Network map of SARS-CoV-2 signaling pathway

No Pathway Network information available for Network map of SARS-CoV-2 signaling pathway

Pathways in the Network map of SARS-CoV-2 signaling pathway SuperPath

#	Name	Source	Genes
1	Network map of SARS-CoV-2 signaling pathway	WikiPathways	ACE2 AKT1 AKT1S1 CASP3 CCL2 CD2 CD247 CD3E CD3G CD4 CD8A CD8B CRP CXCL8 EIF4EBP1 FYN HIF1A HLA-DRA HLA-DRB1 HLA-DRB4 HLA-DRB5 IFNB1 IGHE IGHG1 IGHG2 IGHG4 IGLC2 IGLL1 IL6 IRAK1 LARP1 LBP LCK MAP1LC3B MAVS MMP25 NKRF NLRP1 PRG3 SMAD1 SMAD5 TBK1 TRAC TRAF3 TRAF6 TRBC1 ULK1 ZAP70 (see all 48) (see less)
2	Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex	WikiPathways	CD2 CD247 CD3E CD3G CD4 CD8A CD8B CRP CXCL8 FYN HLA-DRA HLA-DRB1 HLA-DRB4 HLA-DRB5 IGHE IGHG1 IGHG2 IGHG4 IGLC2 IGLL1 IL6 LBP LCK MMP25 NKRF PRG3 TRAC TRBC1 ZAP70 (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MMP25	Matrix Metallopeptidase 25	Protein Coding	2
2	PRG3	Proteoglycan 3, Pro Eosinophil Major Basic Protein 2	Protein Coding	2
3	CD8B	CD8 Subunit Beta	Protein Coding	2
4	CD8A	CD8 Subunit Alpha	Protein Coding	2
5	CD4	CD4 Molecule	Protein Coding	2
6	CD247	CD247 Molecule	Protein Coding	2
7	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
8	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
9	CD2	CD2 Molecule	Protein Coding	2
10	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	2
11	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
12	LBP	Lipopolysaccharide Binding Protein	Protein Coding	2
13	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	2
14	IL6	Interleukin 6	Protein Coding	2
15	IGLL1	Immunoglobulin Lambda Like Polypeptide 1	Protein Coding	2
16	IGHG2	Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)	Protein Coding	2
17	IGHG1	Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)	Protein Coding	2
18	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	2
19	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	2
20	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	2
21	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	2
22	TRAC	T Cell Receptor Alpha Constant	Protein Coding	2
23	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
24	CRP	C-Reactive Protein	Protein Coding	2
25	NKRF	NFKB Repressing Factor	Protein Coding	2
26	IGLC2	Immunoglobulin Lambda Constant 2	Protein Coding	2
27	IGHG4	Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)	Protein Coding	2
28	IGHE	Immunoglobulin Heavy Constant Epsilon	Protein Coding	2
29	TRBC1	T Cell Receptor Beta Constant 1	Protein Coding	2
30	IFNB1	Interferon Beta 1	Protein Coding	1
31	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
32	AKT1S1	AKT1 Substrate 1	Protein Coding	1
33	CASP3	Caspase 3	Protein Coding	1
34	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	1
35	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
36	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
37	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
38	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	1
39	SMAD5	SMAD Family Member 5	Protein Coding	1
40	SMAD1	SMAD Family Member 1	Protein Coding	1
41	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
42	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
43	TBK1	TANK Binding Kinase 1	Protein Coding	1
44	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	1
45	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
46	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
47	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
48	LARP1	La Ribonucleoprotein 1, Translational Regulator	Protein Coding	1

