NF-kappaB Signaling

No Pathway Network information available for NF-kappaB Signaling

Pathways in the NF-kappaB Signaling SuperPath

#	Name	Source	Genes
1	NF-kappaB Signaling	Cell Signaling Technology	AGER AICDA AIM2 ALOX5 APEX1 ARIH2 ATRAID B2M BACH2 BATF BCL10 BCL11B BCL6 BLK BLNK BMX BTK C1QBP CABIN1 CARD11 CARD9 CBL CBLB CCL2 CCL5 CCR2 CD19 CD2 CD274 CD276 CD28 CD2AP CD34 CD38 CD3E CD40LG CD44 CD46 CD63 CD74 CD79A CD82 CD83 CD8A CDCP1 CDIP1 CEACAM1 CEACAM5 CEBPA CEBPB CEBPD CHUK CIITA CISH CSF2RB CTLA4 CXCL10 CXCL12 CXCR4 CXCR5 CYLD DAPP1 DCLRE1C DHX58 EGR1 ENPP3 EOMES ERC1 FAS FASLG FER FLI1 FOXP3 FYB1 GATA1 GATA2 GATA3 GATA6 GDF15 GFI1B GIMAP5 GPX1 GRK6 GZMA GZMB HAVCR1 HAVCR2 HCK HCLS1 HMOX1 ICAM2 ICOS ID3 IDO1 IFI16 IFIH1 IFNA1 IFNG IKBKB IKBKE IKBKG IKZF1 IKZF3 IL10 IL17A IL1B IL1RN IL2 IL2RA IL2RB IL3 IL4 IL6ST INPP5D INPPL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8 ITCH ITGB2 ITK JAK1 JAK2 JAK3 JUNB KIT KITLG L1CAM LAG3 LAT LAT2 LCK LCP1 LCP2 LGALS1 LGALS3 LGALS9 LILRB1 LITAF LSP1 LYN MAGEA3 MALT1 MAP3K14 MAP3K7 MAP4K1 MAVS MECOM MLANA MNDA MPL MPO MRTFA MYB MYD88 NCAM1 NCF1 NCF4 NCK1 NDRG1 NFATC1 NFATC2 NFATC3 NFATC4 NFIL3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NLRP1 NLRX1 NOD1 NQO1 NR1D1 NR4A1 NT5E OAS1 OTUD5 OTUD7B OTULIN PAWR PAX5 PBX1 PDCD1 PDCD1LG2 PDLIM2 PECAM1 PELI1 PIAS1 PIAS3 PIAS4 PIM1 PIM2 PIM3 PIR PLCG2 PPIA PPP3CA PPP3CB PPP3CC PRAME PRDM1 PRKCQ PRLR PSIP1 PSMB8 PTGS1 PTGS2 PTK2B PTPN2 PTPN22 PTPN6 PTPRC PVR RABGEF1 RAG1 REL RELA RELB RIGI RIPK1 RIPK2 RIPK3 RIPK4 RNASEL RSAD2 RUNX1 RUNX1T1 SARM1 SH2D1A SH3KBP1 SHARPIN SIRPA SIVA1 SOCS1 SOCS2 SOCS3 SPI1 SPIB STAM2 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 STK17B SWAP70 SYK TAB1 TAB2 TAB3 TAL1 TANK TAP1 TAP2 TAX1BP1 TBK1 TBKBP1 TBX21 TCF12 TCF3 TEC THEMIS TICAM1 TLR1 TLR2 TLR3 TLR6 TLR7 TLR8 TLR9 TNF TNFAIP3 TNFRSF10B TNFRSF10D TNFRSF11A TNFRSF12A TNFRSF17 TNFRSF18 TNFRSF1A TNFRSF1B TNFRSF25 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF11 TNFSF12 TNFSF13B TNFSF15 TNFSF4 TNIP1 TOLLIP TPT1 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIB2 TRIM25 TXN TYK2 TYROBP UBD UBE2N USP15 VCAM1 VSIR VTCN1 XRCC5 ZAP70 ZBTB16 ZBTB7B (see all 327) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	1
2	AICDA	Activation Induced Cytidine Deaminase	Protein Coding	1
3	AIM2	Absent In Melanoma 2	Protein Coding	1
4	IKZF3	IKAROS Family Zinc Finger 3	Protein Coding	1
5	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	1
6	RIPK4	Receptor Interacting Serine/Threonine Kinase 4	Protein Coding	1
7	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
8	ATRAID	All-Trans Retinoic Acid Induced Differentiation Factor	Protein Coding	1
9	ARIH2	Ariadne RBR E3 Ubiquitin Protein Ligase 2	Protein Coding	1
10	DCLRE1C	DNA Cross-Link Repair 1C	Protein Coding	1
11	B2M	Beta-2-Microglobulin	Protein Coding	1
12	BACH2	BACH Transcriptional Regulator 2	Protein Coding	1
13	TNFSF13B	TNF Superfamily Member 13b	Protein Coding	1
14	BATF	Basic Leucine Zipper ATF-Like Transcription Factor	Protein Coding	1
15	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	1
16	BCL11B	BCL11 Transcription Factor B	Protein Coding	1
17	BCL6	BCL6 Transcription Repressor	Protein Coding	1
18	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
19	BLNK	B Cell Linker	Protein Coding	1
20	BTK	Bruton Tyrosine Kinase	Protein Coding	1
21	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
22	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
23	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
24	C1QBP	Complement C1q Binding Protein	Protein Coding	1
25	CABIN1	Calcineurin Binding Protein 1	Protein Coding	1
26	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	1
27	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	1
28	CBL	Cbl Proto-Oncogene	Protein Coding	1
29	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
30	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
31	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
32	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	1
33	CD19	CD19 Molecule	Protein Coding	1
34	CD2	CD2 Molecule	Protein Coding	1
35	CD276	CD276 Molecule	Protein Coding	1
36	CD28	CD28 Molecule	Protein Coding	1
37	CD2AP	CD2 Associated Protein	Protein Coding	1
38	CD34	CD34 Molecule	Protein Coding	1
39	CD38	CD38 Molecule	Protein Coding	1
40	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
41	CD40LG	CD40 Ligand	Protein Coding	1
42	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
43	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
44	CD46	CD46 Molecule	Protein Coding	1
45	CD63	CD63 Molecule	Protein Coding	1
46	CD74	CD74 Molecule	Protein Coding	1
47	CD82	CD82 Molecule	Protein Coding	1
48	CD83	CD83 Molecule	Protein Coding	1
49	CD8A	CD8 Subunit Alpha	Protein Coding	1
50	CDCP1	CUB Domain Containing Protein 1	Protein Coding	1
51	CDIP1	Cell Death Inducing P53 Target 1	Protein Coding	1
52	CEACAM1	CEA Cell Adhesion Molecule 1	Protein Coding	1
53	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	1
54	OTUD7B	OTU Deubiquitinase 7B	Protein Coding	1
55	CIITA	Class II Major Histocompatibility Complex Transactivator	Protein Coding	1
56	CISH	Cytokine Inducible SH2 Containing Protein	Protein Coding	1
57	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	1
58	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
59	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	1
60	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
61	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
62	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
63	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	1
64	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	1
65	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
66	DAPP1	Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1	Protein Coding	1
67	RIGI	RNA Sensor RIG-I	Protein Coding	1
68	DHX58	DExH-Box Helicase 58	Protein Coding	1
69	STK17B	Serine/Threonine Kinase 17b	Protein Coding	1
70	TCF3	Transcription Factor 3	Protein Coding	1
71	NFIL3	Nuclear Factor, Interleukin 3 Regulated	Protein Coding	1
72	EGR1	Early Growth Response 1	Protein Coding	1
73	ENPP3	Ectonucleotide Pyrophosphatase/Phosphodiesterase 3	Protein Coding	1
74	EOMES	Eomesodermin	Protein Coding	1
75	ERC1	ELKS/RAB6-Interacting/CAST Family Member 1	Protein Coding	1
76	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	1
77	MECOM	MDS1 And EVI1 Complex Locus	Protein Coding	1
78	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	1
79	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
80	FASLG	Fas Ligand	Protein Coding	1
81	UBD	Ubiquitin Like Modifier D	Protein Coding	1
82	FER	FER Tyrosine Kinase	Protein Coding	1
83	FLI1	Fli-1 Proto-Oncogene, ETS Transcription Factor	Protein Coding	1
84	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
85	LGALS1	Galectin 1	Protein Coding	1
86	LGALS3	Galectin 3	Protein Coding	1
87	LGALS9	Galectin 9	Protein Coding	1
88	GATA1	GATA Binding Protein 1	Protein Coding	1
