NRP1-triggered signaling pathways in pancreatic cancer

No Pathway Network information available for NRP1-triggered signaling pathways in pancreatic cancer

Pathways in the NRP1-triggered signaling pathways in pancreatic cancer SuperPath

#	Name	Source	Genes
1	NRP1-triggered signaling pathways in pancreatic cancer	WikiPathways	AKT1 AKT2 AKT3 BCAR1 CCN2 CCNE1 CCNE2 CDH5 CDK2 CDKN1B CHD1 CHD2 COL1A1 COL1A2 EGF EGFR FLT1 GSK3A HGF KDR MAP2K1 MAP2K2 MAPK1 MAPK3 MET MMP2 MMP9 NFKB1 NFKB2 NRP1 PECAM1 PLXNA1 PLXNA2 PLXNA4 PTK2 RAC1 REL RELB SEMA3A SLC39A4 SMAD2 SMAD3 SMAD4 SNAI1 SNAI2 SRC TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 VEGFA (see all 53) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLXNA2	Plexin A2	Protein Coding	1
2	SLC39A4	Solute Carrier Family 39 Member 4	Protein Coding	1
3	CHD2	Chromodomain Helicase DNA Binding Protein 2	Protein Coding	1
4	CCNE2	Cyclin E2	Protein Coding	1
5	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
6	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
7	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
8	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
9	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
10	PLXNA4	Plexin A4	Protein Coding	1
11	CCNE1	Cyclin E1	Protein Coding	1
12	CHD1	Chromodomain Helicase DNA Binding Protein 1	Protein Coding	1
13	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
14	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
15	HGF	Hepatocyte Growth Factor	Protein Coding	1
16	CDH5	Cadherin 5	Protein Coding	1
17	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
18	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
19	EGF	Epidermal Growth Factor	Protein Coding	1
20	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
21	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
22	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
23	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	1
24	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
25	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
26	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
27	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
28	SNAI2	Snail Family Transcriptional Repressor 2	Protein Coding	1
29	SMAD4	SMAD Family Member 4	Protein Coding	1
30	SMAD2	SMAD Family Member 2	Protein Coding	1
31	SMAD3	SMAD Family Member 3	Protein Coding	1
32	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
33	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
34	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
35	PLXNA1	Plexin A1	Protein Coding	1
36	SEMA3A	Semaphorin 3A	Protein Coding	1
37	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
38	RAC1	Rac Family Small GTPase 1	Protein Coding	1
39	KDR	Kinase Insert Domain Receptor	Protein Coding	1
40	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
41	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
42	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
43	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
44	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
45	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
46	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
47	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
48	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
49	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
50	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
51	NRP1	Neuropilin 1	Protein Coding	1
52	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
53	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1

