Netrin-1 signaling

Pathway network for the Netrin-1 signaling SuperPath

Sources:

Reactome
PubChem

Pathways in the Netrin-1 signaling SuperPath

#	Name	Source	Genes
1	Netrin-1 signaling	Reactome	ABLIM1 ABLIM2 ABLIM3 AGAP2 CDC42 DOCK1 DSCAM DSCAML1 EZR FYN HJV MYO10 NCK1 NEO1 NTN1 NTN4 PITPNA PLCG1 PTK2 PTPN11 RAC1 RGMA RGMB ROBO1 SIAH1 SIAH2 SLIT1 SLIT2 SLIT3 SRC TRIO TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 UNC5A UNC5B UNC5C UNC5D WASL (see all 42) (see less)
2	Netrin-mediated signaling events	PubChem	AGAP2 BCAR1 CAMK2A CDC42 DAPK1 DCC DOCK1 ELMO1 FYN MAP1B MAP2K1 MAPK3 MYO10 NCK1 NTN1 PAK1 PIK3CA PIK3R1 PITPNA PLCG1 PTK2 RAC1 RHOA SRC TRIO UNC5A UNC5B UNC5C WASL (see all 29) (see less)
3	DCC mediated attractive signaling	Reactome	ABLIM1 ABLIM2 ABLIM3 CDC42 DOCK1 FYN NCK1 NTN1 PTK2 RAC1 SRC TRIO WASL (see all 13) (see less)
4	Role of second messengers in netrin-1 signaling	Reactome	NTN1 PITPNA PLCG1 TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 (see all 9) (see less)
5	Netrin mediated repulsion signals	Reactome	NTN1 PTPN11 SRC UNC5A UNC5B UNC5C UNC5D (see all 7) (see less)
6	DSCAM interactions	Reactome	DSCAM DSCAML1 NTN1

