Notch Signaling Pathways

No Pathway Network information available for Notch Signaling Pathways

Pathways in the Notch Signaling Pathways SuperPath

#	Name	Source	Genes
1	Notch Signaling Pathways	R&D Systems	ADAM17 AKT1 AKT2 AKT3 AP2A1 APH1A BCL2 BCL6 BEND6 CCN3 CCND1 CDK8 CHUK CIRSR CLTC CLTCL1 CNTN1 CNTN6 CSNK2A1 CSNK2A2 CSNK2B CTBP1 CTNNB1 DLK1 DLL1 DLL3 DLL4 DNER DNM1 DNM2 DNM3 DYRK1A EHMT1 EHMT2 EP300 EPN1 EPN2 EPN3 FBXW7 FURIN H3-3A H4C16 HDAC1 HDAC2 HES1 HEY1 HIF1A IKBKB IKBKE IKBKG JAG1 JAG2 KAT2A KDM1A MAML1 MAML2 MAML3 MFAP5 MFNG MIB1 MTOR MYC NCOR1 NCOR2 NCSTN NFKB1 NFKB2 NKAP NLK NOTCH1 NOTCH2 NOTCH3 NOTCH4 NRARP NTN1 NUMB PICALM PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 POFUT1 PSEN1 PSEN2 PSENEN RBPJ RFNG RUNX2 RUNX3 SAP30 SIRT1 SMAD1 SMAD3 SNW1 SPEN TACC3 TAF6L THBS2 THBS4 (see all 100) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	1
2	EPN1	Epsin 1	Protein Coding	1
3	EPN2	Epsin 2	Protein Coding	1
4	EPN3	Epsin 3	Protein Coding	1
5	CLTC	Clathrin Heavy Chain	Protein Coding	1
6	CLTCL1	Clathrin Heavy Chain Like 1	Protein Coding	1
7	PICALM	Phosphatidylinositol Binding Clathrin Assembly Protein	Protein Coding	1
8	DNM1	Dynamin 1	Protein Coding	1
9	DNM2	Dynamin 2	Protein Coding	1
10	DNM3	Dynamin 3	Protein Coding	1
11	NOTCH1	Notch Receptor 1	Protein Coding	1
12	NOTCH2	Notch Receptor 2	Protein Coding	1
13	NOTCH3	Notch Receptor 3	Protein Coding	1
14	NOTCH4	Notch Receptor 4	Protein Coding	1
15	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
16	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
17	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
18	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
19	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
20	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
21	PSEN1	Presenilin 1	Protein Coding	1
22	PSEN2	Presenilin 2	Protein Coding	1
23	NCSTN	Nicastrin	Protein Coding	1
24	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
25	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
26	CCN3	Cellular Communication Network Factor 3	Protein Coding	1
27	CNTN1	Contactin 1	Protein Coding	1
28	CNTN6	Contactin 6	Protein Coding	1
29	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
30	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1
31	MFAP5	Microfibril Associated Protein 5	Protein Coding	1
32	NTN1	Netrin 1	Protein Coding	1
33	THBS2	Thrombospondin 2	Protein Coding	1
34	CTNNB1	Catenin Beta 1	Protein Coding	1
35	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
36	MFNG	MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
37	RFNG	RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	1
38	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
39	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
40	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
41	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
42	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
43	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
44	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
45	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
46	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
47	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
48	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
49	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
50	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
51	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
52	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
53	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
54	POFUT1	Protein O-Fucosyltransferase 1	Protein Coding	1
55	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
56	SNW1	SNW Domain Containing 1	Protein Coding	1
57	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	1
58	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	1
59	H3-3A	H3.3 Histone A	Protein Coding	1
60	H4C16	H4 Histone 16	Protein Coding	1
61	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
62	NRARP	NOTCH Regulated Ankyrin Repeat Protein	Protein Coding	1
63	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	1
64	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	1
65	TACC3	Transforming Acidic Coiled-Coil Containing Protein 3	Protein Coding	1
66	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
67	TAF6L	TATA-Box Binding Protein Associated Factor 6 Like	Protein Coding	1
68	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
69	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
70	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	1
71	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	1
72	CDK8	Cyclin Dependent Kinase 8	Protein Coding	1
73	DYRK1A	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A	Protein Coding	1
74	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
75	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
76	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
77	NLK	Nemo Like Kinase	Protein Coding	1
78	SMAD1	SMAD Family Member 1	Protein Coding	1
79	SMAD3	SMAD Family Member 3	Protein Coding	1
80	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
81	KDM1A	Lysine Demethylase 1A	Protein Coding	1
82	BCL6	BCL6 Transcription Repressor	Protein Coding	1
83	BEND6	BEN Domain Containing 6	Protein Coding	1
84	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
85	CIRSR	Corepressor Of RBPJ And Splicing Regulator	Protein Coding	1
86	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
87	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
88	NKAP	NFKB Activating Protein	Protein Coding	1
89	SAP30	Sin3A Associated Protein 30	Protein Coding	1
90	SPEN	Spen Family Transcriptional Repressor	Protein Coding	1
91	HDAC1	Histone Deacetylase 1	Protein Coding	1
92	HDAC2	Histone Deacetylase 2	Protein Coding	1
93	SIRT1	Sirtuin 1	Protein Coding	1
94	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
95	THBS4	Thrombospondin 4	Protein Coding	1
96	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	1
97	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
98	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
99	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
100	CCND1	Cyclin D1	Protein Coding	1

