Nephrin family interactions

No Pathway Network information available for Nephrin family interactions

Pathways in the Nephrin family interactions SuperPath

#	Name	Source	Genes
1	Nephrin family interactions	Reactome	ACTN1 ACTN2 ACTN3 ACTN4 CASK CD2AP FYN IQGAP1 KIRREL1 KIRREL2 KIRREL3 MAGI2 NCK1 NCK2 NPHS1 NPHS2 PIK3CA PIK3CB PIK3R1 PIK3R2 SPTAN1 SPTBN1 WASL (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD2AP	CD2 Associated Protein	Protein Coding	1
2	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
3	NCK1	NCK Adaptor Protein 1	Protein Coding	1
4	NPHS1	NPHS1 Adhesion Molecule, Nephrin	Protein Coding	1
5	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
6	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
7	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
8	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
9	KIRREL1	Kirre Like Nephrin Family Adhesion Molecule 1	Protein Coding	1
10	SPTAN1	Spectrin Alpha, Non-Erythrocytic 1	Protein Coding	1
11	SPTBN1	Spectrin Beta, Non-Erythrocytic 1	Protein Coding	1
12	NPHS2	NPHS2 Stomatin Family Member, Podocin	Protein Coding	1
13	ACTN4	Actinin Alpha 4	Protein Coding	1
14	KIRREL2	Kirre Like Nephrin Family Adhesion Molecule 2	Protein Coding	1
15	NCK2	NCK Adaptor Protein 2	Protein Coding	1
16	KIRREL3	Kirre Like Nephrin Family Adhesion Molecule 3	Protein Coding	1
17	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	1
18	ACTN1	Actinin Alpha 1	Protein Coding	1
19	ACTN2	Actinin Alpha 2	Protein Coding	1
20	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
21	ACTN3	Actinin Alpha 3	Protein Coding	1
22	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
23	MAGI2	Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 2	Protein Coding	1

