Netrin Signaling

No Pathway Network information available for Netrin Signaling

Pathways in the Netrin Signaling SuperPath

#	Name	Source	Genes
1	Netrin Signaling	QIAGEN	ABLIM1 ABLIM2 ABLIM3 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1S CACNA2D1 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 DCC ENAH NCK1 NCK2 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NTN1 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKG1 RAC1 RAC2 RAC3 RYR1 RYR2 RYR3 UNC5A UNC5B UNC5C UNC5CL UNC5D (see all 49) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABLIM1	Actin Binding LIM Protein 1	Protein Coding	1
2	ABLIM2	Actin Binding LIM Protein Family Member 2	Protein Coding	1
3	ABLIM3	Actin Binding LIM Protein Family Member 3	Protein Coding	1
4	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
5	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	1
6	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
7	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
8	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	1
9	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	1
10	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	1
11	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	1
12	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	1
13	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	1
14	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	1
15	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	1
16	DCC	DCC Netrin 1 Receptor	Protein Coding	1
17	ENAH	ENAH Actin Regulator	Protein Coding	1
18	NCK1	NCK Adaptor Protein 1	Protein Coding	1
19	NCK2	NCK Adaptor Protein 2	Protein Coding	1
20	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	1
21	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
22	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
23	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
24	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
25	NTN1	Netrin 1	Protein Coding	1
26	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
27	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
28	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
29	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
30	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
31	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
32	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
33	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
34	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
35	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
36	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
37	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
38	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
39	RAC1	Rac Family Small GTPase 1	Protein Coding	1
40	RAC2	Rac Family Small GTPase 2	Protein Coding	1
41	RAC3	Rac Family Small GTPase 3	Protein Coding	1
42	RYR1	Ryanodine Receptor 1	Protein Coding	1
43	RYR2	Ryanodine Receptor 2	Protein Coding	1
44	RYR3	Ryanodine Receptor 3	Protein Coding	1
45	UNC5A	Unc-5 Netrin Receptor A	Protein Coding	1
46	UNC5B	Unc-5 Netrin Receptor B	Protein Coding	1
47	UNC5C	Unc-5 Netrin Receptor C	Protein Coding	1
48	UNC5CL	Unc-5 Family C-Terminal Like	Protein Coding	1
49	UNC5D	Unc-5 Netrin Receptor D	Protein Coding	1

