Neural crest differentiation

No Pathway Network information available for Neural crest differentiation

Pathways in the Neural crest differentiation SuperPath

#	Name	Source	Genes
1	Neural crest differentiation	WikiPathways	ASCL1 AXIN1 AXIN2 BMP4 BMP7 CDH1 CDH2 CDH6 CDH7 COL11A2 COL2A1 CTBP2 CTNNB1 DCT DLL1 DLL3 DLL4 DLX5 DMBX1 DVL1 DVL2 DVL3 ETS1 FGF19 FGF2 FGF8 FGFR1 FGFR2 FGFR3 FOXD3 FZD3 GBX2 GFAP GJB1 GSK3B HAND1 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY2 HOXA1 HOXB1 ID1 ISL1 ITGB1 LHX1 LHX2 LHX5 MBP MIA MITF MPZ MSX1 MSX2 MYB MYC NEUROG1 NFKB1 NFKB2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OLIG1 OLIG2 OLIG3 PAX3 PAX7 PHOX2B PMP22 PRTG RBPJ RHOB SMAD1 SNAI1 SNAI2 SOX10 SOX5 SOX9 TBX6 TCF4 TCF7L1 TFAP2A TFAP2B TLX2 TWIST1 WNT1 WNT3A WNT8A ZIC1 ZIC5 (see all 101) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HDAC10	Histone Deacetylase 10	Protein Coding	1
2	HDAC11	Histone Deacetylase 11	Protein Coding	1
3	HDAC7	Histone Deacetylase 7	Protein Coding	1
4	HDAC8	Histone Deacetylase 8	Protein Coding	1
5	CDH1	Cadherin 1	Protein Coding	1
6	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
7	HDAC4	Histone Deacetylase 4	Protein Coding	1
8	HDAC9	Histone Deacetylase 9	Protein Coding	1
9	HAND1	Heart And Neural Crest Derivatives Expressed 1	Protein Coding	1
10	LHX2	LIM Homeobox 2	Protein Coding	1
11	WNT3A	Wnt Family Member 3A	Protein Coding	1
12	PHOX2B	Paired Like Homeobox 2B	Protein Coding	1
13	HDAC3	Histone Deacetylase 3	Protein Coding	1
14	ZIC5	Zic Family Zinc Finger 5	Protein Coding	1
15	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
16	AXIN2	Axin 2	Protein Coding	1
17	AXIN1	Axin 1	Protein Coding	1
18	MIA	MIA SH3 Domain Containing	Protein Coding	1
19	ZIC1	Zic Family Zinc Finger 1	Protein Coding	1
20	WNT8A	Wnt Family Member 8A	Protein Coding	1
21	WNT1	Wnt Family Member 1	Protein Coding	1
22	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
23	TFAP2B	Transcription Factor AP-2 Beta	Protein Coding	1
24	TFAP2A	Transcription Factor AP-2 Alpha	Protein Coding	1
25	TCF4	Transcription Factor 4	Protein Coding	1
26	TBX6	T-Box Transcription Factor 6	Protein Coding	1
27	SOX10	SRY-Box Transcription Factor 10	Protein Coding	1
28	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
29	SOX5	SRY-Box Transcription Factor 5	Protein Coding	1
30	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
31	SNAI2	Snail Family Transcriptional Repressor 2	Protein Coding	1
32	BMP7	Bone Morphogenetic Protein 7	Protein Coding	1
33	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
34	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
35	PMP22	Peripheral Myelin Protein 22	Protein Coding	1
36	PAX7	Paired Box 7	Protein Coding	1
37	PAX3	Paired Box 3	Protein Coding	1
38	NOTCH4	Notch Receptor 4	Protein Coding	1
39	NOTCH3	Notch Receptor 3	Protein Coding	1
40	NOTCH2	Notch Receptor 2	Protein Coding	1
41	NOTCH1	Notch Receptor 1	Protein Coding	1
42	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
43	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
44	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
45	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	1
46	MSX2	Msh Homeobox 2	Protein Coding	1
47	MSX1	Msh Homeobox 1	Protein Coding	1
48	MPZ	Myelin Protein Zero	Protein Coding	1
49	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	1
50	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
51	MBP	Myelin Basic Protein	Protein Coding	1
52	SMAD1	SMAD Family Member 1	Protein Coding	1
53	LHX1	LIM Homeobox 1	Protein Coding	1
54	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	1
55	RHOB	Ras Homolog Family Member B	Protein Coding	1
56	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
57	ISL1	ISL LIM Homeobox 1	Protein Coding	1
58	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
59	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
60	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
61	HOXB1	Homeobox B1	Protein Coding	1
62	HOXA1	Homeobox A1	Protein Coding	1
63	HDAC2	Histone Deacetylase 2	Protein Coding	1
64	HDAC1	Histone Deacetylase 1	Protein Coding	1
65	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
66	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
67	PRTG	Protogenin	Protein Coding	1
68	GJB1	Gap Junction Protein Beta 1	Protein Coding	1
69	FOXD3	Forkhead Box D3	Protein Coding	1
70	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	1
71	GBX2	Gastrulation Brain Homeobox 2	Protein Coding	1
72	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	1
73	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
74	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
75	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
76	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
77	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
78	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
79	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
80	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
81	DLX5	Distal-Less Homeobox 5	Protein Coding	1
82	CTNNB1	Catenin Beta 1	Protein Coding	1
83	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
84	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	1
85	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	1
86	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
87	CDH7	Cadherin 7	Protein Coding	1
88	CDH6	Cadherin 6	Protein Coding	1
89	HDAC5	Histone Deacetylase 5	Protein Coding	1
90	HDAC6	Histone Deacetylase 6	Protein Coding	1
91	CDH2	Cadherin 2	Protein Coding	1
92	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
93	OLIG3	Oligodendrocyte Transcription Factor 3	Protein Coding	1
94	DCT	Dopachrome Tautomerase	Protein Coding	1
95	DMBX1	Diencephalon/Mesencephalon Homeobox 1	Protein Coding	1
96	OLIG1	Oligodendrocyte Transcription Factor 1	Protein Coding	1
97	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	1
98	FZD3	Frizzled Class Receptor 3	Protein Coding	1
99	LHX5	LIM Homeobox 5	Protein Coding	1
100	NEUROG1	Neurogenin 1	Protein Coding	1
101	TLX2	T Cell Leukemia Homeobox 2	Protein Coding	1

