Neuroinflammation and glutamatergic signaling

No Pathway Network information available for Neuroinflammation and glutamatergic signaling

Pathways in the Neuroinflammation and glutamatergic signaling SuperPath

#	Name	Source	Genes
1	Neuroinflammation and glutamatergic signaling	WikiPathways	ADCY1 ADCY3 ADCY8 AKT1 ARC BCL2 BDNF CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CFL1 CNTF CREB1 DAO DISC1 DLAT DLD FGF2 FOS GFAP GLS GLS2 GLUL GOT1 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GRM1 GRM2 GRM4 GRM5 GRM7 GRM8 IFNG IFNGR1 IFNGR2 IGF1 IL10 IL10RA IL10RB IL12A IL12B IL13 IL13RA1 IL1A IL1B IL1R1 IL1R2 IL4 IL4R IL6 IL6R IL6ST INSR IRS1 JAK1 LIF LRRC8A LRRC8B LRRC8C LRRC8D LRRC8E LTA MAPK1 MAPK3 NFKB1 NFKB2 NGF NOS1 NSMF PDHA1 PHGDH PLCB1 PLCB2 PLCB3 PLCB4 PPP1CA PPP1CB PPP1CC PRKACA PRKCA PRKCB PRKCG PSAT1 PSPH SHMT1 SHMT2 SLC17A6 SLC17A7 SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A6 SLC2A1 SLC2A3 SLC38A1 SLC38A2 SLC38A3 SLC38A5 SLC6A9 SLC7A10 SMAD2 SMAD3 SMAD4 SMAD7 SOCS3 SRR STAT1 STAT3 STAT6 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TNF TNFRSF1A TNFRSF1B TRAF5 TRPM4 (see all 140) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GLUL	Glutamate-Ammonia Ligase	Protein Coding	1
2	PLCB3	Phospholipase C Beta 3	Protein Coding	1
3	PLCB2	Phospholipase C Beta 2	Protein Coding	1
4	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
5	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	1
6	LRRC8C	Leucine Rich Repeat Containing 8 VRAC Subunit C	Protein Coding	1
7	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
8	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
9	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
10	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
11	CALM1	Calmodulin 1	Protein Coding	1
12	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	1
13	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
14	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
15	TNF	Tumor Necrosis Factor	Protein Coding	1
16	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
17	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
18	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
19	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
20	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
21	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
22	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
23	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
24	SLC6A9	Solute Carrier Family 6 Member 9	Protein Coding	1
25	SLC2A3	Solute Carrier Family 2 Member 3	Protein Coding	1
26	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
27	SLC1A4	Solute Carrier Family 1 Member 4	Protein Coding	1
28	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	1
29	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	1
30	SLC1A1	Solute Carrier Family 1 Member 1	Protein Coding	1
31	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	1
32	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	1
33	SRR	Serine Racemase	Protein Coding	1
34	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
35	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
36	PSPH	Phosphoserine Phosphatase	Protein Coding	1
37	SLC17A6	Solute Carrier Family 17 Member 6	Protein Coding	1
38	SLC17A7	Solute Carrier Family 17 Member 7	Protein Coding	1
39	LRRC8A	Leucine Rich Repeat Containing 8 VRAC Subunit A	Protein Coding	1
40	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
41	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
42	PRKCG	Protein Kinase C Gamma	Protein Coding	1
43	PRKCB	Protein Kinase C Beta	Protein Coding	1
44	PRKCA	Protein Kinase C Alpha	Protein Coding	1
45	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
46	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
47	TRPM4	Transient Receptor Potential Cation Channel Subfamily M Member 4	Protein Coding	1
48	SLC38A2	Solute Carrier Family 38 Member 2	Protein Coding	1
49	PLCB4	Phospholipase C Beta 4	Protein Coding	1
50	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
51	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
52	NGF	Nerve Growth Factor	Protein Coding	1
53	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
54	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
55	SMAD7	SMAD Family Member 7	Protein Coding	1
56	SMAD4	SMAD Family Member 4	Protein Coding	1
57	SMAD3	SMAD Family Member 3	Protein Coding	1
58	SMAD2	SMAD Family Member 2	Protein Coding	1
59	LTA	Lymphotoxin Alpha	Protein Coding	1
60	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	1
61	JAK1	Janus Kinase 1	Protein Coding	1