Disorders associated with Notch Signaling Pathways SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, BCL6, MYC	6.41
2	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	4.88
3	Colorectal cancer	Enrichment	AKT1, CCND1, CTNNB1, EP300, FBXW7, PIK3R1	4.37
4	Intravascular large b-cell lymphoma	Enrichment	BCL2, BCL6	4.27
5	Autism spectrum disorder	Enrichment	CNTN6, CSNK2A1, CSNK2B, DYRK1A, EHMT1, SPEN	3.82
6	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	3.79
7	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.79
8	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.79
9	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	3.79
10	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3R2	3.50
11	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.50
12	Enophthalmos	Enrichment	CSNK2B, DYRK1A	3.50
13	Dowling-degos disease	Enrichment	POFUT1, PSENEN	3.50
14	Follicular lymphoma	Enrichment	BCL2, BCL6	3.28
15	Hemimegalencephaly	Enrichment	AKT3, MTOR	3.28
16	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.96
17	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	2.96
18	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	2.96
19	Polymicrogyria	Enrichment	AKT3, EHMT1	2.63
20	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.63
21	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MFAP5, NOTCH1, SMAD3	2.38
22	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1, SMAD3	2.34
23	Rare genetic intellectual disability	Enrichment	EP300, MTOR	2.28
24	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC, CSNK2B, DLL1	2.23
25	Proteus syndrome	Enrichment	AKT1	2.13
26	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.13
27	Incontinentia pigmenti	Enrichment	IKBKG	2.13
28	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.13
29	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.13
30	Alagille syndrome 2	Enrichment	NOTCH2	2.13
31	Acne inversa, familial, 1	Enrichment	NCSTN	2.13
32	Lateral meningocele syndrome	Enrichment	NOTCH3	2.13
33	Congenital myopathy 12	Enrichment	CNTN1	2.13
34	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.13
35	Fetal encasement syndrome	Enrichment	CHUK	2.13
36	Intellectual developmental disorder, autosomal dominant 7	Enrichment	DYRK1A	2.13
37	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.13
38	Immunodeficiency 15b	Enrichment	IKBKB	2.13
39	Adams-oliver syndrome 6	Enrichment	DLL4	2.13
40	Immunodeficiency 15a	Enrichment	IKBKB	2.13
41	Short syndrome	Enrichment	PIK3R1	2.13
42	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.13
43	Intellectual developmental disorder, x-linked, syndromic, hackmann-di donato type	Enrichment	NKAP	2.13
44	Mirror movements 4	Enrichment	NTN1	2.13
45	Aortic aneurysm, familial thoracic 9	Enrichment	MFAP5	2.13
46	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.13
47	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.13
48	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.13
49	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.13
50	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.13
51	Dowling-degos disease 2	Enrichment	POFUT1	2.13
52	Cowden syndrome 6	Enrichment	AKT1	2.13
53	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.13
54	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.13
55	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.13
56	Radio-tartaglia syndrome	Enrichment	SPEN	2.13
57	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.13
58	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.13
59	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.13
60	Acne inversa, familial, 3	Enrichment	PSEN1	2.13
61	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.13
62	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.13
63	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.13
