Notch signaling pathway (Pathway Interaction Database)

No Pathway Network information available for Notch signaling pathway (Pathway Interaction Database)

Pathways in the Notch signaling pathway (Pathway Interaction Database) SuperPath

#	Name	Source	Genes
1	Notch signaling pathway	PubChem	ADAM10 ADAM12 APH1A APH1B BTRC CBL CCND1 CDKN1A CNTN1 CNTN6 CTBP1 CUL1 DLK1 DLL1 DLL3 DLL4 DNER DNM1 DTX1 ENO1 EP300 EPS15 FBXW7 FURIN GATA3 HDAC1 IL4 ITCH JAG1 JAG2 KDM1A LNX1 MAML1 MARK2 MFAP5 MIB1 MYC MYCBP NCSTN NEURL1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 NUMB PSENEN PTCRA RAB11A RBBP8 RBPJ SKP1 SKP2 SPEN YY1 (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LNX1	Ligand Of Numb-Protein X 1	Protein Coding	1
2	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
3	MFAP5	Microfibril Associated Protein 5	Protein Coding	1
4	NEURL1	Neuralized E3 Ubiquitin Protein Ligase 1	Protein Coding	1
5	SPEN	Spen Family Transcriptional Repressor	Protein Coding	1
6	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
7	MARK2	Microtubule Affinity Regulating Kinase 2	Protein Coding	1
8	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
9	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
10	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
11	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	1
12	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	1
13	MYCBP	MYC Binding Protein	Protein Coding	1
14	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
15	IL4	Interleukin 4	Protein Coding	1
16	GATA3	GATA Binding Protein 3	Protein Coding	1
17	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
18	PTCRA	Pre T Cell Antigen Receptor Alpha	Protein Coding	1
19	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
20	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
21	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
22	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
23	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1
24	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
25	NOTCH1	Notch Receptor 1	Protein Coding	1
26	CCND1	Cyclin D1	Protein Coding	1
27	NOTCH4	Notch Receptor 4	Protein Coding	1
28	NOTCH2	Notch Receptor 2	Protein Coding	1
29	NOTCH3	Notch Receptor 3	Protein Coding	1
30	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
31	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
32	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
33	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
34	KDM1A	Lysine Demethylase 1A	Protein Coding	1
35	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
36	YY1	YY1 Transcription Factor	Protein Coding	1
37	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
38	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
39	DNM1	Dynamin 1	Protein Coding	1
40	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
41	NCSTN	Nicastrin	Protein Coding	1
42	CNTN1	Contactin 1	Protein Coding	1
43	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
44	CNTN6	Contactin 6	Protein Coding	1
45	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	1
46	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	1
47	CUL1	Cullin 1	Protein Coding	1
48	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	1
49	ENO1	Enolase 1	Protein Coding	1
50	CBL	Cbl Proto-Oncogene	Protein Coding	1
51	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
52	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
53	HDAC1	Histone Deacetylase 1	Protein Coding	1
54	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1

