Notch Signaling (Qiagen)

No Pathway Network information available for Notch Signaling (Qiagen)

Pathways in the Notch Signaling (Qiagen) SuperPath

#	Name	Source	Genes
1	Notch Signaling	QIAGEN	ADAM17 FBXW7 HAT1 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 LFNG MAML1 MAML2 MAML3 MFNG NCOR2 NCSTN NOTCH1 NOTCH2 NOTCH3 NOTCH4 PSEN1 PSEN2 RBPJ RFNG SNW1 (see all 29) (see less)
2	Notch-HLH transcription pathway	Reactome	CREBBP HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RBPJ SNW1 TBL1X TBL1XR1 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HDAC1	Histone Deacetylase 1	Protein Coding	2
2	HDAC10	Histone Deacetylase 10	Protein Coding	2
3	HDAC11	Histone Deacetylase 11	Protein Coding	2
4	HDAC2	Histone Deacetylase 2	Protein Coding	2
5	HDAC3	Histone Deacetylase 3	Protein Coding	2
6	HDAC5	Histone Deacetylase 5	Protein Coding	2
7	HDAC6	Histone Deacetylase 6	Protein Coding	2
8	HDAC7	Histone Deacetylase 7	Protein Coding	2
9	HDAC8	Histone Deacetylase 8	Protein Coding	2
10	HDAC9	Histone Deacetylase 9	Protein Coding	2
11	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	2
12	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	2
13	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	2
14	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	2
15	NOTCH1	Notch Receptor 1	Protein Coding	2
16	NOTCH2	Notch Receptor 2	Protein Coding	2
17	NOTCH3	Notch Receptor 3	Protein Coding	2
18	NOTCH4	Notch Receptor 4	Protein Coding	2
19	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	2
20	SNW1	SNW Domain Containing 1	Protein Coding	2
21	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
22	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
23	HAT1	Histone Acetyltransferase 1	Protein Coding	1
24	LFNG	LFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
25	MFNG	MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
26	NCSTN	Nicastrin	Protein Coding	1
27	PSEN1	Presenilin 1	Protein Coding	1
28	PSEN2	Presenilin 2	Protein Coding	1
29	RFNG	RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
30	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	1
31	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
32	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
33	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	1
34	TBL1XR1	TBL1X/Y Related 1	Protein Coding	1
35	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
36	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
37	HDAC4	Histone Deacetylase 4	Protein Coding	1