Disorders associated with Netrin Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	4.42
2	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B, CACNA2D1, PPP3CA	4.32
3	Mirror movements 1	Enrichment	DCC, NTN1	4.12
4	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C, RYR2	4.12
5	Malignant hyperthermia	Enrichment	CACNA1S, RYR1	4.12
6	Brugada syndrome	Enrichment	CACNA1C, CACNA2D1, CACNB2	3.96
7	Heart conduction disease	Enrichment	CACNA1C, RYR2	3.90
8	Long qt syndrome	Enrichment	CACNA1C, CACNA1S, RYR2	3.73
9	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.34
10	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C, RAC1	3.34
11	Hydrops fetalis	Enrichment	RYR1, RYR3	3.34
12	Cardiac conduction defect	Enrichment	CACNA1C, RYR2	3.08
13	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	RYR1, RYR2	2.83
14	Congenital myopathy	Enrichment	CACNA1S, RYR1	2.68
15	Centronuclear myopathy	Enrichment	CACNA1S, RYR1	2.59
16	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.44
17	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	2.44
18	Epilepsy, idiopathic generalized 9	Enrichment	CACNB4	2.44
19	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.44
20	Carney complex, type 1	Enrichment	PRKAR1A	2.44
21	Brugada syndrome 4	Enrichment	CACNB2	2.44
22	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.44
23	Episodic ataxia, type 5	Enrichment	CACNB4	2.44
24	Congenital myopathy 20	Enrichment	RYR3	2.44
25	Congenital myopathy 18	Enrichment	CACNA1S	2.44
26	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.44
27	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.44
28	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.44
29	Mirror movements 4	Enrichment	NTN1	2.44
30	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.44
31	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.44
32	Myxoma, intracardiac	Enrichment	PRKAR1A	2.44
33	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.44
34	Brugada syndrome 3	Enrichment	CACNA1C	2.44
35	Malignant hyperthermia 5	Enrichment	CACNA1S	2.44
36	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.44
37	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.44
38	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	2.44
39	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.44
40	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	2.44
41	Gaze palsy, familial horizontal, with progressive scoliosis 2, with impaired intellectual development	Enrichment	DCC	2.44
42	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.44
43	Congenital myopathy with myasthenic-like onset	Enrichment	RYR1	2.44
44	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.44
45	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.44
46	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.44
47	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.44
48	Atypical timothy syndrome	Enrichment	CACNA1C	2.44
49	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.44
50	Timothy syndrome type 2	Enrichment	CACNA1C	2.44
51	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	2.44
52	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.44
53	Calf-predominant weakness-gastrocnemius medialis atrophy-distal myopathy	Enrichment	RYR1	2.44
54	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.44
55	Timothy syndrome type 1	Enrichment	CACNA1C	2.44
56	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.44
57	Cacna1c-related disorders	Enrichment	CACNA1C	2.44
58	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.44
59	Benign samaritan congenital myopathy	Enrichment	RYR1	2.44
60	Malignant hyperthermia 1	Enrichment	RYR1	2.14
61	Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome	Enrichment	RYR2	2.14
62	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.14
63	Timothy syndrome	Enrichment	CACNA1C	2.14
64	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.14
65	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.14
66	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.14
67	Long qt syndrome 8	Enrichment	CACNA1C	2.14
68	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.14
69	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.14
70	Usher syndrome, type iv	Enrichment	PRKAR1A	2.14
71	Ventricular tachycardia, catecholaminergic polymorphic, 2	Enrichment	RYR2	2.14
72	King-denborough syndrome	Enrichment	RYR1	2.14
73	Acrodysostosis	Enrichment	PRKAR1A	2.14
74	Fibrolamellar carcinoma	Enrichment	PRKACA	2.14
75	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.14
76	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.14
77	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	2.14
78	Horizontal gaze palsy with progressive scoliosis	Enrichment	DCC	2.14
79	Exercise-induced malignant hyperthermia	Enrichment	RYR1	2.14
80	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.14
81	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.14
82	Progressive bulbar palsy	Enrichment	CACNA1A	2.14
83	Cerebral palsy	Enrichment	CACNA1A, CACNA1C	2.06
84	Van der woude syndrome 1	Enrichment	CACNA1E	1.97
85	Lynch syndrome 5	Enrichment	RYR1	1.97
86	Bronchopulmonary dysplasia	Enrichment	RYR1	1.97
87	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.97
88	Hereditary episodic ataxia	Enrichment	CACNA1A	1.97
89	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.84
90	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	RYR1	1.84
91	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.84
92	Myopathy, centronuclear, 2	Enrichment	RYR1	1.84
93	Sacral defect with anterior meningocele	Enrichment	RYR1	1.84
94	Amyotrophy, monomelic	Enrichment	RYR3	1.84
95	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	1.84
96	Carney complex variant	Enrichment	PRKAR1A	1.84
97	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.84
98	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.84
99	Intellectual developmental disorder, autosomal dominant 26	Enrichment	RYR1	1.84
100	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	1.84
101	Congenital myopathy 1a	Enrichment	RYR1	1.84
102	Episodic ataxia	Enrichment	CACNA1A	1.84
103	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	1.84
104	Paroxysmal familial ventricular fibrillation	Enrichment	RYR2	1.84
105	Episodic ataxia, type 2	Enrichment	CACNA1A	1.75
106	Congenital myopathy 1b, autosomal recessive	Enrichment	RYR1	1.75
107	Cardiac arrest	Enrichment	CACNA2D1	1.75
108	Congenital short qt syndrome	Enrichment	CACNA2D1	1.75
109	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	1.67
110	Myopathy, centronuclear, 1	Enrichment	RYR1	1.67
111	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	RYR2	1.67
112	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.67
113	Esophageal cancer	Enrichment	DCC	1.60
114	Brugada syndrome 1	Enrichment	CACNA2D1	1.60
115	Multiple pterygium syndrome, lethal type	Enrichment	RYR1	1.54
116	Lennox-gastaut syndrome	Enrichment	CACNA1A	1.54
117	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.54
118	Congenital muscular dystrophy	Enrichment	RYR1	1.54
119	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	RYR2	1.54
120	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	RYR2	1.54
121	Difference of sex development	Enrichment	CACNA1A	1.54
122	Migraine with or without aura 1	Enrichment	CACNA1A	1.41
123	Epilepsy, myoclonic juvenile	Enrichment	CACNB4	1.41
124	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	RYR2	1.37
125	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	RYR2	1.37
126	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	RYR1	1.34
127	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.34
128	Clubfoot	Enrichment	RYR1	1.34
129	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	RYR2	1.31
130	Congenital myopathy 4a, autosomal dominant	Enrichment	RYR1	1.28
131	Corpus callosum, agenesis of	Enrichment	DCC	1.28
132	Isolated corpus callosum agenesis	Enrichment	DCC	1.28
133	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	DCC	1.28
134	Alzheimer disease, familial, 1	Enrichment	UNC5C	1.22
135	Beckwith-wiedemann syndrome	Enrichment	RYR1	1.20
136	Neuromuscular disease	Enrichment	RYR1	1.20
137	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.14
138	Complex neurodevelopmental disorder	Enrichment	CACNA1C, RAC3	1.13
139	Kallmann syndrome	Enrichment	DCC	1.10
140	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	1.08
141	Scoliosis	Enrichment	RYR1	1.08
142	Auditory neuropathy	Enrichment	CACNA1A	1.05
143	Strabismus	Enrichment	CACNA1A	1.03
144	Long qt syndrome 1	Enrichment	CACNA1C	0.99
145	Left ventricular noncompaction	Enrichment	RYR2	0.92
146	Developmental and epileptic encephalopathy	Enrichment	CACNA1E	0.91
147	Fetal akinesia deformation sequence 1	Enrichment	RYR1	0.90
148	Myopathy	Enrichment	RYR1	0.87
149	Distal arthrogryposis	Enrichment	RYR1	0.85
150	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	0.83
151	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.78
152	Spastic ataxia	Enrichment	CACNB4	0.76
153	Primary ovarian insufficiency	Enrichment	RYR3	0.72
154	Breast cancer	Enrichment	CACNA2D1	0.62
155	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.62
156	Colorectal cancer	Enrichment	DCC	0.57
157	Congenital nervous system abnormality	Enrichment	CACNA1A	0.50
158	Nervous system disease	Enrichment	CACNA1A	0.50
159	Autism spectrum disorder	Enrichment	DCC	0.49
160	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Netrin Signaling

Pathway Network for Netrin Signaling

Member Pathways for Netrin Signaling

Pathways in the Netrin Signaling SuperPath

Associated Genes for Netrin Signaling

Associated Disorders for Netrin Signaling

Disorders associated with Netrin Signaling SuperPath

STRING Interaction Network for Netrin Signaling

Sources for Netrin Signaling