NR1H2 and NR1H3-mediated signaling

Pathway network for the NR1H2 and NR1H3-mediated signaling SuperPath

Sources:

Reactome

Pathways in the NR1H2 and NR1H3-mediated signaling SuperPath

#	Name	Source	Genes
1	NR1H2 and NR1H3-mediated signaling	Reactome	ABCA1 ABCG1 ABCG5 ABCG8 AGO1 AGO2 AGO3 AGO4 ANGPTL3 APOC1 APOC2 APOC4 APOD APOE ARL4C CETP EEPD1 EP300 FABP6 FASN GPS2 HDAC3 KDM1A KDM1B KDM3A KDM4A MOV10 MYLIP NCOA1 NCOR1 NCOR2 NR1H2 NR1H3 NRIP1 PCK1 PLIN1 PLTP RXRA RXRB SCD SREBF1 TBL1X TBL1XR1 TNRC6A TNRC6B TNRC6C UGT1A3 (see all 47) (see less)
2	NR1H3 and NR1H2 regulate gene expression linked to cholesterol transport and efflux	Reactome	ABCA1 ABCG1 ABCG5 ABCG8 AGO1 AGO2 AGO3 AGO4 APOC1 APOC2 APOC4 APOD APOE ARL4C CETP EEPD1 EP300 GPS2 HDAC3 KDM1A KDM1B KDM3A KDM4A MOV10 NCOA1 NCOR1 NCOR2 NR1H2 NR1H3 PLTP RXRA RXRB TBL1X TBL1XR1 TNRC6A TNRC6B TNRC6C (see all 37) (see less)
3	NR1H2 and NR1H3 regulate gene expression linked to lipogenesis	Reactome	ANGPTL3 FASN NR1H2 NR1H3 NRIP1 RXRA RXRB SCD SREBF1 (see all 9) (see less)
4	NR1H2 and NR1H3 regulate gene expression to control bile acid homeostasis	Reactome	FABP6 NCOA1 NCOR1 NCOR2 NR1H2 NR1H3 RXRA RXRB UGT1A3 (see all 9) (see less)
5	NR1H2 and NR1H3 regulate gene expression to limit cholesterol uptake	Reactome	MYLIP NR1H2 NR1H3 RXRA RXRB
6	NR1H2 and NR1H3 regulate gene expression linked to gluconeogenesis	Reactome	NR1H3 NRIP1 PCK1 RXRA RXRB
7	NR1H2 and NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose	Reactome	NR1H2 NR1H3 PLIN1 RXRA RXRB

Gene overlap in member pathways for NR1H2 and NR1H3-mediated signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	7
2	RXRA	Retinoid X Receptor Alpha	Protein Coding	7
3	RXRB	Retinoid X Receptor Beta	Protein Coding	7
4	NR1H2	Nuclear Receptor Subfamily 1 Group H Member 2	Protein Coding	6
5	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	3
6	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	3
7	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	3
8	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	3
9	ARL4C	ARF Like GTPase 4C	Protein Coding	2
10	CETP	Cholesteryl Ester Transfer Protein	Protein Coding	2
11	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	2
12	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	2
13	AGO4	Argonaute RISC Component 4	Protein Coding	2
14	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
15	FABP6	Fatty Acid Binding Protein 6	Protein Coding	2
16	FASN	Fatty Acid Synthase	Protein Coding	2
17	KDM1B	Lysine Demethylase 1B	Protein Coding	2
18	KDM1A	Lysine Demethylase 1A	Protein Coding	2
19	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	2
20	AGO1	Argonaute RISC Component 1	Protein Coding	2
21	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	2
22	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	2
23	ANGPTL3	Angiopoietin Like 3	Protein Coding	2
24	GPS2	G Protein Pathway Suppressor 2	Protein Coding	2
25	MYLIP	Myosin Regulatory Light Chain Interacting Protein	Protein Coding	2
26	APOC1	Apolipoprotein C1	Protein Coding	2
27	APOC2	Apolipoprotein C2	Protein Coding	2
28	APOC4	Apolipoprotein C4	Protein Coding	2
29	APOD	Apolipoprotein D	Protein Coding	2
30	APOE	Apolipoprotein E	Protein Coding	2
31	MOV10	Mov10 RNA Helicase	Protein Coding	2
32	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	2
33	PLIN1	Perilipin 1	Protein Coding	2
34	PLTP	Phospholipid Transfer Protein	Protein Coding	2
35	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	2
36	KDM3A	Lysine Demethylase 3A	Protein Coding	2
37	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	2
38	SCD	Stearoyl-CoA Desaturase	Protein Coding	2
39	ABCG5	ATP Binding Cassette Subfamily G Member 5	Protein Coding	2
40	ABCG8	ATP Binding Cassette Subfamily G Member 8	Protein Coding	2
41	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	2
42	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	2
43	TBL1XR1	TBL1X/Y Related 1	Protein Coding	2
44	EEPD1	Endonuclease/Exonuclease/Phosphatase Family Domain Containing 1	Protein Coding	2
45	HDAC3	Histone Deacetylase 3	Protein Coding	2
46	ABCG1	ATP Binding Cassette Subfamily G Member 1	Protein Coding	2
47	KDM4A	Lysine Demethylase 4A	Protein Coding	2

