NO/cGMP/PKG mediated neuroprotection

No Pathway Network information available for NO/cGMP/PKG mediated neuroprotection

Pathways in the NO/cGMP/PKG mediated neuroprotection SuperPath

#	Name	Source	Genes
1	NO/cGMP/PKG mediated neuroprotection	WikiPathways	ACTN2 AKAP9 BAD BCL2 CALM1 CAMK2A CAMK2B CAMK2D CAMK2G CASP9 CNGA1 CNGA2 CNGA3 CNGA4 CNGB1 CNGB3 CREB1 CYCS DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GUCY1A1 GUCY1A2 GUCY1B1 GUCY1B2 NEFL NFKB1 NFKBIA NOS1 NOS2 NOS3 NPPA NPPB NPR1 PDE2A PDE3A PPID PRKG2 RELA TSPO XIAP (see all 44) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTN2	Actinin Alpha 2	Protein Coding	1
2	CASP9	Caspase 9	Protein Coding	1
3	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
4	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
5	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
6	CALM1	Calmodulin 1	Protein Coding	1
7	TSPO	Translocator Protein	Protein Coding	1
8	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
9	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
10	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
11	CNGB3	Cyclic Nucleotide Gated Channel Subunit Beta 3	Protein Coding	1
12	CYCS	Cytochrome C, Somatic	Protein Coding	1
13	PDE3A	Phosphodiesterase 3A	Protein Coding	1
14	PDE2A	Phosphodiesterase 2A	Protein Coding	1
15	NPR1	Natriuretic Peptide Receptor 1	Protein Coding	1
16	NPPB	Natriuretic Peptide B	Protein Coding	1
17	NPPA	Natriuretic Peptide A	Protein Coding	1
18	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
19	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
20	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
21	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
22	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
23	NEFL	Neurofilament Light Chain	Protein Coding	1
24	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
25	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
26	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
27	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
28	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
29	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
30	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
31	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	1
32	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
33	CNGA3	Cyclic Nucleotide Gated Channel Subunit Alpha 3	Protein Coding	1
34	CNGA1	Cyclic Nucleotide Gated Channel Subunit Alpha 1	Protein Coding	1
35	CNGB1	Cyclic Nucleotide Gated Channel Subunit Beta 1	Protein Coding	1
36	AKAP9	A-Kinase Anchoring Protein 9	Protein Coding	1
37	CNGA4	Cyclic Nucleotide Gated Channel Subunit Alpha 4	Protein Coding	1
38	CNGA2	Cyclic Nucleotide Gated Channel Subunit Alpha 2	Protein Coding	1
39	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
40	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	1
41	PPID	Peptidylprolyl Isomerase D	Protein Coding	1
42	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
43	GUCY1B2	Guanylate Cyclase 1 Soluble Subunit Beta 2 (Pseudogene)	Pseudogene	1
44	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	1

