Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

No Pathway Network information available for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Pathways in the Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling SuperPath

#	Name	Source	Genes
1	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling	GeneGo (Thomson Reuters)	ADCY5 CALM1 CALM2 CALM3 CDK5 CDK5R1 CREB1 CSNK1E DRD1 GABRB1 GABRB2 GABRB3 GNAQ GNAS GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRM1 ITPR1 ITPR2 ITPR3 PDYN PLCB1 PLCB2 PPP1CA PPP1CB PPP1CC PPP1R1A PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTPA STRN STRN3 (see all 64) (see less)
2	DARPP-32 events	Reactome	CALM1 CALM2 CALM3 CDK5 PDE4A PDE4B PDE4C PDE4D PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CALM1	Calmodulin 1	Protein Coding	2
2	CALM2	Calmodulin 2	Protein Coding	2
3	CALM3	Calmodulin 3	Protein Coding	2
4	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
5	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	2
6	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
7	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
8	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
9	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
10	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	2
11	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
12	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
13	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
14	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
15	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
16	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
17	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
18	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	2
19	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	2
20	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	2
21	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	2
22	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	2
23	ADCY5	Adenylate Cyclase 5	Protein Coding	1
24	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
25	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
26	DRD1	Dopamine Receptor D1	Protein Coding	1
27	GABRB1	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1	Protein Coding	1
28	GABRB2	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta2	Protein Coding	1
29	GABRB3	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3	Protein Coding	1
30	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
31	GNAS	GNAS Complex Locus	Protein Coding	1
32	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	1
33	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
34	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
35	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
36	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
37	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
38	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
39	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1
40	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
41	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	1
42	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
43	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
44	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
45	PDYN	Prodynorphin	Protein Coding	1
46	PLCB2	Phospholipase C Beta 2	Protein Coding	1
47	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
48	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
49	PPP1R1A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A	Protein Coding	1
50	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
51	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	1
52	PPP2R2C	Protein Phosphatase 2 Regulatory Subunit Bgamma	Protein Coding	1
53	PPP2R3A	Protein Phosphatase 2 Regulatory Subunit B''''Alpha	Protein Coding	1
54	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
55	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
56	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	1
57	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	1
58	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	1
59	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
60	STRN	Striatin	Protein Coding	1
61	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
62	PLCB1	Phospholipase C Beta 1	Protein Coding	1
63	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	1
64	STRN3	Striatin 3	Protein Coding	1
65	PDE4A	Phosphodiesterase 4A	Protein Coding	1
66	PDE4B	Phosphodiesterase 4B	Protein Coding	1
67	PDE4C	Phosphodiesterase 4C	Protein Coding	1
68	PDE4D	Phosphodiesterase 4D	Protein Coding	1

