NF-kB (NFkB) Pathway

No Pathway Network information available for NF-kB (NFkB) Pathway

Pathways in the NF-kB (NFkB) Pathway SuperPath

#	Name	Source	Genes
1	NF-kB (NFkB) Pathway	Sino Biological	BTK CD14 CD4 ECSIT FADD FYN GBP1 GBP2 GBP5 GBP6 GSK3B HLA-E IKBKB IKBKE IRAK4 IRF6 LBP LCK LY96 LYN MALT1 MAP3K14 MAP3K3 MAP3K7 MAP3K8 MAPK1 MAPK12 MAPK15 MAPK3 MAPK6 MAPK7 MYD88 NFKB1 NFKBIA NFKBIB PDK1 PIK3CB RELA RIPK1 RIPK2 RPS6KA1 RPS6KA5 SUMO1 SUMO2 SUMO3 SUMO4 SYK TANK TBK1 TLR4 TNF TNFRSF1A TRADD TRAF3 ZAP70 (see all 55) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BTK	Bruton Tyrosine Kinase	Protein Coding	1
2	CD14	CD14 Molecule	Protein Coding	1
3	CD4	CD4 Molecule	Protein Coding	1
4	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
5	FADD	Fas Associated Via Death Domain	Protein Coding	1
6	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
7	GBP1	Guanylate Binding Protein 1	Protein Coding	1
8	GBP2	Guanylate Binding Protein 2	Protein Coding	1
9	GBP5	Guanylate Binding Protein 5	Protein Coding	1
10	GBP6	Guanylate Binding Protein Family Member 6	Protein Coding	1
11	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
12	HLA-E	Major Histocompatibility Complex, Class I, E	Protein Coding	1
13	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
14	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
15	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	1
16	IRF6	Interferon Regulatory Factor 6	Protein Coding	1
17	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
18	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
19	LY96	Lymphocyte Antigen 96	Protein Coding	1
20	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
21	MALT1	MALT1 Paracaspase	Protein Coding	1
22	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
23	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
24	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
25	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
26	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
27	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
28	MAPK15	Mitogen-Activated Protein Kinase 15	Protein Coding	1
29	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
30	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
31	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
32	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
33	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
34	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
35	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
36	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
37	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
38	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
39	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
40	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
41	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
42	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
43	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	1
44	SUMO2	Small Ubiquitin Like Modifier 2	Protein Coding	1
45	SUMO3	Small Ubiquitin Like Modifier 3	Protein Coding	1
46	SUMO4	Small Ubiquitin Like Modifier 4	Protein Coding	1
47	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
48	TANK	TRAF Family Member Associated NFKB Activator	Protein Coding	1
49	TBK1	TANK Binding Kinase 1	Protein Coding	1
50	TLR4	Toll Like Receptor 4	Protein Coding	1
51	TNF	Tumor Necrosis Factor	Protein Coding	1
52	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
53	TRADD	TNFRSF1A Associated Via Death Domain	Protein Coding	1
54	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
55	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1