Disorders associated with NO/cGMP/PKG mediated neuroprotection SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Achromatopsia 3	Enrichment	CNGA3, CNGB3	4.99
2	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GRIN1, GRIN2B	4.70
3	Achromatopsia	Enrichment	CNGA3, CNGB3	3.34
4	Cone-rod dystrophy 2	Enrichment	CNGA1, CNGA3, CNGB3	2.86
5	Hypertension and brachydactyly syndrome	Enrichment	PDE3A	2.49
6	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.49
7	Achromatopsia 2	Enrichment	CNGA3	2.49
8	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.49
9	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.49
10	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.49
11	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.49
12	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.49
13	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	2.49
14	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.49
15	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.49
16	Congenital myopathy 8	Enrichment	ACTN2	2.49
17	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.49
18	Intellectual developmental disorder with paroxysmal dyskinesia or seizures	Enrichment	PDE2A	2.49
19	Long qt syndrome 11	Enrichment	AKAP9	2.49
20	Thrombocytopenia 4	Enrichment	CYCS	2.49
21	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.49
22	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.49
23	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.49
24	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.49
25	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.49
26	Retinitis pigmentosa 45	Enrichment	CNGB1	2.49
27	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.49
28	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.49
29	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.49
30	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.49
31	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.49
32	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.49
33	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.49
34	Landau-kleffner syndrome	Enrichment	GRIN2A	2.49
35	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.49
36	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.49
37	Grin2a-related disorders	Enrichment	GRIN2A	2.49
38	Long qt syndrome 1	Enrichment	AKAP9, CALM1	2.37
39	Long qt syndrome	Enrichment	AKAP9, CALM1	2.35
40	Eye disease	Enrichment	CNGA3, CNGB3	2.24
41	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.19
42	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.19
43	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.19
44	Atrial fibrillation, familial, 6	Enrichment	NPPA	2.19
45	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.19
46	Long qt syndrome 14	Enrichment	CALM1	2.19
47	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.19
48	Retinitis pigmentosa 49	Enrichment	CNGA1	2.19
49	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.19
50	Rela fusion-positive ependymoma	Enrichment	RELA	2.19
51	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.19
52	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.19
53	Acromesomelic dysplasia 4	Enrichment	PRKG2	2.19
54	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.19
55	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.19
56	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.19
57	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.19
58	Isolated atrial standstill	Enrichment	NPPA	2.19
59	Common variable immunodeficiency 12	Enrichment	NFKB1	2.19
60	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.19
61	Epilepsy	Enrichment	GRIN2A, GRIN2B	2.13
62	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	2.11
63	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	2.07
64	Optic atrophy plus syndrome	Enrichment	CNGA3, CNGB3	2.05
65	West syndrome	Enrichment	GRIN1, GRIN2B	2.05
66	Anosmia, isolated congenital	Enrichment	CNGA2	2.01
67	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.01
68	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.01
69	Atrial standstill 2	Enrichment	NPPA	2.01
70	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	2.01
71	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.01
72	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.01
73	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.01
74	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.01
75	Dlg4-related synaptopathy	Enrichment	DLG4	2.01
76	Melanoma of soft tissue	Enrichment	CREB1	2.01
77	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	1.89
78	Astigmatism	Enrichment	GRIN2B	1.89
79	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.89
80	Color blindness	Enrichment	CNGA3	1.89
81	Idiopathic achalasia	Enrichment	NOS1	1.89
82	Hereditary retinal dystrophy	Enrichment	CNGA1, CNGA3, CNGB1, CNGB3	1.85
83	Fundus dystrophy	Enrichment	CNGA1, CNGA3, CNGB1, CNGB3	1.85
84	Alzheimer disease 2	Enrichment	NOS3	1.79
85	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PDE2A	1.79
86	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	1.79
87	Pre-eclampsia	Enrichment	NOS3	1.79
88	Follicular lymphoma	Enrichment	BCL2	1.79
89	Macular degeneration	Enrichment	CNGA3	1.79
90	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.79
91	Sleep disorder	Enrichment	GRIN2B	1.79
92	Moyamoya disease 1	Enrichment	GUCY1A1	1.71
93	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.71
94	Common variable immunodeficiency	Enrichment	NFKB1	1.65
95	Paroxysmal dystonia	Enrichment	PDE2A	1.65
96	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.59
97	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.59
98	Choreatic disease	Enrichment	PDE2A	1.59
99	Retinitis pigmentosa	Enrichment	CNGA1, CNGB1, CNGB3	1.51
100	Stroke, ischemic	Enrichment	NOS3	1.50
101	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.50
102	Cone-rod dystrophy 6	Enrichment	CNGB3	1.35
103	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	1.30
104	Gliosarcoma	Enrichment	NFKBIA	1.30
105	Alzheimer disease, familial, 1	Enrichment	NOS3	1.27
106	Hypertension, essential	Enrichment	NOS3	1.27
107	Giant cell glioblastoma	Enrichment	NFKBIA	1.27
108	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.25
109	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	NEFL	1.22
110	Microcephaly	Enrichment	CAMK2B, GRIN2B	1.22
111	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIN2B	1.21
112	Craniosynostosis	Enrichment	GRIN2B	1.20
113	Myocardial infarction	Enrichment	GUCY1A1	1.16
114	Malaria	Enrichment	NOS2	1.14
115	Familial atrial fibrillation	Enrichment	NPPA	1.12
116	Cone dystrophy	Enrichment	CNGA3	1.12
117	Autoinflammatory disease	Enrichment	XIAP	1.12
118	Scoliosis	Enrichment	GRIN2B	1.12
119	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.11
120	Brugada syndrome	Enrichment	AKAP9	1.09
121	Auditory neuropathy	Enrichment	NEFL	1.09
122	Stargardt disease 1	Enrichment	CNGB3	1.03
123	Peripheral nervous system disease	Enrichment	NEFL	1.01
124	Neuropathy	Enrichment	NEFL	1.01
125	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2	0.99
126	Left ventricular noncompaction	Enrichment	ACTN2	0.97
127	Dystonia	Enrichment	CAMK2B	0.97
128	Cerebral palsy	Enrichment	GRIN2B	0.92
129	Charcot-marie-tooth disease	Enrichment	NEFL	0.90
130	Hypertrophic cardiomyopathy	Enrichment	ACTN2	0.88
131	Sensorineural hearing loss	Enrichment	NEFL	0.84
132	Thrombocytopenia	Enrichment	CYCS	0.84
133	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2	0.80
134	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	0.78
135	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.76
136	Primary ovarian insufficiency	Enrichment	NOS3	0.76
137	Autism	Enrichment	CAMK2G	0.68
138	Dilated cardiomyopathy	Enrichment	ACTN2	0.64
139	Leber plus disease	Enrichment	CNGB3	0.57
140	Congenital nervous system abnormality	Enrichment	CAMK2B	0.53
141	Nervous system disease	Enrichment	CAMK2B	0.53
142	Autism spectrum disorder	Enrichment	GRIN2B	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NO/cGMP/PKG mediated neuroprotection

Pathway Network for NO/cGMP/PKG mediated neuroprotection

Member Pathways for NO/cGMP/PKG mediated neuroprotection

Pathways in the NO/cGMP/PKG mediated neuroprotection SuperPath

Associated Genes for NO/cGMP/PKG mediated neuroprotection

Associated Disorders for NO/cGMP/PKG mediated neuroprotection

Disorders associated with NO/cGMP/PKG mediated neuroprotection SuperPath

STRING Interaction Network for NO/cGMP/PKG mediated neuroprotection

Sources for NO/cGMP/PKG mediated neuroprotection