NGF Pathway

Pathway network for the NGF Pathway SuperPath

Sources:

QIAGEN
WikiPathways

Pathways in the NGF Pathway SuperPath

#	Name	Source	Genes
1	NGF Pathway	QIAGEN	AKT1 ARAF ATF4 BAX BRAF CASP9 CDC42 CHUK CREB1 CREB3 CREB3L4 CREBBP CRK ELK1 FOXO3 FRS3 GAB1 GRB2 HRAS IKBKB IKBKE IKBKG KRAS MAP2K1 MAP2K2 MAP2K4 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK7 MAPK8 MAPK9 MRAS MYC NFKB1 NGF NGFR NRAS NTRK1 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCD PRKCZ RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RHOA RHOG ROCK1 ROCK2 RPS6KA1 RRAS RRAS2 SMPD1 SMPD2 SMPD3 SNTA1 SOS1 SOS2 SRF TP53 TRAF2 TRAF4 TRAF6 TRIO (see all 78) (see less)
2	TRKA Signaling	QIAGEN	AKT1 AKT2 AKT3 APAF1 ARAF ATF4 BAX BRAF CASP3 CASP9 CDC42 CREB1 CREB3 CREB3L4 CREBBP CRK CYCS ELK1 ELK3 ELK4 FRS3 GAB1 GRB2 HRAS HRK JUN KRAS MAP2K1 MAP2K2 MAP2K4 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK7 MAPK8 MAPK9 MRAS MYC NGF NRAS NTRK1 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCD PRKCZ RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RHOA RHOG ROCK1 ROCK2 RPS6KA1 RRAS RRAS2 SNTA1 SOS1 SOS2 SRF TP53 TRIO (see all 74) (see less)
3	MAPK and NFkB signaling pathways inhibited by Yersinia YopJ	WikiPathways	CHUK IKBKB IKBKG MAPK1 NFKB1 RAF1 RRAS TRAF6 (see all 8) (see less)

Gene overlap in member pathways for NGF Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
2	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	3
3	RRAS	RAS Related	Protein Coding	3
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
5	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
6	RHOA	Ras Homolog Family Member A	Protein Coding	2
7	RHOG	Ras Homolog Family Member G	Protein Coding	2
8	ATF4	Activating Transcription Factor 4	Protein Coding	2
9	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	2
10	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
11	CASP9	Caspase 9	Protein Coding	2
12	CDC42	Cell Division Cycle 42	Protein Coding	2
13	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
14	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
15	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	2
16	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	2
17	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	2
18	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
19	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
20	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
21	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
22	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
23	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
24	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
25	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
26	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
27	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
28	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
29	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	2
30	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	2
31	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
32	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
33	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
34	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
35	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
36	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
37	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
38	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	2
39	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	2
40	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
41	NGF	Nerve Growth Factor	Protein Coding	2
42	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
43	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	2
44	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
45	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	2
46	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
47	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
48	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
49	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
50	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
51	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
52	PRKCD	Protein Kinase C Delta	Protein Coding	2
53	PRKCZ	Protein Kinase C Zeta	Protein Coding	2
54	RAC1	Rac Family Small GTPase 1	Protein Coding	2
55	RAC2	Rac Family Small GTPase 2	Protein Coding	2
56	RAC3	Rac Family Small GTPase 3	Protein Coding	2
57	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
58	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	2
59	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	2
60	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	2
61	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
62	RRAS2	RAS Related 2	Protein Coding	2
63	FRS3	Fibroblast Growth Factor Receptor Substrate 3	Protein Coding	2
64	SNTA1	Syntrophin Alpha 1	Protein Coding	2
65	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
66	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	2
67	SRF	Serum Response Factor	Protein Coding	2
68	TP53	Tumor Protein P53	Protein Coding	2
69	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	2
70	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	2
71	FOXO3	Forkhead Box O3	Protein Coding	1
72	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
73	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
74	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
75	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
76	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1
77	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
78	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
79	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
80	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
81	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
82	CASP3	Caspase 3	Protein Coding	1
83	CYCS	Cytochrome C, Somatic	Protein Coding	1
84	ELK3	ETS Transcription Factor ELK3	Protein Coding	1
85	ELK4	ETS Transcription Factor ELK4	Protein Coding	1
86	HRK	Harakiri, BCL2 Interacting Protein	Protein Coding	1
87	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1