62	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
63	INSR	Insulin Receptor	Protein Coding	1
64	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	1
65	IL13	Interleukin 13	Protein Coding	1
66	IL12B	Interleukin 12B	Protein Coding	1
67	IL12A	Interleukin 12A	Protein Coding	1
68	IL10RB	Interleukin 10 Receptor Subunit Beta	Protein Coding	1
69	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
70	IL10	Interleukin 10	Protein Coding	1
71	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
72	IL6R	Interleukin 6 Receptor	Protein Coding	1
73	IL6	Interleukin 6	Protein Coding	1
74	IL4R	Interleukin 4 Receptor	Protein Coding	1
75	IL4	Interleukin 4	Protein Coding	1
76	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
77	IL1B	Interleukin 1 Beta	Protein Coding	1
78	IL1A	Interleukin 1 Alpha	Protein Coding	1
79	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
80	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
81	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
82	IFNG	Interferon Gamma	Protein Coding	1
83	PSAT1	Phosphoserine Aminotransferase 1	Protein Coding	1
84	GRM8	Glutamate Metabotropic Receptor 8	Protein Coding	1
85	GRM7	Glutamate Metabotropic Receptor 7	Protein Coding	1
86	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	1
87	GRM4	Glutamate Metabotropic Receptor 4	Protein Coding	1
88	GRM2	Glutamate Metabotropic Receptor 2	Protein Coding	1
89	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	1
90	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
91	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
92	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
93	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
94	GRIK5	Glutamate Ionotropic Receptor Kainate Type Subunit 5	Protein Coding	1
95	GRIK3	Glutamate Ionotropic Receptor Kainate Type Subunit 3	Protein Coding	1
96	GRIK2	Glutamate Ionotropic Receptor Kainate Type Subunit 2	Protein Coding	1
97	GRIK1	Glutamate Ionotropic Receptor Kainate Type Subunit 1	Protein Coding	1
98	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
99	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
100	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
101	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	1
102	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	1
103	GLS	Glutaminase	Protein Coding	1
104	DISC1	DISC1 Scaffold Protein	Protein Coding	1
105	GLS2	Glutaminase 2	Protein Coding	1
106	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	1
107	PHGDH	Phosphoglycerate Dehydrogenase	Protein Coding	1
108	NSMF	NMDA Receptor Synaptonuclear Signaling And Neuronal Migration Factor	Protein Coding	1
109	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
110	ARC	Activity Regulated Cytoskeleton Associated Protein	Protein Coding	1
111	PLCB1	Phospholipase C Beta 1	Protein Coding	1
112	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
113	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
114	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	1
115	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	1
116	DAO	D-Amino Acid Oxidase	Protein Coding	1
117	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
118	CNTF	Ciliary Neurotrophic Factor	Protein Coding	1
119	GRIN3A	Glutamate Ionotropic Receptor NMDA Type Subunit 3A	Protein Coding	1
120	ADCY8	Adenylate Cyclase 8	Protein Coding	1
121	ADCY3	Adenylate Cyclase 3	Protein Coding	1
122	CFL1	Cofilin 1	Protein Coding	1
123	ADCY1	Adenylate Cyclase 1	Protein Coding	1
124	CAMKK2	Calcium/Calmodulin Dependent Protein Kinase Kinase 2	Protein Coding	1
125	SLC38A5	Solute Carrier Family 38 Member 5	Protein Coding	1
126	GRIN3B	Glutamate Ionotropic Receptor NMDA Type Subunit 3B	Protein Coding	1
127	SLC38A3	Solute Carrier Family 38 Member 3	Protein Coding	1
128	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
129	SLC38A1	Solute Carrier Family 38 Member 1	Protein Coding	1
130	LRRC8E	Leucine Rich Repeat Containing 8 VRAC Subunit E	Protein Coding	1
131	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	1
132	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
133	SLC1A6	Solute Carrier Family 1 Member 6	Protein Coding	1
134	SLC7A10	Solute Carrier Family 7 Member 10	Protein Coding	1
135	LRRC8D	Leucine Rich Repeat Containing 8 VRAC Subunit D	Protein Coding	1
136	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
137	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1
138	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1
139	GRIK4	Glutamate Ionotropic Receptor Kainate Type Subunit 4	Protein Coding	1
140	LRRC8B	Leucine Rich Repeat Containing 8 VRAC Subunit B	Protein Coding	1

Disorders associated with Neuroinflammation and glutamatergic signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	9.98
2	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, IL10RA, IL10RB, TGFB1	6.79
3	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	6.52
4	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	5.97
5	Behcet syndrome	Enrichment	IFNGR1, IL10, IL12A, TNFRSF1A	4.43
6	West syndrome	Enrichment	GRIA3, GRIN1, GRIN2B, PLCB1, SLC2A1	4.07
7	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.98
8	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	3.98
9	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	3.91
10	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GRIA1, GRIN1, GRIN2B	3.80
11	Psoriatic arthritis	Enrichment	LTA, TNF	3.50
12	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	3.50
13	Hepatitis b	Enrichment	IFNGR1, IL10RB	3.20
14	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.20
15	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A, PLCB1, SLC2A1	3.09
16	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	3.03
17	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A, PLCB1, SLC2A1	3.01
18	Inflammatory bowel disease 25, autosomal recessive	Enrichment	IL10RB, TGFB1	2.81
19	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.67
20	Alternating hemiplegia of childhood	Enrichment	SLC1A3, SLC2A1	2.55
21	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIK2, GRIN1, GRM7	2.52
22	Asthma	Enrichment	IL13, TNF	2.26
23	Epilepsy	Enrichment	GRIN2A, GRIN2B, SLC2A1	2.09
24	Microcephaly	Enrichment	CAMK2B, GRIN2B, GRM7, MAPK1, SLC2A1	2.05
25	Type 2 diabetes mellitus	Enrichment	IL6, INSR, IRS1	2.04
26	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	1.99
27	Proteus syndrome	Enrichment	AKT1	1.99
28	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	1.99
29	Neu-laxova syndrome 1	Enrichment	PHGDH	1.99
30	Donohue syndrome	Enrichment	INSR	1.99
31	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	1.99
32	Dicarboxylic aminoaciduria	Enrichment	SLC1A1	1.99
33	Helicobacter pylori infection	Enrichment	IFNGR1	1.99
34	Phosphoglycerate dehydrogenase deficiency	Enrichment	PHGDH	1.99
35	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	1.99
36	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	1.99
37	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	1.99
38	Leprosy 4	Enrichment	LTA	1.99
39	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	1.99
40	Dermatitis, atopic, 4	Enrichment	SOCS3	1.99
41	Episodic ataxia, type 6	Enrichment	SLC1A3	1.99
42	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.99
43	Deafness, autosomal recessive 44	Enrichment	ADCY1	1.99
44	Developmental and epileptic encephalopathy 41	Enrichment	SLC1A2	1.99
45	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	1.99
46	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	1.99
47	Immunodeficiency 27a	Enrichment	IFNGR1	1.99
48	Schizophrenia 18	Enrichment	SLC1A1	1.99
49	Immunodeficiency 69	Enrichment	IFNG	1.99
50	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	1.99
51	Noonan syndrome 13	Enrichment	MAPK1	1.99
52	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	1.99
53	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	1.99
54	Neurodevelopmental disorder with impaired language and ataxia and with or without seizures	Enrichment	GRIK2	1.99
55	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	1.99
56	Casgid syndrome	Enrichment	GLS	1.99
57	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	1.99
58	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	1.99
59	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	1.99
60	Progressive familial heart block, type ib	Enrichment	TRPM4	1.99
61	Graft-versus-host disease	Enrichment	IL10	1.99
62	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.99
63	Erythrokeratodermia variabilis et progressiva 6	Enrichment	TRPM4	1.99
64	Phosphoserine aminotransferase deficiency	Enrichment	PSAT1	1.99
65	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.99
66	Developmental and epileptic encephalopathy 102	Enrichment	SLC38A3	1.99
67	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	1.99
68	Allergic rhinitis	Enrichment	IL13	1.99
69	Intellectual developmental disorder, autosomal recessive 6	Enrichment	GRIK2	1.99
70	Immunodeficiency 27b	Enrichment	IFNGR1	1.99
71	Camurati-engelmann disease 2	Enrichment	TGFB2	1.99
72	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	1.99
73	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.99
74	Developmental and epileptic encephalopathy 71	Enrichment	GLS	1.99
75	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.99
76	Agammaglobulinemia 5, autosomal dominant	Enrichment	LRRC8A	1.99
77	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	1.99
78	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	1.99
79	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	1.99