Disorders associated with Neural crest differentiation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3, TWIST1	5.80
2	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3, TWIST1, ZIC1	5.80
3	Colorectal cancer	Enrichment	AXIN2, CDH1, CTNNB1, FGFR2, FGFR3, FZD3, SOX9	5.43
4	Hypertrophic neuropathy of dejerine-sottas	Enrichment	GJB1, MPZ, PMP22	5.40
5	Waardenburg syndrome	Enrichment	MITF, PAX3, SOX10	5.10
6	Waardenburg syndrome, type 1	Enrichment	MITF, PAX3, SOX10	4.86
7	Waardenburg syndrome, type 2e	Enrichment	MITF, SNAI2, SOX10	4.86
8	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	4.86
9	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL11A2, COL2A1	4.26
10	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.26
11	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.26
12	Roussy-levy hereditary areflexic dystasia	Enrichment	MPZ, PMP22	4.26
13	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL11A2, COL2A1	4.26
14	Connective tissue disease	Enrichment	COL2A1, FGFR3, NOTCH1, SOX9	4.05
15	Cleft lip/palate	Enrichment	BMP4, CDH1, MSX1	3.86
16	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.79
17	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	3.79
18	Waardenburg syndrome, type 2a	Enrichment	MITF, SOX10	3.79
19	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	3.79
20	Charcot-marie-tooth disease type 1	Enrichment	MPZ, PMP22	3.79
21	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	3.79
22	Microform holoprosencephaly	Enrichment	DLL1, FGF8, FGFR1	3.68
23	Lobar holoprosencephaly	Enrichment	DLL1, FGF8, FGFR1	3.68
24	Semilobar holoprosencephaly	Enrichment	DLL1, FGF8, FGFR1	3.52
25	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3	3.49
26	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3	3.49
27	Haddad syndrome	Enrichment	ASCL1, PHOX2B	3.49
28	Craniosynostosis	Enrichment	FGFR2, FGFR3, TFAP2B	3.38
29	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.27
30	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3	3.27
31	Rhabdomyosarcoma 2	Enrichment	PAX3, PAX7	3.27
32	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3	3.27
33	Holoprosencephaly	Enrichment	FGF8, FGFR1	3.27
34	Sensory peripheral neuropathy	Enrichment	GJB1, MPZ	3.27
35	Tooth agenesis	Enrichment	AXIN2, FGFR1, MSX1	3.25
36	Kallmann syndrome	Enrichment	FGF8, FGFR1, SOX10	3.20
37	Scoliosis	Enrichment	COL2A1, GFAP, TBX6	3.14
38	Split-hand/foot malformation 1	Enrichment	DLX5, FGFR2	3.09
39	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	3.09
40	Waardenburg syndrome, type 4a	Enrichment	MITF, SOX10	3.09
41	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3	3.09
42	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3, TBX6	3.09
43	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.95
44	Hirschsprung disease 1	Enrichment	AXIN2, PHOX2B, SOX10	2.90
45	Peripheral nervous system disease	Enrichment	GJB1, MPZ, PMP22	2.77
46	Neuropathy	Enrichment	GJB1, MPZ, PMP22	2.77
47	Tooth agenesis, selective, 1	Enrichment	AXIN2, MSX1	2.72
48	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	2.72
49	Stickler syndrome	Enrichment	BMP4, COL2A1	2.62
50	Rare genetic deafness	Enrichment	COL11A2, MITF, PAX3, SOX10	2.55
51	Epicanthus	Enrichment	TCF4, TFAP2A	2.46
52	Renal hypodysplasia/aplasia 3	Enrichment	BMP4, FGFR3	2.46
53	Charcot-marie-tooth disease	Enrichment	GJB1, MPZ, PMP22	2.46
54	Hydrocephalus	Enrichment	FGFR2, FZD3	2.27
55	Septopreoptic holoprosencephaly	Enrichment	DLL1, FGF8	2.27
56	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1, FGF8	2.27
57	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.21
58	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.16
59	Alobar holoprosencephaly	Enrichment	DLL1, FGF8	2.16
60	Stickler syndrome, type i	Enrichment	COL2A1	2.13
61	Charcot-marie-tooth disease and deafness	Enrichment	PMP22	2.13
62	Craniofacial-deafness-hand syndrome	Enrichment	PAX3	2.13
