Notch signaling (WikiPathways)

No Pathway Network information available for Notch signaling (WikiPathways)

Pathways in the Notch signaling (WikiPathways) SuperPath

#	Name	Source	Genes
1	Notch signaling	WikiPathways	ADAM17 APH1A APH1B CREBBP CTBP1 CTBP2 DLL1 DLL3 DLL4 DTX1 DTX2 DTX3 DTX3L DTX4 DVL1 DVL2 DVL3 HDAC1 HDAC2 HES1 HES5 INPP5K JAG1 JAG2 KAT2A KAT2B KCNJ5 LFNG MAML1 MAML3 MFNG NCOR2 NCSTN NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUMB NUMBL PSEN1 PSEN2 PTCRA RBPJ RBPJL RFNG (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MFNG	MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
2	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
3	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
4	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
5	RFNG	RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
6	PSEN2	Presenilin 2	Protein Coding	1
7	PSEN1	Presenilin 1	Protein Coding	1
8	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	1
9	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
10	INPP5K	Inositol Polyphosphate-5-Phosphatase K	Protein Coding	1
11	NOTCH4	Notch Receptor 4	Protein Coding	1
12	NOTCH3	Notch Receptor 3	Protein Coding	1
13	NOTCH2	Notch Receptor 2	Protein Coding	1
14	NOTCH1	Notch Receptor 1	Protein Coding	1
15	LFNG	LFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
16	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	1
17	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	1
18	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
19	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
20	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
21	HDAC2	Histone Deacetylase 2	Protein Coding	1
22	HDAC1	Histone Deacetylase 1	Protein Coding	1
23	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
24	NCSTN	Nicastrin	Protein Coding	1
25	DTX4	Deltex E3 Ubiquitin Ligase 4	Protein Coding	1
26	DTX3	Deltex E3 Ubiquitin Ligase 3	Protein Coding	1
27	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
28	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
29	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
30	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
31	PTCRA	Pre T Cell Antigen Receptor Alpha	Protein Coding	1
32	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
33	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
34	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
35	DTX2	Deltex E3 Ubiquitin Ligase 2	Protein Coding	1
36	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
37	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
38	DTX3L	Deltex E3 Ubiquitin Ligase 3L	Protein Coding	1
39	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
40	NUMBL	NUMB Like Endocytic Adaptor Protein	Protein Coding	1
41	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
42	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
43	RBPJL	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region Like	Protein Coding	1
44	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
45	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1