Disorders associated with NRP1-triggered signaling pathways in pancreatic cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	10.79
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	10.76
3	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, SMAD3, TGFB2, TGFBR2	8.08
4	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	7.25
5	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, TGFBR1	5.95
6	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	5.18
7	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.82
8	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	4.82
9	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.82
10	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	4.82
11	Osteoporosis	Enrichment	COL1A1, COL1A2, SRC	4.70
12	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.35
13	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.05
14	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.05
15	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.05
16	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	4.05
17	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.05
18	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	3.65
19	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	3.65
20	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.51
21	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.51
22	Colorectal cancer	Enrichment	AKT1, MET, SMAD4, SRC	3.44
23	Ovarian cancer	Enrichment	AKT1, CDKN1B, EGFR, MET	3.19
24	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.18
25	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.09
26	Lung non-small cell carcinoma	Enrichment	EGFR, MAP2K1	3.09
27	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	2.94
28	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	2.82
29	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	2.82
30	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, EGFR, MET, SMAD4	2.76
31	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	2.44
32	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.44
33	Proteus syndrome	Enrichment	AKT1	2.41
34	Acrodermatitis enteropathica, zinc-deficiency type	Enrichment	SLC39A4	2.41
35	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.41
36	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.41
37	Hypomagnesemia 4, renal	Enrichment	EGF	2.41
38	Deafness, autosomal recessive 39	Enrichment	HGF	2.41
39	Melorheostosis, isolated	Enrichment	MAP2K1	2.41
40	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.41
41	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.41
42	Noonan syndrome 13	Enrichment	MAPK1	2.41
43	Immunodeficiency 92	Enrichment	REL	2.41
44	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.41
45	Acrodermatitis enteropathica	Enrichment	SLC39A4	2.41
46	Osteofibrous dysplasia	Enrichment	MET	2.41
47	Deafness, autosomal recessive 97	Enrichment	MET	2.41
48	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.41
49	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.41
50	Camurati-engelmann disease 2	Enrichment	TGFB2	2.41
51	Melorheostosis	Enrichment	MAP2K1	2.41
52	Neuroendocrine tumor	Enrichment	CDKN1B	2.41
53	Autism 9	Enrichment	MET	2.41
54	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.41
55	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.41
56	Hypogonadotropic hypogonadism 16 with or without anosmia	Enrichment	SEMA3A	2.41
57	Cowden syndrome 6	Enrichment	AKT1	2.41
58	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.41
59	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.41
60	Thrombocytopenia 6	Enrichment	SRC	2.41
61	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.41
62	Immunodeficiency 53	Enrichment	RELB	2.41
63	Tufted angioma of skin	Enrichment	KDR	2.41
64	Asphyxia neonatorum	Enrichment	COL1A1	2.41
65	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.41
66	Dworschak-punetha neurodevelopmental syndrome	Enrichment	PLXNA1	2.41
67	Arthrogryposis, distal, type 11	Enrichment	MET	2.41
68	Heritable thoracic aortic disease	Enrichment	SMAD4	2.41
69	Capillary hemangioma	Enrichment	AKT3	2.41
70	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.41
71	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.41
72	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.41
73	Rasopathy	Enrichment	MAP2K1, MAP2K2	2.34
74	Lung cancer	Enrichment	EGFR, MET	2.16
75	Connective tissue disease	Enrichment	SMAD3, TGFBR2	2.16
76	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.11
77	Myhre syndrome	Enrichment	SMAD4	2.11
78	Camurati-engelmann disease 1	Enrichment	TGFB1	2.11
79	Bruck syndrome 1	Enrichment	COL1A2	2.11
80	Kyphomelic dysplasia	Enrichment	CCN2	2.11
81	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.11
82	Piebald trait	Enrichment	SNAI2	2.11
83	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.11
84	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.11
85	Sifrim-hitz-weiss syndrome	Enrichment	CHD2	2.11
86	Angioma, tufted	Enrichment	KDR	2.11
87	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.11
88	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.11
89	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.11
90	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.11
91	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	2.11
92	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.11
93	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.11
94	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.11
95	Childhood hepatocellular carcinoma	Enrichment	MET	2.11
96	Senior-loken syndrome 7	Enrichment	AKT3	2.11
97	Papillary renal cell carcinoma	Enrichment	MET	2.11
98	Camurati-engelmann disease	Enrichment	TGFB1	2.11
99	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.11
100	Stickler syndrome, type ii	Enrichment	COL1A1	2.11