89	GATA2	GATA Binding Protein 2~Name Same As:- HGNC:18350	Protein Coding	1
90	GATA3	GATA Binding Protein 3	Protein Coding	1
91	GATA6	GATA Binding Protein 6	Protein Coding	1
92	GDF15	Growth Differentiation Factor 15	Protein Coding	1
93	GFI1B	Growth Factor Independent 1B Transcriptional Repressor	Protein Coding	1
94	GIMAP5	GTPase, IMAP Family Member 5	Protein Coding	1
95	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	1
96	GPX1	Glutathione Peroxidase 1	Protein Coding	1
97	GRK6	G Protein-Coupled Receptor Kinase 6	Protein Coding	1
98	GZMA	Granzyme A	Protein Coding	1
99	GZMB	Granzyme B	Protein Coding	1
100	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
101	HMOX1	Heme Oxygenase 1	Protein Coding	1
102	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1
103	HCLS1	Hematopoietic Cell-Specific Lyn Substrate 1	Protein Coding	1
104	ICAM2	Intercellular Adhesion Molecule 2	Protein Coding	1
105	ICOS	Inducible T Cell Costimulator	Protein Coding	1
106	ID3	Inhibitor Of DNA Binding 3	Protein Coding	1
107	IFI16	Interferon Gamma Inducible Protein 16	Protein Coding	1
108	IFNA1	Interferon Alpha 1	Protein Coding	1
109	IFNG	Interferon Gamma	Protein Coding	1
110	CD79A	CD79a Molecule	Protein Coding	1
111	IKZF1	IKAROS Family Zinc Finger 1	Protein Coding	1
112	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
113	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
114	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
115	NFKBIZ	NFKB Inhibitor Zeta	Protein Coding	1
116	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
117	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
118	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
119	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
120	IL10	Interleukin 10	Protein Coding	1
121	IL17A	Interleukin 17A	Protein Coding	1
122	IL1B	Interleukin 1 Beta	Protein Coding	1
123	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	1
124	IL2	Interleukin 2	Protein Coding	1
125	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
126	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
127	IL3	Interleukin 3	Protein Coding	1
128	IL4	Interleukin 4	Protein Coding	1
129	IDO1	Indoleamine 2,3-Dioxygenase 1	Protein Coding	1
130	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
131	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
132	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	1
133	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	1
134	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
135	IRF2	Interferon Regulatory Factor 2	Protein Coding	1
136	IRF3	Interferon Regulatory Factor 3	Protein Coding	1
137	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
138	IRF5	Interferon Regulatory Factor 5	Protein Coding	1
139	IRF6	Interferon Regulatory Factor 6	Protein Coding	1
140	IRF7	Interferon Regulatory Factor 7	Protein Coding	1
141	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
142	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
143	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
144	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
145	JAK1	Janus Kinase 1	Protein Coding	1
146	JAK2	Janus Kinase 2	Protein Coding	1
147	JAK3	Janus Kinase 3	Protein Coding	1
148	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
149	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
150	XRCC5	X-Ray Repair Cross Complementing 5	Protein Coding	1
151	LCP1	Lymphocyte Cytosolic Protein 1	Protein Coding	1
152	LAT2	Linker For Activation Of T Cells Family Member 2	Protein Coding	1
153	LAG3	Lymphocyte Activating 3	Protein Coding	1
154	LAT	Linker For Activation Of T Cells	Protein Coding	1
155	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
156	PSIP1	PC4 And SRSF1 Interacting Protein 1	Protein Coding	1
157	LILRB1	Leukocyte Immunoglobulin Like Receptor B1	Protein Coding	1
158	LITAF	Lipopolysaccharide Induced TNF Factor	Protein Coding	1
159	LSP1	Lymphocyte Specific Protein 1	Protein Coding	1
160	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
161	MAGEA3	MAGE Family Member A3	Protein Coding	1
162	MALT1	MALT1 Paracaspase	Protein Coding	1
163	MAVS	Mitochondrial Antiviral Signaling Protein	Protein Coding	1
164	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	1
165	MRTFA	Myocardin Related Transcription Factor A	Protein Coding	1
166	MLANA	Melan-A	Protein Coding	1
167	MNDA	Myeloid Cell Nuclear Differentiation Antigen	Protein Coding	1
168	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	1
169	MPO	Myeloperoxidase	Protein Coding	1
170	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	1
171	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
172	NLRP1	NLR Family Pyrin Domain Containing 1	Protein Coding	1
173	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
174	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	1
175	NCK1	NCK Adaptor Protein 1	Protein Coding	1
176	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
177	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
178	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
179	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
180	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
181	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
182	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
183	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
184	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
185	NLRX1	NLR Family Member X1	Protein Coding	1
186	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	1
187	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
188	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	1
189	NT5E	5''-Nucleotidase Ecto	Protein Coding	1
190	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
191	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	1
192	OTUD5	OTU Deubiquitinase 5	Protein Coding	1
193	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	1
194	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1
195	PAWR	Pro-Apoptotic WT1 Regulator	Protein Coding	1
196	PAX5	Paired Box 5	Protein Coding	1
197	PBX1	PBX Homeobox 1	Protein Coding	1
198	PDCD1	Programmed Cell Death 1	Protein Coding	1
199	CD274	CD274 Molecule	Protein Coding	1
200	PDCD1LG2	Programmed Cell Death 1 Ligand 2	Protein Coding	1
201	PDLIM2	PDZ And LIM Domain 2	Protein Coding	1
202	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	1
203	PELI1	Pellino E3 Ubiquitin Protein Ligase 1	Protein Coding	1
204	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
205	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
206	PIAS4	Protein Inhibitor Of Activated STAT 4	Protein Coding	1
207	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
208	PIM2	Pim-2 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
209	PIM3	Pim-3 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
210	PIR	Pirin	Protein Coding	1
211	PRKCQ	Protein Kinase C Theta	Protein Coding	1
212	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
