NOTCH1 regulation of endothelial cell calcification

No Pathway Network information available for NOTCH1 regulation of endothelial cell calcification

Pathways in the NOTCH1 regulation of endothelial cell calcification SuperPath

#	Name	Source	Genes
1	NOTCH1 regulation of endothelial cell calcification	WikiPathways	ALPL CALU DLL1 DLL3 DLL4 FGFR3 GJA5 ITGA1 JAG1 JAG2 LPAR1 NOTCH1 SAT1 SOX6 VEGFA (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CALU	Calumenin	Protein Coding	1
2	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
3	SAT1	Spermidine/Spermine N1-Acetyltransferase 1	Protein Coding	1
4	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
5	NOTCH1	Notch Receptor 1	Protein Coding	1
6	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
7	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
8	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
9	GJA5	Gap Junction Protein Alpha 5	Protein Coding	1
10	ALPL	Alkaline Phosphatase, Biomineralization Associated	Protein Coding	1
11	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
12	LPAR1	Lysophosphatidic Acid Receptor 1	Protein Coding	1
13	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
14	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
15	SOX6	SRY-Box Transcription Factor 6	Protein Coding	1

Disorders associated with NOTCH1 regulation of endothelial cell calcification SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tetralogy of fallot	Enrichment	GJA5, JAG1, NOTCH1	5.55
2	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1	4.62
3	Hepatoblastoma	Enrichment	FGFR3, JAG1	3.63
4	Connective tissue disease	Enrichment	FGFR3, NOTCH1	3.26
5	Hypochondroplasia	Enrichment	FGFR3	2.96
6	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.96
7	Muenke syndrome	Enrichment	FGFR3	2.96
8	Hypophosphatasia, adult	Enrichment	ALPL	2.96
9	Hypophosphatasia, childhood	Enrichment	ALPL	2.96
10	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.96
11	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.96
12	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.96
13	Adams-oliver syndrome 6	Enrichment	DLL4	2.96
14	Tolchin-le caignec syndrome	Enrichment	SOX6	2.96
15	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.96
16	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.96
17	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.96
18	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.96
19	Prenatal benign hypophosphatasia	Enrichment	ALPL	2.96
20	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.96
21	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.96
22	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.96
23	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.96
24	Atrial standstill 1	Enrichment	GJA5	2.66
25	Cervical cancer	Enrichment	FGFR3	2.66
26	Keratosis, seborrheic	Enrichment	FGFR3	2.66
27	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.66
28	Atrial fibrillation, familial, 11	Enrichment	GJA5	2.66
29	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ALPL	2.66
30	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.66
31	Hypophosphatasia	Enrichment	ALPL	2.66
32	Cervix carcinoma	Enrichment	FGFR3	2.66
33	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ALPL	2.66
34	Crouzon syndrome	Enrichment	FGFR3	2.48
35	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR3	2.48
36	Achondroplasia	Enrichment	FGFR3	2.48
37	Larsen syndrome	Enrichment	FGFR3	2.48
38	Alagille syndrome 1	Enrichment	JAG1	2.48
39	Hypophosphatasia, infantile	Enrichment	ALPL	2.48
40	Keratosis follicularis spinulosa decalvans	Enrichment	SAT1	2.48
41	Hamartoma	Enrichment	FGFR3	2.48
42	Testicular germ cell cancer	Enrichment	FGFR3	2.48
43	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	2.48
44	Spermatocytoma	Enrichment	FGFR3	2.48
45	Testicular cancer	Enrichment	FGFR3	2.48
46	Keratoacanthoma	Enrichment	NOTCH1	2.48
47	Saethre-chotzen syndrome	Enrichment	FGFR3	2.35
48	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	2.35
49	Pediatric systemic lupus erythematosus	Enrichment	SAT1	2.35
50	Middle aortic syndrome	Enrichment	JAG1	2.35
51	Hemifacial hyperplasia	Enrichment	FGFR3	2.26
52	Aplasia cutis congenita	Enrichment	DLL4	2.26
53	Testicular germ cell tumor	Enrichment	FGFR3	2.18
54	Lung squamous cell carcinoma	Enrichment	FGFR3	2.18
55	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3	2.18
56	46,xy disorder of sex development	Enrichment	FGFR3	2.18
57	Nevus, epidermal	Enrichment	FGFR3	2.11
58	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	2.05
59	Hypoplastic left heart syndrome	Enrichment	NOTCH1	2.05
60	Primary bone dysplasia	Enrichment	FGFR3	1.96
61	Osteochondrodysplasia	Enrichment	FGFR3	1.92
62	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.88
63	Aortic valve disease 1	Enrichment	NOTCH1	1.85
64	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.81
65	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.78
66	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.78
67	Gliosarcoma	Enrichment	FGFR3	1.76
68	Microform holoprosencephaly	Enrichment	DLL1	1.76
69	Lobar holoprosencephaly	Enrichment	DLL1	1.76
70	Giant cell glioblastoma	Enrichment	FGFR3	1.73
71	Alobar holoprosencephaly	Enrichment	DLL1	1.73
72	Heart, malformation of	Enrichment	JAG1	1.70
73	Semilobar holoprosencephaly	Enrichment	DLL1	1.70
74	Craniosynostosis	Enrichment	FGFR3	1.66
75	Brittle bone disorder	Enrichment	ALPL	1.60
76	Familial atrial fibrillation	Enrichment	GJA5	1.58
77	Bladder cancer	Enrichment	FGFR3	1.50
78	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.32
79	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	1.27
80	Myeloma, multiple	Enrichment	FGFR3	1.22
81	Colorectal cancer	Enrichment	FGFR3	1.04
82	Congenital nervous system abnormality	Enrichment	FGFR3	0.95
83	Nervous system disease	Enrichment	FGFR3	0.95
84	Hereditary retinal dystrophy	Enrichment	JAG1	0.56
85	Fundus dystrophy	Enrichment	JAG1	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NOTCH1 regulation of endothelial cell calcification

Pathway Network for NOTCH1 regulation of endothelial cell calcification

Member Pathways for NOTCH1 regulation of endothelial cell calcification

Pathways in the NOTCH1 regulation of endothelial cell calcification SuperPath

Associated Genes for NOTCH1 regulation of endothelial cell calcification

Associated Disorders for NOTCH1 regulation of endothelial cell calcification

Disorders associated with NOTCH1 regulation of endothelial cell calcification SuperPath

STRING Interaction Network for NOTCH1 regulation of endothelial cell calcification

Sources for NOTCH1 regulation of endothelial cell calcification