Nonalcoholic fatty liver disease

No Pathway Network information available for Nonalcoholic fatty liver disease

Pathways in the Nonalcoholic fatty liver disease SuperPath

#	Name	Source	Genes
1	Nonalcoholic fatty liver disease	WikiPathways	ADIPOQ ATF4 BAK1 BAX BBC3 BCL2L11 BID CASP8 CCL2 CEBPA CYCS CYP2E1 DDIT3 EIF2AK3 EIF2S1 ERN1 FAS FASLG IKBKB IL1A IL6 IL6R INS INSR IRS1 IRS2 ITCH JUN LEP LEPR MAP3K11 MAP3K5 MAPK8 NR1H3 NR1H4 PKLR PPARA RXRA SMAD7 SOCS3 SREBF1 TNF TNFRSF1A TRAF2 VCAM1 XBP1 (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	1
2	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
3	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	1
4	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
5	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
6	CASP8	Caspase 8	Protein Coding	1
7	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
8	XBP1	X-Box Binding Protein 1	Protein Coding	1
9	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
10	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
11	TNF	Tumor Necrosis Factor	Protein Coding	1
12	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
13	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
14	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
15	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
16	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
17	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
18	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
19	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
20	CYCS	Cytochrome C, Somatic	Protein Coding	1
21	PKLR	Pyruvate Kinase L/R	Protein Coding	1
22	ATF4	Activating Transcription Factor 4	Protein Coding	1
23	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
24	SMAD7	SMAD Family Member 7	Protein Coding	1
25	LEPR	Leptin Receptor	Protein Coding	1
26	LEP	Leptin	Protein Coding	1
27	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
28	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
29	INSR	Insulin Receptor	Protein Coding	1
30	INS	Insulin	Protein Coding	1
31	IL6R	Interleukin 6 Receptor	Protein Coding	1
32	IL6	Interleukin 6	Protein Coding	1
33	FASLG	Fas Ligand	Protein Coding	1
34	IL1A	Interleukin 1 Alpha	Protein Coding	1
35	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
36	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
37	BBC3	BCL2 Binding Component 3	Protein Coding	1
38	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	1
39	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
40	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
41	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
42	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
43	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
44	BCL2L11	BCL2 Like 11	Protein Coding	1
45	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
46	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1