Disorders associated with NF-kB (NFkB) Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	IKBKB, LCK, MALT1, ZAP70	5.04
2	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	4.79
3	Herpes simplex virus encephalitis	Enrichment	TBK1, TRAF3	3.80
4	Immune deficiency disease	Enrichment	RIPK1, SYK	3.06
5	Combined immunodeficiency	Enrichment	MALT1, ZAP70	3.06
6	Combined t cell and b cell immunodeficiency	Enrichment	MALT1, ZAP70	3.06
7	Combined t and b cell immunodeficiency	Enrichment	MALT1, ZAP70	3.06
8	Behcet syndrome	Enrichment	TLR4, TNFRSF1A	2.58
9	Diffuse large b-cell lymphoma	Enrichment	BTK, MYD88	2.58
10	Tooth agenesis	Enrichment	IRF6, SUMO1	2.45
11	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.39
12	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.39
13	Immunodeficiency 68	Enrichment	MYD88	2.39
14	Orofacial cleft 6	Enrichment	IRF6	2.39
15	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.39
16	Popliteal pterygium syndrome	Enrichment	IRF6	2.39
17	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.39
18	Immunodeficiency 15b	Enrichment	IKBKB	2.39
19	Noonan syndrome 13	Enrichment	MAPK1	2.39
20	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.39
21	Immunodeficiency 15a	Enrichment	IKBKB	2.39
22	Immunodeficiency 48	Enrichment	ZAP70	2.39
23	Orofacial cleft 10	Enrichment	SUMO1	2.39
24	Okt4 epitope deficiency	Enrichment	CD4	2.39
25	Type 1 diabetes mellitus 5	Enrichment	SUMO4	2.39
26	Immunodeficiency 132a	Enrichment	TRAF3	2.39
27	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.39
28	Immunodeficiency 132b	Enrichment	TRAF3	2.39
29	Immunodeficiency 67	Enrichment	IRAK4	2.39
30	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.39
31	Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction	Enrichment	FADD	2.39
32	Immunodeficiency 12	Enrichment	MALT1	2.39
33	Macular degeneration, age-related, 10	Enrichment	TLR4	2.39
34	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.39
35	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.39
36	Immunodeficiency 22	Enrichment	LCK	2.39
37	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.39
38	Irf6-related disorders	Enrichment	IRF6	2.39
39	Autosomal dominant popliteal pterygium syndrome	Enrichment	IRF6	2.39
40	Corticobasal syndrome	Enrichment	TBK1	2.39
41	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.39
42	Immunodeficiency 79	Enrichment	CD4	2.39
43	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.39
44	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.39
45	Colitis	Enrichment	SYK	2.39
46	Immunodeficiency 112	Enrichment	MAP3K14	2.39
47	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.39
48	Waldenstram macroglobulinemia	Enrichment	MYD88	2.39
49	Verrucous hemangioma	Enrichment	MAP3K3	2.39
50	Nik deficiency	Enrichment	MAP3K14	2.39
51	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.39
52	Scoliosis, isolated 1	Enrichment	MAPK7	2.09
53	Immunodeficiency 33	Enrichment	IRAK4	2.09
54	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.09
55	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.09
56	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.09
57	Agammaglobulinemia, x-linked	Enrichment	BTK	2.09
58	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.09
59	Immunodeficiency 127	Enrichment	TNF	2.09
60	Rela fusion-positive ependymoma	Enrichment	RELA	2.09
61	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.09
62	Congenital dyserythropoietic anemia	Enrichment	IRAK4	2.09
63	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.09
64	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.09
65	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.09
66	Arthritis	Enrichment	SYK	2.09
67	Van der woude syndrome	Enrichment	IRF6	2.09
68	Common variable immunodeficiency 12	Enrichment	NFKB1	2.09
69	Oculootodental syndrome	Enrichment	FADD	2.09
70	Van der woude syndrome 1	Enrichment	IRF6	1.92
71	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.92
72	Psoriatic arthritis	Enrichment	TNF	1.92
73	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.92
74	Agammaglobulinemia 1	Enrichment	BTK	1.92
75	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.92
76	Migraine without aura	Enrichment	TNF	1.92
77	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.79
78	Cerebral malaria	Enrichment	TNF	1.79
79	Cleft lip and alveolus	Enrichment	IRF6	1.79
80	Lymphoma, mucosa-associated lymphoid type	Enrichment	MALT1	1.70
81	Vascular dementia	Enrichment	TNF	1.70
82	Cleft upper lip	Enrichment	IRF6	1.70
83	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.62
84	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.62
85	Motor neuron disease	Enrichment	TBK1	1.55
86	Common variable immunodeficiency	Enrichment	NFKB1	1.55
87	Charge syndrome	Enrichment	TNFRSF1A	1.44
88	Progressive non-fluent aphasia	Enrichment	TBK1	1.44
89	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.40
90	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.40
91	Asthma	Enrichment	TNF	1.36
92	Specific learning disability	Enrichment	MAPK1	1.36
93	Alzheimer's disease	Enrichment	TNF	1.29
94	Nk-cell enteropathy	Enrichment	PIK3CB	1.29
95	Multiple sclerosis	Enrichment	TNFRSF1A	1.26
96	Cleft lip/palate	Enrichment	IRF6	1.26
97	Gliosarcoma	Enrichment	NFKBIA	1.20
98	Cleft palate, isolated	Enrichment	IRF6	1.18
99	Giant cell glioblastoma	Enrichment	NFKBIA	1.18
100	Heart, malformation of	Enrichment	MAPK1	1.15
101	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.07
102	Malaria	Enrichment	TNF	1.05
103	Autoinflammatory disease	Enrichment	TNFRSF1A	1.03
104	Lung cancer	Enrichment	MAP3K8	0.91
105	Systemic lupus erythematosus	Enrichment	TNF	0.83
106	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.70
107	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.68
108	Microcephaly	Enrichment	MAPK1	0.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NF-kB (NFkB) Pathway

Pathway Network for NF-kB (NFkB) Pathway

Member Pathways for NF-kB (NFkB) Pathway

Pathways in the NF-kB (NFkB) Pathway SuperPath

Associated Genes for NF-kB (NFkB) Pathway

Associated Disorders for NF-kB (NFkB) Pathway

Disorders associated with NF-kB (NFkB) Pathway SuperPath

STRING Interaction Network for NF-kB (NFkB) Pathway

Sources for NF-kB (NFkB) Pathway