213	ZBTB16	Zinc Finger And BTB Domain Containing 16	Protein Coding	1
214	PPIA	Peptidylprolyl Isomerase A	Protein Coding	1
215	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
216	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
217	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
218	PRAME	PRAME Nuclear Receptor Transcriptional Regulator	Protein Coding	1
219	PRDM1	PR/SET Domain 1	Protein Coding	1
220	PRLR	Prolactin Receptor	Protein Coding	1
221	PSMB8	Proteasome 20S Subunit Beta 8	Protein Coding	1
222	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
223	PTPN22	Protein Tyrosine Phosphatase Non-Receptor Type 22	Protein Coding	1
224	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
225	PVR	PVR Cell Adhesion Molecule	Protein Coding	1
226	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
227	RABGEF1	RAB Guanine Nucleotide Exchange Factor 1	Protein Coding	1
228	RAG1	Recombination Activating 1	Protein Coding	1
229	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	1
230	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
231	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
232	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
233	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
234	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
235	RNASEL	Ribonuclease L	Protein Coding	1
236	RSAD2	Radical S-Adenosyl Methionine Domain Containing 2	Protein Coding	1
237	RUNX1T1	RUNX1 Partner Transcriptional Co-Repressor 1	Protein Coding	1
238	SARM1	Sterile Alpha And TIR Motif Containing 1	Protein Coding	1
239	KITLG	KIT Ligand	Protein Coding	1
240	SH2D1A	SH2 Domain Containing 1A	Protein Coding	1
241	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	1
242	SHARPIN	SHANK Associated RH Domain Interactor	Protein Coding	1
243	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	1
244	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	1
245	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
246	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1
247	SIVA1	SIVA1 Apoptosis Inducing Factor	Protein Coding	1
248	FYB1	FYN Binding Protein 1	Protein Coding	1
249	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
250	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
251	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	1
252	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
253	SPIB	Spi-B Transcription Factor	Protein Coding	1
254	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	1
255	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
256	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
257	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
258	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	1
259	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
260	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	1
261	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
262	SWAP70	Switching B Cell Complex Subunit SWAP70	Protein Coding	1
263	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
264	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
265	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	1
266	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	1
267	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
268	TAL1	TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor	Protein Coding	1
269	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
270	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	1
271	TAP2	Transporter 2, ATP Binding Cassette Subfamily B Member	Protein Coding	1
272	TAX1BP1	Tax1 Binding Protein 1	Protein Coding	1
273	TBK1	TANK Binding Kinase 1	Protein Coding	1
274	TBKBP1	TBK1 Binding Protein 1	Protein Coding	1
275	TBX21	T-Box Transcription Factor 21	Protein Coding	1
276	TCF12	Transcription Factor 12	Protein Coding	1
277	TEC	Tec Protein Tyrosine Kinase	Protein Coding	1
278	THEMIS	Thymocyte Selection Associated	Protein Coding	1
279	TICAM1	TIR Domain Containing Adaptor Molecule 1	Protein Coding	1
280	HAVCR1	Hepatitis A Virus Cellular Receptor 1	Protein Coding	1
281	HAVCR2	Hepatitis A Virus Cellular Receptor 2	Protein Coding	1
282	TLR1	Toll Like Receptor 1	Protein Coding	1
283	TLR2	Toll Like Receptor 2	Protein Coding	1
284	TLR3	Toll Like Receptor 3	Protein Coding	1
285	TLR6	Toll Like Receptor 6	Protein Coding	1
286	TLR7	Toll Like Receptor 7	Protein Coding	1
287	TLR8	Toll Like Receptor 8	Protein Coding	1
288	TLR9	Toll Like Receptor 9	Protein Coding	1
289	TNF	Tumor Necrosis Factor	Protein Coding	1
290	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
291	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
292	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
293	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	1
294	TNFRSF17	TNF Receptor Superfamily Member 17	Protein Coding	1
295	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	1
296	TNFRSF25	TNF Receptor Superfamily Member 25	Protein Coding	1
297	TNFRSF4	TNF Receptor Superfamily Member 4	Protein Coding	1
298	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	1
299	TNFRSF9	TNF Receptor Superfamily Member 9	Protein Coding	1
300	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
301	TNFSF12	TNF Superfamily Member 12	Protein Coding	1
302	TNFSF15	TNF Superfamily Member 15	Protein Coding	1
303	TNFSF4	TNF Superfamily Member 4	Protein Coding	1
304	TNIP1	TNFAIP3 Interacting Protein 1	Protein Coding	1
305	TOLLIP	Toll Interacting Protein	Protein Coding	1
306	TPT1	Tumor Protein, Translationally-Controlled 1	Protein Coding	1
307	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
308	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
309	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
310	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
311	TRAF5	TNF Receptor Associated Factor 5	Protein Coding	1
312	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
313	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
314	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
315	TRIB2	Tribbles Pseudokinase 2	Protein Coding	1
316	TRIM25	Tripartite Motif Containing 25	Protein Coding	1
317	TNFRSF12A	TNF Receptor Superfamily Member 12A	Protein Coding	1
318	TXN	Thioredoxin	Protein Coding	1
319	TYK2	Tyrosine Kinase 2	Protein Coding	1
320	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	1
321	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
322	USP15	Ubiquitin Specific Peptidase 15	Protein Coding	1
323	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
324	VSIR	V-Set Immunoregulatory Receptor	Protein Coding	1
325	VTCN1	V-Set Domain Containing T Cell Activation Inhibitor 1	Protein Coding	1
326	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
327	ZBTB7B	Zinc Finger And BTB Domain Containing 7B	Protein Coding	1

Disorders associated with NF-kappaB Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Systemic lupus erythematosus	Enrichment	BLK, CTLA4, IL10, IRAK1, IRF5, PDCD1, PTPN22, SOCS1, STAT4, TLR7, TNF, TNFAIP3, TNFSF4, TNIP1	11.34