Disorders associated with Nonalcoholic fatty liver disease SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 2 diabetes mellitus	Enrichment	IL6, INSR, IRS1, IRS2	4.93
2	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	4.17
3	Leptin deficiency or dysfunction	Enrichment	LEP, LEPR	4.17
4	Type 1 diabetes mellitus	Enrichment	IL6, INS	3.78
5	Lung cancer	Enrichment	CASP8, FAS, FASLG	3.77
6	Multiple sclerosis	Enrichment	NR1H3, TNFRSF1A	3.00
7	Behcet syndrome	Enrichment	FAS, TNFRSF1A	2.73
8	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.47
9	Adenosine triphosphate, elevated, of erythrocytes	Enrichment	PKLR	2.47
10	Donohue syndrome	Enrichment	INSR	2.47
11	Anemia, congenital, nonspherocytic hemolytic, 2	Enrichment	PKLR	2.47
12	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.47
13	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.47
14	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.47
15	Caspase 8 deficiency	Enrichment	CASP8	2.47
16	Dermatitis, atopic, 4	Enrichment	SOCS3	2.47
17	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.47
18	Immunodeficiency 15b	Enrichment	IKBKB	2.47
19	Immunodeficiency 15a	Enrichment	IKBKB	2.47
20	Ifap syndrome 2	Enrichment	SREBF1	2.47
21	Thrombocytopenia 4	Enrichment	CYCS	2.47
22	Major affective disorder 7	Enrichment	XBP1	2.47
23	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.47
24	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.47
25	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.47
26	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.47
27	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.47
28	Colorectal cancer 3	Enrichment	SMAD7	2.47
29	Cholestasis, progressive familial intrahepatic, 5	Enrichment	NR1H4	2.47
30	Leptin receptor deficiency	Enrichment	LEPR	2.47
31	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.47
32	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.47
33	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.47
34	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	2.17
35	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.17
36	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.17
37	Hyperproinsulinemia	Enrichment	INS	2.17
38	Immunodeficiency 127	Enrichment	TNF	2.17
39	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.17
40	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.17
41	Type 1 diabetes mellitus 2	Enrichment	INS	1.99
42	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.99
43	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	1.99
44	Menkes disease	Enrichment	EIF2AK3	1.99
45	Psoriatic arthritis	Enrichment	TNF	1.99
46	Adiponectin deficiency	Enrichment	ADIPOQ	1.99
47	Myxoid liposarcoma	Enrichment	DDIT3	1.99
48	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.99
49	Migraine without aura	Enrichment	TNF	1.99
50	Vogt-koyanagi-harada disease	Enrichment	FAS	1.99
51	Kaposi sarcoma	Enrichment	IL6	1.87
52	Neonatal diabetes mellitus	Enrichment	INS	1.87
53	Intrahepatic cholestasis of pregnancy	Enrichment	NR1H4	1.87
54	Cerebral malaria	Enrichment	TNF	1.87
55	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.87
56	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.77
57	Vascular dementia	Enrichment	TNF	1.77
58	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.77
59	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.77
60	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.77
61	Cholestasis, progressive familial intrahepatic, 1	Enrichment	NR1H4	1.70
62	46,xy disorder of sex development	Enrichment	INSR	1.70
63	Hemolytic anemia	Enrichment	PKLR	1.63
64	Breast cancer	Enrichment	CASP8, JUN	1.57
65	Permanent neonatal diabetes mellitus	Enrichment	INS	1.57
66	Charge syndrome	Enrichment	TNFRSF1A	1.52
67	Inflammatory bowel disease 1	Enrichment	IL6	1.52
68	Adult hepatocellular carcinoma	Enrichment	CASP8	1.52
69	Asthma	Enrichment	TNF	1.44
70	Diabetes mellitus	Enrichment	INS	1.44
71	Alzheimer's disease	Enrichment	TNF	1.36
72	Human immunodeficiency virus type 1	Enrichment	CCL2	1.23
73	Arteriovenous malformations of the brain	Enrichment	IL6	1.20
74	Maturity-onset diabetes of the young	Enrichment	INS	1.18
75	Hepatocellular carcinoma	Enrichment	CASP8	1.14
76	Malaria	Enrichment	TNF	1.12
77	Autoinflammatory disease	Enrichment	TNFRSF1A	1.11
78	Hirschsprung disease 1	Enrichment	SREBF1	1.03
79	Severe combined immunodeficiency	Enrichment	IKBKB	0.97
80	Systemic lupus erythematosus	Enrichment	TNF	0.91
81	Leukemia, acute myeloid	Enrichment	CEBPA	0.90
82	Thrombocytopenia	Enrichment	CYCS	0.82
83	Body mass index quantitative trait locus 11	Enrichment	LEPR	0.81
84	Myeloma, multiple	Enrichment	RXRA	0.76
85	Colorectal cancer	Enrichment	BAX	0.59
86	Inherited cancer-predisposing syndrome	Enrichment	CEBPA	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nonalcoholic fatty liver disease

Pathway Network for Nonalcoholic fatty liver disease

Member Pathways for Nonalcoholic fatty liver disease

Pathways in the Nonalcoholic fatty liver disease SuperPath

Associated Genes for Nonalcoholic fatty liver disease

Associated Disorders for Nonalcoholic fatty liver disease

Disorders associated with Nonalcoholic fatty liver disease SuperPath

STRING Interaction Network for Nonalcoholic fatty liver disease

Sources for Nonalcoholic fatty liver disease