NgR-p75(NTR)-Mediated Signaling

No Pathway Network information available for NgR-p75(NTR)-Mediated Signaling

Pathways in the NgR-p75(NTR)-Mediated Signaling SuperPath

#	Name	Source	Genes
1	NgR-p75(NTR)-Mediated Signaling	QIAGEN	ARG1 ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF2 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 GDAP1 GNAI1 GNAI2 GNAI3 GPR119 MAG MCF2L MYL9 MYLK NET1 NGFR P2RY13 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B RAC1 RASA1 RHOA ROCK1 ROCK2 RTN4 RTN4R (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARG1	Arginase 1	Protein Coding	1
2	RHOA	Ras Homolog Family Member A	Protein Coding	1
3	ARHGEF1	Rho Guanine Nucleotide Exchange Factor 1	Protein Coding	1
4	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	1
5	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	1
6	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
7	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	1
8	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	1
9	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
10	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
11	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	1
12	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	1
13	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	1
14	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
15	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
16	GDAP1	Ganglioside Induced Differentiation Associated Protein 1	Protein Coding	1
17	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
18	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
19	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
20	GPR119	G Protein-Coupled Receptor 119	Protein Coding	1
21	P2RY13	Purinergic Receptor P2Y13	Protein Coding	1
22	MAG	Myelin Associated Glycoprotein	Protein Coding	1
23	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
24	MYL9	Myosin Light Chain 9	Protein Coding	1
25	MYLK	Myosin Light Chain Kinase	Protein Coding	1
26	NET1	Neuroepithelial Cell Transforming 1	Protein Coding	1
27	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
28	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
29	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
30	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
31	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
32	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	1
33	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
34	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
35	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
36	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
37	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
38	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
39	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
40	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
41	RAC1	Rac Family Small GTPase 1	Protein Coding	1
42	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
43	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
44	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
45	RTN4	Reticulon 4	Protein Coding	1
46	RTN4R	Reticulon 4 Receptor	Protein Coding	1

Disorders associated with NgR-p75(NTR)-Mediated Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.40
2	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.47
3	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.47
4	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.47
5	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	2.47
6	Carney complex, type 1	Enrichment	PRKAR1A	2.47
7	Ventricular tachycardia, familial	Enrichment	GNAI2	2.47
8	Immunodeficiency 62	Enrichment	ARHGEF1	2.47
9	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.47
10	Knobloch syndrome 2	Enrichment	PAK2	2.47
11	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.47
12	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	2.47
13	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.47
14	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.47
15	Myxoma, intracardiac	Enrichment	PRKAR1A	2.47
16	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	2.47
17	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.47
18	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	2.47
19	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.47
20	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.47
21	Spastic paraplegia 75, autosomal recessive	Enrichment	MAG	2.47
22	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.47
23	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.47
24	Gorham's disease	Enrichment	RASA1	2.47
25	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.47
26	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.17
27	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.17
28	Argininemia	Enrichment	ARG1	2.17
29	Charcot-marie-tooth disease, demyelinating, type 4a	Enrichment	GDAP1	2.17
30	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.17
31	Charcot-marie-tooth disease, axonal, with vocal cord paresis, autosomal recessive	Enrichment	GDAP1	2.17
32	Charcot-marie-tooth disease, recessive intermediate a	Enrichment	GDAP1	2.17
33	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.17
34	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.17
35	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.17
36	Usher syndrome, type iv	Enrichment	PRKAR1A	2.17
37	Acrodysostosis	Enrichment	PRKAR1A	2.17
38	Charcot-marie-tooth disease, axonal, type 2h	Enrichment	GDAP1	2.17
39	Fibrolamellar carcinoma	Enrichment	PRKACA	2.17
40	Axonal neuropathy	Enrichment	GDAP1	2.17
41	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.17
42	Hypopituitarism	Enrichment	GNAI2	2.17
43	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	2.17
44	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.17
45	Charcot-marie-tooth disease type 4a	Enrichment	GDAP1	2.17
46	Charcot-marie-tooth disease	Enrichment	ARHGEF10, GDAP1	2.07
47	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	1.99
48	Charcot-marie-tooth disease, axonal, type 2k	Enrichment	GDAP1	1.99
49	Wieacker-wolff syndrome	Enrichment	RASA1	1.99
50	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	1.87
51	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.87
52	Carney complex variant	Enrichment	PRKAR1A	1.87
53	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.87
54	Achromatopsia 4	Enrichment	GNAI3	1.87
55	Knobloch syndrome	Enrichment	PAK2	1.87
56	Capillary malformations, congenital	Enrichment	RASA1	1.77
57	Visceral myopathy 1	Enrichment	MYLK	1.77
58	Knobloch syndrome 1	Enrichment	PAK2	1.77
59	Mosaic variegated aneuploidy syndrome 1	Enrichment	PAK6	1.77
60	Polyneuropathy	Enrichment	GDAP1	1.77
61	Sensory peripheral neuropathy	Enrichment	GDAP1	1.77
62	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.70
63	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.70
64	Hemihyperplasia, isolated	Enrichment	RHOA	1.70
65	Hemangioma, capillary infantile	Enrichment	RASA1	1.70
66	Basal cell carcinoma 1	Enrichment	RASA1	1.70
67	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.70
68	Capillary malformation-arteriovenous malformation 1	Enrichment	RASA1	1.63
69	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.63
70	Mosaic variegated aneuploidy syndrome	Enrichment	PAK6	1.57
71	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.52
72	Arteriovenous malformation	Enrichment	RASA1	1.52
73	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.52
74	Myopathy, x-linked, with excessive autophagy	Enrichment	RASA1	1.48
75	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.36
76	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.33
77	Creatine phosphokinase, elevated serum	Enrichment	GDAP1	1.28
78	Isolated elevated serum creatine phosphokinase levels	Enrichment	GDAP1	1.28
79	Peripheral nervous system disease	Enrichment	GDAP1	0.99
80	Neuropathy	Enrichment	GDAP1	0.99
81	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.94
82	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.94
83	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MYLK	0.86
84	Schizophrenia	Enrichment	RTN4R	0.74
85	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.64
86	Microcephaly	Enrichment	PAK3	0.47
87	Complex neurodevelopmental disorder	Enrichment	PAK3	0.46
88	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NgR-p75(NTR)-Mediated Signaling

Pathway Network for NgR-p75(NTR)-Mediated Signaling

Member Pathways for NgR-p75(NTR)-Mediated Signaling

Pathways in the NgR-p75(NTR)-Mediated Signaling SuperPath

Associated Genes for NgR-p75(NTR)-Mediated Signaling

Associated Disorders for NgR-p75(NTR)-Mediated Signaling

Disorders associated with NgR-p75(NTR)-Mediated Signaling SuperPath

STRING Interaction Network for NgR-p75(NTR)-Mediated Signaling

Sources for NgR-p75(NTR)-Mediated Signaling