NO-dependent CFTR activation (normal and CF)

No Pathway Network information available for NO-dependent CFTR activation (normal and CF)

Pathways in the NO-dependent CFTR activation (normal and CF) SuperPath

#	Name	Source	Genes
1	NO-dependent CFTR activation (normal and CF)	GeneGo (Thomson Reuters)	ARG1 CFTR GUCY1A2 GUCY1B1 NOS1 NOS2 NOS3 PDE5A PRKG2 SCNN1A SCNN1B SCNN1D SCNN1G (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARG1	Arginase 1	Protein Coding	1
2	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
3	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
4	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
5	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
6	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
7	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
8	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	1
9	SCNN1A	Sodium Channel Epithelial 1 Subunit Alpha	Protein Coding	1
10	SCNN1B	Sodium Channel Epithelial 1 Subunit Beta	Protein Coding	1
11	SCNN1D	Sodium Channel Epithelial 1 Subunit Delta	Protein Coding	1
12	SCNN1G	Sodium Channel Epithelial 1 Subunit Gamma	Protein Coding	1
13	PDE5A	Phosphodiesterase 5A	Protein Coding	1

Disorders associated with NO-dependent CFTR activation (normal and CF) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Idiopathic bronchiectasis	Enrichment	CFTR, SCNN1A, SCNN1B, SCNN1G	10.37
2	Liddle syndrome 1	Enrichment	SCNN1A, SCNN1B, SCNN1G	9.16
3	Pseudohypoaldosteronism, type ib1, autosomal recessive	Enrichment	SCNN1A, SCNN1B, SCNN1G	9.16
4	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR, SCNN1B	4.52
5	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	3.02
6	Bronchiectasis with or without elevated sweat chloride 2	Enrichment	SCNN1A	3.02
7	Bronchiectasis with or without elevated sweat chloride 3	Enrichment	SCNN1G	3.02
8	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	3.02
9	Pseudohypoaldosteronism, type ib2, autosomal recessive	Enrichment	SCNN1B	3.02
10	Liddle syndrome 2	Enrichment	SCNN1G	3.02
11	Liddle syndrome 3	Enrichment	SCNN1A	3.02
12	Pseudohypoaldosteronism, type ib3, autosomal recessive	Enrichment	SCNN1G	3.02
13	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	3.02
14	Argininemia	Enrichment	ARG1	2.72
15	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.72
16	Polymyoclonus, infantile	Enrichment	SCNN1B	2.72
17	Acromesomelic dysplasia 4	Enrichment	PRKG2	2.72
18	Pseudohypoaldosteronism	Enrichment	SCNN1A	2.72
19	Nuchal bleb, familial	Enrichment	CFTR	2.54
20	Idiopathic achalasia	Enrichment	NOS1	2.42
21	Alzheimer disease 2	Enrichment	NOS3	2.32
22	Pre-eclampsia	Enrichment	NOS3	2.32
23	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	2.07
24	Stroke, ischemic	Enrichment	NOS3	2.02
25	Hereditary chronic pancreatitis	Enrichment	CFTR	1.87
26	Lynch syndrome	Enrichment	CFTR	1.85
27	Alzheimer disease, familial, 1	Enrichment	NOS3	1.79
28	Hypertension, essential	Enrichment	NOS3	1.79
29	Pancreatitis, hereditary	Enrichment	CFTR	1.79
30	Malaria	Enrichment	NOS2	1.66
31	Brugada syndrome	Enrichment	SCNN1A	1.61
32	Cystic fibrosis	Enrichment	CFTR	1.52
33	Male infertility	Enrichment	CFTR	1.49
34	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	1.28
35	Primary ovarian insufficiency	Enrichment	NOS3	1.26

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NO-dependent CFTR activation (normal and CF)

Pathway Network for NO-dependent CFTR activation (normal and CF)

Member Pathways for NO-dependent CFTR activation (normal and CF)

Pathways in the NO-dependent CFTR activation (normal and CF) SuperPath

Associated Genes for NO-dependent CFTR activation (normal and CF)

Associated Disorders for NO-dependent CFTR activation (normal and CF)

Disorders associated with NO-dependent CFTR activation (normal and CF) SuperPath

STRING Interaction Network for NO-dependent CFTR activation (normal and CF)

Sources for NO-dependent CFTR activation (normal and CF)