Neurotransmitter clearance

Sources:

#	Name	Source	Genes
1	Neurotransmitter clearance	Reactome	ACHE ALDH2 BCHE COMT LRTOMT MAOA SLC22A1 SLC22A2 SLC6A3 SLC6A4 (see all 10) (see less)
2	Dopamine clearance from the synaptic cleft	Reactome	COMT LRTOMT MAOA SLC6A3
3	Serotonin clearance from the synaptic cleft	Reactome	ALDH2 MAOA SLC6A4
4	Enzymatic degradation of dopamine by COMT	Reactome	COMT LRTOMT MAOA
5	Metabolism of serotonin	Reactome	ALDH2 MAOA
6	Enzymatic degradation of Dopamine by monoamine oxidase	Reactome	COMT MAOA
7	Flavan-3-ol metabolic pathway	WikiPathways	COMT

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAOA	Monoamine Oxidase A	Protein Coding	6
2	COMT	Catechol-O-Methyltransferase	Protein Coding	5
3	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	3
4	LRTOMT	Leucine Rich Transmembrane And O-Methyltransferase Domain Containing	Protein Coding	3
5	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	2
6	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	2
7	ACHE	Acetylcholinesterase (Yt Blood Group)	Protein Coding	1
8	BCHE	Butyrylcholinesterase	Protein Coding	1
9	SLC22A1	Solute Carrier Family 22 Member 1	Protein Coding	1
10	SLC22A2	Solute Carrier Family 22 Member 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	4.13
2	Brunner syndrome	Enrichment	MAOA	3.83
3	Alcohol sensitivity, acute	Enrichment	ALDH2	3.83
4	Amed syndrome, digenic	Enrichment	ALDH2	3.53
5	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	3.53
6	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	3.53
7	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	3.53
8	Obsessive-compulsive disorder	Enrichment	SLC6A4	3.35
9	Yt blood group antigen	Enrichment	ACHE	3.13
10	Butyrylcholinesterase deficiency	Enrichment	BCHE	3.13
11	Alcohol dependence	Enrichment	ALDH2	3.05
12	Digeorge syndrome	Enrichment	COMT	3.05
13	Deafness, autosomal recessive 63	Enrichment	LRTOMT	2.96
14	Tobacco addiction	Enrichment	SLC6A3	2.93
15	Anxiety	Enrichment	SLC6A4	2.88
16	Bardet-biedl syndrome	Enrichment	COMT	2.51
17	Schizophrenia	Enrichment	COMT	2.36
18	Rare genetic deafness	Enrichment	LRTOMT	1.76
19	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	LRTOMT	1.71

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Neurotransmitter clearance