NOTCH2 Activation and Transmission of Signal to the Nucleus

Pathway network for the NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

Sources:

Reactome

Pathways in the NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

#	Name	Source	Genes
1	NOTCH2 Activation and Transmission of Signal to the Nucleus	Reactome	ADAM10 APH1A APH1B CNTN1 DLL1 DLL4 JAG1 JAG2 MDK MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH2 NOTCH2NLA NOTCH2NLB NOTCH2NLC PSEN1 PSEN2 PSENEN RPS27A UBA52 UBB UBC (see all 25) (see less)
2	Signaling by NOTCH2	Reactome	ADAM10 APH1A APH1B CNTN1 CREB1 DLL1 DLL4 EP300 FCER2 HES1 HES5 JAG1 JAG2 MAML1 MAML2 MAML3 MAMLD1 MDK MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH2 NOTCH2NLA NOTCH2NLB NOTCH2NLC PSEN1 PSEN2 PSENEN RBPJ RPS27A UBA52 UBB UBC (see all 35) (see less)
3	Activated NOTCH1 Transmits Signal to the Nucleus	Reactome	ADAM10 ADAM17 APH1A APH1B ARRB1 ARRB2 CNTN1 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 ITCH JAG1 JAG2 MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH1 NUMB PSEN1 PSEN2 PSENEN RPS27A UBA52 UBB UBC (see all 31) (see less)
4	NOTCH3 Activation and Transmission of Signal to the Nucleus	Reactome	ADAM10 APH1A APH1B DLL1 DLL4 EGF EGFR JAG1 JAG2 MIB1 MIB2 NCSTN NEURL1 NEURL1B NOTCH3 PSEN1 PSEN2 PSENEN RPS27A TACC3 UBA52 UBB UBC WWP2 YBX1 (see all 25) (see less)
5	Signaling by NOTCH1 HD Domain Mutants in Cancer	Reactome	ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 MIB1 MIB2 NEURL1 NEURL1B NOTCH1 RPS27A UBA52 UBB UBC (see all 15) (see less)
6	Constitutive Signaling by NOTCH1 HD Domain Mutants	Reactome	ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 MIB1 MIB2 NEURL1 NEURL1B NOTCH1 RPS27A UBA52 UBB UBC (see all 15) (see less)
7	NOTCH2 intracellular domain regulates transcription	Reactome	CREB1 EP300 FCER2 HES1 HES5 MAML1 MAML2 MAML3 MAMLD1 NOTCH2 RBPJ (see all 11) (see less)
8	Noncanonical activation of NOTCH3	Reactome	APH1A APH1B NCSTN NOTCH3 PSEN1 PSEN2 PSENEN YBX1 (see all 8) (see less)
9	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant	Reactome	ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 NOTCH1 (see all 7) (see less)
10	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	Reactome	ADAM10 ADAM17 DLL1 DLL4 JAG1 JAG2 NOTCH1 (see all 7) (see less)