80	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	1.99
81	Immunodeficiency 31a	Enrichment	STAT1	1.99
82	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	1.99
83	Multiple sclerosis 5	Enrichment	TNFRSF1A	1.99
84	Immunodeficiency 29	Enrichment	IL12B	1.99
85	Cowden syndrome 6	Enrichment	AKT1	1.99
86	Phosphoserine phosphatase deficiency	Enrichment	PSPH	1.99
87	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	1.99
88	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	1.99
89	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	1.99
90	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.99
91	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.99
92	Colorectal cancer 3	Enrichment	SMAD7	1.99
93	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	1.99
94	Immunodeficiency 31b	Enrichment	STAT1	1.99
95	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	1.99
96	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	1.99
97	Loeys-dietz syndrome 5	Enrichment	TGFB3	1.99
98	Glycine encephalopathy with normal serum glycine	Enrichment	SLC6A9	1.99
99	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.99
100	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.99
101	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	1.99
102	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	1.99
103	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	1.99
104	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	1.99
105	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	1.99
106	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	1.99
107	Spinocerebellar ataxia 44	Enrichment	GRM1	1.99
108	Developmental and epileptic encephalopathy 116	Enrichment	GLUL	1.99
109	Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities	Enrichment	GRM7	1.99
110	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	1.99
111	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	1.99
112	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.99
113	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	1.99
114	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.99
115	Neu-laxova syndrome 2	Enrichment	PSAT1	1.99
116	Heritable thoracic aortic disease	Enrichment	SMAD4	1.99
117	Telangiectasia, impaired intellectual development, microcephaly, metaphyseal dysplasia, eye abnormalities, and short stature	Enrichment	LRRC8C	1.99
118	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	1.99
119	Hot water epilepsy	Enrichment	SLC1A1	1.99
120	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	1.99
121	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	1.99
122	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.99
123	Landau-kleffner syndrome	Enrichment	GRIN2A	1.99
124	Epilepsy with myoclonic absences	Enrichment	SLC2A1	1.99
125	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	1.99
126	Neurometabolic disorder due to serine deficiency	Enrichment	PSAT1	1.99
127	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	1.99
128	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	1.99
129	Grin2a-related disorders	Enrichment	GRIN2A	1.99
130	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	1.99
131	Neu-laxova syndrome due to 3-phosphoserine phosphatase deficiency	Enrichment	PSPH	1.99
132	Chondromyxoid fibroma	Enrichment	GRM1	1.99
133	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.99
134	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	1.99
135	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	1.99
136	Human immunodeficiency virus type 1	Enrichment	IFNG, IL10	1.84
137	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1, GRM7	1.84
138	Body mass index quantitative trait locus 11	Enrichment	ADCY3, BDNF, GRIA4	1.83
139	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D, SLC1A2, SLC38A3	1.70
140	Myhre syndrome	Enrichment	SMAD4	1.69
141	Camurati-engelmann disease 1	Enrichment	TGFB1	1.69
142	Alexander disease	Enrichment	GFAP	1.69
143	Hemangiopericytoma, malignant	Enrichment	STAT6	1.69
144	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	1.69
145	Dystonia 9	Enrichment	SLC2A1	1.69
146	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.69
147	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	1.69
148	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.69
149	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.69
150	Glutamine deficiency, congenital	Enrichment	GLUL	1.69
151	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.69
152	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	1.69
153	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.69
154	Schizophrenia 9	Enrichment	DISC1	1.69
155	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	1.69
156	Pyruvate dehydrogenase e2 deficiency	Enrichment	DLAT	1.69
157	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.69
158	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.69
