Notch Signaling Pathway (sino)

No Pathway Network information available for Notch Signaling Pathway (sino)

Pathways in the Notch Signaling Pathway (sino) SuperPath

#	Name	Source	Genes
1	Notch Signaling Pathway	Sino Biological	ADAM10 ADAM12 ADAM15 ADAM17 ADAM22 ADAM7 ADAM9 APH1A C1R CDK8 CRB1 CRB3 CTBP1 CTBP2 DTX1 DTX3 FBXW7 FURIN HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC8 NEDD4 POFUT1 RBPJ SNW1 TBK1 (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
2	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	1
3	ADAM15	ADAM Metallopeptidase Domain 15	Protein Coding	1
4	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
5	ADAM22	ADAM Metallopeptidase Domain 22	Protein Coding	1
6	ADAM7	ADAM Metallopeptidase Domain 7	Protein Coding	1
7	ADAM9	ADAM Metallopeptidase Domain 9	Protein Coding	1
8	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
9	C1R	Complement C1r	Protein Coding	1
10	CDK8	Cyclin Dependent Kinase 8	Protein Coding	1
11	CRB1	Crumbs Cell Polarity Complex Component 1	Protein Coding	1
12	CRB3	Crumbs Cell Polarity Complex Component 3	Protein Coding	1
13	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
14	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
15	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
16	DTX3	Deltex E3 Ubiquitin Ligase 3	Protein Coding	1
17	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
18	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
19	HDAC1	Histone Deacetylase 1	Protein Coding	1
20	HDAC10	Histone Deacetylase 10	Protein Coding	1
21	HDAC11	Histone Deacetylase 11	Protein Coding	1
22	HDAC2	Histone Deacetylase 2	Protein Coding	1
23	HDAC3	Histone Deacetylase 3	Protein Coding	1
24	HDAC4	Histone Deacetylase 4	Protein Coding	1
25	HDAC8	Histone Deacetylase 8	Protein Coding	1
26	NEDD4	NEDD4 E3 Ubiquitin Protein Ligase	Protein Coding	1
27	POFUT1	Protein O-Fucosyltransferase 1	Protein Coding	1
28	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
29	SNW1	SNW Domain Containing 1	Protein Coding	1
30	TBK1	TANK Binding Kinase 1	Protein Coding	1

Disorders associated with Notch Signaling Pathway (sino) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pigmented paravenous chorioretinal atrophy	Enrichment	CRB1	2.66
2	Cone-rod dystrophy 9	Enrichment	ADAM9	2.66
3	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.66
4	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.66
5	Retinitis pigmentosa 12	Enrichment	CRB1	2.66
6	Alzheimer disease 18	Enrichment	ADAM10	2.66
7	Dowling-degos disease 2	Enrichment	POFUT1	2.66
8	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.66
9	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.66
10	Leber congenital amaurosis 8	Enrichment	CRB1	2.66
11	Developmental and epileptic encephalopathy 61	Enrichment	ADAM22	2.66
12	Corticobasal syndrome	Enrichment	TBK1	2.66
13	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.66
14	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.66
15	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.66
16	Pigmented paravenous retinochoroidal atrophy	Enrichment	CRB1	2.66
17	Ebstein anomaly	Enrichment	CDK8	2.35
18	Retinitis pigmentosa 13	Enrichment	CRB1	2.35
19	Syndactyly, type iii	Enrichment	HDAC8	2.35
20	Adams-oliver syndrome 3	Enrichment	RBPJ	2.35
21	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.35
22	Retinitis pigmentosa-deafness syndrome	Enrichment	CRB1	2.35
23	Wilson-turner syndrome	Enrichment	HDAC8	2.35
24	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.35
25	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.35
26	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	2.35
27	Periodontal ehlers-danlos syndrome	Enrichment	C1R	2.35
28	Ehlers-danlos syndrome, periodontal type, 1	Enrichment	C1R	2.18
29	Ehlers-danlos syndrome, periodontal type, 2	Enrichment	C1R	2.18
30	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.18
31	Dowling-degos disease 1	Enrichment	ADAM10	2.05
32	Bestrophinopathy, autosomal recessive	Enrichment	CRB1	2.05
33	Dowling-degos disease	Enrichment	POFUT1	2.05
34	Cone-rod dystrophy 2	Enrichment	ADAM9, CRB1	2.01
35	Systemic lupus erythematosus 16	Enrichment	C1R	1.96
36	Pervasive developmental disorder	Enrichment	FBXW7	1.96
37	Herpes simplex virus encephalitis	Enrichment	TBK1	1.96
38	Rare pervasive developmental disorder	Enrichment	FBXW7	1.96
39	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.88
40	Adams-oliver syndrome	Enrichment	RBPJ	1.81
41	Motor neuron disease	Enrichment	TBK1	1.81
42	Fanconi anemia, complementation group c	Enrichment	HDAC8	1.76
43	Leber congenital amaurosis 1	Enrichment	CRB1	1.76
44	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1R	1.76
45	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.70
46	Progressive non-fluent aphasia	Enrichment	TBK1	1.70
47	Cornelia de lange syndrome	Enrichment	HDAC8	1.70
48	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	TBK1	1.66
49	Nanophthalmos	Enrichment	CRB1	1.62
50	Atrial heart septal defect	Enrichment	HDAC8	1.62
51	Interatrial communication	Enrichment	HDAC8	1.62
52	Diaphragmatic hernia, congenital	Enrichment	CDK8	1.55
53	Hydrocephalus, congenital, 1	Enrichment	CDK8	1.46
54	Heart, malformation of	Enrichment	CDK8	1.41
55	Polycystic kidney disease	Enrichment	HDAC8	1.41
56	Ehlers-danlos syndrome	Enrichment	C1R	1.38
57	Cone dystrophy	Enrichment	CRB1	1.29
58	Stargardt disease 1	Enrichment	CRB1	1.19
59	Usher syndrome	Enrichment	CRB1	1.15
60	Eye disease	Enrichment	CRB1	1.13
61	Retinitis pigmentosa	Enrichment	ADAM9, CRB1	1.10
62	Type 2 diabetes mellitus	Enrichment	RBPJ	1.05
63	Optic atrophy plus syndrome	Enrichment	CRB1	1.03
64	Myeloma, multiple	Enrichment	HDAC4	0.93
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	TBK1	0.92
66	Hereditary retinal dystrophy	Enrichment	ADAM9, CRB1	0.87
67	Fundus dystrophy	Enrichment	ADAM9, CRB1	0.87
68	Colorectal cancer	Enrichment	FBXW7	0.76
69	Leber plus disease	Enrichment	CRB1	0.72
70	Microcephaly	Enrichment	HDAC8	0.62
71	Complex neurodevelopmental disorder	Enrichment	CDK8	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Notch Signaling Pathway (sino)

Pathway Network for Notch Signaling Pathway (sino)

Member Pathways for Notch Signaling Pathway (sino)

Pathways in the Notch Signaling Pathway (sino) SuperPath

Associated Genes for Notch Signaling Pathway (sino)

Associated Disorders for Notch Signaling Pathway (sino)

Disorders associated with Notch Signaling Pathway (sino) SuperPath

STRING Interaction Network for Notch Signaling Pathway (sino)

Sources for Notch Signaling Pathway (sino)