63	Hypochondroplasia	Enrichment	FGFR3	2.13
64	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.13
65	Parietal foramina with cleidocranial dysplasia	Enrichment	MSX2	2.13
66	Osteoglophonic dysplasia	Enrichment	FGFR1	2.13
67	Guillain-barre syndrome, familial	Enrichment	PMP22	2.13
68	Waardenburg syndrome, type 3	Enrichment	PAX3	2.13
69	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.13
70	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.13
71	Trigonocephaly 1	Enrichment	FGFR1	2.13
72	Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive	Enrichment	DLX5	2.13
73	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.13
74	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.13
75	Muenke syndrome	Enrichment	FGFR3	2.13
76	Deafness, autosomal recessive 53	Enrichment	COL11A2	2.13
77	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.13
78	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	2.13
79	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.13
80	Czech dysplasia	Enrichment	COL2A1	2.13
81	Char syndrome	Enrichment	TFAP2B	2.13
82	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.13
83	Charcot-marie-tooth disease, axonal, type 2j	Enrichment	MPZ	2.13
84	Neuropathy, hereditary, with liability to pressure palsies	Enrichment	PMP22	2.13
85	Kniest dysplasia	Enrichment	COL2A1	2.13
86	Apert syndrome	Enrichment	FGFR2	2.13
87	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.13
88	Alagille syndrome 2	Enrichment	NOTCH2	2.13
89	Heterochromia iridis	Enrichment	MITF	2.13
90	Parietal foramina 1	Enrichment	MSX2	2.13
91	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.13
92	Tietz albinism-deafness syndrome	Enrichment	MITF	2.13
93	Lateral meningocele syndrome	Enrichment	NOTCH3	2.13
94	Lamb-shaffer syndrome	Enrichment	SOX5	2.13
95	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.13
96	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.13
97	Caudal duplication anomaly	Enrichment	AXIN1	2.13
98	Craniosynostosis 6	Enrichment	ZIC1	2.13
99	Facial paresis, hereditary congenital, 3	Enrichment	HOXB1	2.13
100	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.13
101	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.13
102	Achondrogenesis, type ii	Enrichment	COL2A1	2.13
103	46,xy sex reversal 10	Enrichment	SOX9	2.13
104	Adams-oliver syndrome 6	Enrichment	DLL4	2.13
105	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.13
106	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.13
107	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.13
108	46,xx sex reversal 2	Enrichment	SOX9	2.13
109	Microphthalmia, syndromic 6	Enrichment	BMP4	2.13
110	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.13
111	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.13
112	Orofacial cleft 11	Enrichment	BMP4	2.13
113	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.13
114	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.13
115	Athabaskan brainstem dysgenesis syndrome	Enrichment	HOXA1	2.13
116	Deafness, autosomal dominant 13	Enrichment	COL11A2	2.13
117	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.13
118	Craniosynostosis 2	Enrichment	MSX2	2.13
119	Charcot-marie-tooth disease, dominant intermediate d	Enrichment	MPZ	2.13
120	Charcot-marie-tooth disease, axonal, type 2i	Enrichment	MPZ	2.13
121	Congenital myopathy 19	Enrichment	PAX7	2.13
122	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.13
123	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.13
124	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.13
125	Fibrochondrogenesis 2	Enrichment	COL11A2	2.13
126	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	2.13
127	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.13
128	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.13
129	Structural brain anomalies with impaired intellectual development and craniosynostosis	Enrichment	ZIC1	2.13
130	Patent ductus arteriosus 2	Enrichment	TFAP2B	2.13
