Non-integrin membrane-ECM interactions

Pathway network for the Non-integrin membrane-ECM interactions SuperPath

Sources:

Reactome
QIAGEN

Pathways in the Non-integrin membrane-ECM interactions SuperPath

#	Name	Source	Genes
1	Non-integrin membrane-ECM interactions	Reactome	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 ACTN1 AGRN CASK COL10A1 COL11A1 COL11A2 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 DAG1 DDR1 DDR2 DMD DRP2 DTNA DTNB FGF2 FN1 HSPG2 ITGA2 ITGA6 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 NRXN1 NTN4 PDGFA PDGFB PRKCA SDC1 SDC2 SDC3 SDC4 SGCA SGCB SGCD SGCE SGCG SGCZ SNTA1 SNTB1 SNTB2 SNTG2 SSPN TGFB1 THBS1 TNC TRAPPC4 TTR UTRN VTN (see all 80) (see less)
2	Formation of the dystrophin-glycoprotein complex (DGC)	Reactome	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 AGRN DAG1 DMD DRP2 DTNA DTNB HSPG2 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 SGCA SGCB SGCD SGCE SGCG SGCZ SNTA1 SNTB1 SNTB2 SNTG2 SSPN UTRN (see all 36) (see less)
3	Syndecan interactions	Reactome	ACTN1 CASK COL1A1 COL1A2 COL3A1 COL5A1 COL5A2 COL5A3 FGF2 FN1 ITGA2 ITGA6 ITGAV ITGB1 ITGB3 ITGB4 ITGB5 PRKCA SDC1 SDC2 SDC3 SDC4 TGFB1 THBS1 TNC TRAPPC4 VTN (see all 27) (see less)
4	Muscular Dystrophies and Dystrophin-Glycoprotein Complex	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 AGRN DAG1 DMD DTNA DTNB HSPG2 LAMA2 NOS1 NRXN1 NRXN2 NRXN3 SNTA1 SNTB1 SSPN (see all 19) (see less)

