Neural crest cell migration in cancer

Pathway network for the Neural crest cell migration in cancer SuperPath

Sources:

WikiPathways

Pathways in the Neural crest cell migration in cancer SuperPath

#	Name	Source	Genes
1	Neural crest cell migration in cancer	WikiPathways	AKT1 ARF1 BDNF EPHB6 F2RL2 JUN KIDINS220 MMP2 MMP8 MMP9 NGFR NTRK2 PAK1 PAK2 PIK3CG RAC1 RHOA SORT1 STAT3 TWIST1 (see all 20) (see less)
2	Cell migration and invasion through p75NTR	WikiPathways	ADAMTS13 AKT1 AKT2 AKT3 ARF1 BDNF EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3 JUN KIDINS220 MMP2 MMP8 MMP9 NGFR NTRK2 PAK1 PARD3 RAC1 RHOA STAT3 TIAM1 TRIO TWIST1 (see all 29) (see less)
3	Neural crest cell migration during development	WikiPathways	AKT1 ARF1 BDNF EPHB6 F2RL2 JUN MMP2 MMP8 MMP9 NGFR PAK1 PAK2 PIK3CG RAC1 RHOA STAT3 TWIST1 (see all 17) (see less)

Gene overlap in member pathways for Neural crest cell migration in cancer SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	3
2	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
3	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	3
4	RAC1	Rac Family Small GTPase 1	Protein Coding	3
5	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	3
6	NGFR	Nerve Growth Factor Receptor	Protein Coding	3
7	MMP9	Matrix Metallopeptidase 9	Protein Coding	3
8	MMP8	Matrix Metallopeptidase 8	Protein Coding	3
9	MMP2	Matrix Metallopeptidase 2	Protein Coding	3
10	RHOA	Ras Homolog Family Member A	Protein Coding	3
11	ARF1	ARF GTPase 1	Protein Coding	3
12	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
13	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
14	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
15	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
16	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	2
17	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	2
18	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	2
19	EPHB6	EPH Receptor B6	Protein Coding	2
20	SORT1	Sortilin 1	Protein Coding	1
21	EFNA2	Ephrin A2	Protein Coding	1
22	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	1
23	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
24	PARD3	Par-3 Family Cell Polarity Regulator	Protein Coding	1
25	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
26	EFNB2	Ephrin B2	Protein Coding	1
27	EFNB1	Ephrin B1	Protein Coding	1
28	EFNA5	Ephrin A5	Protein Coding	1
29	EFNA1	Ephrin A1	Protein Coding	1
30	ADAMTS13	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13	Protein Coding	1
31	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
32	EFNB3	Ephrin B3	Protein Coding	1
33	EFNA4	Ephrin A4	Protein Coding	1
34	EFNA3	Ephrin A3	Protein Coding	1

Disorders associated with Neural crest cell migration in cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	2.90
2	Knobloch syndrome 2	Enrichment	PAK2	2.90
3	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.90
4	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.90
5	Cowden syndrome 6	Enrichment	AKT1	2.90
6	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.90
7	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.90
8	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.90
9	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.90
10	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.90
11	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.90
12	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.90
13	Low density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SORT1	2.83
14	Ventriculomegaly and arthrogryposis	Enrichment	KIDINS220	2.83
15	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.83
16	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.83
17	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.67
18	Craniofrontonasal syndrome	Enrichment	EFNB1	2.67
19	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.67
20	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.67
21	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.67
22	Capillary hemangioma	Enrichment	AKT3	2.67
23	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.67
24	Robinow-sorauf syndrome	Enrichment	TWIST1	2.60
25	Sweeney-cox syndrome	Enrichment	TWIST1	2.60
26	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.60
27	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.60
28	Preterm premature rupture of the membranes	Enrichment	MMP8	2.60
29	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.60
30	Metaphyseal anadysplasia	Enrichment	MMP9	2.60
31	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	2.60
32	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	KIDINS220	2.53
33	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.43
34	Craniosynostosis 1	Enrichment	TWIST1	2.43
35	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.43
36	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.43
37	Hyper ige syndrome	Enrichment	STAT3	2.43
38	Breast cancer	Enrichment	AKT1, JUN	2.41
39	Thrombotic thrombocytopenic purpura, hereditary	Enrichment	ADAMTS13	2.37
40	Deafness, autosomal recessive 28	Enrichment	TRIO	2.37
41	Senior-loken syndrome 7	Enrichment	AKT3	2.37
42	Thrombotic thrombocytopenic purpura	Enrichment	ADAMTS13	2.37
43	Bardet-biedl syndrome 16	Enrichment	AKT3	2.37
44	Saethre-chotzen syndrome	Enrichment	TWIST1	2.30
45	Knobloch syndrome	Enrichment	PAK2	2.30
46	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	2.30
47	Knobloch syndrome 1	Enrichment	PAK2	2.20
48	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	2.19
49	Hemihyperplasia, isolated	Enrichment	RHOA	2.13
50	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	2.13
51	Breast adenocarcinoma	Enrichment	AKT1	2.13
52	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.07
53	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.07
54	Kabuki syndrome 1	Enrichment	KIDINS220	2.05
55	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.00
56	Pilomyxoid astrocytoma	Enrichment	NTRK2	1.99
57	Hemifacial hyperplasia	Enrichment	EFNB1	1.97
58	Hemimegalencephaly	Enrichment	AKT3	1.97
59	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.95
60	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.95
61	Cowden syndrome	Enrichment	AKT1	1.95
62	Megacolon	Enrichment	AKT3	1.83
63	Meningioma	Enrichment	AKT1	1.83
64	Acute promyelocytic leukemia	Enrichment	STAT3	1.79
65	Periventricular nodular heterotopia	Enrichment	ARF1	1.76
66	Polymicrogyria	Enrichment	AKT3	1.67
67	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.63
68	Neural tube defects	Enrichment	PARD3	1.56
69	Atypical hemolytic-uremic syndrome	Enrichment	ADAMTS13	1.50
70	Syndromic intellectual disability	Enrichment	TRIO	1.45
71	Hereditary breast carcinoma	Enrichment	AKT1	1.27
72	Cerebral palsy	Enrichment	KIDINS220	1.25
73	Body mass index quantitative trait locus 11	Enrichment	BDNF	1.22
74	West syndrome	Enrichment	NTRK2	1.20
75	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	1.10
76	Type 2 diabetes mellitus	Enrichment	AKT2	1.07
77	Thrombocytopenia	Enrichment	ADAMTS13	1.01
78	Colorectal cancer	Enrichment	AKT1	0.98
79	Hypertelorism	Enrichment	EFNB1	0.98
80	Ovarian cancer	Enrichment	AKT1	0.92
81	Microcephaly	Enrichment	TRIO	0.63
82	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neural crest cell migration in cancer

Pathway Network for Neural crest cell migration in cancer

Pathway network for the Neural crest cell migration in cancer SuperPath

Member Pathways for Neural crest cell migration in cancer

Pathways in the Neural crest cell migration in cancer SuperPath

Gene overlap in member pathways for Neural crest cell migration in cancer SuperPath

Associated Genes for Neural crest cell migration in cancer

Associated Disorders for Neural crest cell migration in cancer

Disorders associated with Neural crest cell migration in cancer SuperPath

STRING Interaction Network for Neural crest cell migration in cancer

Sources for Neural crest cell migration in cancer