131	Hartsfield syndrome	Enrichment	FGFR1	2.13
132	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.13
133	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.13
134	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.13
135	Autosomal dominant intermediate charcot-marie-tooth disease with neuropathic pain	Enrichment	MPZ	2.13
136	Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay	Enrichment	NEUROG1	2.13
137	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.13
138	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.13
139	Adenoid ameloblastoma	Enrichment	CTNNB1	2.13
140	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.13
141	Charcot-marie-tooth disease type 2i	Enrichment	MPZ	2.13
142	Congenital hereditary facial paralysis-variable hearing loss syndrome	Enrichment	HOXB1	2.13
143	Transient cerebral ischemia	Enrichment	NOTCH3	2.13
144	Breast lobular carcinoma	Enrichment	CDH1	2.13
145	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.13
146	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.13
147	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.13
148	Hypochondrogenesis	Enrichment	COL2A1	2.13
149	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.13
150	Split hand-foot malformation 1 with sensorineural hearing loss	Enrichment	DLX5	2.13
151	Charcot-marie-tooth disease type 2j	Enrichment	MPZ	2.13
152	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.13
153	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.13
154	Cystic lymphangioma	Enrichment	COL11A2	2.13
155	Bosley-salih-alorainy syndrome	Enrichment	HOXA1	2.13
156	Hirschsprung disease-ganglioneuroblastoma syndrome	Enrichment	PHOX2B	2.13
157	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.13
158	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.13
159	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.13
160	Autosomal dominant spondylocostal dysostosis	Enrichment	TBX6	2.13
161	Microcystic stromal tumor	Enrichment	CTNNB1	2.13
162	Heart, malformation of	Enrichment	COL11A2, COL2A1	2.11
163	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF8, FGFR1	2.11
164	Endometrial cancer	Enrichment	CDH1, FGFR2	1.98
165	Hepatoblastoma	Enrichment	CTNNB1, FGFR3	1.98
166	Hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	1.94
167	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB, MYC	1.90
168	Ear malformation	Enrichment	COL11A2, MITF	1.87
169	Charcot-marie-tooth disease, demyelinating, type 1a	Enrichment	PMP22	1.83
170	Charcot-marie-tooth disease, demyelinating, type 1b	Enrichment	MPZ	1.83
171	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.83
172	Burkitt lymphoma	Enrichment	MYC	1.83
173	Campomelic dysplasia	Enrichment	SOX9	1.83
174	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1	1.83
175	Alexander disease	Enrichment	GFAP	1.83
176	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1	1.83
177	Robinow-sorauf syndrome	Enrichment	TWIST1	1.83
178	Spinocerebellar ataxia, x-linked 1	Enrichment	GJB1	1.83
179	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.83
180	Cervical cancer	Enrichment	FGFR3	1.83
181	Waardenburg syndrome, type 4c	Enrichment	SOX10	1.83
182	Keratoderma, palmoplantar, with nail dystrophy and hereditary motor-sensory neuropathy	Enrichment	MPZ	1.83
183	Piebald trait	Enrichment	SNAI2	1.83
184	Aural atresia, congenital	Enrichment	FGFR2	1.83
185	Legg-calve-perthes disease	Enrichment	COL2A1	1.83
186	Keratosis, seborrheic	Enrichment	FGFR3	1.83
187	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	MPZ	1.83
188	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.83
189	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	1.83
190	Orofacial cleft 5	Enrichment	MSX1	1.83
191	Adams-oliver syndrome 5	Enrichment	NOTCH1	1.83
192	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3	1.83
193	Witkop syndrome	Enrichment	MSX1	1.83
