Neurotrophic factor-mediated Trk receptor signaling

No Pathway Network information available for Neurotrophic factor-mediated Trk receptor signaling

Pathways in the Neurotrophic factor-mediated Trk receptor signaling SuperPath

#	Name	Source	Genes
1	Neurotrophic factor-mediated Trk receptor signaling	PubChem	ABL1 ACKR1 BDNF CCND1 CDC42 CRKL DNAJA3 DNM1 DOCK1 DYNLT1 EHD4 ELMO1 FAIM FRS2 GAB1 GAB2 GIPC1 GRB2 KIDINS220 MAGED1 MAP2K1 MAPK3 MATK MCF2L NEDD4L NGF NGFR NTF3 NTF4 NTRK1 NTRK2 NTRK3 PIK3CA PIK3R1 PLCG1 PTPN11 RAC1 RAPGEF1 RASA1 RASGRF1 RGS19 RHOA RHOG RIT1 RIT2 SHC1 SOS1 SQSTM1 STAT3 TIAM1 (see all 50) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RIT1	Ras Like Without CAAX 1	Protein Coding	1
2	RIT2	Ras Like Without CAAX 2	Protein Coding	1
3	DNAJA3	DnaJ Heat Shock Protein Family (Hsp40) Member A3	Protein Coding	1
4	EHD4	EH Domain Containing 4	Protein Coding	1
5	FAIM	Fas Apoptotic Inhibitory Molecule	Protein Coding	1
6	DYNLT1	Dynein Light Chain Tctex-Type 1	Protein Coding	1
7	RGS19	Regulator Of G Protein Signaling 19	Protein Coding	1
8	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
9	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
10	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
11	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
12	RHOG	Ras Homolog Family Member G	Protein Coding	1
13	CCND1	Cyclin D1	Protein Coding	1
14	ACKR1	Atypical Chemokine Receptor 1 (Duffy Blood Group)	Protein Coding	1
15	NEDD4L	NEDD4 Like E3 Ubiquitin Protein Ligase	Protein Coding	1
16	MATK	Megakaryocyte-Associated Tyrosine Kinase	Protein Coding	1
17	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
18	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	1
19	NTF4	Neurotrophin 4	Protein Coding	1
20	NTF3	Neurotrophin 3	Protein Coding	1
21	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
22	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
23	KIDINS220	Kinase D Interacting Substrate 220	Protein Coding	1
24	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
25	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
26	NGF	Nerve Growth Factor	Protein Coding	1
27	GIPC1	GIPC PDZ Domain Containing Family Member 1	Protein Coding	1
28	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
29	MAGED1	MAGE Family Member D1	Protein Coding	1
30	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
31	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
32	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
33	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
34	DNM1	Dynamin 1	Protein Coding	1
35	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
36	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
37	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
38	CDC42	Cell Division Cycle 42	Protein Coding	1
39	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
40	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
41	RHOA	Ras Homolog Family Member A	Protein Coding	1
42	RAC1	Rac Family Small GTPase 1	Protein Coding	1
43	SQSTM1	Sequestosome 1	Protein Coding	1
44	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
45	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
46	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
47	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
48	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
49	SHC1	SHC Adaptor Protein 1	Protein Coding	1
50	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Neurotrophic factor-mediated Trk receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, PTPN11, RIT1, SOS1	6.66
2	Noonan syndrome 1	Enrichment	MAP2K1, PTPN11, RIT1, SOS1	5.86
3	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA, RASA1	5.79
4	Rasopathy	Enrichment	MAP2K1, PTPN11, RIT1, SOS1	5.64
5	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA, RASA1	5.41
6	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA, RASA1	5.26
7	Noonan syndrome 8	Enrichment	PIK3CA, RIT1	4.88
8	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.40
9	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, RIT1	4.10
10	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	4.10
11	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	3.88
12	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	3.70
13	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.70
14	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	3.56
15	Noonan syndrome 3	Enrichment	PTPN11, SOS1	3.56
16	Lung non-small cell carcinoma	Enrichment	MAP2K1, PIK3CA	3.14
17	Lip and oral cavity carcinoma	Enrichment	ABL1, PIK3CA	3.07
18	Heart disease	Enrichment	ABL1, RIT1	2.93
19	Macrodactyly	Enrichment	PIK3CA	2.43
20	Metachondromatosis	Enrichment	PTPN11	2.43
21	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.43
22	Paget disease of bone 3	Enrichment	SQSTM1	2.43
23	Deafness, autosomal recessive 26	Enrichment	GAB1	2.43
24	Noonan syndrome 4	Enrichment	SOS1	2.43
25	Melorheostosis, isolated	Enrichment	MAP2K1	2.43
26	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.43