Disorders associated with Notch signaling pathway (Pathway Interaction Database) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	5.69
2	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	4.33
3	Seckel syndrome 2	Enrichment	RBBP8	2.40
4	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.40
5	Alagille syndrome 2	Enrichment	NOTCH2	2.40
6	Acne inversa, familial, 1	Enrichment	NCSTN	2.40
7	Lateral meningocele syndrome	Enrichment	NOTCH3	2.40
8	Congenital myopathy 12	Enrichment	CNTN1	2.40
9	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.40
10	Adams-oliver syndrome 6	Enrichment	DLL4	2.40
11	Intellectual developmental disorder, autosomal dominant 76	Enrichment	MARK2	2.40
12	Aortic aneurysm, familial thoracic 9	Enrichment	MFAP5	2.40
13	Jawad syndrome	Enrichment	RBBP8	2.40
14	Alzheimer disease 18	Enrichment	ADAM10	2.40
15	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.40
16	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.40
17	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.40
18	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.40
19	Radio-tartaglia syndrome	Enrichment	SPEN	2.40
20	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.40
21	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.40
22	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.40
23	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.40
24	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.40
25	Immunodeficiency 126	Enrichment	PTCRA	2.40
26	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.40
27	Transient cerebral ischemia	Enrichment	NOTCH3	2.40
28	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.40
29	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.40
30	Pash syndrome	Enrichment	NCSTN	2.40
31	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	2.32
32	Colorectal cancer	Enrichment	CCND1, EP300, FBXW7	2.30
33	Burkitt lymphoma	Enrichment	MYC	2.10
34	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	2.10
35	Ovarian germ cell cancer	Enrichment	CBL	2.10
36	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.10
37	Adams-oliver syndrome 3	Enrichment	RBPJ	2.10
38	Gabriele-de vries syndrome	Enrichment	YY1	2.10
39	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.10
40	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.10
41	Menke-hennekam syndrome 2	Enrichment	EP300	2.10
42	Infantile myofibromatosis	Enrichment	NOTCH3	2.10
43	Left ventricular noncompaction 7	Enrichment	MIB1	2.10
44	Central precocious puberty	Enrichment	DLK1	2.10
45	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.10
46	Depressive disorder	Enrichment	NOTCH3	2.10
47	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.10
48	Insulinoma	Enrichment	YY1	2.10
49	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	2.10
50	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	2.10
51	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	2.10
52	Malignant germ cell tumor of ovary	Enrichment	CBL	2.10
53	Autism spectrum disorder	Enrichment	CNTN6, MARK2, SPEN	2.03
54	Alagille syndrome 1	Enrichment	JAG1	1.92
55	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.92
56	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.92
57	Precocious puberty, central, 2	Enrichment	DLK1	1.92
58	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	1.92
59	Migraine without aura	Enrichment	NOTCH3	1.92
60	End stage renal disease	Enrichment	GATA3	1.92
61	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.92
62	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MFAP5, NOTCH1	1.88
63	Dowling-degos disease 1	Enrichment	ADAM10	1.80
64	Kagami-ogata syndrome	Enrichment	DLK1	1.80
65	Temple syndrome	Enrichment	DLK1	1.80
66	Mantle cell lymphoma	Enrichment	CCND1	1.80
67	Dowling-degos disease	Enrichment	PSENEN	1.80
68	Cerebrovascular disease	Enrichment	NOTCH3	1.80
69	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	1.80
70	Genetic central precocious puberty in male	Enrichment	DLK1	1.80
71	Middle aortic syndrome	Enrichment	JAG1	1.80
72	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1, RAB11A	1.77
73	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.70
74	Von hippel-lindau syndrome	Enrichment	CCND1	1.70
75	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.70
76	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.70
77	Pervasive developmental disorder	Enrichment	FBXW7	1.70
78	Myeloproliferative neoplasm	Enrichment	CBL	1.70
79	Aplasia cutis congenita	Enrichment	DLL4	1.70
80	Vascular dementia	Enrichment	NOTCH3	1.70
81	Aggressive systemic mastocytosis	Enrichment	CBL	1.70
82	Rare pervasive developmental disorder	Enrichment	FBXW7	1.70
83	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.63
84	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.63
85	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.63
86	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3	1.63
87	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.56
88	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.50
89	Lennox-gastaut syndrome	Enrichment	DNM1	1.50
90	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.50
91	Isolated split hand-split foot malformation	Enrichment	BTRC	1.50
92	Charge syndrome	Enrichment	EP300	1.45
93	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.41
94	Stroke, ischemic	Enrichment	NOTCH3	1.41
95	Migraine with or without aura 1	Enrichment	NOTCH3	1.37
96	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.33
97	Aortic valve disease 1	Enrichment	NOTCH1	1.30
98	Chromosome 1p36 deletion syndrome	Enrichment	SPEN	1.30
99	Stereotypic movement disorder	Enrichment	DNM1	1.30
100	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.26
101	Seckel syndrome	Enrichment	RBBP8	1.26
102	Polydactyly, postaxial, type a1	Enrichment	EP300	1.24
103	Rare genetic intellectual disability	Enrichment	EP300	1.24
104	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.24
105	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.24
106	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.24
107	Rhabdomyosarcoma	Enrichment	CBL	1.21
108	Isolated congenital microcephaly	Enrichment	RAB11A	1.21
109	Microform holoprosencephaly	Enrichment	DLL1	1.21
110	Lobar holoprosencephaly	Enrichment	DLL1	1.21
111	Alobar holoprosencephaly	Enrichment	DLL1	1.18
112	Heart, malformation of	Enrichment	JAG1	1.16
113	Semilobar holoprosencephaly	Enrichment	DLL1	1.16
114	Hepatoblastoma	Enrichment	JAG1	1.09
115	Skin disease	Enrichment	NCSTN	1.08
116	Noonan syndrome 1	Enrichment	CBL	1.06
117	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.06
118	Pancreatic cancer	Enrichment	RBBP8	1.02
119	Rasopathy	Enrichment	CBL	1.01
120	Auditory neuropathy	Enrichment	NOTCH3	1.01
121	Bladder cancer	Enrichment	CDKN1A	0.96
122	Connective tissue disease	Enrichment	NOTCH1	0.92
123	Cakut	Enrichment	GATA3	0.90
124	Left ventricular noncompaction	Enrichment	MIB1	0.88
125	Type 2 diabetes mellitus	Enrichment	RBPJ	0.81
126	West syndrome	Enrichment	DNM1	0.79
127	Myeloma, multiple	Enrichment	CCND1	0.70
128	Undetermined early-onset epileptic encephalopathy	Enrichment	DNM1	0.70
129	Schizophrenia	Enrichment	CNTN6	0.68
130	Primary ovarian insufficiency	Enrichment	NOTCH2	0.68
131	Autism	Enrichment	CNTN6	0.60
132	Microcephaly	Enrichment	EP300	0.41
133	Hereditary retinal dystrophy	Enrichment	JAG1	0.16
134	Fundus dystrophy	Enrichment	JAG1	0.16

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Notch signaling pathway (Pathway Interaction Database)

Pathway Network for Notch signaling pathway (Pathway Interaction Database)

Member Pathways for Notch signaling pathway (Pathway Interaction Database)

Pathways in the Notch signaling pathway (Pathway Interaction Database) SuperPath

Associated Genes for Notch signaling pathway (Pathway Interaction Database)

Associated Disorders for Notch signaling pathway (Pathway Interaction Database)

Disorders associated with Notch signaling pathway (Pathway Interaction Database) SuperPath

STRING Interaction Network for Notch signaling pathway (Pathway Interaction Database)

Sources for Notch signaling pathway (Pathway Interaction Database)