194	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.83
195	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.83
196	Syndactyly, type iii	Enrichment	HDAC8	1.83
197	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	GFAP	1.83
198	Adams-oliver syndrome 3	Enrichment	RBPJ	1.83
199	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.83
200	Oculocutaneous albinism, type viii	Enrichment	DCT	1.83
201	Sweeney-cox syndrome	Enrichment	TWIST1	1.83
202	Neuropathy, congenital hypomyelinating, 2	Enrichment	MPZ	1.83
203	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	1.83
204	Infantile myofibromatosis	Enrichment	NOTCH3	1.83
205	Charcot-marie-tooth disease type 1b	Enrichment	MPZ	1.83
206	Melanoma, cutaneous malignant 8	Enrichment	MITF	1.83
207	Fibrochondrogenesis	Enrichment	COL11A2	1.83
208	Wilson-turner syndrome	Enrichment	HDAC8	1.83
209	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.83
210	Bladder exstrophy	Enrichment	ISL1	1.83
211	Parietal foramina	Enrichment	MSX2	1.83
212	Acute basophilic leukemia	Enrichment	MYB	1.83
213	Split hand-foot malformation	Enrichment	FGFR2	1.83
214	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	1.83
215	Charcot-marie-tooth disease type 1a	Enrichment	PMP22	1.83
216	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	1.83
217	Depressive disorder	Enrichment	NOTCH3	1.83
218	Papillary renal cell carcinoma	Enrichment	MITF	1.83
219	Peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease	Enrichment	SOX10	1.83
220	Angiocentric glioma	Enrichment	MYB	1.83
221	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	1.83
222	Cervix carcinoma	Enrichment	FGFR3	1.83
223	Esotropia	Enrichment	TFAP2A	1.83
224	Isolated dandy-walker malformation with hydrocephalus	Enrichment	ZIC1	1.83
225	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.83
226	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.83
227	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.83
228	Teratoma	Enrichment	CTNNB1	1.83
229	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	1.83
230	Common variable immunodeficiency 12	Enrichment	NFKB1	1.83
231	Lens subluxation	Enrichment	TFAP2A	1.83
232	Familial patent arterial duct	Enrichment	TFAP2B	1.83
233	Campomelic dysplasia and related disorders	Enrichment	SOX9	1.83
234	Tetralogy of fallot	Enrichment	HEY2, NOTCH1	1.80
235	Auditory neuropathy	Enrichment	CDH2, NOTCH3	1.80
236	Inherited cancer-predisposing syndrome	Enrichment	AXIN2, CDH1, MITF, PHOX2B	1.77
237	Strabismus	Enrichment	DMBX1, SOX5	1.77
238	Bladder cancer	Enrichment	CTNNB1, FGFR3	1.71
239	Desmoid disease, hereditary	Enrichment	CTNNB1	1.65
240	Achondroplasia	Enrichment	FGFR3	1.65
241	Mccune-albright syndrome	Enrichment	COL2A1	1.65
242	Craniosynostosis 1	Enrichment	TWIST1	1.65
243	Jacobsen syndrome	Enrichment	ETS1	1.65
244	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.65
245	Larsen syndrome	Enrichment	FGFR3	1.65
246	Spondylocostal dysostosis 5	Enrichment	TBX6	1.65
247	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	1.65
248	Hypophosphatasia, infantile	Enrichment	COL11A2	1.65
249	46,xx sex reversal 1	Enrichment	SOX9	1.65
250	Autoimmune disease 1	Enrichment	FOXD3	1.65
251	Charcot-marie-tooth disease, x-linked dominant, 1	Enrichment	GJB1	1.65
252	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.65
253	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.65
254	Chromosome 17q12 deletion syndrome	Enrichment	LHX1	1.65
255	Neuroblastoma 2	Enrichment	PHOX2B	1.65
256	Anus, imperforate	Enrichment	CTNNB1	1.65
257	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.65
258	Desmoid tumor	Enrichment	CTNNB1	1.65
259	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.65
260	Hamartoma	Enrichment	FGFR3	1.65
261	Testicular germ cell cancer	Enrichment	FGFR3	1.65
262	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	1.65
263	Migraine without aura	Enrichment	NOTCH3	1.65
264	Adenoid cystic carcinoma	Enrichment	MYB	1.65