159	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	GFAP	1.69
160	Long qt syndrome 14	Enrichment	CALM1	1.69
161	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.69
162	Hypogonadotropic hypogonadism 9 with or without anosmia	Enrichment	NSMF	1.69
163	Immunodeficiency 31c	Enrichment	STAT1	1.69
164	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	1.69
165	Spastic tetraplegia, thin corpus callosum, and progressive microcephaly	Enrichment	SLC1A4	1.69
166	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.69
167	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.69
168	Immunodeficiency 127	Enrichment	TNF	1.69
169	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	1.69
170	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.69
171	Developmental and epileptic encephalopathy 16	Enrichment	GLUL	1.69
172	Bilateral generalized polymicrogyria	Enrichment	GRIN1	1.69
173	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	1.69
174	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	1.69
175	Camurati-engelmann disease	Enrichment	TGFB1	1.69
176	Inflammatory bowel disease 28	Enrichment	IL10RA	1.69
177	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.69
178	Fibrolamellar carcinoma	Enrichment	PRKACA	1.69
179	Ocular melanoma	Enrichment	PLCB4	1.69
180	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.69
181	Congenital brain dysgenesis due to glutamine synthetase deficiency	Enrichment	GLUL	1.69
182	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.69
183	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	1.69
184	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.69
185	Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome	Enrichment	SLC1A4	1.69
186	Common variable immunodeficiency 12	Enrichment	NFKB1	1.69
187	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	1.69
188	Cerebral visual impairment	Enrichment	GRIK2	1.69
189	Scoliosis	Enrichment	GFAP, GRIN2B	1.60
190	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1, SLC2A1	1.57
191	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.51
192	Juvenile polyposis syndrome	Enrichment	SMAD4	1.51
193	Takayasu arteritis	Enrichment	IL12B	1.51
194	Mycosis fungoides	Enrichment	TNFRSF1B	1.51
195	Tuberous sclerosis 1	Enrichment	IFNG	1.51
196	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.51
197	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.51
198	Hepatitis c virus	Enrichment	IFNG	1.51
199	Tuberous sclerosis 2	Enrichment	IFNG	1.51
200	Immunodeficiency 28	Enrichment	IFNGR2	1.51
201	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	1.51
202	Hyper ige syndrome	Enrichment	STAT3	1.51
203	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	1.51
204	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.51
205	Inflammatory bowel disease 25	Enrichment	IL10RB	1.51
206	Migraine without aura	Enrichment	TNF	1.51
207	Melanoma of soft tissue	Enrichment	CREB1	1.51
208	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.51
209	Saczary syndrome	Enrichment	TNFRSF1B	1.51
210	Kaposi sarcoma	Enrichment	IL6	1.39
211	Huntington disease	Enrichment	SLC2A3	1.39
212	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1	1.39
213	Astigmatism	Enrichment	GRIN2B	1.39
214	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.39
215	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.39
216	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.39
217	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.39
218	Congenital generalized lipodystrophy	Enrichment	FOS	1.39
219	Hereditary ataxia	Enrichment	PRKCG	1.39
220	Idiopathic achalasia	Enrichment	NOS1	1.39
221	Hereditary progressive cardiac conduction defect	Enrichment	TRPM4	1.39
222	Cerebral malaria	Enrichment	TNF	1.39
223	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.39
224	Atypical glycine encephalopathy	Enrichment	SLC6A9	1.39
225	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.37
226	Dystonia	Enrichment	CAMK2B, GRIA3	1.30
227	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.30
228	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.30
229	Insulin-like growth factor i	Enrichment	IGF1	1.30
230	Follicular lymphoma	Enrichment	BCL2	1.30
231	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.30
232	Histiocytoid hemangioma	Enrichment	FOS	1.30
233	Vascular dementia	Enrichment	TNF	1.30
234	Sleep disorder	Enrichment	GRIN2B	1.30
235	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.30
236	Idiopathic aplastic anemia	Enrichment	IFNG	1.30
237	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.30
238	Atrial septal defect 1	Enrichment	TGFB2	1.22
239	Melanoma, uveal	Enrichment	PLCB4	1.22
240	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.22
241	Metachromatic leukodystrophy	Enrichment	GFAP	1.22
242	Type 1 diabetes mellitus	Enrichment	IL6	1.22
243	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.22
