	Enrichment	ACVRL1	2.60
22	Mastocytosis, cutaneous	Enrichment	KIT	2.60
23	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.60
24	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	2.60
25	Lateral meningocele syndrome	Enrichment	NOTCH3	2.60
26	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.60
27	Whim syndrome 1	Enrichment	CXCR4	2.60
28	Angioedema, hereditary, 5	Enrichment	ANGPT1	2.60
29	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.60
30	Noonan syndrome 13	Enrichment	MAPK1	2.60
31	Adams-oliver syndrome 6	Enrichment	DLL4	2.60
32	Immunodeficiency 92	Enrichment	REL	2.60
33	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	2.60
34	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	2.60
35	Camurati-engelmann disease 2	Enrichment	TGFB2	2.60
36	Cowden syndrome 6	Enrichment	AKT1	2.60
37	Pulmonary hypertension, primary, 2	Enrichment	SMAD9	2.60
38	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.60
39	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.60
40	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.60
41	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.60
42	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	2.60
43	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.60
44	Immunodeficiency 53	Enrichment	RELB	2.60
45	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.60
46	Chronic mast cell leukemia	Enrichment	KIT	2.60
47	Telangiectasis	Enrichment	ACVRL1	2.60
48	Tufted angioma of skin	Enrichment	KDR	2.60
49	Deafness, autosomal dominant 69	Enrichment	KITLG	2.60
50	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.60
51	Transient cerebral ischemia	Enrichment	NOTCH3	2.60
52	Isolated bone marrow mastocytosis	Enrichment	KIT	2.60
53	Smoldering systemic mastocytosis	Enrichment	KIT	2.60
54	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.60
55	Mastocytosis	Enrichment	KIT	2.60
56	Familial progressive hyperpigmentation	Enrichment	KITLG	2.60
57	Cutaneous mastocytoma	Enrichment	KIT	2.60
58	Typical urticaria pigmentosa	Enrichment	KIT	2.60
59	Nodular urticaria pigmentosa	Enrichment	KIT	2.60
60	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.60
61	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.60
62	Acute mast cell leukemia	Enrichment	KIT	2.60
63	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	2.60
64	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.60
65	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	2.60
66	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.60
67	Vein of galen aneurysmal malformation	Enrichment	EPHB4	2.60
68	Testis seminoma	Enrichment	KIT	2.60
69	Non-immune hydrops fetalis	Enrichment	EPHB4, FLT4	2.57
70	Camurati-engelmann disease 1	Enrichment	TGFB1	2.30
71	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.30
72	Loeys-dietz syndrome 2	Enrichment	TGFBR1	2.30
73	Piebald trait	Enrichment	KIT	2.30
74	Angioma, tufted	Enrichment	KDR	2.30
75	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.30
76	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.30
77	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.30
78	Waardenburg syndrome, type 2f	Enrichment	KITLG	2.30
79	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.30
80	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.30
81	Infantile myofibromatosis	Enrichment	NOTCH3	2.30
82	Rela fusion-positive ependymoma	Enrichment	RELA	2.30
83	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.30
84	Depressive disorder	Enrichment	NOTCH3	2.30
85	Camurati-engelmann disease	Enrichment	TGFB1	2.30
86	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.30
87	Metaphyseal anadysplasia	Enrichment	MMP9	2.30
88	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.30
89	Common variable immunodeficiency 12	Enrichment	NFKB1	2.30
90	Alagille syndrome 1	Enrichment	JAG1	2.12
91	Lymphatic malformation 7	Enrichment	EPHB4	2.12
92	Testicular germ cell cancer	Enrichment	KIT	2.12
93	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	2.12
94	Migraine without aura	Enrichment	NOTCH3	2.12
95	Enchondromatosis	Enrichment	HIF1A	2.12
96	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	SMAD9	2.12
97	Hemophilia a	Enrichment	ACVRL1	2.00
98	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.00
99	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.00
100	Factor viii deficiency	Enrichment	ACVRL1	2.00
101	Cerebrovascular disease	Enrichment	NOTCH3	2.00
102	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	2.00
103	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	2.00
104	Middle aortic syndrome	Enrichment	JAG1	2.00
105	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	ANGPT1	2.00
106	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.90
107	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.90
108	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.90
109	Acute myeloid leukemia with maturation	Enrichment	KIT	1.90
110	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.90
111	Aplasia cutis congenita	Enrichment	DLL4	1.90
112	Vascular dementia	Enrichment	NOTCH3	1.90
113	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	1.90
114	Atrial septal defect 1	Enrichment	TGFB2	1.83
115	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	ACVRL1	1.83
116	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.83
117	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.83
118	Breast adenocarcinoma	Enrichment	AKT1	1.83
119	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.83
120	Gastrointestinal stromal tumor	Enrichment	KIT	1.76
121	Waardenburg syndrome, type 2e	Enrichment	KITLG	1.76
122	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4	1.76
123	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.76
124	Adams-oliver syndrome	Enrichment	DLL4	1.76
125	Hereditary hemorrhagic telangiectasia	Enrichment	ACVRL1	1.76
126	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB	1.70
127	Arteriovenous malformation	Enrichment	EPHB4	1.65
128	Cowden syndrome	Enrichment	AKT1	1.65
129	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.65
130	Stroke, ischemic	Enrichment	NOTCH3	1.61
131	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4	1.61
132	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.61
133	Ovarian cancer	Enrichment	AKT1, KIT	1.58
134	Migraine with or without aura 1	Enrichment	NOTCH3	1.56
135	Pectus excavatum	Enrichment	TGFBR1	1.56
136	Meningioma, familial	Enrichment	PDGFB	1.56
137	Specific learning disability	Enrichment	MAPK1	1.56
138	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.53
139	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.53
140	Lip and oral cavity carcinoma	Enrichment	KIT	1.53
141	Pulmonary hypertension, primary, 1	Enrichment	ACVRL1	1.49
142	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.46
143	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.46
144	Human immunodeficiency virus type 1	Enrichment	CXCL12	1.35
145	Hepatoblastoma	Enrichment	JAG1	1.29
146	Auditory neuropathy	Enrichment	NOTCH3	1.20
147	Prostate cancer	Enrichment	EPHB2	1.15
148	Cystic fibrosis	Enrichment	TGFB1	1.11
149	Connective tissue disease	Enrichment	SMAD3	1.11
150	Leukemia, acute myeloid	Enrichment	KIT	1.02
151	Hereditary breast carcinoma	Enrichment	AKT1	0.98
152	Thrombocytopenia	Enrichment	ACVRL1	0.94
153	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	KITLG	0.91
154	Primary ovarian insufficiency	Enrichment	KDR	0.86
155	Breast cancer	Enrichment	AKT1	0.76
156	Colorectal cancer	Enrichment	AKT1	0.71
157	Microcephaly	Enrichment	MAPK1	0.57
158	Inherited cancer-predisposing syndrome	Enrichment	KIT	0.55
159	Hereditary retinal dystrophy	Enrichment	JAG1	0.28
160	Fundus dystrophy	Enrichment	JAG1	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neovascularisation processes

Pathway Network for Neovascularisation processes

Member Pathways for Neovascularisation processes

Pathways in the Neovascularisation processes SuperPath

Associated Genes for Neovascularisation processes

Associated Disorders for Neovascularisation processes

Disorders associated with Neovascularisation processes SuperPath

STRING Interaction Network for Neovascularisation processes

Sources for Neovascularisation processes