265	Spermatocytoma	Enrichment	FGFR3	1.65
266	Multiple epiphyseal dysplasia	Enrichment	COL2A1	1.65
267	Testicular cancer	Enrichment	FGFR3	1.65
268	Isolated dandy-walker malformation without hydrocephalus	Enrichment	ZIC1	1.65
269	Branchiooculofacial syndrome	Enrichment	TFAP2A	1.53
270	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.53
271	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.53
272	Pitt-hopkins syndrome	Enrichment	TCF4	1.53
273	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.53
274	Pilomatrixoma	Enrichment	CTNNB1	1.53
275	Alazami syndrome	Enrichment	CTNNB1	1.53
276	Central hypoventilation syndrome, congenital, 1	Enrichment	PHOX2B	1.53
277	Cerebrovascular disease	Enrichment	NOTCH3	1.53
278	Craniopharyngioma	Enrichment	CTNNB1	1.53
279	Glioma	Enrichment	FGFR2	1.53
280	Cleft lip and alveolus	Enrichment	MSX1	1.53
281	Clear cell papillary renal cell carcinoma	Enrichment	MITF	1.53
282	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	MPZ	1.44
283	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.44
284	Retinal detachment	Enrichment	COL2A1	1.44
285	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.44
286	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	SOX10	1.44
287	Ventricular septal defect 1	Enrichment	BMP7	1.44
288	Cholangitis, primary sclerosing	Enrichment	TCF4	1.44
289	Congenital heart defects, multiple types, 4	Enrichment	BMP7	1.44
290	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.44
291	Amblyopia	Enrichment	TFAP2A	1.44
292	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9	1.44
293	Aplasia cutis congenita	Enrichment	DLL4	1.44
294	Vascular dementia	Enrichment	NOTCH3	1.44
295	Cleft upper lip	Enrichment	MSX1	1.44
296	Genetic motor neuron disease	Enrichment	MPZ	1.44
297	Farsightedness	Enrichment	DMBX1	1.44
298	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.44
299	Nonsyndromic hearing loss	Enrichment	COL11A2, MITF	1.41
300	Ovarian cancer	Enrichment	AXIN2, CDH1, CTNNB1	1.40
301	Gastric cancer	Enrichment	CDH1, FGFR2	1.39
302	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	HEY2, NOTCH1	1.37
303	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.36
304	Branchiootorenal syndrome 1	Enrichment	TFAP2A	1.36
305	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.36
306	Pierre robin syndrome	Enrichment	SOX9	1.36
307	Metachromatic leukodystrophy	Enrichment	GFAP	1.36
308	Testicular germ cell tumor	Enrichment	FGFR3	1.36
309	Anterior segment dysgenesis 5	Enrichment	BMP4	1.36
310	Intestinal pseudo-obstruction	Enrichment	TFAP2B	1.36
311	Pain disorder	Enrichment	GJB1	1.36
312	Adrenocortical carcinoma	Enrichment	CTNNB1	1.36
313	Lung squamous cell carcinoma	Enrichment	FGFR3	1.36
314	46,xy disorder of sex development	Enrichment	FGFR3	1.36
315	Multicystic kidney dysplasia	Enrichment	FZD3	1.36
316	Albinism	Enrichment	DCT	1.36
317	Cleft lip with or without cleft palate	Enrichment	CDH1	1.36
318	Multicystic dysplastic kidney	Enrichment	FZD3	1.36
319	Nevus, epidermal	Enrichment	FGFR3	1.29
320	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1	1.29
321	Branchiootorenal syndrome	Enrichment	TFAP2A	1.29
322	Motor neuron disease	Enrichment	MPZ	1.29
323	Gallbladder cancer	Enrichment	CTNNB1	1.29
324	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.29
325	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1, TCF4	1.27
326	Hypertelorism	Enrichment	FGFR2, TFAP2A	1.24
327	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	COL11A2, MITF	1.24
328	Melanocytic nevus syndrome, congenital	Enrichment	SOX5	1.24
329	Spastic paraplegia 4, autosomal dominant	Enrichment	TCF4	1.24
330	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.24
331	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.24
332	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.24
333	Neuroblastoma	Enrichment	PHOX2B	1.24
334	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.24