Gene overlap in member pathways for Non-integrin membrane-ECM interactions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DAG1	Dystroglycan 1	Protein Coding	3
2	DMD	Dystrophin	Protein Coding	3
3	DTNA	Dystrobrevin Alpha	Protein Coding	3
4	DTNB	Dystrobrevin Beta	Protein Coding	3
5	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	3
6	AGRN	Agrin	Protein Coding	3
7	LAMA2	Laminin Subunit Alpha 2	Protein Coding	3
8	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	3
9	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	3
10	ACTB	Actin Beta	Protein Coding	3
11	SNTA1	Syntrophin Alpha 1	Protein Coding	3
12	SNTB1	Syntrophin Beta 1	Protein Coding	3
13	ACTG1	Actin Gamma 1	Protein Coding	3
14	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	3
15	SSPN	Sarcospan	Protein Coding	3
16	LAMC3	Laminin Subunit Gamma 3	Protein Coding	2
17	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	2
18	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	2
19	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	2
20	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	2
21	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	2
22	SGCZ	Sarcoglycan Zeta	Protein Coding	2
23	DRP2	Dystrophin Related Protein 2	Protein Coding	2
24	FGF2	Fibroblast Growth Factor 2	Protein Coding	2
25	FN1	Fibronectin 1	Protein Coding	2
26	LAMA1	Laminin Subunit Alpha 1	Protein Coding	2
27	TNC	Tenascin C	Protein Coding	2
28	ITGA6	Integrin Subunit Alpha 6	Protein Coding	2
29	ITGA2	Integrin Subunit Alpha 2	Protein Coding	2
30	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
31	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
32	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
33	ITGB4	Integrin Subunit Beta 4	Protein Coding	2
34	ITGB5	Integrin Subunit Beta 5	Protein Coding	2
35	LAMA3	Laminin Subunit Alpha 3	Protein Coding	2
36	LAMA4	Laminin Subunit Alpha 4	Protein Coding	2
37	LAMA5	Laminin Subunit Alpha 5	Protein Coding	2
38	LAMB1	Laminin Subunit Beta 1	Protein Coding	2
39	LAMB2	Laminin Subunit Beta 2	Protein Coding	2
40	LAMB3	Laminin Subunit Beta 3	Protein Coding	2
41	LAMC1	Laminin Subunit Gamma 1	Protein Coding	2
42	LAMC2	Laminin Subunit Gamma 2	Protein Coding	2
43	COL5A3	Collagen Type V Alpha 3 Chain	Protein Coding	2
44	TRAPPC4	Trafficking Protein Particle Complex Subunit 4	Protein Coding	2
45	SNTG2	Syntrophin Gamma 2	Protein Coding	2
46	PRKCA	Protein Kinase C Alpha	Protein Coding	2
47	SDC1	Syndecan 1	Protein Coding	2
48	SDC2	Syndecan 2	Protein Coding	2
49	SDC4	Syndecan 4	Protein Coding	2
50	SGCA	Sarcoglycan Alpha	Protein Coding	2
51	SGCB	Sarcoglycan Beta	Protein Coding	2
52	SGCD	Sarcoglycan Delta	Protein Coding	2
53	SGCG	Sarcoglycan Gamma	Protein Coding	2
54	SNTB2	Syntrophin Beta 2	Protein Coding	2
55	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	2
56	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	2
57	THBS1	Thrombospondin 1	Protein Coding	2
58	UTRN	Utrophin	Protein Coding	2
59	VTN	Vitronectin	Protein Coding	2
60	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	2
61	ACTN1	Actinin Alpha 1	Protein Coding	2
62	SGCE	Sarcoglycan Epsilon	Protein Coding	2
63	NRXN1	Neurexin 1	Protein Coding	2
64	SDC3	Syndecan 3	Protein Coding	2
65	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	1
66	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
67	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
68	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
69	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	1
70	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	1
71	COL4A6	Collagen Type IV Alpha 6 Chain	Protein Coding	1
72	COL10A1	Collagen Type X Alpha 1 Chain	Protein Coding	1
73	COL11A1	Collagen Type XI Alpha 1 Chain	Protein Coding	1
74	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	1
75	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	1
76	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
77	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
78	NTN4	Netrin 4	Protein Coding	1
79	TTR	Transthyretin	Protein Coding	1
80	DDR1	Discoidin Domain Receptor Tyrosine Kinase 1	Protein Coding	1
81	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
82	NRXN2	Neurexin 2	Protein Coding	1
83	NRXN3	Neurexin 3	Protein Coding	1

