Neurotransmitter release cycle

Pathway network for the Neurotransmitter release cycle SuperPath

Sources:

Reactome

Pathways in the Neurotransmitter release cycle SuperPath

#	Name	Source	Genes
1	Neurotransmitter release cycle	Reactome	ABAT ALDH5A1 APBA1 ARL6IP5 CASK CHAT CPLX1 DNAJC5 GAD1 GAD2 GLS GLS2 HSPA8 LIN7A LIN7B LIN7C MAOA NAAA PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC17A7 SLC18A2 SLC18A3 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC22A1 SLC22A2 SLC32A1 SLC38A2 SLC5A7 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 TSPOAP1 UNC13B VAMP2 (see all 51) (see less)
2	Glutamate Neurotransmitter Release Cycle	Reactome	ARL6IP5 CPLX1 GLS GLS2 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC17A7 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 SLC38A2 SNAP25 STX1A STXBP1 SYT1 TSPOAP1 UNC13B VAMP2 (see all 24) (see less)
3	Dopamine Neurotransmitter Release Cycle	Reactome	APBA1 CASK CPLX1 LIN7A LIN7B LIN7C PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A2 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 TSPOAP1 UNC13B VAMP2 (see all 23) (see less)
4	GABA synthesis, release, reuptake and degradation	Reactome	ABAT ALDH5A1 CPLX1 DNAJC5 GAD1 GAD2 HSPA8 RAB3A RIMS1 SLC32A1 SLC6A1 SLC6A11 SLC6A12 SLC6A13 SNAP25 STX1A STXBP1 SYT1 VAMP2 (see all 19) (see less)
5	Norepinephrine Neurotransmitter Release Cycle	Reactome	CPLX1 MAOA PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A2 SLC22A1 SLC22A2 SNAP25 STX1A STXBP1 SYT1 TSPOAP1 UNC13B VAMP2 (see all 18) (see less)
6	Serotonin Neurotransmitter Release Cycle	Reactome	CPLX1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A2 SNAP25 STX1A STXBP1 SYN1 SYN2 SYN3 SYT1 TSPOAP1 UNC13B VAMP2 (see all 18) (see less)
7	Acetylcholine Neurotransmitter Release Cycle	Reactome	CHAT CPLX1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 RAB3A RIMS1 SLC18A3 SLC5A7 SNAP25 STX1A STXBP1 SYT1 TSPOAP1 UNC13B VAMP2 (see all 17) (see less)

Gene overlap in member pathways for Neurotransmitter release cycle SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CPLX1	Complexin 1	Protein Coding	7
2	RIMS1	Regulating Synaptic Membrane Exocytosis 1	Protein Coding	7
3	RAB3A	RAB3A, Member RAS Oncogene Family	Protein Coding	7
4	SNAP25	Synaptosome Associated Protein 25	Protein Coding	7
5	STX1A	Syntaxin 1A	Protein Coding	7
6	STXBP1	Syntaxin Binding Protein 1	Protein Coding	7
7	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	7
8	SYT1	Synaptotagmin 1	Protein Coding	7
9	UNC13B	Unc-13 Homolog B	Protein Coding	6
10	PPFIA4	PPFI Scaffold Protein A4	Protein Coding	6
11	PPFIA2	PPFI Scaffold Protein A2	Protein Coding	6
12	PPFIA1	PPFI Scaffold Protein A1	Protein Coding	6
13	PPFIA3	PPFI Scaffold Protein A3	Protein Coding	6
14	TSPOAP1	TSPO Associated Protein 1	Protein Coding	6
15	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	4
16	SYN1	Synapsin I	Protein Coding	3
17	SYN2	Synapsin II	Protein Coding	3
18	SYN3	Synapsin III	Protein Coding	3
19	ARL6IP5	ARF Like GTPase 6 Interacting Protein 5	Protein Coding	2
20	CHAT	Choline O-Acetyltransferase	Protein Coding	2
21	SLC32A1	Solute Carrier Family 32 Member 1	Protein Coding	2
22	ABAT	4-Aminobutyrate Aminotransferase	Protein Coding	2
23	GAD1	Glutamate Decarboxylase 1	Protein Coding	2
24	GAD2	Glutamate Decarboxylase 2	Protein Coding	2
25	GLS2	Glutaminase 2	Protein Coding	2
26	GLS	Glutaminase	Protein Coding	2
27	APBA1	Amyloid Beta Precursor Protein Binding Family A Member 1	Protein Coding	2
28	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	2
29	MAOA	Monoamine Oxidase A	Protein Coding	2
30	SLC38A2	Solute Carrier Family 38 Member 2	Protein Coding	2
31	LIN7C	Lin-7 Cell Polarity Scaffold C	Protein Coding	2
32	SLC17A7	Solute Carrier Family 17 Member 7	Protein Coding	2
33	SLC5A7	Solute Carrier Family 5 Member 7	Protein Coding	2
34	LIN7B	Lin-7 Cell Polarity Scaffold B	Protein Coding	2
35	SLC1A1	Solute Carrier Family 1 Member 1	Protein Coding	2
36	SLC1A2	Solute Carrier Family 1 Member 2	Protein Coding	2
37	SLC1A3	Solute Carrier Family 1 Member 3	Protein Coding	2
38	SLC1A6	Solute Carrier Family 1 Member 6	Protein Coding	2
39	SLC1A7	Solute Carrier Family 1 Member 7	Protein Coding	2
40	SLC6A1	Solute Carrier Family 6 Member 1	Protein Coding	2
41	SLC6A11	Solute Carrier Family 6 Member 11	Protein Coding	2
42	SLC6A12	Solute Carrier Family 6 Member 12	Protein Coding	2
43	SLC6A13	Solute Carrier Family 6 Member 13	Protein Coding	2
44	SLC18A3	Solute Carrier Family 18 Member A3	Protein Coding	2
45	SLC22A1	Solute Carrier Family 22 Member 1	Protein Coding	2
46	SLC22A2	Solute Carrier Family 22 Member 2	Protein Coding	2
47	ALDH5A1	Aldehyde Dehydrogenase 5 Family Member A1	Protein Coding	2
48	DNAJC5	DnaJ Heat Shock Protein Family (Hsp40) Member C5	Protein Coding	2
49	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	2
50	LIN7A	Lin-7 Cell Polarity Scaffold A	Protein Coding	2
51	NAAA	N-Acylethanolamine Acid Amidase	Protein Coding	1