335	Isolated split hand-split foot malformation	Enrichment	DLX5	1.24
336	Microcephaly	Enrichment	CTNNB1, HDAC8, TCF4	1.19
337	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.19
338	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.19
339	Congenital central hypoventilation syndrome	Enrichment	PHOX2B	1.19
340	Cornelia de lange syndrome	Enrichment	HDAC8	1.19
341	Myeloma, multiple	Enrichment	FGFR3, HDAC4	1.19
342	Cat eye syndrome	Enrichment	TFAP2A	1.14
343	Marfan syndrome	Enrichment	COL2A1	1.14
344	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.14
345	Peters-plus syndrome	Enrichment	BMP4	1.14
346	Stroke, ischemic	Enrichment	NOTCH3	1.14
347	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.14
348	Melanoma	Enrichment	MITF	1.14
349	Primary bone dysplasia	Enrichment	FGFR3	1.14
350	Migraine with or without aura 1	Enrichment	NOTCH3	1.10
351	Atrial heart septal defect	Enrichment	HDAC8	1.10
352	46,xy complete gonadal dysgenesis	Enrichment	SOX9	1.10
353	Osteochondrodysplasia	Enrichment	FGFR3	1.10
354	Interatrial communication	Enrichment	HDAC8	1.10
355	Septooptic dysplasia	Enrichment	FGFR1	1.07
356	Aortic valve disease 1	Enrichment	NOTCH1	1.03
357	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.03
358	Neural tube defects	Enrichment	ITGB1	1.03
359	Stereotypic movement disorder	Enrichment	TCF4	1.03
360	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.00
361	Osteoporosis	Enrichment	WNT1	1.00
362	Medulloblastoma	Enrichment	CTNNB1	1.00
363	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.00
364	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	1.00
365	46,xy partial gonadal dysgenesis	Enrichment	SOX9	1.00
366	Corpus callosum, agenesis of	Enrichment	CDH2	0.97
367	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.97
368	Myopia	Enrichment	COL2A1	0.97
369	Isolated corpus callosum agenesis	Enrichment	CDH2	0.97
370	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	0.97
371	Melanoma, cutaneous malignant 1	Enrichment	MITF	0.92
372	Polycystic liver disease	Enrichment	CTNNB1	0.92
373	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.92
374	Charcot-marie-tooth disease type 4	Enrichment	MPZ	0.90
375	Polycystic kidney disease	Enrichment	HDAC8	0.90
376	Arteriovenous malformations of the brain	Enrichment	CDH2	0.88
377	Microphthalmia	Enrichment	TFAP2A	0.82
378	Brittle bone disorder	Enrichment	WNT1	0.80
379	Congenital nervous system abnormality	Enrichment	CTNNB1, FGFR3	0.73
380	Nervous system disease	Enrichment	CTNNB1, FGFR3	0.73
381	Prostate cancer	Enrichment	CDH1	0.71
382	Stargardt disease 1	Enrichment	COL2A1	0.70
383	Non-syndromic genetic deafness	Enrichment	MITF	0.63
384	Systemic lupus erythematosus	Enrichment	ETS1	0.60
385	Type 2 diabetes mellitus	Enrichment	RBPJ	0.57
386	Distal arthrogryposis	Enrichment	FZD3	0.57
387	Hereditary breast carcinoma	Enrichment	CDH1	0.55
388	Sensorineural hearing loss	Enrichment	COL11A2	0.52
389	Hereditary breast ovarian cancer syndrome	Enrichment	MITF	0.47
390	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	0.47
391	Primary ovarian insufficiency	Enrichment	NOTCH2	0.45
392	Breast cancer	Enrichment	CDH1	0.37
393	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	COL11A2	0.31
394	Autism spectrum disorder	Enrichment	TCF4	0.25
395	Hereditary retinal dystrophy	Enrichment	COL11A2, COL2A1	0.19
396	Fundus dystrophy	Enrichment	COL11A2, COL2A1	0.19

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neural crest differentiation

Pathway Network for Neural crest differentiation

Member Pathways for Neural crest differentiation

Pathways in the Neural crest differentiation SuperPath

Associated Genes for Neural crest differentiation

Associated Disorders for Neural crest differentiation

Disorders associated with Neural crest differentiation SuperPath

STRING Interaction Network for Neural crest differentiation

Sources for Neural crest differentiation