Disorders associated with Notch Signaling (Qiagen) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	4.91
2	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	4.88
3	Adams-oliver syndrome	Enrichment	NOTCH1, RBPJ	4.07
4	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	4.04
5	Myeloma, multiple	Enrichment	CREBBP, HDAC4, NCOR2	3.69
6	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TBL1XR1	3.16
7	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.69
8	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.69
9	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.69
10	Alagille syndrome 2	Enrichment	NOTCH2	2.69
11	Lateral meningocele syndrome	Enrichment	NOTCH3	2.69
12	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.69
13	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.69
14	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.69
15	Hypospadias 2, x-linked	Enrichment	MAMLD1	2.69
16	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.69
17	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.69
18	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.69
19	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.69
20	Transient cerebral ischemia	Enrichment	NOTCH3	2.69
21	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.69
22	Menke-hennekam syndrome	Enrichment	CREBBP	2.69
23	46,xy ovotesticular disorder of sex development	Enrichment	MAMLD1	2.69
24	Spondylocostal dysostosis 3, autosomal recessive	Enrichment	LFNG	2.67
25	Acne inversa, familial, 1	Enrichment	NCSTN	2.67
26	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.67
27	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.67
28	Acne inversa, familial, 3	Enrichment	PSEN1	2.67
29	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.67
30	Pash syndrome	Enrichment	NCSTN	2.67
31	Huntington's disease-like	Enrichment	PSEN2	2.67
32	Thumb deformity	Enrichment	CREBBP	2.38
33	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.38
34	Syndactyly, type iii	Enrichment	HDAC8	2.38
35	Adams-oliver syndrome 3	Enrichment	RBPJ	2.38
36	Infantile myofibromatosis	Enrichment	NOTCH3	2.38
37	Wilson-turner syndrome	Enrichment	HDAC8	2.38
38	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.38
39	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.38
40	Depressive disorder	Enrichment	NOTCH3	2.38
41	Posterior hypospadias	Enrichment	MAMLD1	2.38
42	X-linked myotubular myopathy-abnormal genitalia syndrome	Enrichment	MAMLD1	2.38
43	Alzheimer disease 3	Enrichment	PSEN1	2.37
44	Pick disease of brain	Enrichment	PSEN1	2.37
45	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.37
46	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	2.25
47	Pierpont syndrome	Enrichment	TBL1XR1	2.21
48	Tethered spinal cord syndrome	Enrichment	CREBBP	2.21
49	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.21
50	Migraine without aura	Enrichment	NOTCH3	2.21
51	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	2.21
52	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.19
53	Cerebrovascular disease	Enrichment	NOTCH3	2.08
54	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.99
55	Vascular dementia	Enrichment	NOTCH3	1.99
56	Pervasive developmental disorder	Enrichment	FBXW7	1.97
57	Dementia	Enrichment	PSEN1	1.97
58	Rare pervasive developmental disorder	Enrichment	FBXW7	1.97
59	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.91
60	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.91
61	Hypertrichosis	Enrichment	CREBBP	1.91
62	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.89
63	Spondylocostal dysostosis, autosomal recessive	Enrichment	LFNG	1.89
64	Semantic dementia	Enrichment	PSEN1	1.83
65	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.79
66	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.79
67	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.73
68	Cornelia de lange syndrome	Enrichment	HDAC8	1.73
69	Progressive non-fluent aphasia	Enrichment	PSEN1	1.72
70	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.72
71	Stroke, ischemic	Enrichment	NOTCH3	1.69
72	Migraine with or without aura 1	Enrichment	NOTCH3	1.65
73	Atrial heart septal defect	Enrichment	HDAC8	1.65
74	Interatrial communication	Enrichment	HDAC8	1.65
75	Frontotemporal dementia 1	Enrichment	PSEN1	1.63
76	Aortic valve disease 1	Enrichment	NOTCH1	1.58
77	Acute promyelocytic leukemia	Enrichment	TBL1XR1	1.58
78	Alzheimer's disease	Enrichment	PSEN1	1.56
79	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.54
80	Heart disease	Enrichment	CREBBP	1.54
81	Corpus callosum, agenesis of	Enrichment	CREBBP	1.52
82	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.52
83	Rare genetic intellectual disability	Enrichment	CREBBP	1.52
84	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.52
85	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.45
86	Polycystic kidney disease	Enrichment	HDAC8	1.44
87	Skin disease	Enrichment	NCSTN	1.34
88	Scoliosis	Enrichment	CREBBP	1.31
89	Tetralogy of fallot	Enrichment	NOTCH1	1.28
90	Auditory neuropathy	Enrichment	NOTCH3	1.28
91	Connective tissue disease	Enrichment	NOTCH1	1.19
92	Type 2 diabetes mellitus	Enrichment	RBPJ	1.08
93	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.06
94	Primary ovarian insufficiency	Enrichment	NOTCH2	0.94
95	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.93
96	Autism	Enrichment	CREBBP	0.86
97	Colorectal cancer	Enrichment	FBXW7	0.77
98	Congenital nervous system abnormality	Enrichment	CREBBP	0.70
99	Nervous system disease	Enrichment	CREBBP	0.70
100	Microcephaly	Enrichment	HDAC8	0.65

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Notch Signaling (Qiagen)

Pathway Network for Notch Signaling (Qiagen)

Member Pathways for Notch Signaling (Qiagen)

Pathways in the Notch Signaling (Qiagen) SuperPath

Associated Genes for Notch Signaling (Qiagen)

Associated Disorders for Notch Signaling (Qiagen)

Disorders associated with Notch Signaling (Qiagen) SuperPath

STRING Interaction Network for Notch Signaling (Qiagen)

Sources for Notch Signaling (Qiagen)