Disorders associated with NGF Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.86
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	10.60
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.08
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	9.08
6	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	8.72
7	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	7.55
8	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	7.25
9	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.81
10	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, NTRK1	6.35
11	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.21
12	Breast adenocarcinoma	Enrichment	AKT1, KRAS, TP53	5.51
13	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.27
14	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	5.27
15	Gallbladder cancer	Enrichment	BRAF, KRAS, TP53	5.27
16	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	5.27
17	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	5.27
18	Colorectal cancer	Enrichment	AKT1, BAX, BRAF, NRAS, PIK3R1, TP53	5.12
19	Myeloma, multiple	Enrichment	BRAF, CREBBP, KRAS, PIK3R2, TP53	4.89
20	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.53
21	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.53
22	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.48
23	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, TP53	4.48
24	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS, TP53	4.26
25	Tethered spinal cord syndrome	Enrichment	BRAF, CREBBP	4.06
26	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.06
27	Diffuse large b-cell lymphoma	Enrichment	BRAF, CREBBP, TP53	3.85
28	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	3.76
29	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.76
30	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.76
31	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	3.76
32	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.76
33	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.76
34	Ovarian cancer	Enrichment	AKT1, KRAS, NTRK1, RRAS2, TP53	3.65
35	Bladder cancer	Enrichment	HRAS, KRAS, TP53	3.29
36	Incontinentia pigmenti	Enrichment	IKBKG	3.23
37	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	3.23
38	Noonan syndrome 5	Enrichment	RAF1	3.23
39	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	3.23
40	Fetal encasement syndrome	Enrichment	CHUK	3.23
41	Immunodeficiency 15b	Enrichment	IKBKB	3.23
42	Noonan syndrome 13	Enrichment	MAPK1	3.23
43	Immunodeficiency 15a	Enrichment	IKBKB	3.23
44	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	3.23
45	Leopard syndrome 2	Enrichment	RAF1	3.23
46	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.23
47	Trigonitis	Enrichment	RAF1	3.23
48	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.23
49	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	3.22
50	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.22
51	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	3.22
52	Breast cancer	Enrichment	AKT1, JUN, KRAS, TP53	3.13
53	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	3.09
54	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.99
55	Primary hyperaldosteronism	Enrichment	BRAF, TP53	2.99
56	Immunodeficiency 33	Enrichment	IKBKG	2.93
57	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.93
58	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	2.93
59	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.93
60	Common variable immunodeficiency 12	Enrichment	NFKB1	2.93
61	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.89
62	Leukemia, acute myeloid	Enrichment	KRAS, NRAS, TP53	2.88
63	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, TP53	2.76
64	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.63
65	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.53
66	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.53
67	Rhabdomyosarcoma	Enrichment	HRAS, TP53	2.47
68	Common variable immunodeficiency	Enrichment	NFKB1	2.38
69	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	2.33
70	Coronary heart disease 5	Enrichment	IKBKG	2.28
71	Proteus syndrome	Enrichment	AKT1	2.26
72	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.26
73	Oculoectodermal syndrome	Enrichment	KRAS	2.26
74	Pallister-killian syndrome	Enrichment	ARAF	2.26
75	Deafness, autosomal recessive 26	Enrichment	GAB1	2.26
76	Noonan syndrome 4	Enrichment	SOS1	2.26
77	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.26
78	Melorheostosis, isolated	Enrichment	MAP2K1	2.26
79	Noonan syndrome 7	Enrichment	BRAF	2.26
80	Leopard syndrome 3	Enrichment	BRAF	2.26
81	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.26
82	Melanosis, neurocutaneous	Enrichment	NRAS	2.26
83	Noonan syndrome 9	Enrichment	SOS2	2.26
84	Noonan syndrome 6	Enrichment	NRAS	2.26
85	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.26
86	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.26
87	Noonan syndrome 11	Enrichment	MRAS	2.26
88	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.26
89	Short syndrome	Enrichment	PIK3R1	2.26
90	Bone marrow failure syndrome 5	Enrichment	TP53	2.26
91	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.26
92	Papilloma of choroid plexus	Enrichment	TP53	2.26
93	Basal cell carcinoma 7	Enrichment	TP53	2.26
94	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.26
95	Anaplastic thyroid carcinoma	Enrichment	TP53	2.26