101	Bardet-biedl syndrome 16	Enrichment	AKT3	2.11
102	Metaphyseal anadysplasia	Enrichment	MMP9	2.11
103	Dentinogenesis imperfecta	Enrichment	COL1A2	2.11
104	Common variable immunodeficiency 12	Enrichment	NFKB1	2.11
105	Tafro syndrome	Enrichment	MAP2K2	2.11
106	Juvenile polyposis syndrome	Enrichment	SMAD4	1.93
107	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	1.93
108	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.93
109	Caffey disease	Enrichment	COL1A1	1.93
110	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.93
111	Pilarowski-bjornsson syndrome	Enrichment	CHD1	1.93
112	Developmental and epileptic encephalopathy 94	Enrichment	CHD2	1.93
113	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.93
114	Renal cell carcinoma	Enrichment	MET	1.93
115	Thrombocytopenia	Enrichment	SMAD4, SRC	1.82
116	Phenylketonuria	Enrichment	COL1A1	1.81
117	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.81
118	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.81
119	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.81
120	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.81
121	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.81
122	Primary hyperparathyroidism	Enrichment	CDKN1B	1.81
123	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.71
124	Pre-eclampsia	Enrichment	FLT1	1.71
125	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.71
126	Hemimegalencephaly	Enrichment	AKT3	1.71
127	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.71
128	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.71
129	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.71
130	Atrial septal defect 1	Enrichment	TGFB2	1.63
131	Cowden syndrome 1	Enrichment	EGFR	1.63
132	Hemangioma, capillary infantile	Enrichment	KDR	1.63
133	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.63
134	Keratoconus	Enrichment	COL1A1	1.63
135	Limited scleroderma	Enrichment	CCN2	1.63
136	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.63
137	Breast adenocarcinoma	Enrichment	AKT1	1.63
138	Lung squamous cell carcinoma	Enrichment	EGFR	1.63
139	Esophageal cancer	Enrichment	TGFBR2	1.57
140	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.57
141	Myelofibrosis	Enrichment	SRC	1.57
142	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.57
143	Waardenburg syndrome, type 2e	Enrichment	SNAI2	1.57
144	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.57
145	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.57
146	Gallbladder cancer	Enrichment	SMAD4	1.57
147	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.57
148	Megacolon	Enrichment	AKT3	1.57
149	Arthrogryposis, distal, type 1a	Enrichment	MET	1.51
150	Lennox-gastaut syndrome	Enrichment	CHD2	1.51
151	Myoclonic-atonic epilepsy	Enrichment	CHD2	1.46
152	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.46
153	Arteriovenous malformation	Enrichment	MAP2K1	1.46
154	Adult hepatocellular carcinoma	Enrichment	EGF	1.46
155	Cowden syndrome	Enrichment	AKT1	1.46
156	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.46
157	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.42
158	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.42
159	Polymicrogyria	Enrichment	AKT3	1.42
160	Pectus excavatum	Enrichment	TGFBR1	1.38
161	Specific learning disability	Enrichment	MAPK1	1.38
162	Meningioma	Enrichment	AKT1	1.34
163	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.34
164	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.34
165	Lip and oral cavity carcinoma	Enrichment	EGFR	1.34
166	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	1.33
167	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.27
168	Lung cancer susceptibility 3	Enrichment	EGFR	1.27
169	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.27
170	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.24
171	Lynch syndrome	Enrichment	TGFBR2	1.24
172	Gliosarcoma	Enrichment	EGFR	1.22
173	Giant cell glioblastoma	Enrichment	EGFR	1.19
174	Autism spectrum disorder	Enrichment	CHD2, MAP2K1	1.17
175	Heart, malformation of	Enrichment	MAPK1	1.17
176	Arteriovenous malformations of the brain	Enrichment	EGFR	1.14
177	Hepatocellular carcinoma	Enrichment	MET	1.08
178	Complex neurodevelopmental disorder	Enrichment	CHD2, PLXNA1	1.07
179	Kallmann syndrome	Enrichment	SEMA3A	1.06
180	Pancreatic cancer	Enrichment	SMAD4	1.03
181	Tetralogy of fallot	Enrichment	KDR	1.01
182	Brugada syndrome	Enrichment	SEMA3A	1.01
183	Bladder cancer	Enrichment	EGFR	0.97
184	Cystic fibrosis	Enrichment	TGFB1	0.93
185	Epilepsy	Enrichment	CHD2	0.84
186	Benign epilepsy with centrotemporal spikes	Enrichment	CHD2	0.83
187	Type 2 diabetes mellitus	Enrichment	AKT2	0.82
188	Centralopathic epilepsy	Enrichment	CHD2	0.81
189	Gastric cancer	Enrichment	SMAD4	0.81
190	Hereditary breast carcinoma	Enrichment	AKT1	0.80
191	Sensorineural hearing loss	Enrichment	HGF	0.77
192	Hypertelorism	Enrichment	COL1A1	0.73
193	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.71
194	Primary ovarian insufficiency	Enrichment	KDR	0.68
195	Breast cancer	Enrichment	AKT1	0.59
196	Microcephaly	Enrichment	MAPK1	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

NRP1-triggered signaling pathways in pancreatic cancer

Pathway Network for NRP1-triggered signaling pathways in pancreatic cancer

Member Pathways for NRP1-triggered signaling pathways in pancreatic cancer

Pathways in the NRP1-triggered signaling pathways in pancreatic cancer SuperPath

Associated Genes for NRP1-triggered signaling pathways in pancreatic cancer

Associated Disorders for NRP1-triggered signaling pathways in pancreatic cancer

Disorders associated with NRP1-triggered signaling pathways in pancreatic cancer SuperPath

STRING Interaction Network for NRP1-triggered signaling pathways in pancreatic cancer

Sources for NRP1-triggered signaling pathways in pancreatic cancer