2	Severe combined immunodeficiency	Enrichment	CD3E, DCLRE1C, IKBKB, JAK3, LCK, MALT1, PTPRC, RAG1, ZAP70	7.24
3	Human immunodeficiency virus type 1	Enrichment	CCL2, CCL5, CCR2, CXCL12, IFNG, IL10, TLR3	6.95
4	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, PTPN2, PTPN22, STAT4	6.80
5	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB, PTPN2, PTPN22, STAT4	6.80
6	Herpes simplex virus encephalitis	Enrichment	TBK1, TICAM1, TLR3, TRAF3	5.79
7	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA, KIT, RUNX1, RUNX1T1	5.79
8	Multisystem inflammatory syndrome in children	Enrichment	IFIH1, IRAK3, IRF3, TLR3, TLR6, TRAF3	5.00
9	Mycosis fungoides	Enrichment	CD28, CTLA4, TNFRSF1B	4.86
10	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	4.86
11	Saczary syndrome	Enrichment	CD28, CTLA4, TNFRSF1B	4.86
12	Rheumatoid arthritis	Enrichment	CIITA, IL10, IRF5, TLR1	4.42
13	Immunodeficiency, common variable, 1	Enrichment	CTLA4, ICOS, NFKB2	4.26
14	Immunodeficiency by defective expression of mhc class i	Enrichment	B2M, TAP1, TAP2	4.26
15	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, CD79A, SPI1, TCF3	4.21
16	Testicular germ cell tumor	Enrichment	BCL10, KIT, KITLG	3.58
17	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1, NFKB2	3.34
18	Storage pool platelet disease	Enrichment	GFI1B, RUNX1	3.24
19	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	3.24
20	Acute basophilic leukemia	Enrichment	GATA1, MYB	3.24
21	Lymphoproliferative syndrome	Enrichment	ITK, SH2D1A	3.24
22	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	3.24
23	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	PBX1, TCF3	3.24
24	Singleton-merten syndrome	Enrichment	IFIH1, RIGI	3.24
25	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	3.24
26	Behcet syndrome	Enrichment	FAS, IL10, STAT4, TNFRSF1A	3.02
27	Diffuse large b-cell lymphoma	Enrichment	BTK, MYD88, SOCS1, STAT3	3.02
28	Thrombocytopenia	Enrichment	FLI1, GATA1, GFI1B, MECOM, MPL, RUNX1	3.01
29	Primary biliary cholangitis	Enrichment	IRF5, SPIB, TNFSF15	2.98
30	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG, TLR8	2.77
31	Adult-onset myasthenia gravis	Enrichment	CTLA4, TNFRSF11A	2.77
32	Vogt-koyanagi-harada disease	Enrichment	FAS, PTPN22	2.77
33	Immune deficiency disease	Enrichment	IKZF1, RIPK1, SYK	2.70
34	Asthma	Enrichment	ALOX5, CARD11, TNF	2.70
35	Combined immunodeficiency	Enrichment	BCL11B, MALT1, ZAP70	2.70
36	Combined t cell and b cell immunodeficiency	Enrichment	BCL11B, MALT1, ZAP70	2.70
37	Combined t and b cell immunodeficiency	Enrichment	BCL11B, MALT1, ZAP70	2.70
38	Autoinflammatory disease	Enrichment	IL1RN, PSMB8, SH2D1A, TNFRSF1A	2.62
39	Leukemia, acute myeloid	Enrichment	CEBPA, GATA2, JAK2, KIT, RUNX1	2.59
40	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B, ZBTB16	2.48
41	Anemia, autoimmune hemolytic	Enrichment	SOCS1, TLR8	2.47
42	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	2.47
43	Mhc class i deficiency 1	Enrichment	TAP1, TAP2	2.47
44	Mhc class i deficiency	Enrichment	TAP1, TAP2	2.47
45	Pediatric systemic lupus erythematosus	Enrichment	IRAK1, STAT4	2.47
46	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	2.26
47	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3, RAG1	2.26
48	Follicular lymphoma	Enrichment	BCL10, BCL6	2.26
49	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	2.26
50	Aggressive systemic mastocytosis	Enrichment	CBL, RUNX1	2.26
51	Granulomatosis with polyangiitis	Enrichment	CTLA4, PTPN22	2.09
52	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, RIPK1	2.09
53	Myelofibrosis	Enrichment	JAK2, MPL	1.95
54	Essential thrombocythemia	Enrichment	JAK2, MPL	1.95
55	Lymphoma, non-hodgkin, familial	Enrichment	B2M, BCL10	1.83
56	Malaria	Enrichment	CISH, IKBKG, TNF	1.76
57	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB, TAL1, ZBTB16	1.76
58	Leukemia, acute lymphoblastic 3	Enrichment	JAK2, PAX5	1.73
59	Chronic granulomatous disease	Enrichment	NCF1, NCF4	1.73
60	Hydrops fetalis	Enrichment	FOXP3, L1CAM	1.73
61	Omenn syndrome	Enrichment	DCLRE1C, RAG1	1.64
62	Ciliary dyskinesia, primary, 3	Enrichment	BACH2, NFKB1	1.64
63	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	1.62
64	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	1.62
65	Leprosy 3	Enrichment	TLR2	1.62
66	Calcification of joints and arteries	Enrichment	NT5E	1.62
67	Immunodeficiency 103 fungal infections	Enrichment	CARD9	1.62
68	Chand syndrome	Enrichment	RIPK4	1.62
69	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	1.62
70	Charcot-marie-tooth disease, demyelinating, type 1c	Enrichment	LITAF	1.62
71	Incontinentia pigmenti	Enrichment	IKBKG	1.62
72	Type 1 diabetes mellitus 10	Enrichment	IL2RA	1.62
73	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	1.62
74	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	1.62
75	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	1.62
76	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.62
77	Thrombocythemia 2	Enrichment	MPL	1.62
78	Immunodeficiency 35	Enrichment	TYK2	1.62
79	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	1.62
80	Immunodeficiency 61	Enrichment	SH3KBP1	1.62
81	Prostate cancer, hereditary, 1	Enrichment	RNASEL	1.62
82	Immunodeficiency 68	Enrichment	MYD88	1.62
83	Osteopetrosis, autosomal recessive 7	Enrichment	TNFRSF11A	1.62
84	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	1.62
85	Mastocytosis, cutaneous	Enrichment	KIT	1.62
86	Orofacial cleft 6	Enrichment	IRF6	1.62
87	Celiac disease 3	Enrichment	CTLA4	1.62
88	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	1.62
89	Dermatitis, atopic, 4	Enrichment	SOCS3	1.62
90	Popliteal pterygium syndrome	Enrichment	IRF6	1.62
91	Vitiligo-associated multiple autoimmune disease susceptibility 1	Enrichment	NLRP1	1.62
92	Skeletal defects, genital hypoplasia, and impaired intellectual development	Enrichment	ZBTB16	1.62
93	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	1.62
94	Immunodeficiency 83 viral infections	Enrichment	TLR3	1.62
95	Immunodeficiency 16	Enrichment	TNFRSF4	1.62
96	Polycystic lung disease	Enrichment	CCR2	1.62
97	Immunodeficiency 39 viral infections	Enrichment	IRF7	1.62
98	Amegakaryocytic thrombocytopenia, congenital, 1	Enrichment	MPL	1.62
99	Multiple fibroadenomas of the breast	Enrichment	PRLR	1.62
100	Leprosy 5	Enrichment	TLR1	1.62
101	Fetal encasement syndrome	Enrichment	CHUK	1.62
102	Immunodeficiency 116	Enrichment	CD8A	1.62
103	Encephalopathy, acute, infection-induced 7	Enrichment	IRF3	1.62
104	Immunodeficiency 43	Enrichment	B2M	1.62
105	Bleeding disorder, platelet-type, 21	Enrichment	FLI1	1.62
106	Alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	Enrichment	RAG1	1.62
107	Singleton-merten syndrome 1	Enrichment	IFIH1	1.62
108	Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis	Enrichment	IL1RN	1.62
109	Whim syndrome 1	Enrichment	CXCR4	1.62
110	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	1.62
111	Immunodeficiency 49, severe combined	Enrichment	BCL11B	1.62
