Nicotine Pathway, Pharmacokinetics
Pathway network for the Nicotine Pathway, Pharmacokinetics SuperPath
Sources:
- PharmGKB
- WikiPathways
- PubChem
Pathways in the Nicotine Pathway, Pharmacokinetics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Nicotine Pathway, Pharmacokinetics | PharmGKB | |
| 2 | Nicotine metabolism in liver cells | WikiPathways | |
| 3 | nicotine degradation IV | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | UGT1A4 | UDP Glucuronosyltransferase Family 1 Member A4 | Protein Coding | 3 |
| 2 | AOX1 | Aldehyde Oxidase 1 | Protein Coding | 3 |
| 3 | FMO3 | Flavin Containing Dimethylaniline Monoxygenase 3 | Protein Coding | 3 |
| 4 | CYP2A6 | Cytochrome P450 Family 2 Subfamily A Member 6 | Protein Coding | 3 |
| 5 | UGT1A9 | UDP Glucuronosyltransferase Family 1 Member A9 | Protein Coding | 2 |
| 6 | CYP2B6 | Cytochrome P450 Family 2 Subfamily B Member 6 | Protein Coding | 2 |
| 7 | UGT2B4 | UDP Glucuronosyltransferase Family 2 Member B4 | Protein Coding | 1 |
| 8 | UGT2B7 | UDP Glucuronosyltransferase Family 2 Member B7 | Protein Coding | 1 |
| 9 | UGT2B10 | UDP Glucuronosyltransferase Family 2 Member B10 | Protein Coding | 1 |
| 10 | UGT2B15 | UDP Glucuronosyltransferase Family 2 Member B15 | Protein Coding | 1 |
| 11 | UGT1A1 | UDP Glucuronosyltransferase Family 1 Member A1 | Protein Coding | 1 |
| 12 | CYP2A13 | Cytochrome P450 Family 2 Subfamily A Member 13 | Protein Coding | 1 |
Disorders associated with Nicotine Pathway, Pharmacokinetics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Crigler-najjar syndrome, type i | Enrichment | UGT1A1, UGT1A4, UGT1A9 | 7.20 |
| 2 | Hyperbilirubinemia, transient familial neonatal | Enrichment | UGT1A1, UGT1A4, UGT1A9 | 7.20 |
| 3 | Bilirubin, serum level of, quantitative trait locus 1 | Enrichment | UGT1A1, UGT1A4, UGT1A9 | 7.20 |
| 4 | Crigler-najjar syndrome, type ii | Enrichment | UGT1A1, UGT1A4, UGT1A9 | 7.20 |
| 5 | Gilbert syndrome | Enrichment | UGT1A1, UGT1A4, UGT1A9 | 7.06 |
| 6 | Bilirubin metabolic disorder | Enrichment | UGT1A1, UGT1A4, UGT1A9 | 7.06 |
| 7 | Severe primary trimethylaminuria | Enrichment | FMO3 | 3.53 |
| 8 | Letrozole toxicity | Enrichment | CYP2A6 | 3.53 |
| 9 | Efavirenz, poor metabolism of | Enrichment | CYP2B6 | 3.35 |
| 10 | Trimethylaminuria | Enrichment | FMO3 | 3.23 |
| 11 | Primary trimethylaminuria | Enrichment | FMO3 | 3.23 |
| 12 | Coumarin resistance | Enrichment | CYP2A6 | 3.05 |
| 13 | Tobacco addiction | Enrichment | CYP2A6 | 2.93 |
| 14 | Lung cancer | Enrichment | CYP2A6 | 2.03 |
