Notch-mediated HES/HEY network

No Pathway Network information available for Notch-mediated HES/HEY network

Pathways in the Notch-mediated HES/HEY network SuperPath

#	Name	Source	Genes
1	Notch-mediated HES/HEY network	PubChem	AR ARNT ASCL1 BGLAP CAMK2D CD4 CDKN1B CREBBP CTBP1 E2F1 EP300 GAA GATA1 GATA4 GATA6 GHR HDAC1 HES1 HES6 HEY1 HEY2 HIF1A JAK2 KDM1A KDR MAML1 MYB MYOD1 NCOA1 NEUROG3 NOTCH1 PARP1 PTF1A PTGDS RB1 RBBP8 RBPJ RCAN1 RUNX2 SPEN STAT3 TCF3 TLE1 TWIST1 YY1 (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HES6	Hes Family BHLH Transcription Factor 6	Protein Coding	1
2	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
3	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
4	MYOD1	Myogenic Differentiation 1	Protein Coding	1
5	SPEN	Spen Family Transcriptional Repressor	Protein Coding	1
6	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
7	RCAN1	Regulator Of Calcineurin 1	Protein Coding	1
8	GAA	Alpha Glucosidase	Protein Coding	1
9	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	1
10	GHR	Growth Hormone Receptor	Protein Coding	1
11	GATA1	GATA Binding Protein 1	Protein Coding	1
12	CD4	CD4 Molecule	Protein Coding	1
13	GATA6	GATA Binding Protein 6	Protein Coding	1
14	GATA4	GATA Binding Protein 4	Protein Coding	1
15	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
16	AR	Androgen Receptor	Protein Coding	1
17	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
18	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	1
19	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
20	NOTCH1	Notch Receptor 1	Protein Coding	1
21	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
22	E2F1	E2F Transcription Factor 1	Protein Coding	1
23	PTGDS	Prostaglandin D2 Synthase	Protein Coding	1
24	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
25	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	1
26	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	1
27	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
28	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
29	KDM1A	Lysine Demethylase 1A	Protein Coding	1
30	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
31	YY1	YY1 Transcription Factor	Protein Coding	1
32	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
33	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
34	NEUROG3	Neurogenin 3	Protein Coding	1
35	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
36	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
37	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
38	PTF1A	Pancreas Associated Transcription Factor 1a	Protein Coding	1
39	TCF3	Transcription Factor 3	Protein Coding	1
40	JAK2	Janus Kinase 2	Protein Coding	1
41	KDR	Kinase Insert Domain Receptor	Protein Coding	1
42	PARP1	Poly(ADP-Ribose) Polymerase 1	Protein Coding	1
43	HDAC1	Histone Deacetylase 1	Protein Coding	1
44	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
45	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1