Disorders associated with Non-integrin membrane-ECM interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2, COL5A1, COL5A2	9.68
2	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL5A1, COL5A2	9.68
3	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL3A1, COL5A1, COL5A2	9.57
4	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4, LAMA3, LAMB3, LAMC2	9.10
5	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1, DMD, DTNA, LAMA2, SGCB, SGCD	8.86
6	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4, LAMA3, LAMB3, LAMC2	7.78
7	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4, LAMA3, LAMB3, LAMC2	7.78
8	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	SGCA, SGCB, SGCD, SGCG	6.80
9	Nephrotic syndrome	Enrichment	COL4A3, COL4A4, COL4A5, FN1, LAMA5, LAMB2	6.75
10	Digenic alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	6.70
11	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3, LAMB3, LAMC2	6.47
12	Creatine phosphokinase, elevated serum	Enrichment	DAG1, DMD, LAMA2	5.89
13	Isolated elevated serum creatine phosphokinase levels	Enrichment	DAG1, DMD, LAMA2	5.89
14	Kidney disease	Enrichment	COL4A3, COL4A4, COL4A5, LAMB2	5.84
15	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1, COL5A1, COL5A2	5.80
16	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.73
17	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3, COL4A4, COL4A5	5.71
18	Autosomal dominant alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	5.71
19	Alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	5.71
20	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.42
21	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.42
22	Keratoconus	Enrichment	COL1A1, COL4A1, COL5A2	5.41
23	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, DMD, LAMA4, SGCD	4.95
24	Ehlers-danlos syndrome, classic type, 2	Enrichment	COL5A1, COL5A2	4.94
25	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.94
26	Muscular dystrophy, duchenne type	Enrichment	DMD, UTRN	4.69
27	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.64
28	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.64
29	Muscular dystrophy	Enrichment	DMD, SGCA, SGCD	4.48
30	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1, FN1	4.46
31	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1, FN1	4.46
32	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL11A2, COL2A1	4.46
33	Dermatofibrosarcoma protuberans	Enrichment	COL1A1, PDGFB	4.46
34	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL11A2, COL2A1	4.46
35	Fibrochondrogenesis	Enrichment	COL11A1, COL11A2	4.46
36	Stickler syndrome, type ii	Enrichment	COL11A1, COL1A1	4.46
37	X-linked diffuse leiomyomatosis-alport syndrome	Enrichment	COL4A5, COL4A6	4.46
38	Connective tissue disease	Enrichment	ACTA2, COL11A1, COL2A1, COL5A1	4.45
39	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	4.24
40	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	4.24
41	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGB3	4.24
42	Multiple sclerosis	Enrichment	ITGB4, LAMA5, LAMB1	4.16
43	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	4.10
44	Myopia	Enrichment	COL11A1, COL2A1, COL4A4	4.07
45	Hematuria, benign familial, 1	Enrichment	COL4A3, COL4A4	3.99
46	Telecanthus	Enrichment	COL11A1, COL5A2	3.99
47	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1, ITGB3	3.77
48	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.77
49	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	3.69
50	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3, COL4A4	3.69
51	Autosomal recessive alport syndrome	Enrichment	COL4A3, COL4A4	3.69
52	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.68
53	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, COL11A1, COL11A2, TNC	3.61
54	Skin disease	Enrichment	ITGB4, LAMB3, LAMC2	3.55
55	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.53
56	Epidermolysis bullosa	Enrichment	ITGA6, LAMB3	3.47
57	Familial porencephaly	Enrichment	COL4A1, COL4A2	3.47
58	Osteoporosis	Enrichment	COL1A1, COL1A2	3.47
59	Presynaptic congenital myasthenic syndromes	Enrichment	AGRN, LAMA5	3.43
60	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.40
61	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	3.29
62	Brittle bone disorder	Enrichment	COL1A1, COL1A2	3.03
63	Neuromuscular disease	Enrichment	ACTA1, SGCD	2.99
64	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.85
65	Hyperopia, high	Enrichment	NRXN1	2.85
66	Baraitser-winter syndrome 1	Enrichment	ACTB	2.85
67	Muscular dystrophy, becker type	Enrichment	DMD	2.85
68	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.85
69	Muscular dystrophy-dystroglycanopathy , type a, 9	Enrichment	DAG1	2.85
