Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

No Pathway Network information available for Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Pathways in the Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics	PharmGKB	ADCY2 CDK5 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 DDC DRD2 DRD3 DRD4 GNAI1 GNB1 GNG2 KCNK3 KCNK9 PPP1CA PPP1R1B PRKACA SEC22A SEC22B SLC18A2 SNAP25 STX10 STX11 STX12 STX16 STX17 STX18 STX19 STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 TH VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAMP8 YKT6 (see all 47) (see less)
2	Nicotine effect on dopaminergic neurons	WikiPathways	ADCY2 CDK5 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 DDC DRD2 DRD3 DRD4 GNAI1 GNB1 GNG2 KCNK3 KCNK9 PPP1CA PPP1R1B PRKACA SLC18A2 TH (see all 21) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TH	Tyrosine Hydroxylase	Protein Coding	2
2	DRD2	Dopamine Receptor D2	Protein Coding	2
3	DRD3	Dopamine Receptor D3	Protein Coding	2
4	DRD4	Dopamine Receptor D4	Protein Coding	2
5	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	2
6	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
7	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
8	KCNK3	Potassium Two Pore Domain Channel Subfamily K Member 3	Protein Coding	2
9	KCNK9	Potassium Two Pore Domain Channel Subfamily K Member 9	Protein Coding	2
10	CHRNA6	Cholinergic Receptor Nicotinic Alpha 6 Subunit	Protein Coding	2
11	DDC	Dopa Decarboxylase	Protein Coding	2
12	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
13	GNB1	G Protein Subunit Beta 1	Protein Coding	2
14	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	2
15	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
16	CHRNA3	Cholinergic Receptor Nicotinic Alpha 3 Subunit	Protein Coding	2
17	CHRNA4	Cholinergic Receptor Nicotinic Alpha 4 Subunit	Protein Coding	2
18	CHRNA5	Cholinergic Receptor Nicotinic Alpha 5 Subunit	Protein Coding	2
19	CHRNB2	Cholinergic Receptor Nicotinic Beta 2 Subunit	Protein Coding	2
20	ADCY2	Adenylate Cyclase 2	Protein Coding	2
21	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	2
22	STX1A	Syntaxin 1A	Protein Coding	1
23	STX3	Syntaxin 3	Protein Coding	1
24	STX4	Syntaxin 4	Protein Coding	1
25	STX5	Syntaxin 5	Protein Coding	1
26	VAMP1	Vesicle Associated Membrane Protein 1	Protein Coding	1
27	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	1
28	SNAP25	Synaptosome Associated Protein 25	Protein Coding	1
29	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	1
30	STX6	Syntaxin 6	Protein Coding	1
31	VAMP8	Vesicle Associated Membrane Protein 8	Protein Coding	1
32	VAMP4	Vesicle Associated Membrane Protein 4	Protein Coding	1
33	STX16	Syntaxin 16	Protein Coding	1
34	STX11	Syntaxin 11	Protein Coding	1
35	STX10	Syntaxin 10	Protein Coding	1
36	STX7	Syntaxin 7	Protein Coding	1
37	STX2	Syntaxin 2	Protein Coding	1
38	STX12	Syntaxin 12	Protein Coding	1
39	STX18	Syntaxin 18	Protein Coding	1
40	VAMP5	Vesicle Associated Membrane Protein 5	Protein Coding	1
41	STX8	Syntaxin 8	Protein Coding	1
42	SEC22B	SEC22 Homolog B, Vesicle Trafficking Protein	Protein Coding	1
43	STX1B	Syntaxin 1B	Protein Coding	1
44	SEC22A	SEC22 Homolog A, Vesicle Trafficking Protein	Protein Coding	1
45	STX19	Syntaxin 19	Protein Coding	1
46	STX17	Syntaxin 17	Protein Coding	1
47	YKT6	YKT6 Vesicular SNARE Protein	Protein Coding	1

