Non-Canonical Wnt Pathway

No Pathway Network information available for Non-Canonical Wnt Pathway

Pathways in the Non-Canonical Wnt Pathway SuperPath

#	Name	Source	Genes
1	Non-Canonical Wnt Pathway	Sino Biological	ATF2 CAMK2A CAMK2B CAMK2G CDC42 CSNK1A1 CTNNB1 DAG1 FZD1 FZD10 FZD2 FZD4 FZD5 FZD9 LEF1 MAP2K3 MAP2K6 MAPK1 MAPK14 MAPK6 MAPK7 NFATC1 NFATC3 NLK NR2C2 PFN1 PFN2 PFN4 PPP3CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PXN RAC1 RHOA ROCK2 TCF21 TCF25 TCF4 TK1 WNT1 WNT10A WNT11 WNT16 WNT2 WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT9A (see all 59) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATF2	Activating Transcription Factor 2	Protein Coding	1
2	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
3	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
4	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
5	CDC42	Cell Division Cycle 42	Protein Coding	1
6	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
7	CTNNB1	Catenin Beta 1	Protein Coding	1
8	DAG1	Dystroglycan 1	Protein Coding	1
9	FZD1	Frizzled Class Receptor 1	Protein Coding	1
10	FZD10	Frizzled Class Receptor 10	Protein Coding	1
11	FZD2	Frizzled Class Receptor 2	Protein Coding	1
12	FZD4	Frizzled Class Receptor 4	Protein Coding	1
13	FZD5	Frizzled Class Receptor 5	Protein Coding	1
14	FZD9	Frizzled Class Receptor 9	Protein Coding	1
15	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
16	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
17	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
18	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
19	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
20	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
21	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
22	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
23	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
24	NLK	Nemo Like Kinase	Protein Coding	1
25	NR2C2	Nuclear Receptor Subfamily 2 Group C Member 2	Protein Coding	1
26	PFN1	Profilin 1	Protein Coding	1
27	PFN2	Profilin 2	Protein Coding	1
28	PFN4	Profilin Family Member 4	Protein Coding	1
29	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
30	PRKCA	Protein Kinase C Alpha	Protein Coding	1
31	PRKCB	Protein Kinase C Beta	Protein Coding	1
32	PRKCD	Protein Kinase C Delta	Protein Coding	1
33	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
34	PRKCG	Protein Kinase C Gamma	Protein Coding	1
35	PRKCH	Protein Kinase C Eta	Protein Coding	1
36	PRKCI	Protein Kinase C Iota	Protein Coding	1
37	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
38	PXN	Paxillin	Protein Coding	1
39	RAC1	Rac Family Small GTPase 1	Protein Coding	1
40	RHOA	Ras Homolog Family Member A	Protein Coding	1
41	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
42	TCF21	Transcription Factor 21	Protein Coding	1
43	TCF25	TCF25 Ribosome Quality Control Complex Subunit	Protein Coding	1
44	TCF4	Transcription Factor 4	Protein Coding	1
45	TK1	Thymidine Kinase 1	Protein Coding	1
46	WNT1	Wnt Family Member 1	Protein Coding	1
47	WNT10A	Wnt Family Member 10A	Protein Coding	1
48	WNT11	Wnt Family Member 11	Protein Coding	1
49	WNT16	Wnt Family Member 16	Protein Coding	1
50	WNT2	Wnt Family Member 2	Protein Coding	1
51	WNT3	Wnt Family Member 3	Protein Coding	1
52	WNT3A	Wnt Family Member 3A	Protein Coding	1
53	WNT4	Wnt Family Member 4	Protein Coding	1
54	WNT5A	Wnt Family Member 5A	Protein Coding	1
55	WNT5B	Wnt Family Member 5B	Protein Coding	1
56	WNT6	Wnt Family Member 6	Protein Coding	1
57	WNT7A	Wnt Family Member 7A	Protein Coding	1
58	WNT7B	Wnt Family Member 7B	Protein Coding	1
59	WNT9A	Wnt Family Member 9A	Protein Coding	1