Gene overlap in member pathways for Netrin-1 signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NTN1	Netrin 1	Protein Coding	6
2	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	4
3	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	3
4	UNC5B	Unc-5 Netrin Receptor B	Protein Coding	3
5	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
6	NCK1	NCK Adaptor Protein 1	Protein Coding	3
7	PITPNA	Phosphatidylinositol Transfer Protein Alpha	Protein Coding	3
8	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
9	PTK2	Protein Tyrosine Kinase 2	Protein Coding	3
10	RAC1	Rac Family Small GTPase 1	Protein Coding	3
11	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	3
12	UNC5C	Unc-5 Netrin Receptor C	Protein Coding	3
13	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	3
14	UNC5A	Unc-5 Netrin Receptor A	Protein Coding	3
15	CDC42	Cell Division Cycle 42	Protein Coding	3
16	AGAP2	ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 2	Protein Coding	2
17	UNC5D	Unc-5 Netrin Receptor D	Protein Coding	2
18	DSCAM	DS Cell Adhesion Molecule	Protein Coding	2
19	ABLIM3	Actin Binding LIM Protein Family Member 3	Protein Coding	2
20	ABLIM1	Actin Binding LIM Protein 1	Protein Coding	2
21	MYO10	Myosin X	Protein Coding	2
22	TRPC7	Transient Receptor Potential Cation Channel Subfamily C Member 7	Protein Coding	2
23	DSCAML1	DS Cell Adhesion Molecule Like 1	Protein Coding	2
24	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
25	TRPC1	Transient Receptor Potential Cation Channel Subfamily C Member 1	Protein Coding	2
26	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	2
27	TRPC4	Transient Receptor Potential Cation Channel Subfamily C Member 4	Protein Coding	2
28	TRPC5	Transient Receptor Potential Cation Channel Subfamily C Member 5	Protein Coding	2
29	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	2
30	ABLIM2	Actin Binding LIM Protein Family Member 2	Protein Coding	2
31	HJV	Hemojuvelin BMP Co-Receptor	Protein Coding	1
32	RGMB	Repulsive Guidance Molecule BMP Co-Receptor B	Protein Coding	1
33	NEO1	Neogenin 1	Protein Coding	1
34	RGMA	Repulsive Guidance Molecule BMP Co-Receptor A	Protein Coding	1
35	NTN4	Netrin 4	Protein Coding	1
36	ROBO1	Roundabout Guidance Receptor 1	Protein Coding	1
37	SIAH1	Siah E3 Ubiquitin Protein Ligase 1	Protein Coding	1
38	SIAH2	Siah E3 Ubiquitin Protein Ligase 2	Protein Coding	1
39	SLIT1	Slit Guidance Ligand 1	Protein Coding	1
40	SLIT3	Slit Guidance Ligand 3	Protein Coding	1
41	EZR	Ezrin	Protein Coding	1
42	SLIT2	Slit Guidance Ligand 2	Protein Coding	1
43	DAPK1	Death Associated Protein Kinase 1	Protein Coding	1
44	MAP1B	Microtubule Associated Protein 1B	Protein Coding	1
45	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
46	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
47	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
48	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
49	DCC	DCC Netrin 1 Receptor	Protein Coding	1
50	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
51	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
52	RHOA	Ras Homolog Family Member A	Protein Coding	1
53	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
54	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Netrin-1 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.88
2	Mirror movements 1	Enrichment	DCC, NTN1	4.58
3	Colorectal cancer	Enrichment	DCC, PIK3CA, PIK3R1, SRC	4.48
4	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	4.25
5	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.18
6	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	4.04
7	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.80
8	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.71
9	Mirror movements 4	Enrichment	NTN1	3.66
10	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	3.62
11	Thrombocytopenia	Enrichment	PTPN11, SRC	3.59
12	Metachondromatosis	Enrichment	PTPN11	3.29
13	Leopard syndrome 1	Enrichment	PTPN11	3.29
14	Thrombocytopenia 6	Enrichment	SRC	3.29
15	Malignant astrocytoma	Enrichment	PTPN11	3.29
16	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	3.18
17	Spinocerebellar ataxia 41	Enrichment	TRPC3	3.18
18	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.18
19	Takenouchi-kosaki syndrome	Enrichment	CDC42	3.02
20	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	3.02
21	Nocarh syndrome	Enrichment	CDC42	3.02
22	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.02
23	Temporomandibular joint anomaly	Enrichment	DOCK1	3.02
24	Werner syndrome	Enrichment	PTPN11	2.99
25	Tricuspid valve insufficiency	Enrichment	PTPN11	2.81
26	Autism spectrum disorder	Enrichment	DCC, MAP1B, MAP2K1	2.80
27	Deafness, autosomal recessive 28	Enrichment	TRIO	2.72
28	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.72
29	Immune system disease	Enrichment	CDC42	2.72
30	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.69
31	Macrodactyly	Enrichment	PIK3CA	2.67
32	Melorheostosis, isolated	Enrichment	MAP2K1	2.67
33	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.67
34	Cowden syndrome 5	Enrichment	PIK3CA	2.67
35	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.67
36	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.67
37	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.67
38	Short syndrome	Enrichment	PIK3R1	2.67
39	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.67
40	Deafness, autosomal dominant 83	Enrichment	MAP1B	2.67
41	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.67
42	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.67
43	Melorheostosis	Enrichment	MAP2K1	2.67
44	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.67
45	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.67
46	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.67
47	Gaze palsy, familial horizontal, with progressive scoliosis 2, with impaired intellectual development	Enrichment	DCC	2.67
48	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.67
49	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.67
50	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.67
51	Hypospadias	Enrichment	PIK3CA	2.67
52	Rare venous malformation	Enrichment	PIK3CA	2.67
53	Diaphragmatic eventration	Enrichment	PIK3CA	2.67
54	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.67