70	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.85
71	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.85
72	Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2	Enrichment	DTNA	2.85
73	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.85
74	Cardiomyopathy, dilated, 3b	Enrichment	DMD	2.85
75	Pitt-hopkins-like syndrome 2	Enrichment	NRXN1	2.85
76	Left ventricular noncompaction 1	Enrichment	DTNA	2.85
77	Becker nevus syndrome	Enrichment	ACTB	2.85
78	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.85
79	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.85
80	Long qt syndrome 12	Enrichment	SNTA1	2.85
81	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.85
82	Chromosome 2p16.3 deletion syndrome	Enrichment	NRXN1	2.85
83	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.85
84	Muscular dystrophy-dystroglycanopathy , type c, 9	Enrichment	DAG1	2.85
85	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.85
86	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.85
87	Nrxn1-related severe neurodevelopmental disorder-motor stereotypies-chronic constipation-sleep-wake cycle disturbance	Enrichment	NRXN1	2.85
88	Baraitser-winter syndrome	Enrichment	ACTB	2.85
89	Symptomatic form of muscular dystrophy of duchenne and becker in female carriers	Enrichment	DMD	2.85
90	Zebra body myopathy	Enrichment	ACTA1	2.85
91	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.85
92	Duchenne and becker muscular dystrophy	Enrichment	DMD	2.85
93	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.85
94	Muscle-eye-brain disease with bilateral multicystic leucodystrophy	Enrichment	DAG1	2.85
95	Actin-accumulation myopathy	Enrichment	ACTA1	2.85
96	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.85
97	Qualitative or quantitative defects of dystrophin	Enrichment	DMD	2.85
98	Actg2 visceral myopathy	Enrichment	ACTG2	2.85
99	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	2.85
100	Myopathy	Enrichment	ACTA1, DMD	2.85
101	Stickler syndrome	Enrichment	COL11A1, COL2A1	2.82
102	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.70
103	Deafness, autosomal dominant 56	Enrichment	TNC	2.70
104	Acrogeria, gottron type	Enrichment	COL3A1	2.70
105	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.70
106	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.70
107	Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy	Enrichment	TRAPPC4	2.70
108	Asphyxia neonatorum	Enrichment	COL1A1	2.70
109	Cask-related intellectual disability	Enrichment	CASK	2.70
110	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.70
111	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.70
112	Pneumothorax	Enrichment	COL5A1	2.70
113	Abdominal aortic aneurysm	Enrichment	COL3A1	2.70
114	Chronic kidney disease	Enrichment	COL4A4, COL4A5	2.59
115	Muscular dystrophy, limb-girdle, autosomal recessive 6	Enrichment	SGCD	2.58
116	Cardiomyopathy, dilated, 1jj	Enrichment	LAMA4	2.58
117	Lissencephaly 5	Enrichment	LAMB1	2.58
118	Muscular dystrophy, limb-girdle, autosomal recessive 5	Enrichment	SGCG	2.58
119	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.58
120	Cardiomyopathy, dilated, 1l	Enrichment	SGCD	2.58
121	Autosomal recessive limb-girdle muscular dystrophy type 2c	Enrichment	SGCG	2.58
122	Cortical malformations, occipital	Enrichment	LAMC3	2.58
123	Autosomal recessive limb-girdle muscular dystrophy type 2f	Enrichment	SGCD	2.58
124	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.58
125	Occipital pachygyria and polymicrogyria	Enrichment	LAMC3	2.58
126	Qualitative or quantitative defects of sarcoglycan	Enrichment	SGCA	2.58
127	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.58
128	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.55
129	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.55
130	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.55
131	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.55
132	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.55
133	Moyamoya disease 5	Enrichment	ACTA2	2.55
134	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	2.55
135	Intestinal obstruction	Enrichment	ACTG2	2.55
136	Walker-warburg syndrome	Enrichment	COL4A1, DAG1	2.53
137	Schizophrenia	Enrichment	DMD, NRXN1	2.52
138	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1, DMD	2.46
139	Left ventricular noncompaction	Enrichment	ACTC1, DTNA	2.41
140	Hypertension	Enrichment	COL4A4, COL4A5	2.41
141	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.40
142	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.40
143	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.40