64	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.13
65	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.13
66	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.13
67	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.13
68	Adenoid ameloblastoma	Enrichment	CTNNB1	2.13
69	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.13
70	Congenital insensitivity to pain with severe intellectual disability	Enrichment	CLTCL1	2.13
71	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.13
72	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.13
73	Capillary hemangioma	Enrichment	AKT3	2.13
74	Transient cerebral ischemia	Enrichment	NOTCH3	2.13
75	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.13
76	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.13
77	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.13
78	Pash syndrome	Enrichment	NCSTN	2.13
79	Huntington's disease-like	Enrichment	PSEN2	2.13
80	Microcystic stromal tumor	Enrichment	CTNNB1	2.13
81	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.13
82	Heart, malformation of	Enrichment	CDK8, JAG1	2.12
83	Myeloma, multiple	Enrichment	CCND1, NCOR2, PIK3R2	2.09
84	Ehlers-danlos syndrome	Enrichment	SMAD3, THBS2	2.07
85	Hepatoblastoma	Enrichment	CTNNB1, JAG1	1.99
86	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC, PICALM	1.91
87	Burkitt lymphoma	Enrichment	MYC	1.83
88	Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly	Enrichment	RUNX2	1.83
89	Ebstein anomaly	Enrichment	CDK8	1.83
90	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.83
91	Alzheimer disease 3	Enrichment	PSEN1	1.83
92	Immunodeficiency 33	Enrichment	IKBKG	1.83
93	Pick disease of brain	Enrichment	PSEN1	1.83
94	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.83
95	Adams-oliver syndrome 5	Enrichment	NOTCH1	1.83
96	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.83
97	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.83
98	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.83
99	Adams-oliver syndrome 3	Enrichment	RBPJ	1.83
100	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	1.83
101	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.83
102	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	1.83
103	Cebalid syndrome	Enrichment	MTOR	1.83
104	Menke-hennekam syndrome 2	Enrichment	EP300	1.83
105	Infantile myofibromatosis	Enrichment	NOTCH3	1.83
106	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.83
107	Left ventricular noncompaction 7	Enrichment	MIB1	1.83
108	Senior-loken syndrome 7	Enrichment	AKT3	1.83
109	Kleefstra syndrome	Enrichment	EHMT1	1.83
110	Central precocious puberty	Enrichment	DLK1	1.83
111	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	1.83
112	Depressive disorder	Enrichment	NOTCH3	1.83
113	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	1.83
114	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	1.83
115	Immune system disease	Enrichment	PIK3CD	1.83
116	Bardet-biedl syndrome 16	Enrichment	AKT3	1.83
117	Smith-kingsmore syndrome	Enrichment	MTOR	1.83
118	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.83
119	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.83
120	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	1.83
121	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A	1.83
122	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1	1.83
123	Teratoma	Enrichment	CTNNB1	1.83
124	Primary mediastinal large b-cell lymphoma	Enrichment	BCL6	1.83
125	Common variable immunodeficiency 12	Enrichment	NFKB1	1.83
126	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	1.81
127	Cleidocranial dysplasia 1	Enrichment	RUNX2	1.66
128	Desmoid disease, hereditary	Enrichment	CTNNB1	1.66
129	Prognathism, mandibular	Enrichment	CSNK2B	1.66
130	Alagille syndrome 1	Enrichment	JAG1	1.66
131	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.66
