Noncanonical Wnt signaling pathway

No Pathway Network information available for Noncanonical Wnt signaling pathway

Pathways in the Noncanonical Wnt signaling pathway SuperPath

#	Name	Source	Genes
1	Noncanonical Wnt signaling pathway	PubChem	ARRB2 CAMK2A CDC42 CHD7 CSNK1A1 CTHRC1 DAAM1 DVL2 FLNA FZD2 FZD5 FZD7 MAP3K7 MAPK8 NFATC2 NLK PPARG PRKCZ RAC1 RHOA ROCK1 ROR2 SETDB1 WNT3A WNT5A YES1 (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHD7	Chromodomain Helicase DNA Binding Protein 7	Protein Coding	1
2	CTHRC1	Collagen Triple Helix Repeat Containing 1	Protein Coding	1
3	FZD2	Frizzled Class Receptor 2	Protein Coding	1
4	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
5	FZD7	Frizzled Class Receptor 7	Protein Coding	1
6	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
7	SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1	Protein Coding	1
8	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
9	NLK	Nemo Like Kinase	Protein Coding	1
10	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
11	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	1
12	WNT5A	Wnt Family Member 5A	Protein Coding	1
13	ROR2	Receptor Tyrosine Kinase Like Orphan Receptor 2	Protein Coding	1
14	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
15	FZD5	Frizzled Class Receptor 5	Protein Coding	1
16	WNT3A	Wnt Family Member 3A	Protein Coding	1
17	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
18	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
19	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
20	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
21	ARRB2	Arrestin Beta 2	Protein Coding	1
22	FLNA	Filamin A	Protein Coding	1
23	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
24	CDC42	Cell Division Cycle 42	Protein Coding	1
25	RHOA	Ras Homolog Family Member A	Protein Coding	1
26	RAC1	Rac Family Small GTPase 1	Protein Coding	1

Disorders associated with Noncanonical Wnt signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2, ROR2, WNT5A	7.21
2	Autosomal recessive robinow syndrome	Enrichment	FZD2, ROR2, WNT5A	6.90
3	Frontometaphyseal dysplasia	Enrichment	FLNA, MAP3K7	4.98
4	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2, WNT5A	4.67
5	Autosomal dominant robinow syndrome	Enrichment	FZD2, WNT5A	4.67
6	Cat eye syndrome	Enrichment	CHD7, FZD5	3.80
7	Brachydactyly, type b1	Enrichment	ROR2	2.72
8	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.72
9	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.72
10	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.72
11	Omodysplasia 2	Enrichment	FZD2	2.72
12	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.72
13	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.72
14	Terminal osseous dysplasia	Enrichment	FLNA	2.72
15	Fg syndrome 2	Enrichment	FLNA	2.72
16	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.72
17	Scoliosis, isolated 3	Enrichment	CHD7	2.72
18	Microphthalmia/coloboma 11	Enrichment	FZD5	2.72
19	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.72
20	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.72
21	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.72
22	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.72
23	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.72
24	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.72
25	Nocarh syndrome	Enrichment	CDC42	2.72
26	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.72
27	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.72
28	Chd7 disorder	Enrichment	CHD7	2.72
29	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.42
30	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.42
31	Melnick-needles syndrome	Enrichment	FLNA	2.42
32	Carotid intimal medial thickness 1	Enrichment	PPARG	2.42
33	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.42
34	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	2.42
35	Choanal atresia, posterior	Enrichment	CHD7	2.42
36	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.42
37	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.42
38	Immune system disease	Enrichment	CDC42	2.42
39	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.42
40	Familial partial lipodystrophy	Enrichment	PPARG	2.42
41	Prune belly syndrome	Enrichment	FLNA	2.24
42	Arterial tortuosity syndrome	Enrichment	FLNA	2.24
43	Periventricular nodular heterotopia 1	Enrichment	FLNA	2.24
44	Osteoporosis, juvenile	Enrichment	WNT3A	2.24
45	Congenital short bowel syndrome	Enrichment	FLNA	2.24
46	Hypogonadotropic hypogonadism 5 with or without anosmia	Enrichment	CHD7	2.24
47	Pyloric stenosis	Enrichment	CHD7	2.24
48	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	2.12
49	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	2.12
50	Barrett esophagus	Enrichment	CTHRC1	2.12
51	Leptin deficiency or dysfunction	Enrichment	PPARG	2.12
52	Congenital generalized lipodystrophy	Enrichment	PPARG	2.12
53	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.12
54	Eyelid coloboma	Enrichment	FZD5	2.12
55	Lens coloboma	Enrichment	FZD5	2.12
56	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	2.02
57	Coloboma of choroid and retina	Enrichment	FZD5	2.02
58	Coloboma of optic nerve	Enrichment	FZD5	1.94
59	Hemihyperplasia, isolated	Enrichment	RHOA	1.94
60	Wiedemann-steiner syndrome	Enrichment	CHD7	1.94
61	3mc syndrome	Enrichment	CHD7	1.94
62	Patent ductus arteriosus	Enrichment	FLNA	1.94
63	Fanconi anemia, complementation group c	Enrichment	FLNA	1.82
64	Hypothyroidism	Enrichment	CHD7	1.82
65	Charge syndrome	Enrichment	CHD7	1.77
66	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.77
67	Omenn syndrome	Enrichment	CHD7	1.72
68	Atrial heart septal defect	Enrichment	CHD7	1.68
69	Interatrial communication	Enrichment	CHD7	1.68
70	Microphthalmia/coloboma 12	Enrichment	FZD5	1.61
71	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.61
72	Periventricular nodular heterotopia	Enrichment	FLNA	1.58
73	Heart disease	Enrichment	CHD7	1.58
74	Coloboma of macula	Enrichment	FZD5	1.55
75	Myopia	Enrichment	CHD7	1.55
76	Male infertility with spermatogenesis disorder	Enrichment	CHD7	1.55
77	Gliosarcoma	Enrichment	PPARG	1.52
78	Cleft palate, isolated	Enrichment	FLNA	1.49
79	Giant cell glioblastoma	Enrichment	PPARG	1.49
80	Patent foramen ovale	Enrichment	FLNA	1.47
81	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	CHD7	1.47
82	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.40
83	Kallmann syndrome	Enrichment	CHD7	1.36
84	Scoliosis	Enrichment	CHD7	1.35
85	Differentiated thyroid carcinoma	Enrichment	PPARG	1.27
86	Fetal akinesia deformation sequence 1	Enrichment	ROR2	1.16
87	Type 2 diabetes mellitus	Enrichment	PPARG	1.11
88	Distal arthrogryposis	Enrichment	ROR2	1.11
89	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA	1.09
90	Body mass index quantitative trait locus 11	Enrichment	PPARG	1.04
91	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A	1.04
92	Colorectal cancer	Enrichment	PPARG	0.81

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Noncanonical Wnt signaling pathway

Pathway Network for Noncanonical Wnt signaling pathway

Member Pathways for Noncanonical Wnt signaling pathway

Pathways in the Noncanonical Wnt signaling pathway SuperPath

Associated Genes for Noncanonical Wnt signaling pathway

Associated Disorders for Noncanonical Wnt signaling pathway

Disorders associated with Noncanonical Wnt signaling pathway SuperPath

STRING Interaction Network for Noncanonical Wnt signaling pathway

Sources for Noncanonical Wnt signaling pathway