112	Transient erythroblastopenia of childhood	Enrichment	TEC	1.62
113	Agammaglobulinemia 3, autosomal recessive	Enrichment	CD79A	1.62
114	Atrioventricular septal defect 5	Enrichment	GATA6	1.62
115	Immunodeficiency 32a	Enrichment	IRF8	1.62
116	Bleeding disorder, platelet-type, 17	Enrichment	GFI1B	1.62
117	Encephalopathy, acute, infection-induced 6	Enrichment	TICAM1	1.62
118	Immunodeficiency 15b	Enrichment	IKBKB	1.62
119	Immunodeficiency 69	Enrichment	IFNG	1.62
120	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	1.62
121	Pseudo-torch syndrome 3	Enrichment	STAT2	1.62
122	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	1.62
123	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	1.62
124	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	1.62
125	Immunodeficiency 107 invasive staphylococcus aureus infection	Enrichment	OTULIN	1.62
126	Immunodeficiency 81	Enrichment	LCP2	1.62
127	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	1.62
128	Intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities	Enrichment	BCL11B	1.62
129	Immunodeficiency 15a	Enrichment	IKBKB	1.62
130	Immunodeficiency 92	Enrichment	REL	1.62
131	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	1.62
132	Immunodeficiency 95	Enrichment	IFIH1	1.62
133	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	1.62
134	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	1.62
135	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	1.62
136	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	1.62
137	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	1.62
138	Lymphoproliferative syndrome, x-linked, 1	Enrichment	SH2D1A	1.62
139	Immunodeficiency 131	Enrichment	IRF4	1.62
140	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Enrichment	PBX1	1.62
141	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	1.62
142	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.62
143	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.62
144	Hyperemesis gravidarum	Enrichment	GDF15	1.62
145	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	1.62
146	Immunodeficiency 48	Enrichment	ZAP70	1.62
147	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	1.62
148	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	1.62
149	Autoinflammation with episodic fever and immune dysregulation	Enrichment	SHARPIN	1.62
150	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.62
151	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	1.62
152	Lymphedema, primary, with myelodysplasia	Enrichment	GATA2	1.62
153	Immunodeficiency 60	Enrichment	BACH2	1.62
154	Graft-versus-host disease	Enrichment	IL10	1.62
155	X-linked immunodeficiency 74	Enrichment	TLR7	1.62
156	Thrombocytopenia 3	Enrichment	FYB1	1.62
157	Bartsocas-papas syndrome 1	Enrichment	RIPK4	1.62
158	Immunodeficiency 132a	Enrichment	TRAF3	1.62
159	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.62
160	Respiratory papillomatosis, juvenile recurrent, congenital	Enrichment	NLRP1	1.62
161	Type 1 diabetes mellitus 19	Enrichment	IFIH1	1.62
162	Immunodeficiency 132b	Enrichment	TRAF3	1.62
163	Systemic lupus erythematosus 17	Enrichment	TLR7	1.62
164	Multiple congenital anomalies-neurodevelopmental syndrome, x-linked	Enrichment	OTUD5	1.62
165	Masa syndrome	Enrichment	L1CAM	1.62
166	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.62
167	Hyperprolactinemia	Enrichment	PRLR	1.62
168	Type 1 diabetes mellitus 12	Enrichment	CTLA4	1.62
169	Immunodeficiency 18	Enrichment	CD3E	1.62
170	Systemic lupus erythematosus 11	Enrichment	STAT4	1.62
171	Dialysis-related amyloidosis	Enrichment	B2M	1.62
172	Immunodeficiency 39	Enrichment	IRF7	1.62
173	Persistent polyclonal b-cell lymphocytosis	Enrichment	CARD11	1.62
174	Asthma-related traits 5	Enrichment	IRAK3	1.62
175	Radioulnar synostosis with amegakaryocytic thrombocytopenia 2	Enrichment	MECOM	1.62
176	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	1.62
177	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	1.62
178	Systemic lupus erythematosus 10	Enrichment	IRF5	1.62
179	Systemic lupus erythematosus 2	Enrichment	PDCD1	1.62
180	Microvascular complications of diabetes 4	Enrichment	IL1RN	1.62
181	Lymphoproliferative syndrome 1	Enrichment	ITK	1.62
182	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	1.62
183	Immunodeficiency 67	Enrichment	IRAK4	1.62
184	Focal segmental glomerulosclerosis 3	Enrichment	CD2AP	1.62
185	Glutathione peroxidase deficiency	Enrichment	GPX1	1.62
186	Immunodeficiency 21	Enrichment	GATA2	1.62
187	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	1.62
188	Immunodeficiency 31a	Enrichment	STAT1	1.62
189	Multiple sclerosis 5	Enrichment	TNFRSF1A	1.62
190	Craniosynostosis 3	Enrichment	TCF12	1.62
191	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	1.62
192	Palmoplantar carcinoma, multiple self-healing	Enrichment	NLRP1	1.62
193	Immunodeficiency 12	Enrichment	MALT1	1.62
194	Recombinase activating gene 1 deficiency	Enrichment	RAG1	1.62
195	Hemolytic uremic syndrome, atypical 2	Enrichment	CD46	1.62
196	Immunodeficiency, common variable, 3	Enrichment	CD19	1.62
197	Immunodeficiency 31b	Enrichment	STAT1	1.62
198	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	1.62
199	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	1.62
200	Immunodeficiency 105, severe combined	Enrichment	PTPRC	1.62
201	Inflammatory bowel disease 14	Enrichment	IRF5	1.62
202	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	1.62
203	Atrial septal defect 9	Enrichment	GATA6	1.62
204	Heme oxygenase 1 deficiency	Enrichment	HMOX1	1.62
205	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	1.62
206	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	1.62
207	Immunodeficiency 22	Enrichment	LCK	1.62
208	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.62
209	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	1.62
210	Singleton-merten syndrome 2	Enrichment	RIGI	1.62
211	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	Enrichment	OTULIN	1.62
212	T-cell lymphoma, subcutaneous panniculitis-like	Enrichment	HAVCR2	1.62
213	Irf6-related disorders	Enrichment	IRF6	1.62
214	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	1.62
215	Autosomal dominant popliteal pterygium syndrome	Enrichment	IRF6	1.62
216	Immunodeficiency, common variable, 13	Enrichment	IKZF1	1.62
217	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	1.62
218	Congenital autosomal recessive small-platelet thrombocytopenia	Enrichment	FYB1	1.62
219	Corticobasal syndrome	Enrichment	TBK1	1.62
220	Deafness-lymphedema-leukemia syndrome	Enrichment	GATA2	1.62
221	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	1.62
222	Immunodeficiency 53	Enrichment	RELB	1.62
223	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.62
224	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	1.62
225	Immunodeficiency 60 and autoimmunity	Enrichment	BACH2	1.62
226	Autoinflammation with arthritis and dyskeratosis	Enrichment	NLRP1	1.62
227	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	1.62
228	Cd45 deficiency	Enrichment	PTPRC	1.62
229	Immunodeficiency 88	Enrichment	TBX21	1.62
230	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	1.62
231	Chronic mast cell leukemia	Enrichment	KIT	1.62
232	Sezary's disease	Enrichment	BCL10	1.62
233	Amyloidosis, hereditary systemic 6	Enrichment	B2M	1.62
234	Deafness, autosomal dominant 69	Enrichment	KITLG	1.62
235	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	1.62
236	Aicardi-goutieres syndrome 7	Enrichment	IFIH1	1.62
237	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	1.62
238	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	1.62
239	Combined immunodeficiency due to dimerization defective ikaros mutation	Enrichment	IKZF1	1.62
240	Immunodeficiency 109 with lymphoproliferation	Enrichment	TNFRSF9	1.62
241	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	1.62
242	Charcot-marie-tooth disease type 1c	Enrichment	LITAF	1.62
243	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	1.62
244	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	Enrichment	OTULIN	1.62
245	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	1.62
246	Colitis	Enrichment	SYK	1.62
247	Immunodeficiency 112	Enrichment	MAP3K14	1.62
248	Familial hyperprolactinemia	Enrichment	PRLR	1.62
249	Autoimmune disease, multisystem, infantile-onset, 5	Enrichment	CD274	1.62
250	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.62
251	Agammaglobulinemia	Enrichment	SPI1	1.62
252	Isolated bone marrow mastocytosis	Enrichment	KIT	1.62
253	Isolated delta-storage pool disease	Enrichment	FLI1	1.62
254	Smoldering systemic mastocytosis	Enrichment	KIT	1.62
255	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	1.62
256	Bullous pyoderma gangrenosum	Enrichment	PTPN6	1.62
257	Cd40 ligand deficiency	Enrichment	CD40LG	1.62
258	Combined immunodeficiency-lymphopenia-cancer predisposing syndrome due to aiolos deficiency	Enrichment	IKZF3	1.62
259	Agammaglobulinemia 3	Enrichment	CD79A	1.62
260	Waldenstram macroglobulinemia	Enrichment	MYD88	1.62
261	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	1.62
262	Pustular pyoderma gangrenosum	Enrichment	PTPN6	1.62
263	Atherosclerosis	Enrichment	ALOX5	1.62
264	Mastocytosis	Enrichment	KIT	1.62
265	Early-onset combined immunodeficiency with low ig due to dominant negative ikaros mutation	Enrichment	IKZF1	1.62
266	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.62
267	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	1.62
268	Familial progressive hyperpigmentation	Enrichment	KITLG	1.62
269	Hypogonadotropic hypogonadism 26 with or without anosmia	Enrichment	TCF12	1.62
270	Whipple disease	Enrichment	IRF4	1.62
271	Cutaneous mastocytoma	Enrichment	KIT	1.62
272	Distal monosomy 12p	Enrichment	ERC1	1.62
273	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	1.62
274	Typical urticaria pigmentosa	Enrichment	KIT	1.62
275	Classic pyoderma gangrenosum	Enrichment	PTPN6	1.62
276	Nodular urticaria pigmentosa	Enrichment	KIT	1.62
277	Combined immunodeficiency due to partial rag1 deficiency	Enrichment	RAG1	1.62
278	Common variable immunodeficiency phenotype due to tweak deficiency	Enrichment	TNFSF12	1.62
279	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	1.62
280	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	1.62
281	Acute mast cell leukemia	Enrichment	KIT	1.62
282	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.62
283	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	1.62
284	Mucosa-associated lymphoma	Enrichment	BCL10	1.62
285	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	1.62
286	Plaque-form urticaria pigmentosa	Enrichment	KIT	1.62
287	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	1.62
288	Nik deficiency	Enrichment	MAP3K14	1.62
289	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	1.62
290	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	1.62
291	Polyvalvular heart disease syndrome	Enrichment	TAB2	1.62
292	Testis seminoma	Enrichment	KIT	1.62
293	Mhc class ii deficiency 1	Enrichment	CIITA, TAP2	1.56
294	Leukemia, acute lymphoblastic	Enrichment	IKZF1, PAX5	1.56
295	Alzheimer's disease	Enrichment	MPO, TNF	1.42
296	Nk-cell enteropathy	Enrichment	JAK3, RUNX1T1	1.42
297	Lung cancer	Enrichment	FAS, FASLG, IRF1	1.39
298	Myeloproliferative syndrome, transient	Enrichment	GATA1	1.32
299	Hashimoto thyroiditis	Enrichment	CTLA4	1.32
300	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.32
301	Familial expansile osteolysis	Enrichment	TNFRSF11A	1.32
302	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	1.32
303	Cylindromatosis, familial	Enrichment	CYLD	1.32
304	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	1.32
305	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.32
306	Immunodeficiency 32b	Enrichment	IRF8	1.32
307	Thrombocytopenia, paris-trousseau type	Enrichment	FLI1	1.32
308	Paget disease of bone 5, juvenile-onset	Enrichment	TNFRSF11A	1.32
309	Hemangiopericytoma, malignant	Enrichment	STAT6	1.32
310	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TYROBP	1.32
311	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	1.32
312	Porphyria, congenital erythropoietic	Enrichment	GATA1	1.32
313	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	1.32
314	Ovarian germ cell cancer	Enrichment	CBL	1.32
315	Schneckenbecken dysplasia	Enrichment	INPPL1	1.32
316	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.32
317	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.32
318	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	1.32
319	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.32
320	Piebald trait	Enrichment	KIT	1.32
321	Immunodeficiency with hyper-igm, type 2	Enrichment	AICDA	1.32
322	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	1.32
323	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.32
324	Maturity-onset diabetes of the young, type 11	Enrichment	BLK	1.32
325	Immunodeficiency 11a	Enrichment	CARD11	1.32
326	Immunodeficiency 37	Enrichment	BCL10	1.32
327	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.32
328	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.32
329	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	1.32
330	Thrombocythemia 3	Enrichment	JAK2	1.32
331	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	1.32
332	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1	1.32
333	Immunodeficiency 31c	Enrichment	STAT1	1.32
334	Encephalopathy, acute, infection-induced 10	Enrichment	TPT1	1.32
335	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	1.32
336	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	1.32
337	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	DCLRE1C	1.32
338	Waardenburg syndrome, type 2f	Enrichment	KITLG	1.32
339	Immunodeficiency 11b with atopic dermatitis	Enrichment	CARD11	1.32
340	Diamond-blackfan anemia-like	Enrichment	IKZF1	1.32
341	Agammaglobulinemia, x-linked	Enrichment	BTK	1.32
342	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.32