132	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.66
133	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.66
134	Anus, imperforate	Enrichment	CTNNB1	1.66
135	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.66
136	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.66
137	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.66
138	Ehlers-danlos syndrome, classic-like, 3	Enrichment	THBS2	1.66
139	Desmoid tumor	Enrichment	CTNNB1	1.66
140	Precocious puberty, central, 2	Enrichment	DLK1	1.66
141	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	1.66
142	Cleidocranial dysplasia	Enrichment	RUNX2	1.66
143	Migraine without aura	Enrichment	NOTCH3	1.66
144	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.66
145	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	1.66
146	Enchondromatosis	Enrichment	HIF1A	1.66
147	Connective tissue disease	Enrichment	NOTCH1, SMAD3	1.64
148	Mirror movements 1	Enrichment	NTN1	1.54
149	Kagami-ogata syndrome	Enrichment	DLK1	1.54
150	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.54
151	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.54
152	Pilomatrixoma	Enrichment	CTNNB1	1.54
153	Temple syndrome	Enrichment	DLK1	1.54
154	Alazami syndrome	Enrichment	CTNNB1	1.54
155	Mantle cell lymphoma	Enrichment	CCND1	1.54
156	Syndactyly	Enrichment	CSNK2B	1.54
157	Cerebrovascular disease	Enrichment	NOTCH3	1.54
158	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.54
159	Aortic aneurysm	Enrichment	SMAD3	1.54
160	Craniopharyngioma	Enrichment	CTNNB1	1.54
161	Genetic central precocious puberty in male	Enrichment	DLK1	1.54
162	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.54
163	Middle aortic syndrome	Enrichment	JAG1	1.54
164	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.44
165	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	1.44
166	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.44
167	Von hippel-lindau syndrome	Enrichment	CCND1	1.44
168	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.44
169	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.44
170	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.44
171	Pervasive developmental disorder	Enrichment	FBXW7	1.44
172	Aplasia cutis congenita	Enrichment	DLL4	1.44
173	Vascular dementia	Enrichment	NOTCH3	1.44
174	Dementia	Enrichment	PSEN1	1.44
175	Rare pervasive developmental disorder	Enrichment	FBXW7	1.44
176	Type 2 diabetes mellitus	Enrichment	AKT2, RBPJ	1.42
177	Myopathy, centronuclear, 1	Enrichment	DNM2	1.36
178	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.36
179	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.36
180	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.36
181	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.36
182	Kleefstra syndrome 1	Enrichment	EHMT1	1.36
183	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.36
184	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.36
185	Adrenocortical carcinoma	Enrichment	CTNNB1	1.36
186	Breast adenocarcinoma	Enrichment	AKT1	1.36
187	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3	1.36
188	Intervertebral disc disease	Enrichment	THBS2	1.30
189	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.30
190	Noonan syndrome 3	Enrichment	CLTC	1.30
191	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.30
192	Semantic dementia	Enrichment	PSEN1	1.30
193	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.30
194	Gallbladder cancer	Enrichment	CTNNB1	1.30
195	Megacolon	Enrichment	AKT3	1.30
196	Glioma susceptibility 1	Enrichment	H3-3A	1.24
197	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.24
198	Lennox-gastaut syndrome	Enrichment	DNM1	1.24
199	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.24
200	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.24
201	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	1.24