Gene overlap in member pathways for NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	8
2	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	8
3	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	8
4	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	8
5	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	8
6	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	6
7	NEURL1B	Neuralized E3 Ubiquitin Protein Ligase 1B	Protein Coding	6
8	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	6
9	RPS27A	Ribosomal Protein S27a	Protein Coding	6
10	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	6
11	UBB	Ubiquitin B	Protein Coding	6
12	UBC	Ubiquitin C	Protein Coding	6
13	NEURL1	Neuralized E3 Ubiquitin Protein Ligase 1	Protein Coding	6
14	NCSTN	Nicastrin	Protein Coding	5
15	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	5
16	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	5
17	PSEN1	Presenilin 1	Protein Coding	5
18	PSEN2	Presenilin 2	Protein Coding	5
19	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	5
20	NOTCH1	Notch Receptor 1	Protein Coding	5
21	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	5
22	CNTN1	Contactin 1	Protein Coding	3
23	NOTCH2	Notch Receptor 2	Protein Coding	3
24	NOTCH2NLC	Notch 2 N-Terminal Like C	Protein Coding	2
25	NOTCH2NLB	Notch 2 N-Terminal Like B	Protein Coding	2
26	NOTCH2NLA	Notch 2 N-Terminal Like A	Protein Coding	2
27	MDK	Midkine	Protein Coding	2
28	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	2
29	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
30	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
31	FCER2	Fc Epsilon Receptor II	Protein Coding	2
32	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	2
33	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	2
34	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	2
35	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	2
36	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	2
37	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	2
38	NOTCH3	Notch Receptor 3	Protein Coding	2
39	YBX1	Y-Box Binding Protein 1	Protein Coding	2
40	DTX2	Deltex E3 Ubiquitin Ligase 2	Protein Coding	1
41	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
42	DTX4	Deltex E3 Ubiquitin Ligase 4	Protein Coding	1
43	ARRB1	Arrestin Beta 1	Protein Coding	1
44	ARRB2	Arrestin Beta 2	Protein Coding	1
45	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
46	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
47	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
48	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1
49	TACC3	Transforming Acidic Coiled-Coil Containing Protein 3	Protein Coding	1
50	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
51	EGF	Epidermal Growth Factor	Protein Coding	1
52	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-cell acute lymphoblastic leukemia	Direct
2	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	6.04
3	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	5.20
4	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1	3.98
5	Gliosarcoma	Enrichment	EGFR, TACC3	3.41
6	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	3.38
7	Giant cell glioblastoma	Enrichment	EGFR, TACC3	3.36
8	Acne inversa, familial, 1	Enrichment	NCSTN	3.23
9	Lateral meningocele syndrome	Enrichment	NOTCH3	3.23
10	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	3.23
11	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	3.23
12	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	3.23
13	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	3.23
14	Acne inversa, familial, 3	Enrichment	PSEN1	3.23
15	Transient cerebral ischemia	Enrichment	NOTCH3	3.23
16	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	3.23
17	Pash syndrome	Enrichment	NCSTN	3.23
18	Huntington's disease-like	Enrichment	PSEN2	3.23
19	Hajdu-cheney syndrome	Enrichment	NOTCH2	3.09
20	Alagille syndrome 2	Enrichment	NOTCH2	3.09
21	Hypospadias 2, x-linked	Enrichment	MAMLD1	3.09
22	46,xy ovotesticular disorder of sex development	Enrichment	MAMLD1	3.09
23	Alzheimer disease 3	Enrichment	PSEN1	2.93
24	Pick disease of brain	Enrichment	PSEN1	2.93
25	Infantile myofibromatosis	Enrichment	NOTCH3	2.93
26	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.93
27	Depressive disorder	Enrichment	NOTCH3	2.93
28	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	2.80
29	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.79
30	Adams-oliver syndrome 3	Enrichment	RBPJ	2.79
31	Menke-hennekam syndrome 2	Enrichment	EP300	2.79
32	Posterior hypospadias	Enrichment	MAMLD1	2.79
33	X-linked myotubular myopathy-abnormal genitalia syndrome	Enrichment	MAMLD1	2.79
34	Migraine without aura	Enrichment	NOTCH3	2.75
35	Neuronal intranuclear inclusion disease	Enrichment	NOTCH2NLC	2.73
36	Congenital myopathy 12	Enrichment	CNTN1	2.73
37	Oculopharyngodistal myopathy 3	Enrichment	NOTCH2NLC	2.73
38	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.73
39	Adams-oliver syndrome 6	Enrichment	DLL4	2.73
40	Alzheimer disease 18	Enrichment	ADAM10	2.73
41	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.73
42	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.73
43	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.73
44	Hypomagnesemia 4, renal	Enrichment	EGF	2.73
45	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.73