96	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.26
97	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.26
98	Lymphangioma	Enrichment	BRAF	2.26
99	Thrombocytopenia 4	Enrichment	CYCS	2.26
100	Phace association	Enrichment	BRAF	2.26
101	Melorheostosis	Enrichment	MAP2K1	2.26
102	Long qt syndrome 12	Enrichment	SNTA1	2.26
103	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.26
104	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.26
105	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.26
106	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.26
107	Cowden syndrome 6	Enrichment	AKT1	2.26
108	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.26
109	Ductal carcinoma in situ	Enrichment	TP53	2.26
110	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.26
111	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.26
112	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.26
113	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.26
114	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.26
115	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.26
116	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.26
117	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.26
118	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.26
119	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.26
120	Capillary hemangioma	Enrichment	AKT3	2.26
121	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.26
122	Congenital pulmonary airway malformation	Enrichment	KRAS	2.26
123	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.26
124	Choroid plexus cancer	Enrichment	TP53	2.26
125	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.26
126	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.26
127	Nocarh syndrome	Enrichment	CDC42	2.26
128	Syringocystadenoma papilliferum	Enrichment	BRAF	2.26
129	Menke-hennekam syndrome	Enrichment	CREBBP	2.26
130	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.26
131	Ganglioglioma	Enrichment	BRAF	2.26
132	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.26
133	Phace syndrome	Enrichment	BRAF	2.26
134	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.26
135	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.26
136	Classic hairy cell leukemia	Enrichment	BRAF	2.26
137	Verrucous hemangioma	Enrichment	MAP3K3	2.26
138	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.26
139	Neurocutaneous melanocytosis	Enrichment	NRAS	2.26
140	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.26
141	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.24
142	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.23
143	Specific learning disability	Enrichment	MAPK1	2.19
144	Pancreatic cancer	Enrichment	KRAS, TP53	2.09
145	Heart, malformation of	Enrichment	MAPK1	1.98
146	Burkitt lymphoma	Enrichment	MYC	1.96
147	Fibromatosis, gingival, 1	Enrichment	SOS1	1.96
148	Scoliosis, isolated 1	Enrichment	MAPK7	1.96
149	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.96
150	Costello syndrome	Enrichment	HRAS	1.96
151	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	1.96
152	Thumb deformity	Enrichment	CREBBP	1.96
153	Cervical cancer	Enrichment	TP53	1.96
154	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.96
155	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.96
156	Deafness, autosomal recessive 28	Enrichment	TRIO	1.96
157	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.96
158	Lymphoma, hodgkin, classic	Enrichment	TP53	1.96
159	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	1.96
160	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.96
161	Noonan syndrome 12	Enrichment	RRAS2	1.96
162	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.96
163	Senior-loken syndrome 7	Enrichment	AKT3	1.96
164	Congenital fibrosarcoma	Enrichment	TP53	1.96
165	Li-fraumeni syndrome 1	Enrichment	TP53	1.96
166	Sarcoma	Enrichment	TP53	1.96
167	Cervix carcinoma	Enrichment	TP53	1.96
168	Immune system disease	Enrichment	CDC42	1.96
169	Hodgkin's lymphoma	Enrichment	TP53	1.96
170	Bardet-biedl syndrome 16	Enrichment	AKT3	1.96
171	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.96
172	Tafro syndrome	Enrichment	MAP2K2	1.96
173	Wooly hair nevus	Enrichment	HRAS	1.96
174	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.91
175	Lung cancer	Enrichment	BRAF, KRAS	1.88
176	Malaria	Enrichment	IKBKG	1.87
177	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.85
178	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	1.79
179	Ataxia-telangiectasia	Enrichment	BRAF	1.79
180	Nuchal bleb, familial	Enrichment	SOS1	1.79
181	Osteogenic sarcoma	Enrichment	TP53	1.79
182	Nasopharyngeal carcinoma	Enrichment	TP53	1.79
183	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.79
184	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.79
185	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.79
186	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.79
187	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.79
188	Anaplastic astrocytoma	Enrichment	TP53	1.79
189	Immunodeficiency 14	Enrichment	PIK3R1	1.79
190	Squamous cell carcinoma	Enrichment	TP53	1.79
191	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.79
192	Adenocarcinoma	Enrichment	TP53	1.79
193	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.79
194	Bone osteosarcoma	Enrichment	TP53	1.79
195	Spermatocytoma	Enrichment	HRAS	1.79
196	Melanoma of soft tissue	Enrichment	CREB1	1.79