Disorders associated with Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Smoking as a quantitative trait locus 3	Enrichment	CHRNA3, CHRNA5	5.64
2	Epilepsy, nocturnal frontal lobe, 1	Enrichment	CHRNA4, CHRNB2	5.16
3	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	CHRNA4, CHRNB2	4.86
4	Autosomal dominant sleep-related hypermotor epilepsy	Enrichment	CHRNA4, CHRNB2	4.32
5	Presynaptic congenital myasthenic syndromes	Enrichment	SNAP25, VAMP1	3.20
6	Dystonia	Enrichment	GNB1, TH	2.88
7	Bladder dysfunction, autonomic, with impaired pupillary reflex and secondary cakut	Enrichment	CHRNA3	2.81
8	Tremor, hereditary essential, 1	Enrichment	DRD3	2.81
9	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.81
10	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.81
11	Epilepsy, nocturnal frontal lobe, 3	Enrichment	CHRNB2	2.81
12	Pulmonary hypertension, primary, 4	Enrichment	KCNK3	2.81
13	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.81
14	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.81
15	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.81
16	Autonomic nervous system disease	Enrichment	DRD4	2.81
17	Segawa syndrome, autosomal recessive	Enrichment	TH	2.51
18	Birk-barel syndrome	Enrichment	KCNK9	2.51
19	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.51
20	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.51
21	Fibrolamellar carcinoma	Enrichment	PRKACA	2.51
22	Cerebral visual impairment	Enrichment	GNB1	2.51
23	Diarrhea 12, with microvillus atrophy	Enrichment	STX3	2.46
24	Developmental and epileptic encephalopathy 117	Enrichment	SNAP25	2.46
25	Hemophagocytic lymphohistiocytosis, familial, 4	Enrichment	STX11	2.46
26	Congenital disorder of glycosylation, type iiaa	Enrichment	STX5	2.46
27	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.46
28	Deafness, autosomal recessive 123	Enrichment	STX4	2.46
29	Epilepsy with generalized tonic-clonic seizures	Enrichment	SNAP25	2.46
30	Retinal dystrophy and microvillus inclusion disease	Enrichment	STX3	2.46
31	Generalized epilepsy with febrile seizures plus, type 9	Enrichment	STX1B	2.46
32	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHRNA3, CHRNA4	2.45
33	Dystonia, dopa-responsive	Enrichment	TH	2.33
34	Tobacco addiction	Enrichment	CHRNA4	2.21
35	Spastic ataxia 1, autosomal dominant	Enrichment	VAMP1	2.16
36	Spastic ataxia 1	Enrichment	VAMP1	2.16
37	Myasthenic syndrome, congenital, 25, presynaptic	Enrichment	VAMP1	2.16
38	Dystonia 11, myoclonic	Enrichment	DRD2	2.03
39	Microvillus inclusion disease	Enrichment	STX3	1.98
40	Hypothyroidism	Enrichment	GNB1	1.91
41	Essential tremor	Enrichment	DRD3	1.91
42	Pseudohypoparathyroidism, type ib	Enrichment	STX16	1.86
43	Developmental and epileptic encephalopathy 2	Enrichment	SNAP25	1.86
44	Generalized epilepsy	Enrichment	STX1B	1.86
45	Ellis-van creveld syndrome	Enrichment	PRKACA	1.86
46	Frontotemporal dementia 1	Enrichment	CHRNA4	1.77
47	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.77
48	Myelodysplastic syndrome	Enrichment	GNB1	1.77
49	Heritable pulmonary arterial hypertension	Enrichment	KCNK3	1.77
50	Hemophagocytic lymphohistiocytosis, familial, 1	Enrichment	STX11	1.76
51	Pulmonary hypertension, primary, 1	Enrichment	KCNK3	1.70
52	Focal epilepsy	Enrichment	SNAP25	1.62
53	Cleft palate, isolated	Enrichment	GNB1	1.58
54	Attention deficit-hyperactivity disorder	Enrichment	DRD4	1.47
55	Rasopathy	Enrichment	DDC	1.40
56	Strabismus	Enrichment	GNB1	1.39
57	Stereotypic movement disorder	Enrichment	SNAP25	1.36
58	Generalized epilepsy with febrile seizures plus	Enrichment	STX1B	1.32
59	Congenital myasthenic syndrome	Enrichment	VAMP1	1.32
60	Cerebral palsy	Enrichment	GNB1	1.23
61	Williams-beuren syndrome	Enrichment	STX1A	1.17
62	Microcephaly	Enrichment	GNB1, SNAP25	1.17
63	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.13
64	Schizophrenia	Enrichment	DRD3	1.06
65	Cystic fibrosis	Enrichment	STX1A	0.98
66	Developmental and epileptic encephalopathy	Enrichment	SNAP25	0.93
67	Optic atrophy plus syndrome	Enrichment	SNAP25	0.85
68	Sensorineural hearing loss	Enrichment	STX4	0.81
69	Autism spectrum disorder	Enrichment	GNB1	0.81
70	Autism	Enrichment	STX1A	0.65

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Pathway Network for Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Member Pathways for Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Pathways in the Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics SuperPath

Associated Genes for Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Associated Disorders for Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

Disorders associated with Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics SuperPath

STRING Interaction Network for Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics

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