Disorders associated with Nephrin family interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4, CD2AP, MAGI2, NPHS1, NPHS2	8.62
2	Nephrotic syndrome, type 1	Enrichment	KIRREL2, NPHS1, NPHS2	6.45
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.08
4	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.78
5	Nephrotic syndrome	Enrichment	KIRREL2, NPHS1, NPHS2	4.30
6	Focal segmental glomerulosclerosis	Enrichment	NPHS1, NPHS2	3.29
7	Macrodactyly	Enrichment	PIK3CA	2.77
8	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	2.77
9	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.77
10	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.77
11	Developmental and epileptic encephalopathy 5	Enrichment	SPTAN1	2.77
12	Cowden syndrome 5	Enrichment	PIK3CA	2.77
13	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.77
14	Congenital myopathy 8	Enrichment	ACTN2	2.77
15	Short syndrome	Enrichment	PIK3R1	2.77
16	Developmental delay, impaired speech, and behavioral abnormalities	Enrichment	SPTBN1	2.77
17	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.77
18	Actn3 deficiency	Enrichment	ACTN3	2.77
19	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.77
20	Focal segmental glomerulosclerosis 3	Enrichment	CD2AP	2.77
21	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.77
22	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.77
23	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.77
24	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.77
25	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.77
26	Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia	Enrichment	SPTAN1	2.77
27	Developmental delay with or without epilepsy	Enrichment	SPTAN1	2.77
28	Neuronopathy, distal hereditary motor, autosomal dominant 11	Enrichment	SPTAN1	2.77
29	Hypospadias	Enrichment	PIK3CA	2.77
30	Cask-related intellectual disability	Enrichment	CASK	2.77
31	Rare venous malformation	Enrichment	PIK3CA	2.77
32	Diaphragmatic eventration	Enrichment	PIK3CA	2.77
33	Familial nephrotic syndrome	Enrichment	NPHS1	2.77
34	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.77
35	Rare combined vascular malformation	Enrichment	PIK3CA	2.77
36	Cavernous lymphangioma	Enrichment	PIK3CA	2.77
37	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.77
38	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.77
39	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.77
40	Macrodactyly of toe	Enrichment	PIK3CA	2.77
41	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	SPTAN1	2.47
42	Nephrotic syndrome, type 2	Enrichment	NPHS2	2.47
43	Fg syndrome 4	Enrichment	CASK	2.47
44	Keratosis, seborrheic	Enrichment	PIK3CA	2.47
45	Intellectual developmental disorder, autosomal dominant 4	Enrichment	KIRREL3	2.47
46	Noonan syndrome 8	Enrichment	PIK3CA	2.47
47	Nephrotic syndrome, type 15	Enrichment	MAGI2	2.47
48	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.47
49	Syndromic x-linked intellectual disability	Enrichment	CASK	2.47
50	Nephrotic syndrome, type 23	Enrichment	KIRREL1	2.47
51	Genetic nephrotic syndrome	Enrichment	NPHS2	2.47
52	Idiopathic nephrotic syndrome	Enrichment	NPHS2	2.47
53	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.29
54	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	2.29
55	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.29
56	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	SPTBN1	2.29
57	Short-rib thoracic dysplasia 11 with or without polydactyly	Enrichment	SPTAN1	2.29
58	Nephrotic syndrome, type 24	Enrichment	NPHS2	2.29
59	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.29
60	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	2.29
61	Cerebellar disease	Enrichment	CASK	2.29
62	Immunodeficiency 14	Enrichment	PIK3R1	2.29
63	Keratoacanthoma	Enrichment	PIK3CA	2.29
64	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.17
65	Cerebrovascular disease	Enrichment	PIK3CA	2.17
66	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.17
67	Charcot-marie-tooth hereditary neuropathy	Enrichment	SPTAN1	2.17
68	Capillary malformations, congenital	Enrichment	PIK3CA	2.07
69	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	2.07
70	Pervasive developmental disorder	Enrichment	SPTBN1	2.07
71	Hemimegalencephaly	Enrichment	PIK3CA	2.07
72	Rare pervasive developmental disorder	Enrichment	SPTBN1	2.07
73	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.03
74	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.99
75	Cowden syndrome 1	Enrichment	PIK3CA	1.99
76	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.99
77	Breast adenocarcinoma	Enrichment	PIK3CA	1.99
78	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.99
79	Nevus, epidermal	Enrichment	PIK3CA	1.93
80	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.93
81	Gallbladder cancer	Enrichment	PIK3CA	1.93
82	Focal epilepsy	Enrichment	SPTAN1	1.93
83	Overgrowth syndrome	Enrichment	PIK3R1	1.93
84	Arteriovenous malformation	Enrichment	PIK3CA	1.82
85	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.82
86	Cowden syndrome	Enrichment	PIK3CA	1.82
87	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.77
88	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.77
89	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.77
90	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.73
91	Meningioma	Enrichment	PIK3CA	1.70
92	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.70
93	Chronic kidney disease	Enrichment	NPHS2	1.66
94	Nk-cell enteropathy	Enrichment	PIK3CB	1.66
95	Lynch syndrome	Enrichment	PIK3CA	1.60
96	Kidney disease	Enrichment	NPHS1	1.60
97	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.57
98	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	1.57
99	Isolated congenital microcephaly	Enrichment	CASK	1.57
100	Neuromuscular disease	Enrichment	SPTAN1	1.52
101	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK	1.52
102	Endometrial cancer	Enrichment	PIK3CA	1.46
103	Hepatocellular carcinoma	Enrichment	PIK3CA	1.44
104	Jeune thoracic dystrophy	Enrichment	SPTAN1	1.38
105	Asphyxiating thoracic dystrophy	Enrichment	SPTAN1	1.33
106	Bladder cancer	Enrichment	PIK3CA	1.32
107	Prostate cancer	Enrichment	PIK3CA	1.32
108	Lung cancer	Enrichment	PIK3CA	1.28
109	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	SPTAN1	1.26
110	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2	1.26
111	Left ventricular noncompaction	Enrichment	ACTN2	1.24
112	Dystonia	Enrichment	CASK	1.24
113	Non-syndromic x-linked intellectual disability	Enrichment	CASK	1.23
114	Developmental and epileptic encephalopathy	Enrichment	SPTAN1	1.23
115	Benign epilepsy with centrotemporal spikes	Enrichment	SPTAN1	1.17
116	Hereditary spastic paraplegia	Enrichment	SPTAN1	1.16
117	Centralopathic epilepsy	Enrichment	SPTAN1	1.15
118	Gastric cancer	Enrichment	PIK3CA	1.15
119	Hypertrophic cardiomyopathy	Enrichment	ACTN2	1.15
120	West syndrome	Enrichment	SPTAN1	1.14
121	Hereditary breast carcinoma	Enrichment	PIK3CA	1.14
122	Thrombocytopenia	Enrichment	ACTN1	1.11
123	Autosomal dominant non-syndromic intellectual disability	Enrichment	KIRREL3	1.09
124	Hypertelorism	Enrichment	PIK3CA	1.07
125	Spastic ataxia	Enrichment	SPTAN1	1.06
126	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2	1.06
127	Myeloma, multiple	Enrichment	PIK3R2	1.04
128	Breast cancer	Enrichment	PIK3CA	0.92
129	Dilated cardiomyopathy	Enrichment	ACTN2	0.90
130	Ovarian cancer	Enrichment	PIK3CA	0.80
131	Congenital nervous system abnormality	Enrichment	CASK	0.78
132	Nervous system disease	Enrichment	CASK	0.78
133	Microcephaly	Enrichment	CASK	0.72
134	Complex neurodevelopmental disorder	Enrichment	SPTBN1	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nephrin family interactions

Pathway Network for Nephrin family interactions

Member Pathways for Nephrin family interactions

Pathways in the Nephrin family interactions SuperPath

Associated Genes for Nephrin family interactions

Associated Disorders for Nephrin family interactions

Disorders associated with Nephrin family interactions SuperPath

STRING Interaction Network for Nephrin family interactions

Sources for Nephrin family interactions