27	White blood cell count quantitative trait locus 1	Enrichment	ACKR1	2.43
28	Leopard syndrome 1	Enrichment	PTPN11	2.43
29	Cowden syndrome 5	Enrichment	PIK3CA	2.43
30	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.43
31	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.43
32	Ventriculomegaly and arthrogryposis	Enrichment	KIDINS220	2.43
33	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.43
34	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.43
35	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.43
36	Short syndrome	Enrichment	PIK3R1	2.43
37	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.43
38	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.43
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.43
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.43
41	Melorheostosis	Enrichment	MAP2K1	2.43
42	Oculopharyngodistal myopathy 2	Enrichment	GIPC1	2.43
43	Glaucoma 1, open angle, o	Enrichment	NTF4	2.43
44	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.43
45	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.43
46	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.43
47	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.43
48	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.43
49	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.43
50	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.43
51	Periventricular nodular heterotopia 7	Enrichment	NEDD4L	2.43
52	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.43
53	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.43
54	Hypospadias	Enrichment	PIK3CA	2.43
55	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.43
56	Rare venous malformation	Enrichment	PIK3CA	2.43
57	Gorham's disease	Enrichment	RASA1	2.43
58	Diaphragmatic eventration	Enrichment	PIK3CA	2.43
59	Nocarh syndrome	Enrichment	CDC42	2.43
60	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.43
61	Rare combined vascular malformation	Enrichment	PIK3CA	2.43
62	Cavernous lymphangioma	Enrichment	PIK3CA	2.43
63	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.43
64	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.43
65	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.43
66	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.43
67	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.43
68	Macrodactyly of toe	Enrichment	PIK3CA	2.43
69	Temporomandibular joint anomaly	Enrichment	DOCK1	2.43
70	Malignant astrocytoma	Enrichment	PTPN11	2.43
71	Colorectal cancer	Enrichment	CCND1, PIK3CA, PIK3R1	2.40
72	Hydrops fetalis, nonimmune	Enrichment	PTPN11, RIT1	2.39
73	Differentiated thyroid carcinoma	Enrichment	NTRK1, NTRK3	2.29
74	Non-immune hydrops fetalis	Enrichment	PTPN11, RIT1	2.24
75	Fibromatosis, gingival, 1	Enrichment	SOS1	2.13
76	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	2.13
77	Pulmonic stenosis	Enrichment	SOS1	2.13
78	Welander distal myopathy	Enrichment	SQSTM1	2.13
79	Keratosis, seborrheic	Enrichment	PIK3CA	2.13
80	Spastic paraplegia, intellectual disability, nystagmus, and obesity	Enrichment	KIDINS220	2.13
81	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	2.13
82	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.13
83	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.13
84	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.13
85	Werner syndrome	Enrichment	PTPN11	2.13
86	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.13
87	Congenital mesoblastic nephroma	Enrichment	NTRK3	2.13
88	Immune system disease	Enrichment	CDC42	2.13
89	Fibrosarcoma	Enrichment	NTRK3	2.13
90	Paget's disease of bone	Enrichment	SQSTM1	2.13
91	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.13
92	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.96
93	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	1.96
94	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.96
95	Nuchal bleb, familial	Enrichment	SOS1	1.96
96	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.96
97	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	NEDD4L	1.96
98	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.96
99	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.96
100	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.96
101	Hyper ige syndrome	Enrichment	STAT3	1.96
102	Wieacker-wolff syndrome	Enrichment	RASA1	1.96
103	Immunodeficiency 14	Enrichment	PIK3R1	1.96
104	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.96
105	Tricuspid valve insufficiency	Enrichment	PTPN11	1.96
106	Keratoacanthoma	Enrichment	PIK3CA	1.96
107	West syndrome	Enrichment	DNM1, NTRK2	1.94
108	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.83
109	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.83
110	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	1.83
111	Mantle cell lymphoma	Enrichment	CCND1	1.83
112	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.83
113	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.83
114	Cerebrovascular disease	Enrichment	PIK3CA	1.83
