NRF2-ARE regulation

Pathway network for the NRF2-ARE regulation SuperPath

Sources:

WikiPathways

Pathways in the NRF2-ARE regulation SuperPath

#	Name	Source	Genes
1	NRF2-ARE regulation	WikiPathways	AIMP2 CEBPB CUL3 EPHB2 FYN GCLC GCLM GSK3B GSTA2 HMOX1 INSR KEAP1 MAF MAPK8 NFE2L2 NQO1 PGAM5 PIK3CA PRKCA RBX1 SLC7A11 SRC YES1 (see all 23) (see less)
2	Transcriptional activation by NRF2 in response to phytochemicals	WikiPathways	AIMP2 CEBPB EPHB2 GCLC GCLM GSTA2 HMOX1 KEAP1 MAF MAPK8 NFE2L2 NQO1 PIK3CA PRKCA SLC7A11 (see all 15) (see less)
3	Osteoclast signaling	WikiPathways	AIMP2 MAPK8

Gene overlap in member pathways for NRF2-ARE regulation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
2	AIMP2	Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2	Protein Coding	3
3	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	2
4	PRKCA	Protein Kinase C Alpha	Protein Coding	2
5	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
6	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	2
7	MAF	MAF BZIP Transcription Factor	Protein Coding	2
8	HMOX1	Heme Oxygenase 1	Protein Coding	2
9	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	2
10	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	2
11	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	2
12	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	2
13	EPHB2	EPH Receptor B2	Protein Coding	2
14	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	2
15	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	2
16	PGAM5	PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase	Protein Coding	1
17	RBX1	Ring-Box 1	Protein Coding	1
18	CUL3	Cullin 3	Protein Coding	1
19	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
20	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
21	INSR	Insulin Receptor	Protein Coding	1
22	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
23	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1

Disorders associated with NRF2-ARE regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myocardial infarction	Enrichment	GCLC, GCLM	3.58
2	Leukodystrophy, hypomyelinating, 17	Enrichment	AIMP2	3.53
3	Colorectal cancer	Enrichment	NFE2L2, PIK3CA, SRC	3.39
4	Prostate cancer	Enrichment	EPHB2, PIK3CA	3.34
5	Lung cancer	Enrichment	NFE2L2, PIK3CA	3.26
6	Cystic fibrosis	Enrichment	GCLC, HMOX1	3.26
7	Macrodactyly	Enrichment	PIK3CA	2.96
8	Cataract 21, multiple types	Enrichment	MAF	2.96
9	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.96
10	Cowden syndrome 5	Enrichment	PIK3CA	2.96
11	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.96
12	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.96
13	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.96
14	Ayme-gripp syndrome	Enrichment	MAF	2.96
15	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	2.96
16	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.96
17	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.96
18	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.96
19	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	2.96
20	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.96
21	Hypospadias	Enrichment	PIK3CA	2.96
22	Rare venous malformation	Enrichment	PIK3CA	2.96
23	Diaphragmatic eventration	Enrichment	PIK3CA	2.96
24	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.96
25	Rare combined vascular malformation	Enrichment	PIK3CA	2.96
26	Cavernous lymphangioma	Enrichment	PIK3CA	2.96
27	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.96
28	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.96
29	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.96
30	Macrodactyly of toe	Enrichment	PIK3CA	2.96
31	Donohue syndrome	Enrichment	INSR	2.77
32	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.77
33	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.77
34	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.77
35	Pseudohypoaldosteronism, type iie	Enrichment	CUL3	2.77
36	Neurodevelopmental disorder with or without autism or seizures	Enrichment	CUL3	2.77
37	Thrombocytopenia 6	Enrichment	SRC	2.77
38	Keratosis, seborrheic	Enrichment	PIK3CA	2.66
39	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	KEAP1	2.66
40	Developmental and epileptic encephalopathy 28	Enrichment	MAF	2.66
41	Noonan syndrome 8	Enrichment	PIK3CA	2.66
42	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	MAF	2.66
43	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.66
44	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.48
45	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.48
46	Keratoacanthoma	Enrichment	PIK3CA	2.48
47	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	CUL3	2.47
48	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.47
49	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.35
50	Cerebrovascular disease	Enrichment	PIK3CA	2.35
51	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.35
52	Congenital blue dot cataract	Enrichment	MAF	2.35
53	Pseudohypoaldosteronism, type iia	Enrichment	CUL3	2.29
54	Capillary malformations, congenital	Enrichment	PIK3CA	2.26
55	Hemimegalencephaly	Enrichment	PIK3CA	2.26
56	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.18
57	Cowden syndrome 1	Enrichment	PIK3CA	2.18
58	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.18
59	Breast adenocarcinoma	Enrichment	PIK3CA	2.18
60	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.18
61	Nevus, epidermal	Enrichment	PIK3CA	2.11
62	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.11
63	Gallbladder cancer	Enrichment	PIK3CA	2.11
64	Cataract - microcornea syndrome	Enrichment	MAF	2.05
65	Arteriovenous malformation	Enrichment	PIK3CA	2.00
66	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.00
67	Cowden syndrome	Enrichment	PIK3CA	2.00
68	46,xy disorder of sex development	Enrichment	INSR	1.99
69	Cataract 30, multiple types	Enrichment	MAF	1.96
70	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.96
71	Myelofibrosis	Enrichment	SRC	1.93
72	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.92
73	Meningioma	Enrichment	PIK3CA	1.88
74	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.88
75	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.85
76	Lynch syndrome	Enrichment	PIK3CA	1.78
77	Nk-cell enteropathy	Enrichment	CUL3	1.66
78	Endometrial cancer	Enrichment	PIK3CA	1.64
79	Osteoporosis	Enrichment	SRC	1.63
80	Hepatocellular carcinoma	Enrichment	PIK3CA	1.62
81	Developmental and epileptic encephalopathy 1	Enrichment	MAF	1.56
82	Bladder cancer	Enrichment	PIK3CA	1.50
83	Benign epilepsy with centrotemporal spikes	Enrichment	MAF	1.35
84	Centralopathic epilepsy	Enrichment	MAF	1.33
85	Gastric cancer	Enrichment	PIK3CA	1.33
86	West syndrome	Enrichment	MAF	1.32
87	Hereditary breast carcinoma	Enrichment	PIK3CA	1.32
88	Hypertelorism	Enrichment	PIK3CA	1.25
89	Type 2 diabetes mellitus	Enrichment	INSR	1.16
90	Thrombocytopenia	Enrichment	SRC	1.11
91	Breast cancer	Enrichment	PIK3CA	1.10
92	Ovarian cancer	Enrichment	PIK3CA	0.97
93	Autism spectrum disorder	Enrichment	CUL3	0.77
94	Complex neurodevelopmental disorder	Enrichment	CUL3	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NRF2-ARE regulation

Pathway Network for NRF2-ARE regulation

Pathway network for the NRF2-ARE regulation SuperPath

Member Pathways for NRF2-ARE regulation

Pathways in the NRF2-ARE regulation SuperPath

Gene overlap in member pathways for NRF2-ARE regulation SuperPath

Associated Genes for NRF2-ARE regulation

Associated Disorders for NRF2-ARE regulation

Disorders associated with NRF2-ARE regulation SuperPath

STRING Interaction Network for NRF2-ARE regulation

Sources for NRF2-ARE regulation