46	Left ventricular noncompaction	Enrichment	MIB1, MIB2	2.73
47	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.64
48	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.64
49	Dowling-degos disease	Enrichment	PSENEN	2.63
50	Cerebrovascular disease	Enrichment	NOTCH3	2.63
51	Melanoma of soft tissue	Enrichment	CREB1	2.61
52	Keratoacanthoma	Enrichment	NOTCH2	2.61
53	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	2.53
54	Vascular dementia	Enrichment	NOTCH3	2.53
55	Dementia	Enrichment	PSEN1	2.53
56	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	2.45
57	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.43
58	Left ventricular noncompaction 7	Enrichment	MIB1	2.43
59	Submucosal cleft palate	Enrichment	UBB	2.43
60	Cleft hard palate	Enrichment	UBB	2.43
61	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	2.43
62	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.39
63	Semantic dementia	Enrichment	PSEN1	2.38
64	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.34
65	Central precocious puberty	Enrichment	DLK1	2.34
66	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.34
67	Rubinstein-taybi syndrome 1	Enrichment	EP300	2.31
68	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	2.31
69	Progressive non-fluent aphasia	Enrichment	PSEN1	2.28
70	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	2.28
71	Alagille syndrome 1	Enrichment	JAG1	2.26
72	Uvula, bifid	Enrichment	UBB	2.26
73	Cleft soft palate	Enrichment	UBB	2.26
74	Tremor, hereditary essential, 6	Enrichment	NOTCH2NLC	2.26
75	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.26
76	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.26
77	Stroke, ischemic	Enrichment	NOTCH3	2.23
78	Migraine with or without aura 1	Enrichment	NOTCH3	2.19
79	Frontotemporal dementia 1	Enrichment	PSEN1	2.19
80	Precocious puberty, central, 2	Enrichment	DLK1	2.16
81	Charge syndrome	Enrichment	EP300	2.14
82	Dowling-degos disease 1	Enrichment	ADAM10	2.13
83	Middle aortic syndrome	Enrichment	JAG1	2.13
84	Alzheimer's disease	Enrichment	PSEN1	2.12
85	Kagami-ogata syndrome	Enrichment	DLK1	2.04
86	Temple syndrome	Enrichment	DLK1	2.04
87	Genetic central precocious puberty in male	Enrichment	DLK1	2.04
88	Aplasia cutis congenita	Enrichment	DLL4	2.04
89	Alzheimer disease, familial, 1	Enrichment	PSEN1	2.00
90	Cowden syndrome 1	Enrichment	EGFR	1.96
91	Lung squamous cell carcinoma	Enrichment	EGFR	1.96
92	Polydactyly, postaxial, type a1	Enrichment	EP300	1.92
93	Rare genetic intellectual disability	Enrichment	EP300	1.92
94	Oculopharyngodistal myopathy 1	Enrichment	NOTCH2NLC	1.89
95	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.89
96	Skin disease	Enrichment	NCSTN	1.89
97	Auditory neuropathy	Enrichment	NOTCH3	1.82
98	Adult hepatocellular carcinoma	Enrichment	EGF	1.78
99	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.74
100	Lung non-small cell carcinoma	Enrichment	EGFR	1.70
101	Lip and oral cavity carcinoma	Enrichment	EGFR	1.66
102	Lung cancer susceptibility 3	Enrichment	EGFR	1.59
103	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.56
104	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.56
105	Microform holoprosencephaly	Enrichment	DLL1	1.54
106	Lobar holoprosencephaly	Enrichment	DLL1	1.54
107	Aortic valve disease 1	Enrichment	NOTCH1	1.53
108	Alobar holoprosencephaly	Enrichment	DLL1	1.51
109	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.50
110	Heart, malformation of	Enrichment	JAG1	1.49
111	Semilobar holoprosencephaly	Enrichment	DLL1	1.49
112	Type 2 diabetes mellitus	Enrichment	RBPJ	1.47
113	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	1.47
114	Arteriovenous malformations of the brain	Enrichment	EGFR	1.46
115	Hepatoblastoma	Enrichment	JAG1	1.42
116	Primary ovarian insufficiency	Enrichment	NOTCH2	1.33
117	Bladder cancer	Enrichment	EGFR	1.28
118	Lung cancer	Enrichment	EGFR	1.24
119	Congenital nervous system abnormality	Enrichment	PSEN1	1.22
120	Nervous system disease	Enrichment	PSEN1	1.22
121	Colorectal cancer	Enrichment	EP300	1.17
122	Connective tissue disease	Enrichment	NOTCH1	1.15
123	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	1.05
124	Microcephaly	Enrichment	EP300	1.02
125	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.02
126	Ovarian cancer	Enrichment	EGFR	0.77
127	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.66
128	Hereditary retinal dystrophy	Enrichment	JAG1	0.38
129	Fundus dystrophy	Enrichment	JAG1	0.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NOTCH2 Activation and Transmission of Signal to the Nucleus

Pathway Network for NOTCH2 Activation and Transmission of Signal to the Nucleus

Pathway network for the NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

Member Pathways for NOTCH2 Activation and Transmission of Signal to the Nucleus

Pathways in the NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

Gene overlap in member pathways for NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

Associated Genes for NOTCH2 Activation and Transmission of Signal to the Nucleus

Associated Disorders for NOTCH2 Activation and Transmission of Signal to the Nucleus

Disorders associated with NOTCH2 Activation and Transmission of Signal to the Nucleus SuperPath

STRING Interaction Network for NOTCH2 Activation and Transmission of Signal to the Nucleus

Sources for NOTCH2 Activation and Transmission of Signal to the Nucleus