Disorders associated with Non-Canonical Wnt Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	4.25
2	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, PPP3CA, TCF4	4.19
3	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2, WNT5A	3.95
4	Autosomal dominant robinow syndrome	Enrichment	FZD2, WNT5A	3.95
5	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4	3.73
6	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2, WNT5A	3.73
7	Autosomal recessive robinow syndrome	Enrichment	FZD2, WNT5A	3.56
8	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4	3.29
9	Microcephaly	Enrichment	CAMK2B, CTNNB1, MAPK1, TCF4	2.70
10	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.36
11	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.36
12	Omodysplasia 2	Enrichment	FZD2	2.36
13	Muscular dystrophy-dystroglycanopathy , type a, 9	Enrichment	DAG1	2.36
14	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	2.36
15	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.36
16	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.36
17	Noonan syndrome 13	Enrichment	MAPK1	2.36
18	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.36
19	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.36
20	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.36
21	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.36
22	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.36
23	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.36
24	Santos syndrome	Enrichment	WNT7A	2.36
25	Microphthalmia/coloboma 11	Enrichment	FZD5	2.36
26	Muscular dystrophy-dystroglycanopathy , type c, 9	Enrichment	DAG1	2.36
27	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.36
28	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.36
29	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.36
30	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.36
31	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.36
32	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.36
33	Adenoid ameloblastoma	Enrichment	CTNNB1	2.36
34	Nocarh syndrome	Enrichment	CDC42	2.36
35	Muscle-eye-brain disease with bilateral multicystic leucodystrophy	Enrichment	DAG1	2.36
36	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.36
37	Microcystic stromal tumor	Enrichment	CTNNB1	2.36
38	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.06
39	Scoliosis, isolated 1	Enrichment	MAPK7	2.06
40	Tooth agenesis, selective, 4	Enrichment	WNT10A	2.06
41	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	2.06
42	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	2.06
43	Bladder exstrophy and epispadias complex	Enrichment	WNT3	2.06
44	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.06
45	Odontoonychodermal dysplasia	Enrichment	WNT10A	2.06
46	Tetraamelia syndrome 1	Enrichment	WNT3	2.06
47	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.06
48	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	2.06
49	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	2.06
50	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.06
51	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.06
52	Split hand-foot malformation	Enrichment	LEF1	2.06
53	Immune system disease	Enrichment	CDC42	2.06
54	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.06
55	Teratoma	Enrichment	CTNNB1	2.06
56	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	2.06
57	Desmoid disease, hereditary	Enrichment	CTNNB1	1.89
58	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.89
59	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.89
60	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.89
61	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.89
62	Anus, imperforate	Enrichment	CTNNB1	1.89
63	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.89
64	Desmoid tumor	Enrichment	CTNNB1	1.89
65	Tetraamelia syndrome	Enrichment	WNT3	1.89
66	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.76
67	Pitt-hopkins syndrome	Enrichment	TCF4	1.76
68	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.76
69	Pilomatrixoma	Enrichment	CTNNB1	1.76
70	Alazami syndrome	Enrichment	CTNNB1	1.76
71	Hereditary ataxia	Enrichment	PRKCG	1.76
72	Ectodermal dysplasia	Enrichment	WNT10A	1.76
73	Retinopathy of prematurity	Enrichment	FZD4	1.76
74	Craniopharyngioma	Enrichment	CTNNB1	1.76
75	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.76
76	Eyelid coloboma	Enrichment	FZD5	1.76
77	Lens coloboma	Enrichment	FZD5	1.76
78	Norrie disease	Enrichment	FZD4	1.67
79	Cholangitis, primary sclerosing	Enrichment	TCF4	1.67
80	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.67
81	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.67
82	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.67
83	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.67
84	Coloboma of choroid and retina	Enrichment	FZD5	1.67
85	Coloboma of optic nerve	Enrichment	FZD5	1.59
86	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.59
87	Split-hand/foot malformation 1	Enrichment	LEF1	1.59
88	Hemihyperplasia, isolated	Enrichment	RHOA	1.59
89	Adrenocortical carcinoma	Enrichment	CTNNB1	1.59
90	Coats disease	Enrichment	FZD4	1.52
91	Gallbladder cancer	Enrichment	CTNNB1	1.52
92	Spastic paraplegia 4, autosomal dominant	Enrichment	TCF4	1.46
93	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.41
94	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.41
95	Cat eye syndrome	Enrichment	FZD5	1.37
96	Stroke, ischemic	Enrichment	PRKCH	1.37
97	Specific learning disability	Enrichment	MAPK1	1.33
98	Epicanthus	Enrichment	TCF4	1.29
99	Microphthalmia/coloboma 12	Enrichment	FZD5	1.26
100	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.26
101	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.26
102	Stereotypic movement disorder	Enrichment	TCF4	1.26
103	Osteoporosis	Enrichment	WNT1	1.23
104	Medulloblastoma	Enrichment	CTNNB1	1.23
105	Walker-warburg syndrome	Enrichment	DAG1	1.23
106	Coloboma of macula	Enrichment	FZD5	1.20
107	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.20
108	Creatine phosphokinase, elevated serum	Enrichment	DAG1	1.17
109	Isolated elevated serum creatine phosphokinase levels	Enrichment	DAG1	1.17
110	Polycystic liver disease	Enrichment	CTNNB1	1.15
111	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.15
112	Heart, malformation of	Enrichment	MAPK1	1.12
113	Congenital nervous system abnormality	Enrichment	CAMK2B, CTNNB1	1.11
114	Nervous system disease	Enrichment	CAMK2B, CTNNB1	1.11
115	Macs syndrome	Enrichment	WNT7B	1.08
116	Hepatoblastoma	Enrichment	CTNNB1	1.06
117	Hepatocellular carcinoma	Enrichment	CTNNB1	1.04
118	Microphthalmia	Enrichment	WNT7B	1.04
119	Tooth agenesis	Enrichment	WNT10A	1.04
120	Brittle bone disorder	Enrichment	WNT1	1.02
121	Bladder cancer	Enrichment	CTNNB1	0.92
122	Dystonia	Enrichment	CAMK2B	0.85
123	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.66
124	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PFN1	0.65
125	Autism	Enrichment	CAMK2G	0.57
126	Colorectal cancer	Enrichment	CTNNB1	0.50
127	Ovarian cancer	Enrichment	CTNNB1	0.45
128	Autism spectrum disorder	Enrichment	TCF4	0.42
129	Hereditary retinal dystrophy	Enrichment	FZD4	0.14
130	Fundus dystrophy	Enrichment	FZD4	0.14

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Non-Canonical Wnt Pathway

Pathway Network for Non-Canonical Wnt Pathway

Member Pathways for Non-Canonical Wnt Pathway

Pathways in the Non-Canonical Wnt Pathway SuperPath

Associated Genes for Non-Canonical Wnt Pathway

Associated Disorders for Non-Canonical Wnt Pathway

Disorders associated with Non-Canonical Wnt Pathway SuperPath

STRING Interaction Network for Non-Canonical Wnt Pathway

Sources for Non-Canonical Wnt Pathway