Disorders associated with Notch-mediated HES/HEY network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tetralogy of fallot	Enrichment	GATA4, GATA6, HEY2, KDR, NOTCH1	7.70
2	Acute basophilic leukemia	Enrichment	GATA1, MYB	4.97
3	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.49
4	Congenital heart defects, multiple types, 4	Enrichment	GATA4, GATA6	3.97
5	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.80
6	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.80
7	Adams-oliver syndrome	Enrichment	NOTCH1, RBPJ	3.65
8	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4, NOTCH1	3.02
9	Heart disease	Enrichment	CREBBP, GATA4	3.02
10	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.96
11	Patent foramen ovale	Enrichment	GATA4, GATA6	2.80
12	Diffuse large b-cell lymphoma	Enrichment	CREBBP, STAT3	2.75
13	Familial atrial fibrillation	Enrichment	GATA4, GATA6	2.55
14	Glycoprotein storage disease	Enrichment	GAA	2.48
15	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.48
16	Androgen insensitivity, partial	Enrichment	AR	2.48
17	Anemia, congenital, nonspherocytic hemolytic, 9	Enrichment	GATA1	2.48
18	Thrombocytopenia, x-linked, with or without dyserythropoietic anemia	Enrichment	GATA1	2.48
19	Thrombocytopenia with beta-thalassemia, x-linked	Enrichment	GATA1	2.48
20	Seckel syndrome 2	Enrichment	RBBP8	2.48
21	Diarrhea 4, malabsorptive, congenital, with diabetes mellitus and combined pituitary hormone deficiency	Enrichment	NEUROG3	2.48
22	Pancreatic and cerebellar agenesis	Enrichment	PTF1A	2.48
23	Atrioventricular septal defect 4	Enrichment	GATA4	2.48
24	Atrioventricular septal defect 5	Enrichment	GATA6	2.48
25	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	2.48
26	Anemia, x-linked, with or without neutropenia and/or platelet abnormalities	Enrichment	GATA1	2.48
27	Okt4 epitope deficiency	Enrichment	CD4	2.48
28	Laron syndrome	Enrichment	GHR	2.48
29	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.48
30	Jawad syndrome	Enrichment	RBBP8	2.48
31	Growth hormone insensitivity, partial	Enrichment	GHR	2.48
32	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	2.48
33	Neuroendocrine tumor	Enrichment	CDKN1B	2.48
34	Atrial septal defect 2	Enrichment	GATA4	2.48
35	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.48
36	Congenital myopathy 17	Enrichment	MYOD1	2.48
37	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.48
38	Radio-tartaglia syndrome	Enrichment	SPEN	2.48
39	Atrial septal defect 9	Enrichment	GATA6	2.48
40	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.48
41	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.48
42	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.48
43	Immunodeficiency 79	Enrichment	CD4	2.48
44	Tufted angioma of skin	Enrichment	KDR	2.48
45	Trilateral retinoblastoma	Enrichment	RB1	2.48
46	Acute megakaryoblastic leukemia in children with down syndrome	Enrichment	GATA1	2.48
47	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.48
48	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.48
49	Thrombocytopenia with congenital dyserythropoietic anemia	Enrichment	GATA1	2.48
50	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.48
51	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.48
52	Pompe disease, late-onset	Enrichment	GAA	2.48
53	Complete androgen insensitivity syndrome	Enrichment	AR	2.48
54	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.48
55	Menke-hennekam syndrome	Enrichment	CREBBP	2.48
56	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.48
57	Lung oat cell carcinoma	Enrichment	RB1	2.48
58	Ovarian cancer	Enrichment	AR, CDKN1B, RB1	2.34
59	Myeloproliferative syndrome, transient	Enrichment	GATA1	2.18
60	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	2.18
61	Pancreas, dorsal, agenesis of	Enrichment	PTF1A	2.18
62	Robinow-sorauf syndrome	Enrichment	TWIST1	2.18
63	Thumb deformity	Enrichment	CREBBP	2.18
64	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.18
65	Porphyria, congenital erythropoietic	Enrichment	GATA1	2.18
66	Kallikrein, decreased urinary activity of	Enrichment	PTF1A	2.18
67	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.18
68	Growth hormone deficiency, isolated partial	Enrichment	GHR	2.18
69	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.18
70	Angioma, tufted	Enrichment	KDR	2.18
71	Thrombocythemia 3	Enrichment	JAK2	2.18
72	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.18
73	Adams-oliver syndrome 3	Enrichment	RBPJ	2.18
74	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	2.18
75	Gabriele-de vries syndrome	Enrichment	YY1	2.18
76	Sweeney-cox syndrome	Enrichment	TWIST1	2.18
77	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.18
78	46,xy sex reversal 1	Enrichment	AR	2.18
79	Androgen insensitivity syndrome	Enrichment	AR	2.18
80	Menke-hennekam syndrome 2	Enrichment	EP300	2.18
81	Hypospadias 1, x-linked	Enrichment	AR	2.18
82	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.18
83	Pancreatic agenesis 2	Enrichment	PTF1A	2.18
84	46,xy sex reversal 3	Enrichment	GATA4	2.18
85	Angiocentric glioma	Enrichment	MYB	2.18
86	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.18
87	Insulinoma	Enrichment	YY1	2.18
88	Polycythemia	Enrichment	JAK2	2.18
89	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	2.18
90	Hypereosinophilic syndrome	Enrichment	JAK2	2.18
91	Posterior hypospadias	Enrichment	AR	2.18
92	Familial retinoblastoma	Enrichment	RB1	2.18
93	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	2.18
94	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	2.18
95	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	HEY2, NOTCH1	2.03
96	Cleidocranial dysplasia 1	Enrichment	RUNX2	2.00
97	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.00
98	Craniosynostosis 1	Enrichment	TWIST1	2.00
99	Retinoblastoma	Enrichment	RB1	2.00