244	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.22
245	Breast adenocarcinoma	Enrichment	AKT1	1.22
246	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.22
247	46,xy disorder of sex development	Enrichment	INSR	1.22
248	Systemic lupus erythematosus	Enrichment	IL10, TNF	1.21
249	Esophageal cancer	Enrichment	TGFBR2	1.15
250	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF	1.15
251	Gallbladder cancer	Enrichment	SMAD4	1.15
252	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.15
253	Paroxysmal dystonia	Enrichment	SLC2A1	1.15
254	Gastric cancer	Enrichment	IL1B, SMAD4	1.14
255	Erythrokeratodermia variabilis et progressiva 1	Enrichment	TRPM4	1.10
256	Glycine encephalopathy 1	Enrichment	SLC6A9	1.10
257	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.10
258	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.10
259	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.10
260	Rheumatoid arthritis	Enrichment	IL10	1.05
261	Charge syndrome	Enrichment	TNFRSF1A	1.05
262	Ellis-van creveld syndrome	Enrichment	PRKACA	1.05
263	Inflammatory bowel disease 1	Enrichment	IL6	1.05
264	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.05
265	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.05
266	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.05
267	Primary biliary cholangitis	Enrichment	IL12A	1.05
268	Cowden syndrome	Enrichment	AKT1	1.05
269	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.05
270	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.01
271	Aplastic anemia	Enrichment	IFNG	1.01
272	Autosomal non-syndromic agammaglobulinemia	Enrichment	LRRC8A	1.01
273	Pectus excavatum	Enrichment	TGFBR1	0.97
274	Specific learning disability	Enrichment	MAPK1	0.97
275	Meningioma	Enrichment	AKT1	0.93
276	Lactic acidosis	Enrichment	DLD	0.93
277	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.93
278	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.93
279	Acute promyelocytic leukemia	Enrichment	STAT3	0.90
280	Alzheimer's disease	Enrichment	TNF	0.90
281	Multiple sclerosis	Enrichment	TNFRSF1A	0.87
282	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.87
283	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.87
284	Pituitary stalk interruption syndrome	Enrichment	NSMF	0.87
285	Complex neurodevelopmental disorder	Enrichment	GRIA4, GRIK2, GRIN2B	0.86
286	Lynch syndrome	Enrichment	TGFBR2	0.84
287	Dandy-walker syndrome	Enrichment	PPP1CB	0.79
288	Sudden infant death syndrome	Enrichment	PDHA1	0.79
289	Autism	Enrichment	CAMK2G, DISC1	0.77
290	Heart, malformation of	Enrichment	MAPK1	0.77
291	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	NSMF	0.77
292	Arteriovenous malformations of the brain	Enrichment	IL6	0.75
293	Diffuse large b-cell lymphoma	Enrichment	STAT3	0.75
294	Esophageal atresia/tracheoesophageal fistula	Enrichment	GLS	0.75
295	Craniosynostosis	Enrichment	GRIN2B	0.73
296	Myocardial infarction	Enrichment	LTA	0.69
297	Noonan syndrome 1	Enrichment	PPP1CB	0.67
298	Malaria	Enrichment	TNF	0.67
299	Autoinflammatory disease	Enrichment	TNFRSF1A	0.66
300	Colorectal cancer	Enrichment	AKT1, SMAD4	0.65
301	Pancreatic cancer	Enrichment	SMAD4	0.64
302	Brugada syndrome	Enrichment	TRPM4	0.63
303	Rasopathy	Enrichment	PPP1CB	0.63
304	Strabismus	Enrichment	SLC2A1	0.61
305	Severe covid-19	Enrichment	IL10RB	0.58
306	Long qt syndrome 1	Enrichment	CALM1	0.57
307	Long qt syndrome	Enrichment	CALM1	0.56
308	Cystic fibrosis	Enrichment	TGFB1	0.55
309	Peripheral nervous system disease	Enrichment	NGF	0.55
310	Neuropathy	Enrichment	NGF	0.55
311	Autism spectrum disorder	Enrichment	GRIA1, GRIN2B	0.51
312	Developmental and epileptic encephalopathy	Enrichment	GRIA3	0.51
313	Cerebral palsy	Enrichment	GRIN2B	0.48
314	Hereditary breast carcinoma	Enrichment	AKT1	0.44
315	Thrombocytopenia	Enrichment	SMAD4	0.41
316	Myeloma, multiple	Enrichment	TRAF5	0.36
317	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DAO	0.34
318	Breast cancer	Enrichment	AKT1	0.27
319	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.22
320	Ovarian cancer	Enrichment	AKT1	0.19
321	Congenital nervous system abnormality	Enrichment	CAMK2B	0.17
322	Nervous system disease	Enrichment	CAMK2B	0.17
323	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neuroinflammation and glutamatergic signaling

Pathway Network for Neuroinflammation and glutamatergic signaling

Member Pathways for Neuroinflammation and glutamatergic signaling

Pathways in the Neuroinflammation and glutamatergic signaling SuperPath

Associated Genes for Neuroinflammation and glutamatergic signaling

Associated Disorders for Neuroinflammation and glutamatergic signaling

Disorders associated with Neuroinflammation and glutamatergic signaling SuperPath

STRING Interaction Network for Neuroinflammation and glutamatergic signaling

Sources for Neuroinflammation and glutamatergic signaling