Disorders associated with NR1H2 and NR1H3-mediated signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipid metabolism disorder	Enrichment	ABCG5, ABCG8, APOE, CETP	9.14
2	Coronary heart disease 5	Enrichment	ABCA1, ABCG5, ABCG8	5.81
3	Gallbladder disease 4	Enrichment	ABCG5, ABCG8	5.14
4	Sitosterolemia 1	Enrichment	ABCG5, ABCG8	4.66
5	Sitosterolemia	Enrichment	ABCG5, ABCG8	4.66
6	Homozygous familial hypercholesterolemia	Enrichment	ABCG5, ABCG8	3.70
7	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	3.43
8	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	3.43
9	Myeloma, multiple	Enrichment	NCOR2, RXRA	3.23
10	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	3.18
11	Ifap syndrome 2	Enrichment	SREBF1	3.18
12	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1	2.96
13	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	2.96
14	Hypobetalipoproteinemia, familial, 2	Enrichment	ANGPTL3	2.88
15	Developmental and epileptic encephalopathy 23	Enrichment	ANGPTL3	2.88
16	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.70
17	Sea-blue histiocyte disease	Enrichment	APOE	2.56
18	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	2.56
19	Lipoprotein glomerulopathy	Enrichment	APOE	2.56
20	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.56
21	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.56
22	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.56
23	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.56
24	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.56
25	Hypoalphalipoproteinemia	Enrichment	ABCA1	2.56
26	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, TNRC6B	2.34
27	Multiple sclerosis	Enrichment	NR1H3	2.29
28	Apolipoprotein c-ii deficiency	Enrichment	APOC2	2.26
29	Tangier disease	Enrichment	ABCA1	2.26
30	Alzheimer disease 3	Enrichment	APOE	2.26
31	Premature ovarian failure 3	Enrichment	AGO2	2.26
32	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	2.26
33	Sitosterolemia 2	Enrichment	ABCG5	2.26
34	Menke-hennekam syndrome 2	Enrichment	EP300	2.26
35	Hyperlipoproteinemia, type iii	Enrichment	APOE	2.26
36	Familial apolipoprotein c-ii deficiency	Enrichment	APOC2	2.26
37	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	ABCG5	2.26
38	Crigler-najjar syndrome, type i	Enrichment	UGT1A3	2.18
39	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A3	2.18
40	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A3	2.18
41	Crigler-najjar syndrome, type ii	Enrichment	UGT1A3	2.18
42	Gilbert syndrome	Enrichment	UGT1A3	2.14
43	Bilirubin metabolic disorder	Enrichment	UGT1A3	2.14
44	Hyperalphalipoproteinemia 1	Enrichment	CETP	2.09
45	Pierpont syndrome	Enrichment	TBL1XR1	2.09
46	Alzheimer disease 4	Enrichment	APOE	2.09
47	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1	2.09
48	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	2.09
49	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.09
50	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	2.09
51	Macular degeneration, age-related, 1	Enrichment	APOE	1.96
52	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1	1.96
53	Cakut	Enrichment	NRIP1	1.90
54	Alzheimer disease 2	Enrichment	APOE	1.87
55	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.87
56	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.79
57	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.79
58	Hirschsprung disease 1	Enrichment	SREBF1	1.72
59	Charge syndrome	Enrichment	EP300	1.61
60	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.61
61	Acute promyelocytic leukemia	Enrichment	TBL1XR1	1.46
62	Alzheimer's disease	Enrichment	APOE	1.46
63	Polydactyly, postaxial, type a1	Enrichment	EP300	1.40
64	Familial hypercholesterolemia	Enrichment	APOE	1.40
65	Rare genetic intellectual disability	Enrichment	EP300	1.40
66	Alzheimer disease, familial, 1	Enrichment	APOE	1.34
67	Diffuse large b-cell lymphoma	Enrichment	TBL1XR1	1.30
68	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	ABCG5	1.06
69	Breast cancer	Enrichment	ABCA1	0.73
70	Colorectal cancer	Enrichment	EP300	0.67
71	Autism spectrum disorder	Enrichment	TNRC6B	0.59
72	Microcephaly	Enrichment	EP300	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NR1H2 and NR1H3-mediated signaling

Pathway Network for NR1H2 and NR1H3-mediated signaling

Pathway network for the NR1H2 and NR1H3-mediated signaling SuperPath

Member Pathways for NR1H2 and NR1H3-mediated signaling

Pathways in the NR1H2 and NR1H3-mediated signaling SuperPath

Gene overlap in member pathways for NR1H2 and NR1H3-mediated signaling SuperPath

Associated Genes for NR1H2 and NR1H3-mediated signaling

Associated Disorders for NR1H2 and NR1H3-mediated signaling

Disorders associated with NR1H2 and NR1H3-mediated signaling SuperPath

STRING Interaction Network for NR1H2 and NR1H3-mediated signaling

Sources for NR1H2 and NR1H3-mediated signaling