Disorders associated with Notch signaling (WikiPathways) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	5.93
2	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	4.49
3	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	4.49
4	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3	4.19
5	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3	4.19
6	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3	3.97
7	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3	3.97
8	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3	3.80
9	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3, LFNG	3.80
10	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	3.65
11	Spondylocostal dysostosis 3, autosomal recessive	Enrichment	LFNG	2.48
12	Long qt syndrome 13	Enrichment	KCNJ5	2.48
13	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.48
14	Alagille syndrome 2	Enrichment	NOTCH2	2.48
15	Acne inversa, familial, 1	Enrichment	NCSTN	2.48
16	Lateral meningocele syndrome	Enrichment	NOTCH3	2.48
17	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.48
18	Adams-oliver syndrome 6	Enrichment	DLL4	2.48
19	Hyperaldosteronism, familial, type iii	Enrichment	KCNJ5	2.48
20	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.48
21	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.48
22	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.48
23	Acne inversa, familial, 3	Enrichment	PSEN1	2.48
24	Muscular dystrophy, congenital, with cataracts and impaired intellectual development	Enrichment	INPP5K	2.48
25	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.48
26	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.48
27	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.48
28	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.48
29	Immunodeficiency 126	Enrichment	PTCRA	2.48
30	Transient cerebral ischemia	Enrichment	NOTCH3	2.48
31	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.48
32	Menke-hennekam syndrome	Enrichment	CREBBP	2.48
33	Pash syndrome	Enrichment	NCSTN	2.48
34	Huntington's disease-like	Enrichment	PSEN2	2.48
35	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	2.48
36	Andersen cardiodysrhythmic periodic paralysis	Enrichment	KCNJ5	2.18
37	Thumb deformity	Enrichment	CREBBP	2.18
38	Alzheimer disease 3	Enrichment	PSEN1	2.18
39	Pick disease of brain	Enrichment	PSEN1	2.18
40	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.18
41	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3	2.18
42	Adams-oliver syndrome 3	Enrichment	RBPJ	2.18
43	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.18
44	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.18
45	Infantile myofibromatosis	Enrichment	NOTCH3	2.18
46	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.18
47	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.18
48	Depressive disorder	Enrichment	NOTCH3	2.18
49	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.18
50	Type 2 diabetes mellitus	Enrichment	RBPJ, RBPJL	2.07
51	Alagille syndrome 1	Enrichment	JAG1	2.00
52	Tethered spinal cord syndrome	Enrichment	CREBBP	2.00
53	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	2.00
54	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.00
55	Migraine without aura	Enrichment	NOTCH3	2.00
56	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.00
57	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.88
58	Cerebrovascular disease	Enrichment	NOTCH3	1.88
59	Middle aortic syndrome	Enrichment	JAG1	1.88
60	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	1.88
61	Myeloma, multiple	Enrichment	CREBBP, NCOR2	1.83
62	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.78
63	Aplasia cutis congenita	Enrichment	DLL4	1.78
64	Vascular dementia	Enrichment	NOTCH3	1.78
65	Dementia	Enrichment	PSEN1	1.78
66	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.70
67	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.70
68	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.70
69	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.70
70	Hypertrichosis	Enrichment	CREBBP	1.70
71	Semantic dementia	Enrichment	PSEN1	1.64
72	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.58
73	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.58
74	Progressive non-fluent aphasia	Enrichment	PSEN1	1.53
75	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.53
76	Stroke, ischemic	Enrichment	NOTCH3	1.49
77	Migraine with or without aura 1	Enrichment	NOTCH3	1.44
78	Frontotemporal dementia 1	Enrichment	PSEN1	1.44
79	Aortic valve disease 1	Enrichment	NOTCH1	1.37
80	Alzheimer's disease	Enrichment	PSEN1	1.37
81	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.34
82	Heart disease	Enrichment	CREBBP	1.34
83	Congenital nervous system abnormality	Enrichment	CREBBP, PSEN1	1.32
84	Nervous system disease	Enrichment	CREBBP, PSEN1	1.32
85	Corpus callosum, agenesis of	Enrichment	CREBBP	1.31
86	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.31
87	Rare genetic intellectual disability	Enrichment	CREBBP	1.31
88	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.31
89	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.31
90	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.31
91	Microform holoprosencephaly	Enrichment	DLL1	1.29
92	Lobar holoprosencephaly	Enrichment	DLL1	1.29
93	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.26
94	Alobar holoprosencephaly	Enrichment	DLL1	1.26
95	Heart, malformation of	Enrichment	JAG1	1.24
96	Semilobar holoprosencephaly	Enrichment	DLL1	1.24
97	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.21
98	Hepatoblastoma	Enrichment	JAG1	1.17
99	Skin disease	Enrichment	NCSTN	1.15
100	Familial atrial fibrillation	Enrichment	KCNJ5	1.12
101	Scoliosis	Enrichment	CREBBP	1.12
102	Auditory neuropathy	Enrichment	NOTCH3	1.08
103	Long qt syndrome 1	Enrichment	KCNJ5	1.02
104	Long qt syndrome	Enrichment	KCNJ5	1.01
105	Connective tissue disease	Enrichment	NOTCH1	1.00
106	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	0.87
107	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.81
108	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.76
109	Primary ovarian insufficiency	Enrichment	NOTCH2	0.75
110	Autism	Enrichment	CREBBP	0.67
111	Hereditary retinal dystrophy	Enrichment	JAG1	0.21
112	Fundus dystrophy	Enrichment	JAG1	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Notch signaling (WikiPathways)

Pathway Network for Notch signaling (WikiPathways)

Member Pathways for Notch signaling (WikiPathways)

Pathways in the Notch signaling (WikiPathways) SuperPath

Associated Genes for Notch signaling (WikiPathways)

Associated Disorders for Notch signaling (WikiPathways)

Disorders associated with Notch signaling (WikiPathways) SuperPath

STRING Interaction Network for Notch signaling (WikiPathways)

Sources for Notch signaling (WikiPathways)