Disorders associated with Network map of SARS-CoV-2 signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3E, CD3G, LCK, ZAP70	8.15
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3E	4.88
3	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1, IL6	4.58
4	Herpes simplex virus encephalitis	Enrichment	TBK1, TRAF3	3.91
5	Systemic lupus erythematosus	Enrichment	HLA-DRB1, IGHG1, IRAK1	3.46
6	Immunodeficiency 116	Enrichment	CD8A	2.67
7	Immunodeficiency 48	Enrichment	ZAP70	2.67
8	Okt4 epitope deficiency	Enrichment	CD4	2.67
9	Immunodeficiency 18	Enrichment	CD3E	2.67
10	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.67
11	Immunodeficiency 25	Enrichment	CD247	2.67
12	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.67
13	Agammaglobulinemia 2, autosomal recessive	Enrichment	IGLL1	2.67
14	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.67
15	Immunodeficiency 22	Enrichment	LCK	2.67
16	Immunodeficiency 79	Enrichment	CD4	2.67
17	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.67
18	Multisystem inflammatory syndrome in children	Enrichment	IFNB1, TRAF3	2.57
19	Proteus syndrome	Enrichment	AKT1	2.45
20	Vitiligo-associated multiple autoimmune disease susceptibility 1	Enrichment	NLRP1	2.45
21	Immunodeficiency 132a	Enrichment	TRAF3	2.45
22	Respiratory papillomatosis, juvenile recurrent, congenital	Enrichment	NLRP1	2.45
23	Immunodeficiency 132b	Enrichment	TRAF3	2.45
24	Cowden syndrome 6	Enrichment	AKT1	2.45
25	Palmoplantar carcinoma, multiple self-healing	Enrichment	NLRP1	2.45
26	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.45
27	Corticobasal syndrome	Enrichment	TBK1	2.45
28	Autoinflammation with arthritis and dyskeratosis	Enrichment	NLRP1	2.45
29	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.45
30	Sarcoidosis 1	Enrichment	HLA-DRB1	2.37
31	Immunodeficiency 17	Enrichment	CD3G	2.37
32	Bullous pemphigoid	Enrichment	HLA-DRB1	2.37
33	Pediatric multiple sclerosis	Enrichment	HLA-DRB1	2.37
34	Immunodeficiency 7	Enrichment	TRAC	2.19
35	Recurrent infections associated with rare immunoglobulin isotypes deficiency	Enrichment	IGHG2	2.19
36	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	2.19
37	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.15
38	Kaposi sarcoma	Enrichment	IL6	2.07
39	Temporal arteritis	Enrichment	HLA-DRB1	2.07
40	Enchondromatosis	Enrichment	HIF1A	1.98
41	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.97
42	Narcolepsy 2	Enrichment	HLA-DRB1	1.97
43	Follicular lymphoma	Enrichment	HLA-DRB1	1.97
44	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.97
45	Type 1 diabetes mellitus	Enrichment	IL6	1.89
46	Limited scleroderma	Enrichment	HLA-DRB1	1.89
47	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	1.85
48	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.83
49	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.83
50	Narcolepsy 1	Enrichment	HLA-DRB1	1.77
51	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.76
52	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.76
53	Inflammatory bowel disease 1	Enrichment	IL6	1.72
54	Breast adenocarcinoma	Enrichment	AKT1	1.68
55	Leukemia, chronic lymphocytic	Enrichment	IGHG1	1.67
56	Autosomal non-syndromic agammaglobulinemia	Enrichment	IGLL1	1.67
57	Combined immunodeficiency	Enrichment	ZAP70	1.63
58	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.63
59	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.63
60	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.61
61	Motor neuron disease	Enrichment	TBK1	1.61
62	Multiple sclerosis	Enrichment	HLA-DRB1	1.53
63	Progressive non-fluent aphasia	Enrichment	TBK1	1.50
64	Cowden syndrome	Enrichment	AKT1	1.50
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.46
66	Arteriovenous malformations of the brain	Enrichment	IL6	1.40
67	Meningioma	Enrichment	AKT1	1.38
68	Human immunodeficiency virus type 1	Enrichment	CCL2	1.21
69	Type 2 diabetes mellitus	Enrichment	IL6	1.07
70	Hereditary breast carcinoma	Enrichment	AKT1	0.84
71	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.73
72	Breast cancer	Enrichment	AKT1	0.63
73	Colorectal cancer	Enrichment	AKT1	0.57
74	Ovarian cancer	Enrichment	AKT1	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Network map of SARS-CoV-2 signaling pathway

Pathway Network for Network map of SARS-CoV-2 signaling pathway

Member Pathways for Network map of SARS-CoV-2 signaling pathway

Pathways in the Network map of SARS-CoV-2 signaling pathway SuperPath

Associated Genes for Network map of SARS-CoV-2 signaling pathway

Associated Disorders for Network map of SARS-CoV-2 signaling pathway

Disorders associated with Network map of SARS-CoV-2 signaling pathway SuperPath

STRING Interaction Network for Network map of SARS-CoV-2 signaling pathway

Sources for Network map of SARS-CoV-2 signaling pathway