197	Niemann-pick disease, type a	Enrichment	SMPD1	1.77
198	Niemann-pick disease, type b	Enrichment	SMPD1	1.77
199	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	1.77
200	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.71
201	Severe combined immunodeficiency	Enrichment	IKBKB	1.71
202	Left ventricular noncompaction	Enrichment	RAF1	1.69
203	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.66
204	Small cell cancer of the lung	Enrichment	TP53	1.66
205	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.66
206	Atrial fibrillation	Enrichment	SNTA1	1.66
207	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.66
208	Craniopharyngioma	Enrichment	BRAF	1.66
209	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.66
210	Pilocytic astrocytoma	Enrichment	KRAS	1.66
211	Newborn respiratory distress syndrome	Enrichment	BRAF	1.66
212	Epidermolytic nevus	Enrichment	HRAS	1.66
213	Gingival fibromatosis	Enrichment	SOS1	1.66
214	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.66
215	Gastric cancer	Enrichment	KRAS, TP53	1.64
216	Rhabdomyosarcoma 2	Enrichment	TP53	1.57
217	Lymphoma	Enrichment	TP53	1.57
218	Acute megakaryocytic leukemia	Enrichment	TP53	1.57
219	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.57
220	Hemimegalencephaly	Enrichment	AKT3	1.57
221	Niemann-pick disease, type c1	Enrichment	SMPD1	1.55
222	Niemann-pick disease	Enrichment	SMPD1	1.55
223	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.51
224	Li-fraumeni syndrome	Enrichment	TP53	1.49
225	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.49
226	Hemihyperplasia, isolated	Enrichment	RHOA	1.49
227	Wilms tumor 5	Enrichment	BRAF	1.49
228	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.49
229	Adrenocortical carcinoma	Enrichment	TP53	1.49
230	Lung squamous cell carcinoma	Enrichment	KRAS	1.49
231	Hypertrichosis	Enrichment	CREBBP	1.49
232	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, TP53	1.44
233	Esophageal cancer	Enrichment	TP53	1.43
234	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.43
235	Essential thrombocythemia	Enrichment	TP53	1.43
236	Megacolon	Enrichment	AKT3	1.43
237	Overgrowth syndrome	Enrichment	PIK3R1	1.43
238	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.43
239	Glioma susceptibility 1	Enrichment	TP53	1.37
240	Lennox-gastaut syndrome	Enrichment	MAPK10	1.37
241	Dilated cardiomyopathy	Enrichment	RAF1	1.34
242	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.32
243	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.32
244	Adult hepatocellular carcinoma	Enrichment	TP53	1.32
245	Ventricular septal defect	Enrichment	BRAF	1.32
246	Cowden syndrome	Enrichment	AKT1	1.32
247	Leukemia, chronic lymphocytic	Enrichment	TP53	1.27
248	Polymicrogyria	Enrichment	AKT3	1.27
249	Melanoma	Enrichment	BRAF	1.27
250	Familial colorectal cancer	Enrichment	TP53	1.27
251	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.27
252	Myelodysplastic syndrome	Enrichment	TP53	1.23
253	Meningioma	Enrichment	AKT1	1.20
254	Aortic valve disease 1	Enrichment	SOS1	1.16
255	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.16
256	Protein-deficiency anemia	Enrichment	NRAS	1.16
257	Microcephaly	Enrichment	MAPK1	1.15
258	Heart disease	Enrichment	CREBBP	1.13
259	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.13
260	Wilms tumor 1	Enrichment	BRAF	1.10
261	Corpus callosum, agenesis of	Enrichment	CREBBP	1.10
262	Lynch syndrome	Enrichment	KRAS	1.10
263	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.10
264	Rare genetic intellectual disability	Enrichment	CREBBP	1.10
265	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.10
266	Gliosarcoma	Enrichment	TP53	1.08
267	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.05
268	Dandy-walker syndrome	Enrichment	BRAF	1.05
269	Syndromic intellectual disability	Enrichment	TRIO	1.05
270	Giant cell glioblastoma	Enrichment	TP53	1.05
271	Hepatoblastoma	Enrichment	TP53	0.96
272	Hepatocellular carcinoma	Enrichment	TP53	0.95
273	Diamond-blackfan anemia 1	Enrichment	TP53	0.93
274	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.93
275	Scoliosis	Enrichment	CREBBP	0.91
276	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.88
277	Prostate cancer	Enrichment	TP53	0.83
278	Long qt syndrome 1	Enrichment	SNTA1	0.82
279	Long qt syndrome	Enrichment	SNTA1	0.81
280	Peripheral nervous system disease	Enrichment	NGF	0.79
281	Neuropathy	Enrichment	NGF	0.79
282	Diamond-blackfan anemia	Enrichment	TP53	0.75
283	Type 2 diabetes mellitus	Enrichment	AKT2	0.69
284	Thrombocytopenia	Enrichment	CYCS	0.64
285	Primary ovarian insufficiency	Enrichment	NTRK1	0.56
286	Autism	Enrichment	CREBBP	0.49
287	Congenital nervous system abnormality	Enrichment	CREBBP	0.36
288	Nervous system disease	Enrichment	CREBBP	0.36
289	Autism spectrum disorder	Enrichment	MAP2K1	0.35
290	Complex neurodevelopmental disorder	Enrichment	RAC3	0.31
291	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.29

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NGF Pathway

Pathway Network for NGF Pathway

Pathway network for the NGF Pathway SuperPath

Member Pathways for NGF Pathway

Pathways in the NGF Pathway SuperPath

Gene overlap in member pathways for NGF Pathway SuperPath

Associated Genes for NGF Pathway

Associated Disorders for NGF Pathway

Disorders associated with NGF Pathway SuperPath

STRING Interaction Network for NGF Pathway

Sources for NGF Pathway