55	Rare combined vascular malformation	Enrichment	PIK3CA	2.67
56	Cavernous lymphangioma	Enrichment	PIK3CA	2.67
57	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.67
58	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.67
59	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.67
60	Macrodactyly of toe	Enrichment	PIK3CA	2.67
61	Lymphoma	Enrichment	PTPN11	2.59
62	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	2.54
63	Patent ductus arteriosus	Enrichment	PTPN11	2.51
64	Nystagmus 8, congenital, autosomal recessive	Enrichment	ROBO1	2.51
65	Hemochromatosis, type 2a	Enrichment	HJV	2.51
66	Autosomal recessive congenital nystagmus	Enrichment	ROBO1	2.51
67	Pituitary hormone deficiency, combined or isolated, 8	Enrichment	ROBO1	2.51
68	Neurooculorenal syndrome	Enrichment	ROBO1	2.51
69	Congenital nystagmus	Enrichment	ROBO1	2.51
70	Myelofibrosis	Enrichment	SRC	2.44
71	Noonan syndrome 3	Enrichment	PTPN11	2.44
72	Keratosis, seborrheic	Enrichment	PIK3CA	2.37
73	Noonan syndrome 8	Enrichment	PIK3CA	2.37
74	Periventricular nodular heterotopia 9	Enrichment	MAP1B	2.37
75	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.37
76	Horizontal gaze palsy with progressive scoliosis	Enrichment	DCC	2.37
77	Cakut	Enrichment	ROBO1, SLIT2	2.31
78	Pectus excavatum	Enrichment	PTPN11	2.25
79	Specific learning disability	Enrichment	PTPN11	2.25
80	Epicanthus	Enrichment	PTPN11	2.21
81	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.21
82	Congenital long qt syndrome	Enrichment	PTPN11	2.21
83	Buratti-harel syndrome	Enrichment	SIAH1	2.21
84	Hemochromatosis type 2	Enrichment	HJV	2.21
85	Hjv or hamp-related hemochromatosis	Enrichment	HJV	2.21
86	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.19
87	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.19
88	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	MAP1B	2.19
89	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.19
90	Immunodeficiency 14	Enrichment	PIK3R1	2.19
91	Pyloric stenosis	Enrichment	MAP1B	2.19
92	Keratoacanthoma	Enrichment	PIK3CA	2.19
93	Hirschsprung disease 1	Enrichment	DSCAM	2.19
94	Osteoporosis	Enrichment	SRC	2.14
95	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	2.11
96	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.07
97	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.07
98	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.07
99	Cerebrovascular disease	Enrichment	PIK3CA	2.07
100	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.07
101	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.07
102	Alzheimer disease, familial, 1	Enrichment	UNC5C	2.06
103	Patent foramen ovale	Enrichment	PTPN11	2.03
104	Capillary malformations, congenital	Enrichment	PIK3CA	1.97
105	Hemimegalencephaly	Enrichment	PIK3CA	1.97
106	Noonan syndrome 1	Enrichment	PTPN11	1.93
107	Scoliosis	Enrichment	PTPN11	1.91
108	Amyotrophy, monomelic	Enrichment	SLIT1	1.91
109	Digenic hemochromatosis	Enrichment	HJV	1.91
110	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.89
111	Cowden syndrome 1	Enrichment	PIK3CA	1.89
112	Breast adenocarcinoma	Enrichment	PIK3CA	1.89
113	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.89
114	Focal segmental glomerulosclerosis	Enrichment	TRPC6	1.88
115	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.87
116	Rasopathy	Enrichment	PTPN11	1.87
117	Strabismus	Enrichment	PTPN11	1.86
118	Esophageal cancer	Enrichment	DCC	1.83
119	Nevus, epidermal	Enrichment	PIK3CA	1.83
120	Gallbladder cancer	Enrichment	PIK3CA	1.83
121	Overgrowth syndrome	Enrichment	PIK3R1	1.83
122	Long qt syndrome 1	Enrichment	PTPN11	1.81
123	Non-immune hydrops fetalis	Enrichment	PTPN11	1.80
124	Syndromic intellectual disability	Enrichment	TRIO	1.79
125	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.72
126	Cowden syndrome	Enrichment	PIK3CA	1.72
127	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.67
128	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.66
129	Genetic steroid-resistant nephrotic syndrome	Enrichment	TRPC6	1.65
130	Hemochromatosis, type 1	Enrichment	HJV	1.61
131	Meningioma	Enrichment	PIK3CA	1.60
132	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.60
133	Renal agenesis, bilateral	Enrichment	ROBO1	1.56
134	Nephrotic syndrome	Enrichment	TRPC6	1.55
135	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.54
136	Periventricular nodular heterotopia	Enrichment	MAP1B	1.53
137	Corpus callosum, agenesis of	Enrichment	DCC	1.50
138	Lynch syndrome	Enrichment	PIK3CA	1.50
139	Isolated corpus callosum agenesis	Enrichment	DCC	1.50
140	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	DCC	1.50
141	Pituitary stalk interruption syndrome	Enrichment	ROBO1	1.37
142	Endometrial cancer	Enrichment	PIK3CA	1.36
143	Hepatocellular carcinoma	Enrichment	PIK3CA	1.34
144	Attention deficit-hyperactivity disorder	Enrichment	MAP1B	1.34
145	Kallmann syndrome	Enrichment	DCC	1.32
146	Microcephaly	Enrichment	PTPN11, TRIO	1.26
147	Bladder cancer	Enrichment	PIK3CA	1.22
148	Prostate cancer	Enrichment	PIK3CA	1.22
149	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	1.18
150	Lung cancer	Enrichment	PIK3CA	1.18
151	Tetralogy of fallot	Enrichment	ROBO1	1.11
152	Gastric cancer	Enrichment	PIK3CA	1.06
153	Hereditary breast carcinoma	Enrichment	PIK3CA	1.05
154	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A	0.99
155	Hypertelorism	Enrichment	PIK3CA	0.98
156	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MAP1B	0.98
157	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.95
158	Breast cancer	Enrichment	PIK3CA	0.83
159	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.78
160	Ovarian cancer	Enrichment	PIK3CA	0.71
161	Complex neurodevelopmental disorder	Enrichment	SIAH1	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Netrin-1 signaling

Pathway Network for Netrin-1 signaling

Pathway network for the Netrin-1 signaling SuperPath

Member Pathways for Netrin-1 signaling

Pathways in the Netrin-1 signaling SuperPath

Gene overlap in member pathways for Netrin-1 signaling SuperPath

Associated Genes for Netrin-1 signaling

Associated Disorders for Netrin-1 signaling

Disorders associated with Netrin-1 signaling SuperPath

STRING Interaction Network for Netrin-1 signaling

Sources for Netrin-1 signaling