Nitric oxide stimulates guanylate cyclase

No Pathway Network information available for Nitric oxide stimulates guanylate cyclase

Pathways in the Nitric oxide stimulates guanylate cyclase SuperPath

#	Name	Source	Genes
1	Nitric oxide stimulates guanylate cyclase	Reactome	GUCY1A1 GUCY1A2 GUCY1B1 IRAG1 ITPR1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 NOS1 NOS2 NOS3 PDE10A PDE11A PDE1A PDE1B PDE2A PDE5A PDE9A PRKG1 PRKG2 (see all 22) (see less)
2	cGMP effects	Reactome	IRAG1 ITPR1 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 PDE10A PDE11A PDE1A PDE1B PDE2A PDE5A PDE9A PRKG1 PRKG2 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KCNMB2	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2	Protein Coding	2
2	IRAG1	Inositol 1,4,5-Triphosphate Receptor Associated 1	Protein Coding	2
3	PDE10A	Phosphodiesterase 10A	Protein Coding	2
4	KCNMB3	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3	Protein Coding	2
5	KCNMB4	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4	Protein Coding	2
6	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
7	KCNMA1	Potassium Calcium-Activated Channel Subfamily M Alpha 1	Protein Coding	2
8	KCNMB1	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1	Protein Coding	2
9	PDE11A	Phosphodiesterase 11A	Protein Coding	2
10	PDE1A	Phosphodiesterase 1A	Protein Coding	2
11	PDE2A	Phosphodiesterase 2A	Protein Coding	2
12	PDE9A	Phosphodiesterase 9A	Protein Coding	2
13	PDE1B	Phosphodiesterase 1B	Protein Coding	2
14	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	2
15	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	2
16	PDE5A	Phosphodiesterase 5A	Protein Coding	2
17	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
18	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
19	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
20	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
21	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
22	NOS3	Nitric Oxide Synthase 3	Protein Coding	1

Disorders associated with Nitric oxide stimulates guanylate cyclase SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Dyskinesia, limb and orofacial, infantile-onset	Enrichment	PDE10A	2.93
2	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.93
3	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	2.93
4	Intellectual developmental disorder with paroxysmal dyskinesia or seizures	Enrichment	PDE2A	2.93
5	Striatal degeneration, autosomal dominant 2	Enrichment	PDE10A	2.93
6	Epilepsy, idiopathic generalized 16	Enrichment	KCNMA1	2.93
7	Cerebellar atrophy, developmental delay, and seizures	Enrichment	KCNMA1	2.93
8	Childhood-onset benign chorea with striatal involvement	Enrichment	PDE10A	2.93
9	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.79
10	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.79
11	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.79
12	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.63
13	Hypertension, diastolic	Enrichment	KCNMB1	2.63
14	Pigmented nodular adrenocortical disease, primary, 2	Enrichment	PDE11A	2.63
15	Acromesomelic dysplasia 4	Enrichment	PRKG2	2.63
16	Liang-wang syndrome	Enrichment	KCNMA1	2.63
17	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PDE11A	2.63
18	Isolated micronodular adrenocortical disease	Enrichment	PDE11A	2.63
19	Gillespie syndrome	Enrichment	ITPR1	2.45
20	Paroxysmal nonkinesigenic dyskinesia 3 with or without generalized epilepsy	Enrichment	KCNMA1	2.45
21	Carney complex variant	Enrichment	PDE11A	2.33
22	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.33
23	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PDE2A	2.23
24	Idiopathic achalasia	Enrichment	NOS1	2.19
25	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	2.15
26	Alzheimer disease 2	Enrichment	NOS3	2.09
27	Pre-eclampsia	Enrichment	NOS3	2.09
28	Paroxysmal dystonia	Enrichment	PDE2A	2.08
29	Choreatic disease	Enrichment	PDE2A	2.03
30	Moyamoya disease 1	Enrichment	GUCY1A1	2.01
31	Stroke, ischemic	Enrichment	NOS3	1.79
32	Multiple sclerosis	Enrichment	ITPR1	1.79
33	Anterior segment dysgenesis	Enrichment	ITPR1	1.76
34	Alzheimer disease, familial, 1	Enrichment	NOS3	1.56
35	Hypertension, essential	Enrichment	NOS3	1.56
36	Myocardial infarction	Enrichment	GUCY1A1	1.45
37	Malaria	Enrichment	NOS2	1.44
38	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	1.30
39	Spastic ataxia	Enrichment	ITPR1	1.22
40	Schizophrenia	Enrichment	PDE11A	1.17
41	Primary ovarian insufficiency	Enrichment	NOS3	1.04
42	Autism spectrum disorder	Enrichment	KCNMA1	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nitric oxide stimulates guanylate cyclase

Pathway Network for Nitric oxide stimulates guanylate cyclase

Member Pathways for Nitric oxide stimulates guanylate cyclase

Pathways in the Nitric oxide stimulates guanylate cyclase SuperPath

Associated Genes for Nitric oxide stimulates guanylate cyclase

Associated Disorders for Nitric oxide stimulates guanylate cyclase

Disorders associated with Nitric oxide stimulates guanylate cyclase SuperPath

STRING Interaction Network for Nitric oxide stimulates guanylate cyclase

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