Nephrin/Neph1 signaling in the kidney podocyte

No Pathway Network information available for Nephrin/Neph1 signaling in the kidney podocyte

Pathways in the Nephrin/Neph1 signaling in the kidney podocyte SuperPath

#	Name	Source	Genes
1	Nephrin/Neph1 signaling in the kidney podocyte	PubChem	AKT1 ARRB2 BAD CD2AP F2RL2 FYN GRB2 JUN KIRREL1 MAP2K4 MAPK8 NCK1 NPHS1 NPHS2 PARD6A PIK3CA PIK3CB PIK3R1 PLCG1 RAC1 TJP1 TRPC6 WASL (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NPHS2	NPHS2 Stomatin Family Member, Podocin	Protein Coding	1
2	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	1
3	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1
4	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
5	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
6	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
7	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
8	ARRB2	Arrestin Beta 2	Protein Coding	1
9	KIRREL1	Kirre Like Nephrin Family Adhesion Molecule 1	Protein Coding	1
10	NPHS1	NPHS1 Adhesion Molecule, Nephrin	Protein Coding	1
11	CD2AP	CD2 Associated Protein	Protein Coding	1
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
13	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
14	NCK1	NCK Adaptor Protein 1	Protein Coding	1
15	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
16	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
17	RAC1	Rac Family Small GTPase 1	Protein Coding	1
18	TJP1	Tight Junction Protein 1	Protein Coding	1
19	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
20	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
21	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
22	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
23	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Nephrin/Neph1 signaling in the kidney podocyte SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Genetic steroid-resistant nephrotic syndrome	Enrichment	CD2AP, NPHS1, NPHS2, TRPC6	6.55
2	Focal segmental glomerulosclerosis	Enrichment	NPHS1, NPHS2, TRPC6	5.32
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.08
4	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.39
5	Nephrotic syndrome	Enrichment	NPHS1, NPHS2, TRPC6	4.30
6	Nephrotic syndrome, type 1	Enrichment	NPHS1, NPHS2	4.01
7	Cowden syndrome	Enrichment	AKT1, PIK3CA	4.01
8	Meningioma	Enrichment	AKT1, PIK3CA	3.75
9	Breast cancer	Enrichment	AKT1, JUN, PIK3CA	3.58
10	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.39
11	Macrodactyly	Enrichment	PIK3CA	2.77
12	Proteus syndrome	Enrichment	AKT1	2.77
13	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.77
14	Cowden syndrome 5	Enrichment	PIK3CA	2.77
15	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	2.77
16	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.77
17	Short syndrome	Enrichment	PIK3R1	2.77
18	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.77
19	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.77
20	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.77
21	Focal segmental glomerulosclerosis 3	Enrichment	CD2AP	2.77
22	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.77
23	Cowden syndrome 6	Enrichment	AKT1	2.77
24	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.77
25	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.77
26	Hypospadias	Enrichment	PIK3CA	2.77
27	Rare venous malformation	Enrichment	PIK3CA	2.77
28	Diaphragmatic eventration	Enrichment	PIK3CA	2.77
29	Familial nephrotic syndrome	Enrichment	NPHS1	2.77
30	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.77
31	Rare combined vascular malformation	Enrichment	PIK3CA	2.77
32	Cavernous lymphangioma	Enrichment	PIK3CA	2.77
33	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.77
34	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.77
35	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.77
36	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.77
37	Macrodactyly of toe	Enrichment	PIK3CA	2.77
38	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.60
39	Nephrotic syndrome, type 2	Enrichment	NPHS2	2.47
40	Keratosis, seborrheic	Enrichment	PIK3CA	2.47
41	Noonan syndrome 8	Enrichment	PIK3CA	2.47
42	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.47
43	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.47
44	Nephrotic syndrome, type 23	Enrichment	KIRREL1	2.47
45	Genetic nephrotic syndrome	Enrichment	NPHS2	2.47
46	Idiopathic nephrotic syndrome	Enrichment	NPHS2	2.47
47	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.29
48	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.29
49	Nephrotic syndrome, type 24	Enrichment	NPHS2	2.29
50	Immunodeficiency 14	Enrichment	PIK3R1	2.29
51	Keratoacanthoma	Enrichment	PIK3CA	2.29
52	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.17
53	Cerebrovascular disease	Enrichment	PIK3CA	2.17
54	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.17
55	Capillary malformations, congenital	Enrichment	PIK3CA	2.07
56	Hemimegalencephaly	Enrichment	PIK3CA	2.07
57	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.99
58	Cowden syndrome 1	Enrichment	PIK3CA	1.99
59	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.99
60	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.99
61	Nevus, epidermal	Enrichment	PIK3CA	1.93
62	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.93
63	Gallbladder cancer	Enrichment	PIK3CA	1.93
64	Overgrowth syndrome	Enrichment	PIK3R1	1.93
65	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.90
66	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.82
67	Arteriovenous malformation	Enrichment	PIK3CA	1.82
68	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.82
69	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.77
70	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.77
71	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.73
72	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.70
73	Chronic kidney disease	Enrichment	NPHS2	1.66
74	Nk-cell enteropathy	Enrichment	PIK3CB	1.66
75	Lynch syndrome	Enrichment	PIK3CA	1.60
76	Kidney disease	Enrichment	NPHS1	1.60
77	Endometrial cancer	Enrichment	PIK3CA	1.46
78	Hepatocellular carcinoma	Enrichment	PIK3CA	1.44
79	Bladder cancer	Enrichment	PIK3CA	1.32
80	Prostate cancer	Enrichment	PIK3CA	1.32
81	Lung cancer	Enrichment	PIK3CA	1.28
82	Gastric cancer	Enrichment	PIK3CA	1.15
83	Hypertelorism	Enrichment	PIK3CA	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nephrin/Neph1 signaling in the kidney podocyte

Pathway Network for Nephrin/Neph1 signaling in the kidney podocyte

Member Pathways for Nephrin/Neph1 signaling in the kidney podocyte

Pathways in the Nephrin/Neph1 signaling in the kidney podocyte SuperPath

Associated Genes for Nephrin/Neph1 signaling in the kidney podocyte

Associated Disorders for Nephrin/Neph1 signaling in the kidney podocyte

Disorders associated with Nephrin/Neph1 signaling in the kidney podocyte SuperPath

STRING Interaction Network for Nephrin/Neph1 signaling in the kidney podocyte

Sources for Nephrin/Neph1 signaling in the kidney podocyte