202	Microcephaly	Enrichment	CTNNB1, DYRK1A, EP300	1.20
203	Complex neurodevelopmental disorder	Enrichment	CDK8, CSNK2A1, DYRK1A	1.20
204	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, DNM1	1.19
205	Charge syndrome	Enrichment	EP300	1.19
206	Coronary heart disease 5	Enrichment	IKBKG	1.19
207	Loeys-dietz syndrome	Enrichment	SMAD3	1.19
208	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.19
209	Progressive non-fluent aphasia	Enrichment	PSEN1	1.19
210	Cowden syndrome	Enrichment	AKT1	1.19
211	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.19
212	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.19
213	Schizophrenia	Enrichment	CNTN6, EHMT1	1.15
214	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.15
215	Stroke, ischemic	Enrichment	NOTCH3	1.15
216	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.15
217	Migraine with or without aura 1	Enrichment	NOTCH3	1.11
218	Frontotemporal dementia 1	Enrichment	PSEN1	1.11
219	Meningioma	Enrichment	AKT1	1.07
220	Aortic valve disease 1	Enrichment	NOTCH1	1.04
221	Diaphragmatic hernia, congenital	Enrichment	CDK8	1.04
222	Alzheimer's disease	Enrichment	PSEN1	1.04
223	Chromosome 1p36 deletion syndrome	Enrichment	SPEN	1.04
224	Stereotypic movement disorder	Enrichment	DNM1	1.04
225	Nk-cell enteropathy	Enrichment	PIK3CB	1.04
226	Medulloblastoma	Enrichment	CTNNB1	1.01
227	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	0.98
228	Polydactyly, postaxial, type a1	Enrichment	EP300	0.98
229	Septopreoptic holoprosencephaly	Enrichment	DLL1	0.98
230	Male infertility with spermatogenesis disorder	Enrichment	DYRK1A	0.98
231	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	0.98
232	Hydrocephalus, congenital, 1	Enrichment	CDK8	0.95
233	Gliosarcoma	Enrichment	TACC3	0.95
234	Microform holoprosencephaly	Enrichment	DLL1	0.95
235	Lobar holoprosencephaly	Enrichment	DLL1	0.95
236	Alzheimer disease, familial, 1	Enrichment	PSEN1	0.93
237	Polycystic liver disease	Enrichment	CTNNB1	0.93
238	Giant cell glioblastoma	Enrichment	TACC3	0.93
239	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.93
240	Alobar holoprosencephaly	Enrichment	DLL1	0.93
241	Semilobar holoprosencephaly	Enrichment	DLL1	0.90
242	Centronuclear myopathy	Enrichment	DNM2	0.84
243	Hepatocellular carcinoma	Enrichment	CTNNB1	0.82
244	Microphthalmia	Enrichment	DYRK1A	0.82
245	Skin disease	Enrichment	NCSTN	0.82
246	Malaria	Enrichment	IKBKG	0.81
247	Ovarian cancer	Enrichment	AKT1, CTNNB1	0.77
248	Auditory neuropathy	Enrichment	NOTCH3	0.76
249	Congenital nervous system abnormality	Enrichment	CTNNB1, PSEN1	0.74
250	Nervous system disease	Enrichment	CTNNB1, PSEN1	0.74
251	Bladder cancer	Enrichment	CTNNB1	0.71
252	Severe combined immunodeficiency	Enrichment	IKBKB	0.66
253	Left ventricular noncompaction	Enrichment	MIB1	0.64
254	Leukemia, acute myeloid	Enrichment	PICALM	0.59
255	Myopathy	Enrichment	DNM2	0.59
256	Charcot-marie-tooth disease	Enrichment	DNM2	0.58
257	Nephrotic syndrome	Enrichment	RUNX2	0.56
258	West syndrome	Enrichment	DNM1	0.56
259	Hereditary breast carcinoma	Enrichment	AKT1	0.56
260	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.46
261	Primary ovarian insufficiency	Enrichment	NOTCH2	0.45
262	Autism	Enrichment	CNTN6	0.38
263	Breast cancer	Enrichment	AKT1	0.37
264	Hereditary retinal dystrophy	Enrichment	JAG1	0.05
265	Fundus dystrophy	Enrichment	JAG1	0.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Notch Signaling Pathways

Pathway Network for Notch Signaling Pathways

Member Pathways for Notch Signaling Pathways

Pathways in the Notch Signaling Pathways SuperPath

Associated Genes for Notch Signaling Pathways

Associated Disorders for Notch Signaling Pathways

Disorders associated with Notch Signaling Pathways SuperPath

STRING Interaction Network for Notch Signaling Pathways

Sources for Notch Signaling Pathways