144	Camurati-engelmann disease 1	Enrichment	TGFB1	2.40
145	Bruck syndrome 1	Enrichment	COL1A2	2.40
146	Fg syndrome 4	Enrichment	CASK	2.40
147	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.40
148	Fibromuscular dysplasia, multifocal	Enrichment	COL5A1	2.40
149	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.40
150	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.40
151	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.40
152	Aortic dissection	Enrichment	COL3A1	2.40
153	Syndromic x-linked intellectual disability	Enrichment	CASK	2.40
154	Camurati-engelmann disease	Enrichment	TGFB1	2.40
155	Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies	Enrichment	TRAPPC4	2.40
156	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.40
157	Dentinogenesis imperfecta	Enrichment	COL1A2	2.40
158	Thrombocytopenia	Enrichment	ACTN1, ITGB3	2.39
159	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	2.38
160	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	2.38
161	Lama2-related muscular dystrophy	Enrichment	LAMA2	2.38
162	Autism	Enrichment	DMD, NRXN1	2.35
163	Heart, malformation of	Enrichment	COL11A2, COL2A1	2.31
164	Amelogenesis imperfecta, type ia	Enrichment	LAMB3	2.28
165	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	2.28
166	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	2.28
167	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.28
168	Muscular dystrophy, limb-girdle, autosomal recessive 4	Enrichment	SGCB	2.28
169	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.28
170	Lissencephaly 1	Enrichment	LAMB1	2.28
171	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	SGCA	2.28
172	Pierson syndrome	Enrichment	LAMB2	2.28
173	Atrial septal defect 5	Enrichment	ACTC1	2.28
174	Epidermolysis bullosa, junctional 3b, severe	Enrichment	LAMC2	2.28
175	Epidermolysis bullosa, junctional 3a, intermediate	Enrichment	LAMC2	2.28
176	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	2.28
177	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	2.28
178	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	SGCA	2.28
179	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	2.28
180	Qualitative or quantitative defects of beta-sarcoglycan	Enrichment	SGCB	2.28
181	Glycoproteinosis	Enrichment	SGCB	2.28
182	Sgce myoclonus-dystonia	Enrichment	SGCE	2.28
183	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	2.26
184	Nemaline myopathy 2	Enrichment	ACTA1	2.25
185	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	2.25
186	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	2.25
187	Aminoacylase 1 deficiency	Enrichment	ACTB	2.25
188	Atrial fibrillation	Enrichment	SNTA1	2.25
189	Idiopathic achalasia	Enrichment	NOS1	2.25
190	Intermediate nemaline myopathy	Enrichment	ACTA1	2.25
191	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.25
192	Stickler syndrome, type i	Enrichment	COL2A1	2.23
193	Carpal tunnel syndrome 1	Enrichment	TTR	2.23
194	Hyperthyroxinemia, dystransthyretinemic	Enrichment	TTR	2.23
195	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.23
196	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.23
197	Alport syndrome 1, x-linked	Enrichment	COL4A5	2.23
198	Deafness, autosomal recessive 53	Enrichment	COL11A2	2.23
199	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.23
200	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.23
201	Czech dysplasia	Enrichment	COL2A1	2.23
202	Marshall syndrome	Enrichment	COL11A1	2.23
203	Kniest dysplasia	Enrichment	COL2A1	2.23
204	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.23
205	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.23
206	Amyloidosis, hereditary systemic 1	Enrichment	TTR	2.23
207	Fibrochondrogenesis 1	Enrichment	COL11A1	2.23
208	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.23
209	Achondrogenesis, type ii	Enrichment	COL2A1	2.23
210	Deafness, x-linked 6	Enrichment	COL4A6	2.23
211	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.23
212	Porencephaly	Enrichment	COL4A1	2.23
213	Spondylometaepiphyseal dysplasia, short limb-hand type	Enrichment	DDR2	2.23
214	Deafness, autosomal dominant 37	Enrichment	COL11A1	2.23
215	Deafness, autosomal dominant 13	Enrichment	COL11A2	2.23
216	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.23
217	Fibrochondrogenesis 2	Enrichment	COL11A2	2.23
218	Warburg-cinotti syndrome	Enrichment	DDR2	2.23
219	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.23
220	Amyloidosis	Enrichment	TTR	2.23
221	Col4a1-related disorders	Enrichment	COL4A1	2.23
222	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.23
223	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	2.23
224	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.23