Disorders associated with Neurotransmitter release cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Presynaptic congenital myasthenic syndromes	Enrichment	CHAT, SLC18A3, SLC5A7, SNAP25	9.26
2	Myasthenic syndrome, congenital, 21, presynaptic	Enrichment	CHAT, SLC18A3	5.83
3	Developmental and epileptic encephalopathy	Enrichment	SNAP25, STXBP1	3.04
4	Microcephaly	Enrichment	CASK, SNAP25, STXBP1	2.95
5	Neuronopathy, distal hereditary motor, autosomal dominant 7	Enrichment	SLC5A7	2.90
6	Apnea, central sleep	Enrichment	CHAT	2.90
7	Developmental and epileptic encephalopathy 117	Enrichment	SNAP25	2.90
8	Developmental and epileptic encephalopathy 63	Enrichment	CPLX1	2.90
9	Dystonia 22, adult-onset	Enrichment	TSPOAP1	2.90
10	Baker-gordon syndrome	Enrichment	SYT1	2.90
11	Cone-rod dystrophy 7	Enrichment	RIMS1	2.90
12	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.90
13	Epilepsy with generalized tonic-clonic seizures	Enrichment	SNAP25	2.90
14	Aspiration pneumonia	Enrichment	CHAT	2.90
15	Brunner syndrome	Enrichment	MAOA	2.88
16	Intellectual developmental disorder, x-linked 50	Enrichment	SYN1	2.88
17	Epilepsy, x-linked 1, with variable learning disabilities and behavior disorders	Enrichment	SYN1	2.88
18	X-linked epilepsy with variable learning disabilities and behavior disorders	Enrichment	SYN1	2.88
19	Ceroid lipofuscinosis, neuronal, 4	Enrichment	DNAJC5	2.85
20	Developmental and epileptic encephalopathy 89	Enrichment	GAD1	2.85
21	Gaba aminotransferase deficiency	Enrichment	ABAT	2.85
22	Gaba-transaminase deficiency	Enrichment	ABAT	2.85
23	Generalized epilepsy with febrile seizures plus, type 12	Enrichment	SLC32A1	2.85
24	Developmental and epileptic encephalopathy 114	Enrichment	SLC32A1	2.85
25	Cask-related intellectual disability	Enrichment	CASK	2.77
26	Dicarboxylic aminoaciduria	Enrichment	SLC1A1	2.75
27	Episodic ataxia, type 6	Enrichment	SLC1A3	2.75
28	Developmental and epileptic encephalopathy 41	Enrichment	SLC1A2	2.75
29	Schizophrenia 18	Enrichment	SLC1A1	2.75
30	Casgid syndrome	Enrichment	GLS	2.75
31	Developmental and epileptic encephalopathy 71	Enrichment	GLS	2.75
32	Hot water epilepsy	Enrichment	SLC1A1	2.75
33	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	2.75
34	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK, SLC32A1	2.69
35	Segawa syndrome, autosomal recessive	Enrichment	TSPOAP1	2.60
36	Myoclonic epilepsy, familial infantile	Enrichment	CPLX1	2.60
37	Dystonia 22, juvenile-onset	Enrichment	TSPOAP1	2.60
38	Paul-chao neurodevelopmental syndrome	Enrichment	PPFIA3	2.60
39	Myasthenic syndrome, congenital, 20, presynaptic	Enrichment	SLC5A7	2.60
40	9q33.3q34.11 microdeletion syndrome	Enrichment	STXBP1	2.60
41	Distal hereditary motor neuropathy type 7	Enrichment	SLC5A7	2.60
42	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.58
43	Sorsby fundus dystrophy	Enrichment	SYN3	2.58
44	Slc6a1-related neurodevelopmental disorder	Enrichment	SLC6A1	2.55
45	Fg syndrome 4	Enrichment	CASK	2.47
46	Syndromic x-linked intellectual disability	Enrichment	CASK	2.47
47	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	2.45
48	Autism	Enrichment	STX1A, STXBP1	2.45
49	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	CHAT	2.43
50	Gyrate atrophy of choroid and retina	Enrichment	RIMS1	2.43
51	Bronchopulmonary dysplasia	Enrichment	CHAT	2.43
52	Succinic semialdehyde dehydrogenase deficiency	Enrichment	ALDH5A1	2.38