115	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.83
116	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.83
117	Paget's disease of bone 2	Enrichment	SQSTM1	1.83
118	Glioma	Enrichment	NTRK3	1.83
119	Gingival fibromatosis	Enrichment	SOS1	1.83
120	Hypertelorism	Enrichment	PIK3CA, RIT1	1.80
121	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1, NTRK2	1.74
122	Von hippel-lindau syndrome	Enrichment	CCND1	1.74
123	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.74
124	Lymphoma	Enrichment	PTPN11	1.74
125	Hemimegalencephaly	Enrichment	PIK3CA	1.74
126	Kabuki syndrome 1	Enrichment	KIDINS220	1.66
127	Cowden syndrome 1	Enrichment	PIK3CA	1.66
128	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.66
129	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.66
130	Hemangioma, capillary infantile	Enrichment	RASA1	1.66
131	Basal cell carcinoma 1	Enrichment	RASA1	1.66
132	Patent ductus arteriosus	Enrichment	PTPN11	1.66
133	Breast adenocarcinoma	Enrichment	PIK3CA	1.66
134	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.66
135	Oculopharyngodistal myopathy 1	Enrichment	GIPC1	1.59
136	Nevus, epidermal	Enrichment	PIK3CA	1.59
137	Leukemia, chronic myeloid	Enrichment	ABL1	1.59
138	Gallbladder cancer	Enrichment	PIK3CA	1.59
139	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.59
140	Pilomyxoid astrocytoma	Enrichment	NTRK2	1.59
141	Overgrowth syndrome	Enrichment	PIK3R1	1.59
142	Moyamoya angiopathy	Enrichment	ABL1	1.59
143	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.59
144	Lennox-gastaut syndrome	Enrichment	DNM1	1.54
145	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.54
146	Breast cancer	Enrichment	PIK3CA, SHC1	1.51
147	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.49
148	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.49
149	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.49
150	Cowden syndrome	Enrichment	PIK3CA	1.49
151	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.49
152	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.44
153	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.44
154	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.44
155	Pectus excavatum	Enrichment	PTPN11	1.40
156	Specific learning disability	Enrichment	PTPN11	1.40
157	Epicanthus	Enrichment	PTPN11	1.36
158	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.36
159	Meningioma	Enrichment	PIK3CA	1.36
160	Congenital long qt syndrome	Enrichment	PTPN11	1.36
161	Aortic valve disease 1	Enrichment	SOS1	1.33
162	Acute promyelocytic leukemia	Enrichment	STAT3	1.33
163	Stereotypic movement disorder	Enrichment	DNM1	1.33
164	Periventricular nodular heterotopia	Enrichment	NEDD4L	1.30
165	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.30
166	Ovarian cancer	Enrichment	NTRK1, PIK3CA	1.27
167	Lynch syndrome	Enrichment	PIK3CA	1.27
168	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	1.21
169	Patent foramen ovale	Enrichment	PTPN11	1.19
170	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.17
171	Endometrial cancer	Enrichment	PIK3CA	1.13
172	Microcephaly	Enrichment	ABL1, PTPN11	1.12
173	Hepatocellular carcinoma	Enrichment	PIK3CA	1.11
174	Malaria	Enrichment	ACKR1	1.09
175	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.09
176	Scoliosis	Enrichment	PTPN11	1.07
177	Strabismus	Enrichment	PTPN11	1.02
178	Bladder cancer	Enrichment	PIK3CA	0.99
179	Prostate cancer	Enrichment	PIK3CA	0.99
180	Long qt syndrome 1	Enrichment	PTPN11	0.98
181	Lung cancer	Enrichment	PIK3CA	0.95
182	Peripheral nervous system disease	Enrichment	NGF	0.95
183	Neuropathy	Enrichment	NGF	0.95
184	Cerebral palsy	Enrichment	KIDINS220	0.87
185	Gastric cancer	Enrichment	PIK3CA	0.83
186	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.83
187	Hereditary breast carcinoma	Enrichment	PIK3CA	0.82
188	Thrombocytopenia	Enrichment	PTPN11	0.79
189	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.77
190	Myeloma, multiple	Enrichment	CCND1	0.73
191	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.73
192	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.71
193	Primary ovarian insufficiency	Enrichment	NTRK1	0.71
194	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.43
195	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.41

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Neurotrophic factor-mediated Trk receptor signaling

Pathway Network for Neurotrophic factor-mediated Trk receptor signaling

Member Pathways for Neurotrophic factor-mediated Trk receptor signaling

Pathways in the Neurotrophic factor-mediated Trk receptor signaling SuperPath

Associated Genes for Neurotrophic factor-mediated Trk receptor signaling

Associated Disorders for Neurotrophic factor-mediated Trk receptor signaling

Disorders associated with Neurotrophic factor-mediated Trk receptor signaling SuperPath

STRING Interaction Network for Neurotrophic factor-mediated Trk receptor signaling

Sources for Neurotrophic factor-mediated Trk receptor signaling