225	Hypochondrogenesis	Enrichment	COL2A1	2.23
226	X-linked alport syndrome	Enrichment	COL4A5	2.23
227	Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome	Enrichment	COL11A1	2.23
228	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.23
229	Cystic lymphangioma	Enrichment	COL11A2	2.23
230	Hereditary amyloidosis	Enrichment	TTR	2.23
231	Attrv30m amyloidosis	Enrichment	TTR	2.23
232	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.23
233	Attrv122i amyloidosis	Enrichment	TTR	2.23
234	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.22
235	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.22
236	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	2.22
237	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.22
238	Caffey disease	Enrichment	COL1A1	2.22
239	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	2.22
240	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	2.22
241	Cerebellar disease	Enrichment	CASK	2.22
242	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.22
243	Microcephaly	Enrichment	ACTB, ACTG1, CASK, COL4A1	2.22
244	Focal segmental glomerulosclerosis	Enrichment	COL4A4, COL4A5	2.22
245	Visceral myopathy 1	Enrichment	ACTG2	2.16
246	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	2.16
247	Myasthenic syndrome, congenital, 8	Enrichment	AGRN	2.16
248	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	2.16
249	Coloboma of choroid and retina	Enrichment	ACTG1	2.16
250	Severe congenital nemaline myopathy	Enrichment	ACTA1	2.16
251	Phenylketonuria	Enrichment	COL1A1	2.10
252	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	2.10
253	Poretti-boltshauser syndrome	Enrichment	LAMA1	2.10
254	Moyamoya disease 1	Enrichment	ACTA2	2.08
255	Intestinal pseudo-obstruction	Enrichment	ACTG2	2.08
256	Typical nemaline myopathy	Enrichment	ACTA1	2.08
257	Meniere disease	Enrichment	DTNA	2.01
258	Childhood-onset nemaline myopathy	Enrichment	ACTA1	2.01
259	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	2.00
260	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	2.00
261	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.00
262	Aplasia cutis congenita	Enrichment	ITGB4	2.00
263	Familial cerebral saccular aneurysm	Enrichment	COL3A1	2.00
264	Congenital muscular dystrophy	Enrichment	LAMA2	1.95
265	Rare genetic deafness	Enrichment	ACTG1, COL11A2, COL4A5	1.95
266	Metaphyseal chondrodysplasia, schmid type	Enrichment	COL10A1	1.93
267	Legg-calve-perthes disease	Enrichment	COL2A1	1.93
268	Mononeuropathy of the median nerve, mild	Enrichment	TTR	1.93
269	Specific language impairment 5	Enrichment	COL4A4	1.93
270	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	1.93
271	Glomerulonephritis	Enrichment	COL4A4	1.93
272	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	1.93
273	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.92
274	Inguinal hernia	Enrichment	COL5A1	1.92
275	Pain disorder	Enrichment	COL5A1	1.92
276	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.92
277	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.86
278	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.86
279	Cat eye syndrome	Enrichment	ACTG1	1.86
280	Nemaline myopathy	Enrichment	ACTA1	1.86
281	Pectus excavatum	Enrichment	DMD	1.82
282	Atrial heart septal defect	Enrichment	DMD	1.82
283	Interatrial communication	Enrichment	DMD	1.82
284	Gastroesophageal reflux	Enrichment	COL5A1	1.80
285	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1	1.80
286	Orthostatic intolerance	Enrichment	COL5A1	1.80
287	Dystonia 11, myoclonic	Enrichment	SGCE	1.80
288	Postsynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.78
289	Cakut	Enrichment	ACTG1, COL4A1	1.77
290	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3, LAMA5	1.77
291	Mccune-albright syndrome	Enrichment	COL2A1	1.75
292	Retinal arteries, tortuosity of	Enrichment	COL4A1	1.75
293	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	1.75
294	Megalocornea	Enrichment	COL11A1	1.75
295	Hypophosphatasia, infantile	Enrichment	COL11A2	1.75
296	Brain small vessel disease 2	Enrichment	COL4A2	1.75
297	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	1.75
298	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	1.75
299	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	1.75
300	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	1.75
301	Hematuria, benign familial, 2	Enrichment	COL4A3	1.75
302	Multiple epiphyseal dysplasia	Enrichment	COL2A1	1.75
303	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.75
304	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	1.74
305	Congenital hydrocephalus	Enrichment	SGCD	1.73
306	Non-syndromic x-linked intellectual disability	Enrichment	CASK, DMD	1.72