343	Immunodeficiency 66	Enrichment	MRTFA	1.32
344	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	1.32
345	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	1.32
346	Intravascular large b-cell lymphoma	Enrichment	BCL6	1.32
347	Brooke-spiegler syndrome	Enrichment	CYLD	1.32
348	Immunodeficiency 127	Enrichment	TNF	1.32
349	Stevens-johnson syndrome	Enrichment	IKZF1	1.32
350	Rela fusion-positive ependymoma	Enrichment	RELA	1.32
351	Agammaglobulinemia 4	Enrichment	BLNK	1.32
352	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	1.32
353	Leprosy 1	Enrichment	TLR6	1.32
354	Macrocephaly, dysmorphic facies, and psychomotor retardation	Enrichment	ERC1	1.32
355	B-cell expansion with nfkb and t-cell anergy	Enrichment	CARD11	1.32
356	Congenital dyserythropoietic anemia	Enrichment	IRAK4	1.32
357	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.32
358	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.32
359	Angiocentric glioma	Enrichment	MYB	1.32
360	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.32
361	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	1.32
362	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	1.32
363	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.32
364	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	1.32
365	Polycythemia	Enrichment	JAK2	1.32
366	Immunodeficiency 52	Enrichment	LAT	1.32
367	Portal hypertension, noncirrhotic, 2	Enrichment	GIMAP5	1.32
368	Congenital amegakaryocytic thrombocytopenia	Enrichment	MPL	1.32
369	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	1.32
370	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.32
371	Lymphomatoid papulosis	Enrichment	TYK2	1.32
372	Basal ganglia disease	Enrichment	IFIH1	1.32
373	Radioulnar synostosis	Enrichment	MECOM	1.32
374	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.32
375	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19	1.32
376	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	1.32
377	Arthritis	Enrichment	SYK	1.32
378	Hypereosinophilic syndrome	Enrichment	JAK2	1.32
379	Immunodeficiency 117	Enrichment	IRF1	1.32
380	Van der woude syndrome	Enrichment	IRF6	1.32
381	Malignant germ cell tumor of ovary	Enrichment	CBL	1.32
382	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.32
383	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.32
384	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	MECOM	1.32
385	Renal hypoplasia, bilateral	Enrichment	PBX1	1.32
386	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.32
387	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	1.32
388	Common variable immunodeficiency 12	Enrichment	NFKB1	1.32
389	Tafro syndrome	Enrichment	RUNX1	1.32
390	Laron syndrome with immunodeficiency	Enrichment	STAT5B	1.32
391	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	1.32
392	Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)	Enrichment	MRTFA	1.32
393	B-lymphoblastic leukemia/lymphoma with t(7;9)(q11.2;p13.2)	Enrichment	PAX5	1.32
394	Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome	Enrichment	MECOM	1.32
395	Patent foramen ovale	Enrichment	GATA6, TAB2	1.16
396	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.15
397	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.15
398	Jacobsen syndrome	Enrichment	FLI1	1.15
399	Craniometaphyseal dysplasia, autosomal dominant	Enrichment	OTULIN	1.15
400	Van der woude syndrome 1	Enrichment	IRF6	1.15
401	Pelvic organ prolapse	Enrichment	TAB2	1.15
402	Mesothelioma, malignant	Enrichment	BCL10	1.15
403	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	1.15
404	Combined cellular and humoral immune defects with granulomas	Enrichment	RAG1	1.15
405	Immune thrombocytopenia	Enrichment	SOCS1	1.15
406	Dysosteosclerosis	Enrichment	TNFRSF11A	1.15
407	Opsismodysplasia	Enrichment	INPPL1	1.15
408	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB8	1.15
409	Polycythemia vera	Enrichment	JAK2	1.15
410	Tuberous sclerosis 1	Enrichment	IFNG	1.15
411	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1	1.15
412	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	1.15
413	Neurodegeneration with brain iron accumulation 5	Enrichment	OTUD5	1.15
414	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	1.15
415	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.15
416	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	1.15
417	Psoriatic arthritis	Enrichment	TNF	1.15
418	Hepatitis c virus	Enrichment	IFNG	1.15
419	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.15
420	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	1.15
421	Tuberous sclerosis 2	Enrichment	IFNG	1.15
422	Ehlers-danlos syndrome, kyphoscoliotic type, 1	Enrichment	DCLRE1C	1.15
423	Folate malabsorption, hereditary	Enrichment	SARM1	1.15
424	Dyskeratosis congenita, autosomal dominant 6	Enrichment	MPL	1.15
425	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	1.15
426	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.15
427	Immunodeficiency 84	Enrichment	IKZF3	1.15
428	Agammaglobulinemia 1	Enrichment	BTK	1.15
429	Bacteremia 2	Enrichment	CISH	1.15
430	Hyper ige syndrome	Enrichment	STAT3	1.15
431	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL6	1.15
432	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB8	1.15
433	Asparagine synthetase deficiency	Enrichment	CTLA4	1.15
434	Testicular germ cell cancer	Enrichment	KIT	1.15
435	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.15
436	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	1.15
437	Migraine without aura	Enrichment	TNF	1.15
438	Immunodeficiency 44	Enrichment	STAT2	1.15
439	End stage renal disease	Enrichment	GATA3	1.15
440	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	1.15
441	Adenoid cystic carcinoma	Enrichment	MYB	1.15
442	Plod1-related kyphoscoliotic ehlers-danlos syndrome	Enrichment	DCLRE1C	1.15
443	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	1.15
444	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	1.15
445	Genetic atypical hemolytic-uremic syndrome	Enrichment	CD46	1.15
446	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3E	1.15
447	Stüve-wiedemann syndrome	Enrichment	IL6ST	1.15
448	Testicular cancer	Enrichment	BCL10	1.15
449	Gastric cancer	Enrichment	IL1B, IL1RN, IRF1	1.07
450	Erythrocytosis, familial, 1	Enrichment	JAK2	1.03
451	Myeloperoxidase deficiency	Enrichment	MPO	1.03
452	Temporal arteritis	Enrichment	PTPN22	1.03
453	Down syndrome	Enrichment	GATA1	1.03
454	Granulomatous disease, chronic, x-linked	Enrichment	NCF1	1.03
455	Budd-chiari syndrome	Enrichment	JAK2	1.03
456	Paget disease of bone 2, early-onset	Enrichment	TNFRSF11A	1.03
457	Chondrocalcinosis 2	Enrichment	OTULIN	1.03
458	Aicardi-goutieres syndrome 1	Enrichment	DCLRE1C	1.03
459	Portal hypertension	Enrichment	GIMAP5	1.03
460	Tuberculosis	Enrichment	CISH	1.03
461	Hellp syndrome	Enrichment	CD46	1.03
462	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	1.03
463	Blood platelet disease	Enrichment	RUNX1	1.03
464	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	1.03
465	Adenosine deaminase deficiency	Enrichment	JAK3	1.03
466	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	1.03
467	Paget's disease of bone 2	Enrichment	TNFRSF11A	1.03
468	Cerebral malaria	Enrichment	TNF	1.03
469	Non-syndromic bicoronal craniosynostosis	Enrichment	TCF12	1.03
470	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.03
471	Middle aortic syndrome	Enrichment	GATA6	1.03
472	Cleft lip and alveolus	Enrichment	IRF6	1.03
473	Thrombotic microangiopathy	Enrichment	CD46	1.03
474	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	0.94
475	Amyloidosis, hereditary systemic 2	Enrichment	B2M	0.94
476	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	0.94
477	Chondrosarcoma, extraskeletal myxoid	Enrichment	TCF12	0.94
478	Congenital heart defects, multiple types, 4	Enrichment	GATA6	0.94
479	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	0.94
480	Spastic diplegia	Enrichment	IFIH1	0.94
481	Acute myeloid leukemia with maturation	Enrichment	KIT	0.94
482	Vascular dementia	Enrichment	TNF	0.94
483	Acute megakaryocytic leukemia	Enrichment	GATA1	0.94
484	Cleft upper lip	Enrichment	IRF6	0.94
485	Inherited acute myeloid leukemia	Enrichment	CEBPA	0.94
486	Diffuse cutaneous systemic sclerosis	Enrichment	IRF5	0.94
487	Persistent truncus arteriosus	Enrichment	GATA6	0.94
488	Hereditary pulmonary alveolar proteinosis	Enrichment	CSF2RB	0.94
489	Idiopathic aplastic anemia	Enrichment	IFNG	0.94
490	Dyskeratosis congenita, autosomal dominant 1	Enrichment	MECOM	0.87
491	Conotruncal heart malformations	Enrichment	GATA6	0.87
492	Type 1 diabetes mellitus	Enrichment	FOXP3	0.87
493	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	0.87
494	Pancytopenia	Enrichment	RUNX1	0.87
495	Chronic mucocutaneous candidiasis	Enrichment	STAT1	0.87
496	Limited scleroderma	Enrichment	IRF5	0.87
497	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	CD46	0.87
498	Myeloma, multiple	Enrichment	CYLD, TCF3, TRAF5	0.82
499	Fundus albipunctatus	Enrichment	CD63	0.80
500	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B	0.80
501	Gastrointestinal stromal tumor	Enrichment	KIT	0.80
502	Waardenburg syndrome, type 2e	Enrichment	KITLG	0.80
503	Leukemia, chronic myeloid	Enrichment	RUNX1	0.80
504	Dyskeratosis congenita, autosomal dominant 2	Enrichment	MECOM	0.80
505	Alzheimer's disease 1	Enrichment	MPO	0.80
506	Motor neuron disease	Enrichment	TBK1	0.80
507	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	IKZF1	0.80
508	Primary ovarian insufficiency	Enrichment	JAK2, MECOM, PRLR	0.77
509	Narcolepsy 1	Enrichment	TNFSF4	0.75
510	Ewing sarcoma	Enrichment	FLI1	0.75
511	Permanent neonatal diabetes mellitus	Enrichment	STAT3	0.75
512	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	0.71
513	Charge syndrome	Enrichment	TNFRSF1A	0.71
514	Inflammatory bowel disease 1	Enrichment	PRKCQ	0.71
515	Coronary heart disease 5	Enrichment	IKBKG	0.71
516	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	0.71
517	Progressive non-fluent aphasia	Enrichment	TBK1	0.71
518	Mhc class ii deficiency	Enrichment	CIITA	0.71
519	Aicardi-goutiares syndrome	Enrichment	IFIH1	0.71
520	Inherited cancer-predisposing syndrome	Enrichment	CEBPA, CYLD, KIT, MECOM, RUNX1	0.67
521	Leukemia, chronic lymphocytic	Enrichment	IKZF3	0.66
522	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	0.66
523	Aplastic anemia	Enrichment	IFNG	0.66
524	Aicardi-goutieres syndrome	Enrichment	IFIH1	0.66
525	Autosomal dominant macrothrombocytopenia	Enrichment	GFI1B	0.66
526	Migraine with or without aura 1	Enrichment	TAB2	0.63
527	Myelodysplastic syndrome	Enrichment	GATA2	0.63
528	Lung non-small cell carcinoma	Enrichment	IRF1	0.63
529	Ichthyosis	Enrichment	IL2RB	0.63
530	Juvenile myelomonocytic leukemia	Enrichment	CBL	0.60
531	Lip and oral cavity carcinoma	Enrichment	KIT	0.60
532	Charcot-marie-tooth disease	Enrichment	LITAF, NDRG1	0.59
533	Autism spectrum disorder	Enrichment	ARIH2, BCL11B, PBX1, TCF12	0.57
534	Aortic valve disease 1	Enrichment	TAB2	0.57
535	Diaphragmatic hernia, congenital	Enrichment	GATA6	0.57
536	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	0.57
537	Protein-deficiency anemia	Enrichment	GATA1	0.57
538	Multiple sclerosis	Enrichment	TNFRSF1A	0.54
539	Cleft lip/palate	Enrichment	IRF6	0.54
540	Atypical hemolytic-uremic syndrome	Enrichment	CD46	0.51
541	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	0.51
542	Rhabdomyosarcoma	Enrichment	CBL	0.49
543	Gliosarcoma	Enrichment	NFKBIA	0.49
544	Alzheimer disease, familial, 1	Enrichment	MPO	0.47
545	Cleft palate, isolated	Enrichment	IRF6	0.47
546	Giant cell glioblastoma	Enrichment	NFKBIA	0.47
547	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	0.45
548	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	0.43
549	Hereditary breast ovarian cancer syndrome	Enrichment	LCP1, RIPK1	0.42
550	Williams-beuren syndrome	Enrichment	NCF1	0.41
551	Maturity-onset diabetes of the young	Enrichment	BLK	0.41
552	Craniosynostosis	Enrichment	TCF12	0.41
553	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.40
554	Centronuclear myopathy	Enrichment	FOXP3	0.40
555	Myocardial infarction	Enrichment	TNFSF4	0.38
556	Tooth agenesis	Enrichment	IRF6	0.38
557	Diamond-blackfan anemia 1	Enrichment	GATA1	0.37
558	Noonan syndrome 1	Enrichment	CBL	0.37
559	Congenital stationary night blindness	Enrichment	CD63	0.37
560	Familial atrial fibrillation	Enrichment	GATA6	0.35
561	Tetralogy of fallot	Enrichment	GATA6	0.33
562	Rasopathy	Enrichment	CBL	0.33
563	Prostate cancer	Enrichment	RNASEL	0.29
564	Severe covid-19	Enrichment	JAK3	0.29
565	Differentiated thyroid carcinoma	Enrichment	ERC1	0.29
566	Cystic fibrosis	Enrichment	HMOX1	0.27
567	Nephronophthisis	Enrichment	PIAS1	0.26
568	Cakut	Enrichment	GATA3	0.25
569	Genetic steroid-resistant nephrotic syndrome	Enrichment	CD2AP	0.25
570	Dilated cardiomyopathy	Enrichment	GATA6, TAB2	0.24
571	Diamond-blackfan anemia	Enrichment	GATA1	0.23
572	Colorectal cancer	Enrichment	BCL10, TLR2	0.20
573	Ovarian cancer	Enrichment	KIT, RNASEL	0.15
574	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.15
575	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	KITLG	0.14
576	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.13
577	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.12
578	Breast cancer	Enrichment	IL2	0.08
579	Mitochondrial disease	Enrichment	C1QBP	0.05
580	Microcephaly	Enrichment	BCL11B	0.02
581	Complex neurodevelopmental disorder	Enrichment	OTUD5	0.02
582	Hereditary retinal dystrophy	Enrichment	CD63	0.00
583	Fundus dystrophy	Enrichment	CD63	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NF-kappaB Signaling

Pathway Network for NF-kappaB Signaling

Member Pathways for NF-kappaB Signaling

Pathways in the NF-kappaB Signaling SuperPath

Associated Genes for NF-kappaB Signaling

Associated Disorders for NF-kappaB Signaling

Disorders associated with NF-kappaB Signaling SuperPath

STRING Interaction Network for NF-kappaB Signaling

Sources for NF-kappaB Signaling