100	Glycogen storage disease iv	Enrichment	GAA	2.00
101	Polycythemia vera	Enrichment	JAK2	2.00
102	Pompe disease, infantile-onset	Enrichment	GAA	2.00
103	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	2.00
104	Osteogenic sarcoma	Enrichment	RB1	2.00
105	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.00
106	Hypotrichosis 8	Enrichment	RB1	2.00
107	Tethered spinal cord syndrome	Enrichment	CREBBP	2.00
108	Hyper ige syndrome	Enrichment	STAT3	2.00
109	Cleidocranial dysplasia	Enrichment	RUNX2	2.00
110	Squamous cell carcinoma	Enrichment	RB1	2.00
111	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.00
112	Bone osteosarcoma	Enrichment	RB1	2.00
113	Adenoid cystic carcinoma	Enrichment	MYB	2.00
114	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	2.00
115	Enchondromatosis	Enrichment	HIF1A	2.00
116	Keratoacanthoma	Enrichment	NOTCH1	2.00
117	Erythrocytosis, familial, 1	Enrichment	JAK2	1.88
118	Small cell cancer of the lung	Enrichment	RB1	1.88
119	Glycogen storage disease ia	Enrichment	GAA	1.88
120	Down syndrome	Enrichment	GATA1	1.88
121	Budd-chiari syndrome	Enrichment	JAK2	1.88
122	Saethre-chotzen syndrome	Enrichment	TWIST1	1.88
123	Lynch syndrome 4	Enrichment	RB1	1.88
124	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	1.88
125	Primary hyperparathyroidism	Enrichment	CDKN1B	1.88
126	Transposition of the great arteries	Enrichment	GATA4	1.88
127	Haddad syndrome	Enrichment	ASCL1	1.88
128	Middle aortic syndrome	Enrichment	GATA6	1.88
129	Myeloma, multiple	Enrichment	CREBBP, TCF3	1.83
130	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR, GATA4	1.83
131	Primary ovarian insufficiency	Enrichment	JAK2, KDR	1.79
132	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.78
133	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.78
134	Ventricular septal defect 1	Enrichment	GATA4	1.78
135	Myeloproliferative neoplasm	Enrichment	JAK2	1.78
136	Acute megakaryocytic leukemia	Enrichment	GATA1	1.78
137	Persistent truncus arteriosus	Enrichment	GATA6	1.78
138	Myopathy, centronuclear, 1	Enrichment	MYOD1	1.70
139	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.70
140	Conotruncal heart malformations	Enrichment	GATA6	1.70
141	Hemangioma, capillary infantile	Enrichment	KDR	1.70
142	Hypertrichosis	Enrichment	CREBBP	1.70
143	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.64
144	Myelofibrosis	Enrichment	JAK2	1.64
145	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.64
146	Essential thrombocythemia	Enrichment	JAK2	1.64
147	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.58
148	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.58
149	Difference of sex development	Enrichment	AR	1.58
150	Charge syndrome	Enrichment	EP300	1.53
151	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.53
152	Autosomal non-syndromic agammaglobulinemia	Enrichment	TCF3	1.49
153	46,xy complete gonadal dysgenesis	Enrichment	AR	1.44
154	Glycogen storage disease	Enrichment	GAA	1.44
155	Specific learning disability	Enrichment	GHR	1.44
156	Lip and oral cavity carcinoma	Enrichment	RB1	1.41
157	Aortic valve disease 1	Enrichment	NOTCH1	1.37
158	Diaphragmatic hernia, congenital	Enrichment	GATA6	1.37
159	Hypercholesterolemia, familial, 1	Enrichment	GHR	1.37
160	Acute promyelocytic leukemia	Enrichment	STAT3	1.37
161	Chromosome 1p36 deletion syndrome	Enrichment	SPEN	1.37
162	Protein-deficiency anemia	Enrichment	GATA1	1.37
163	Lung cancer susceptibility 3	Enrichment	RB1	1.34
164	Seckel syndrome	Enrichment	RBBP8	1.34
165	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.34
166	Polydactyly, postaxial, type a1	Enrichment	EP300	1.31
167	Corpus callosum, agenesis of	Enrichment	CREBBP	1.31
168	Familial hypercholesterolemia	Enrichment	GHR	1.31
169	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.31
170	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.31
171	Creatine phosphokinase, elevated serum	Enrichment	GAA	1.29
172	Isolated elevated serum creatine phosphokinase levels	Enrichment	GAA	1.29
173	Heart, malformation of	Enrichment	GATA4	1.24
174	Maturity-onset diabetes of the young	Enrichment	PTF1A	1.19
175	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, RB1	1.15
176	Diamond-blackfan anemia 1	Enrichment	GATA1	1.13
177	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB	1.13
178	Scoliosis	Enrichment	CREBBP	1.12
179	Pancreatic cancer	Enrichment	RBBP8	1.10
180	Bladder cancer	Enrichment	RB1	1.04
181	Prostate cancer	Enrichment	AR	1.04
182	Connective tissue disease	Enrichment	NOTCH1	1.00
183	Male infertility	Enrichment	AR	0.97
184	Diamond-blackfan anemia	Enrichment	GATA1	0.95
185	Fetal akinesia deformation sequence 1	Enrichment	MYOD1	0.94
186	Leukemia, acute myeloid	Enrichment	JAK2	0.90
187	Myopathy	Enrichment	GAA	0.90
188	Type 2 diabetes mellitus	Enrichment	RBPJ	0.88
189	Distal arthrogryposis	Enrichment	MYOD1	0.88
190	Nephrotic syndrome	Enrichment	RUNX2	0.88
191	Thrombocytopenia	Enrichment	GATA1	0.83
192	Autism	Enrichment	CREBBP	0.67
193	Rare genetic deafness	Enrichment	GAA	0.64
194	Dilated cardiomyopathy	Enrichment	GATA6	0.63
195	Colorectal cancer	Enrichment	EP300	0.60
196	Congenital nervous system abnormality	Enrichment	CREBBP	0.53
197	Nervous system disease	Enrichment	CREBBP	0.53
198	Autism spectrum disorder	Enrichment	SPEN	0.52
199	Microcephaly	Enrichment	EP300	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Notch-mediated HES/HEY network

Pathway Network for Notch-mediated HES/HEY network

Member Pathways for Notch-mediated HES/HEY network

Pathways in the Notch-mediated HES/HEY network SuperPath

Associated Genes for Notch-mediated HES/HEY network

Associated Disorders for Notch-mediated HES/HEY network

Disorders associated with Notch-mediated HES/HEY network SuperPath

STRING Interaction Network for Notch-mediated HES/HEY network

Sources for Notch-mediated HES/HEY network