307	Lung cancer susceptibility 3	Enrichment	ACTA2	1.71
308	Congenital myasthenic syndrome	Enrichment	AGRN	1.71
309	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.68
310	Cerebral palsy	Enrichment	COL4A1, COL4A2	1.66
311	Schizencephaly	Enrichment	COL4A1	1.63
312	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	COL4A6	1.63
313	Cutis laxa	Enrichment	COL5A1	1.63
314	Charcot-marie-tooth disease	Enrichment	LAMA2, TTR	1.61
315	Beckwith-wiedemann syndrome	Enrichment	DMD	1.60
316	Nonsyndromic hearing loss	Enrichment	ACTG1, COL11A2	1.60
317	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	COL5A1	1.59
318	Neural tube defects	Enrichment	ITGB1	1.59
319	Clubfoot	Enrichment	COL5A1	1.59
320	Amelogenesis imperfecta, type ie	Enrichment	LAMB3	1.58
321	Congenital myopathy	Enrichment	ACTA1	1.58
322	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.56
323	Cataract	Enrichment	COL5A1	1.56
324	Movement disease	Enrichment	SGCE	1.54
325	Lissencephaly	Enrichment	ACTG1	1.54
326	Centronuclear myopathy	Enrichment	ACTA1	1.54
327	Retinal detachment	Enrichment	COL2A1	1.54
328	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.50
329	Isolated congenital microcephaly	Enrichment	CASK	1.50
330	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	SGCB	1.50
331	Amelogenesis imperfecta	Enrichment	LAMB3	1.47
332	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.46
333	Anterior segment dysgenesis 5	Enrichment	COL4A1	1.46
334	Body mass index quantitative trait locus 11	Enrichment	NRXN1, SDC3	1.46
335	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK	1.45
336	Hydrops fetalis, nonimmune	Enrichment	ACTA1	1.45
337	Hypertelorism	Enrichment	COL11A1, COL1A1	1.42
338	Intervertebral disc disease	Enrichment	COL11A1	1.39
339	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1	1.39
340	Long qt syndrome 1	Enrichment	SNTA1	1.38
341	Long qt syndrome	Enrichment	SNTA1	1.37
342	Non-immune hydrops fetalis	Enrichment	ACTA1	1.37
343	Myocardial infarction	Enrichment	ITGB3	1.37
344	Lung cancer	Enrichment	ACTA2	1.36
345	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB	1.34
346	Patent foramen ovale	Enrichment	ACTC1	1.33
347	Fanconi anemia, complementation group a	Enrichment	DMD	1.32
348	Non-syndromic genetic deafness	Enrichment	ACTG1	1.31
349	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	1.30
350	Severe covid-19	Enrichment	ITGAV	1.25
351	Marfan syndrome	Enrichment	COL2A1	1.24
352	Peters-plus syndrome	Enrichment	COL4A1	1.24
353	Cystic fibrosis	Enrichment	TGFB1	1.21
354	Meningioma, familial	Enrichment	PDGFB	1.20
355	Dystonia	Enrichment	CASK	1.17
356	Meningioma	Enrichment	PDGFB	1.16
357	Isolated macular dystrophy	Enrichment	COL4A5	1.10
358	Corpus callosum, agenesis of	Enrichment	COL4A1	1.07
359	Anterior segment dysgenesis	Enrichment	COL4A1	1.07
360	Atypical hemolytic-uremic syndrome	Enrichment	COL4A5	1.07
361	Isolated corpus callosum agenesis	Enrichment	COL4A1	1.07
362	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1	1.07
363	Cleft palate, isolated	Enrichment	COL11A1	1.02
364	Polycystic kidney disease	Enrichment	COL4A4	1.00
365	Hypertrophic cardiomyopathy	Enrichment	ACTC1	0.97
366	Primary ovarian insufficiency	Enrichment	THBS1	0.95
367	Colorectal cancer	Enrichment	DMD	0.94
368	Ear malformation	Enrichment	COL11A2	0.88
369	Scoliosis	Enrichment	COL2A1	0.88
370	Autism spectrum disorder	Enrichment	NRXN1	0.85
371	Stargardt disease 1	Enrichment	COL2A1	0.79
372	Congenital nervous system abnormality	Enrichment	CASK	0.72
373	Nervous system disease	Enrichment	CASK	0.72
374	Complex neurodevelopmental disorder	Enrichment	TRAPPC4	0.66
375	Hereditary retinal dystrophy	Enrichment	COL11A2, COL2A1, LAMA1	0.61
376	Fundus dystrophy	Enrichment	COL11A2, COL2A1, LAMA1	0.61
377	Sensorineural hearing loss	Enrichment	COL11A2	0.61
378	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	COL11A2	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Non-integrin membrane-ECM interactions

Pathway Network for Non-integrin membrane-ECM interactions

Pathway network for the Non-integrin membrane-ECM interactions SuperPath

Member Pathways for Non-integrin membrane-ECM interactions

Pathways in the Non-integrin membrane-ECM interactions SuperPath

Gene overlap in member pathways for Non-integrin membrane-ECM interactions SuperPath

Associated Genes for Non-integrin membrane-ECM interactions

Associated Disorders for Non-integrin membrane-ECM interactions

Disorders associated with Non-integrin membrane-ECM interactions SuperPath

STRING Interaction Network for Non-integrin membrane-ECM interactions

Sources for Non-integrin membrane-ECM interactions