Disorders associated with Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.46
2	West syndrome	Enrichment	CSNK1E, GRIA3, GRIN1, GRIN2B, PLCB1	5.73
3	Acrodysostosis	Enrichment	PDE4D, PRKAR1A	5.45
4	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.95
5	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.66
6	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1, GRIN2B, PPP3CA	4.05
7	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.90
8	Epilepsy	Enrichment	GABRB3, GRIN2A, GRIN2B	3.06
9	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A, PLCB1	3.03
10	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A, PLCB1	2.97
11	Long qt syndrome	Enrichment	CALM1, CALM2	2.80
12	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.72
13	Carney complex, type 1	Enrichment	PRKAR1A	2.72
14	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.72
15	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.72
16	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.72
17	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.72
18	Myxoma, intracardiac	Enrichment	PRKAR1A	2.72
19	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.72
20	Long qt syndrome 16	Enrichment	CALM3	2.72
21	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	2.72
22	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.72
23	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.72
24	Long qt syndrome 15	Enrichment	CALM2	2.72
25	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.72
26	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.72
27	Undetermined early-onset epileptic encephalopathy	Enrichment	GABRB2, GRIN2D, PPP3CA	2.63
28	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.42
29	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.42
30	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.42
31	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	2.42
32	Long qt syndrome 14	Enrichment	CALM1	2.42
33	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.42
34	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.42
35	Usher syndrome, type iv	Enrichment	PRKAR1A	2.42
36	Fibrolamellar carcinoma	Enrichment	PRKACA	2.42
37	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.42
38	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.42
39	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.42
40	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.33
41	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.33
42	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.33
43	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	2.33
44	Osseous heteroplasia, progressive	Enrichment	GNAS	2.33
45	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.33
46	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.33
47	Sturge-weber syndrome	Enrichment	GNAQ	2.33
48	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.33
49	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.33
50	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.33
51	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.33
52	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.33
53	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.33
54	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.33
55	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.33
56	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.33
57	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.33
58	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.33
59	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.33
60	Epilepsy, childhood absence 5	Enrichment	GABRB3	2.33
61	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.33
62	Disorders of gnas inactivation	Enrichment	GNAS	2.33
63	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.33
64	Developmental and epileptic encephalopathy 92	Enrichment	GABRB2	2.33
65	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.33
66	Developmental and epileptic encephalopathy 43	Enrichment	GABRB3	2.33
67	Developmental and epileptic encephalopathy 45	Enrichment	GABRB1	2.33
68	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.33
69	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.33
70	Spinocerebellar ataxia 44	Enrichment	GRM1	2.33
71	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.33
72	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.33
73	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.33
74	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.33
75	Landau-kleffner syndrome	Enrichment	GRIN2A	2.33
76	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.33
77	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.33
78	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.33
79	Monostotic fibrous dysplasia	Enrichment	GNAS	2.33
80	Grin2a-related disorders	Enrichment	GRIN2A	2.33
81	Chondromyxoid fibroma	Enrichment	GRM1	2.33
82	Mazabraud syndrome	Enrichment	GNAS	2.33
83	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E, GRIN1	2.21
84	Carney complex variant	Enrichment	PRKAR1A	2.12
85	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	2.12
86	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.03
87	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.03
88	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.03
89	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.03
90	Spinocerebellar ataxia 23	Enrichment	PDYN	2.03
91	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.03
92	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.03
93	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.03
94	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.03
95	Pseudohypoparathyroidism	Enrichment	GNAS	2.03
96	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.03
97	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.03
98	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.03
99	Phakomatosis cesioflammea	Enrichment	GNAQ	2.03
100	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.94
101	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.94
102	Mccune-albright syndrome	Enrichment	GNAS	1.85
103	Gillespie syndrome	Enrichment	ITPR1	1.85
104	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	1.85
105	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.85
106	Melanoma of soft tissue	Enrichment	CREB1	1.85
107	Anastomosing haemangioma	Enrichment	GNAQ	1.85
108	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.82
109	Chorea, benign hereditary	Enrichment	ADCY5	1.73
110	Astigmatism	Enrichment	GRIN2B	1.73
111	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.73
112	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.73
113	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.73
114	Complex neurodevelopmental disorder	Enrichment	GRIA4, GRIN2B, PPP2CA	1.68
115	Body mass index quantitative trait locus 11	Enrichment	GNAS, GRIA4	1.63
116	Capillary malformations, congenital	Enrichment	GNAQ	1.63
117	Sleep disorder	Enrichment	GRIN2B	1.63
118	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.61
119	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.55
120	Melanoma, uveal	Enrichment	GNAQ	1.55
121	Epilepsy, childhood absence 1	Enrichment	GABRB3	1.55
122	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.55
123	Childhood absence epilepsy	Enrichment	GABRB3	1.55
124	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	1.51
125	Sudden infant death syndrome	Enrichment	CALM2	1.49
126	Brachydactyly	Enrichment	GNAS	1.49
127	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.43
128	Lennox-gastaut syndrome	Enrichment	GABRB3	1.43
129	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.38
130	Primary hyperaldosteronism	Enrichment	GNAS	1.38
131	Congenital long qt syndrome	Enrichment	ITPR3	1.26
132	Lung cancer	Enrichment	PPP2R1B	1.22
133	Multiple sclerosis	Enrichment	ITPR1	1.19
134	Anterior segment dysgenesis	Enrichment	ITPR1	1.16
135	Dandy-walker syndrome	Enrichment	PPP1CB	1.11
136	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.09
137	Craniosynostosis	Enrichment	GRIN2B	1.04
138	Autism spectrum disorder	Enrichment	GRIA1, GRIN2B	1.03
139	Noonan syndrome 1	Enrichment	PPP1CB	0.99
140	Scoliosis	Enrichment	GRIN2B	0.97
141	Rasopathy	Enrichment	PPP1CB	0.94
142	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.87
143	Dystonia	Enrichment	GRIA3	0.82
144	Developmental and epileptic encephalopathy	Enrichment	GRIA3	0.80
145	Cerebral palsy	Enrichment	GRIN2B	0.77
146	Spastic ataxia	Enrichment	ITPR1	0.65
147	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.65
148	Schizophrenia	Enrichment	GABRB2	0.61
149	Microcephaly	Enrichment	GRIN2B	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Pathway Network for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Member Pathways for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Pathways in the Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling SuperPath

Associated Genes for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Associated Disorders for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Disorders associated with Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling SuperPath

STRING Interaction Network for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling

Sources for Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling