Nongenotropic Androgen signaling

No Pathway Network information available for Nongenotropic Androgen signaling

Pathways in the Nongenotropic Androgen signaling SuperPath

#	Name	Source	Genes
1	Nongenotropic Androgen signaling	PubChem	AKT1 AR CREB1 FOS GNB1 GNG2 GNRH1 HRAS MAP2K1 MAPK1 MAPK3 PELP1 PIK3CA PIK3R1 PTK2 RAF1 SHBG SRC (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SHBG	Sex Hormone Binding Globulin	Protein Coding	1
2	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	1
3	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
4	PELP1	Proline, Glutamate And Leucine Rich Protein 1	Protein Coding	1
5	AR	Androgen Receptor	Protein Coding	1
6	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
7	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
8	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
9	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
10	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
11	GNB1	G Protein Subunit Beta 1	Protein Coding	1
12	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
13	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
14	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
15	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
16	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
17	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
18	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1

Disorders associated with Nongenotropic Androgen signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	6.79
2	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	6.63
3	Lung non-small cell carcinoma	Enrichment	HRAS, MAP2K1, PIK3CA	6.49
4	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, RAF1	6.05
5	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, RAF1	5.47
6	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	5.35
7	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.30
8	Rasopathy	Enrichment	HRAS, MAP2K1, RAF1	5.30
9	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.60
10	Nevus, epidermal	Enrichment	HRAS, PIK3CA	4.46
11	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	4.46
12	Noonan syndrome 3	Enrichment	HRAS, RAF1	4.46
13	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	4.33
14	Cowden syndrome	Enrichment	AKT1, PIK3CA	4.23
15	Meningioma	Enrichment	AKT1, PIK3CA	3.96
16	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.96
17	Ovarian cancer	Enrichment	AKT1, AR, PIK3CA	3.52
18	Bladder cancer	Enrichment	HRAS, PIK3CA	3.18
19	Prostate cancer	Enrichment	AR, PIK3CA	3.18
20	Macrodactyly	Enrichment	PIK3CA	2.88
21	Proteus syndrome	Enrichment	AKT1	2.88
22	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.88
23	Androgen insensitivity, partial	Enrichment	AR	2.88
24	Noonan syndrome 5	Enrichment	RAF1	2.88
25	Melorheostosis, isolated	Enrichment	MAP2K1	2.88
26	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.88
27	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.88
28	Cowden syndrome 5	Enrichment	PIK3CA	2.88
29	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.88
30	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.88
31	Noonan syndrome 13	Enrichment	MAPK1	2.88
32	Short syndrome	Enrichment	PIK3R1	2.88
33	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.88
34	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.88
35	Melorheostosis	Enrichment	MAP2K1	2.88
36	Leopard syndrome 2	Enrichment	RAF1	2.88
37	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.88
38	Hypogonadotropic hypogonadism 12 with or without anosmia	Enrichment	GNRH1	2.88
39	Cowden syndrome 6	Enrichment	AKT1	2.88
40	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.88
41	Thrombocytopenia 6	Enrichment	SRC	2.88
42	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.88
43	Trigonitis	Enrichment	RAF1	2.88
44	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.88
45	Hypospadias	Enrichment	PIK3CA	2.88
46	Rare venous malformation	Enrichment	PIK3CA	2.88
47	Diaphragmatic eventration	Enrichment	PIK3CA	2.88
48	Complete androgen insensitivity syndrome	Enrichment	AR	2.88
49	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.88
50	Rare combined vascular malformation	Enrichment	PIK3CA	2.88
51	Cavernous lymphangioma	Enrichment	PIK3CA	2.88
52	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.88
53	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.88
54	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.88
55	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.88
56	Macrodactyly of toe	Enrichment	PIK3CA	2.88
57	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.82
58	Costello syndrome	Enrichment	HRAS	2.58
59	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.58
60	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.58
61	Keratosis, seborrheic	Enrichment	PIK3CA	2.58
62	Noonan syndrome 8	Enrichment	PIK3CA	2.58
63	46,xy sex reversal 1	Enrichment	AR	2.58
64	Androgen insensitivity syndrome	Enrichment	AR	2.58
65	Hypospadias 1, x-linked	Enrichment	AR	2.58
66	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.58
67	Posterior hypospadias	Enrichment	AR	2.58
68	Cerebral visual impairment	Enrichment	GNB1	2.58
69	Wooly hair nevus	Enrichment	HRAS	2.58
70	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.40
71	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.40
72	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.40
73	Large congenital melanocytic nevus	Enrichment	HRAS	2.40
74	Immunodeficiency 14	Enrichment	PIK3R1	2.40
75	Spermatocytoma	Enrichment	HRAS	2.40
76	Melanoma of soft tissue	Enrichment	CREB1	2.40
77	Keratoacanthoma	Enrichment	PIK3CA	2.40
78	Breast cancer	Enrichment	AKT1, PIK3CA	2.36
79	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.28
80	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.28
81	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.28
82	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.28
83	Congenital generalized lipodystrophy	Enrichment	FOS	2.28
84	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.28
85	Cerebrovascular disease	Enrichment	PIK3CA	2.28
86	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.28
87	Epidermolytic nevus	Enrichment	HRAS	2.28
88	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.28
89	Capillary malformations, congenital	Enrichment	PIK3CA	2.18
90	Histiocytoid hemangioma	Enrichment	FOS	2.18
91	Hemimegalencephaly	Enrichment	PIK3CA	2.18
92	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.10
93	Cowden syndrome 1	Enrichment	PIK3CA	2.10
94	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.10
95	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.10
96	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	2.05
97	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	2.03
98	Myelofibrosis	Enrichment	SRC	2.03
99	Gallbladder cancer	Enrichment	PIK3CA	2.03
100	Pilomyxoid astrocytoma	Enrichment	RAF1	2.03
101	Follicular thyroid carcinoma	Enrichment	HRAS	2.03
102	Overgrowth syndrome	Enrichment	PIK3R1	2.03
103	Hypothyroidism	Enrichment	GNB1	1.98
104	Difference of sex development	Enrichment	AR	1.98
105	Microcephaly	Enrichment	GNB1, MAPK1	1.95
106	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.93
107	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.88
108	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.84
109	Myelodysplastic syndrome	Enrichment	GNB1	1.84
110	46,xy complete gonadal dysgenesis	Enrichment	AR	1.84
111	Specific learning disability	Enrichment	MAPK1	1.84
112	Osteoporosis	Enrichment	SRC	1.73
113	Lynch syndrome	Enrichment	PIK3CA	1.70
114	Rhabdomyosarcoma	Enrichment	HRAS	1.68
115	Cleft palate, isolated	Enrichment	GNB1	1.65
116	Heart, malformation of	Enrichment	MAPK1	1.63
117	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	GNRH1	1.63
118	Endometrial cancer	Enrichment	PIK3CA	1.56
119	Hepatocellular carcinoma	Enrichment	PIK3CA	1.54
120	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.50
121	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.47
122	Strabismus	Enrichment	GNB1	1.45
123	Differentiated thyroid carcinoma	Enrichment	HRAS	1.42
124	Non-immune hydrops fetalis	Enrichment	HRAS	1.39
125	Lung cancer	Enrichment	PIK3CA	1.38
126	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.37
127	Male infertility	Enrichment	AR	1.35
128	Left ventricular noncompaction	Enrichment	RAF1	1.34
129	Dystonia	Enrichment	GNB1	1.34
130	Cerebral palsy	Enrichment	GNB1	1.30
131	Gastric cancer	Enrichment	PIK3CA	1.26
132	Thrombocytopenia	Enrichment	SRC	1.21
133	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.19
134	Hypertelorism	Enrichment	PIK3CA	1.17
135	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.17
136	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	1.14
137	Dilated cardiomyopathy	Enrichment	RAF1	1.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nongenotropic Androgen signaling

Pathway Network for Nongenotropic Androgen signaling

Member Pathways for Nongenotropic Androgen signaling

Pathways in the Nongenotropic Androgen signaling SuperPath

Associated Genes for Nongenotropic Androgen signaling

Associated Disorders for Nongenotropic Androgen signaling

Disorders associated with Nongenotropic Androgen signaling SuperPath

STRING Interaction Network for Nongenotropic Androgen signaling

Sources for Nongenotropic Androgen signaling