53	Developmental and epileptic encephalopathy 94	Enrichment	SLC6A1	2.38
54	Developmental and epileptic encephalopathy 2	Enrichment	SNAP25	2.30
55	Developmental and epileptic encephalopathy 4	Enrichment	STXBP1	2.30
56	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	2.29
57	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	2.29
58	Cerebellar disease	Enrichment	CASK	2.29
59	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	GAD1	2.25
60	Spastic quadriplegic cerebral palsy	Enrichment	GAD1	2.25
61	Wolf-hirschhorn syndrome	Enrichment	CPLX1	2.13
62	Autism spectrum disorder	Enrichment	RIMS1, STXBP1	2.09
63	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	2.07
64	Fetal akinesia deformation sequence 1	Enrichment	ALDH5A1, SLC18A3	2.07
65	Focal epilepsy	Enrichment	SNAP25	2.06
66	Gastroesophageal reflux	Enrichment	CHAT	2.00
67	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	CHAT	1.90
68	Myoclonic-atonic epilepsy	Enrichment	SLC6A1	1.90
69	Alternating hemiplegia of childhood	Enrichment	SLC1A3	1.85
70	Lactic acidosis	Enrichment	CHAT	1.83
71	Stereotypic movement disorder	Enrichment	SNAP25	1.79
72	Congenital myasthenic syndrome	Enrichment	CHAT	1.76
73	Generalized epilepsy with febrile seizures plus	Enrichment	SLC32A1	1.71
74	Neuronal ceroid lipofuscinosis	Enrichment	DNAJC5	1.68
75	Syndromic intellectual disability	Enrichment	SYT1	1.68
76	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	SLC5A7	1.63
77	Williams-beuren syndrome	Enrichment	STX1A	1.61
78	Arteriovenous malformations of the brain	Enrichment	SYN3	1.60
79	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.57
80	Isolated congenital microcephaly	Enrichment	CASK	1.57
81	Esophageal atresia/tracheoesophageal fistula	Enrichment	GLS	1.48
82	Strabismus	Enrichment	STXBP1	1.48
83	Cystic fibrosis	Enrichment	STX1A	1.40
84	Bardet-biedl syndrome	Enrichment	TSPOAP1	1.29
85	Epilepsy	Enrichment	SYN1	1.29
86	Optic atrophy plus syndrome	Enrichment	SNAP25	1.27
87	West syndrome	Enrichment	STXBP1	1.27
88	Benign epilepsy with centrotemporal spikes	Enrichment	SLC6A1	1.25
89	Distal arthrogryposis	Enrichment	ALDH5A1	1.24
90	Dystonia	Enrichment	CASK	1.24
91	Centralopathic epilepsy	Enrichment	SLC6A1	1.23
92	Non-syndromic x-linked intellectual disability	Enrichment	CASK	1.23
93	Spastic ataxia	Enrichment	STXBP1	1.19
94	Autosomal dominant non-syndromic intellectual disability	Enrichment	SLC6A1	1.17
95	Schizophrenia	Enrichment	SYN2	1.12
96	Cone-rod dystrophy 2	Enrichment	RIMS1	1.09
97	Undetermined early-onset epileptic encephalopathy	Enrichment	SLC1A2	1.02
98	Congenital nervous system abnormality	Enrichment	CASK	0.78
99	Nervous system disease	Enrichment	CASK	0.78
100	Hereditary retinal dystrophy	Enrichment	SYN3	0.49
101	Fundus dystrophy	Enrichment	SYN3	0.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neurotransmitter release cycle

Pathway Network for Neurotransmitter release cycle

Pathway network for the Neurotransmitter release cycle SuperPath

Member Pathways for Neurotransmitter release cycle

Pathways in the Neurotransmitter release cycle SuperPath

Gene overlap in member pathways for Neurotransmitter release cycle SuperPath

Associated Genes for Neurotransmitter release cycle

Associated Disorders for Neurotransmitter release cycle

Disorders associated with Neurotransmitter release cycle SuperPath

STRING Interaction Network for Neurotransmitter release cycle

Sources for Neurotransmitter release cycle