Nuclear Events (kinase and transcription factor activation)

No Pathway Network information available for Nuclear Events (kinase and transcription factor activation)

Pathways in the Nuclear Events (kinase and transcription factor activation) SuperPath

#	Name	Source	Genes
1	Nuclear Events (kinase and transcription factor activation)	Reactome	ARC ASCL1 ATF1 ATF2 CDK5 CDK5R1 CDK5R2 CHD4 CREB1 DNM2 DUSP3 DUSP4 DUSP6 DUSP7 EGR1 EGR2 EGR3 EGR4 ELK1 EP300 F3 FOS FOSB FOSL1 ID1 ID2 ID3 ID4 JUNB JUND LYL1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MAPKAPK2 MEF2A MEF2C MEF2D NAB1 NAB2 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D REST RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 RRAD SGK1 SH3GL3 SRF TCF12 TPH1 TRIB1 VGF VRK3 (see all 61) (see less)
2	NGF-stimulated transcription	Reactome	ARC ASCL1 ATF1 ATF2 CDK5 CDK5R1 CDK5R2 CHD4 CREB1 DNM2 EGR1 EGR2 EGR3 EGR4 ELK1 EP300 F3 FOS FOSB FOSL1 ID1 ID2 ID3 ID4 JUNB JUND LYL1 MEF2D NAB1 NAB2 REST RRAD SGK1 SH3GL3 SRF TCF12 TPH1 TRIB1 VGF (see all 39) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK5	Cyclin Dependent Kinase 5	Protein Coding	2
2	TRIB1	Tribbles Pseudokinase 1	Protein Coding	2
3	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	2
4	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
5	ATF2	Activating Transcription Factor 2	Protein Coding	2
6	DNM2	Dynamin 2	Protein Coding	2
7	EGR1	Early Growth Response 1	Protein Coding	2
8	EGR2	Early Growth Response 2	Protein Coding	2
9	EGR3	Early Growth Response 3	Protein Coding	2
10	EGR4	Early Growth Response 4	Protein Coding	2
11	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
12	EP300	EP300 Lysine Acetyltransferase	Protein Coding	2
13	F3	Coagulation Factor III, Tissue Factor	Protein Coding	2
14	ARC	Activity Regulated Cytoskeleton Associated Protein	Protein Coding	2
15	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
16	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
17	ID1	Inhibitor Of DNA Binding 1	Protein Coding	2
18	ID2	Inhibitor Of DNA Binding 2	Protein Coding	2
19	ID3	Inhibitor Of DNA Binding 3	Protein Coding	2
20	ID4	Inhibitor Of DNA Binding 4	Protein Coding	2
21	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
22	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
23	LYL1	LYL1 Basic Helix-Loop-Helix Family Member	Protein Coding	2
24	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	2
25	ASCL1	Achaete-Scute Family BHLH Transcription Factor 1	Protein Coding	2
26	ATF1	Activating Transcription Factor 1	Protein Coding	2
27	NAB1	NGFI-A Binding Protein 1	Protein Coding	2
28	NAB2	NGFI-A Binding Protein 2	Protein Coding	2
29	REST	RE1 Silencing Transcription Factor	Protein Coding	2
30	RRAD	RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator	Protein Coding	2
31	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	2
32	SH3GL3	SH3 Domain Containing GRB2 Like 3, Endophilin A3	Protein Coding	2
33	SRF	Serum Response Factor	Protein Coding	2
34	TCF12	Transcription Factor 12	Protein Coding	2
35	TPH1	Tryptophan Hydroxylase 1	Protein Coding	2
36	VGF	VGF Nerve Growth Factor Inducible	Protein Coding	2
37	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	2
38	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	2
39	CDK5R2	Cyclin Dependent Kinase 5 Regulatory Subunit 2	Protein Coding	2
40	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
41	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	1
42	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	1
43	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
44	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	1
45	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
46	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
47	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	1
48	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
49	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
50	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
51	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
52	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
53	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
54	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
55	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
56	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
57	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
58	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
59	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
60	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
61	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1

Disorders associated with Nuclear Events (kinase and transcription factor activation) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.62
2	Histiocytoid hemangioma	Enrichment	FOS, FOSB	4.10
3	Specific learning disability	Enrichment	MAPK1, RPS6KA3	2.97
4	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.54
5	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.54
6	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.54
7	Wilms tumor 6	Enrichment	REST	2.54
8	Deafness, autosomal dominant 27	Enrichment	REST	2.54
9	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.54
10	Craniosynostosis 3	Enrichment	TCF12	2.54
11	Fibromatosis, gingival, 5	Enrichment	REST	2.54
12	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.54
13	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.54
14	Hypogonadotropic hypogonadism 26 with or without anosmia	Enrichment	TCF12	2.54
15	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.35
16	Noonan syndrome 13	Enrichment	MAPK1	2.35
17	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.35
18	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.35
19	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.35
20	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.35
21	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.35
22	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.35
23	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.35
24	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.35
25	Mef2c-related disorder	Enrichment	MEF2C	2.35
26	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.35
27	Fibromatosis, gingival, 1	Enrichment	REST	2.24
28	Hemangiopericytoma, malignant	Enrichment	NAB2	2.24
29	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.24
30	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	2.24
31	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.24
32	Menke-hennekam syndrome 2	Enrichment	EP300	2.24
33	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.07
34	Charcot-marie-tooth disease type 1	Enrichment	EGR2	2.07
35	Scoliosis, isolated 1	Enrichment	MAPK7	2.05
36	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.05
37	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.05
38	Congenital generalized lipodystrophy	Enrichment	FOS	1.94
39	Non-syndromic bicoronal craniosynostosis	Enrichment	TCF12	1.94
40	Haddad syndrome	Enrichment	ASCL1	1.94
41	Gingival fibromatosis	Enrichment	REST	1.94
42	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.94
43	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.84
44	Chondrosarcoma, extraskeletal myxoid	Enrichment	TCF12	1.84
45	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.84
46	Myopathy, centronuclear, 1	Enrichment	DNM2	1.77
47	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.77
48	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.77
49	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.75
50	Charge syndrome	Enrichment	EP300	1.59
51	Gastroesophageal reflux	Enrichment	RPS6KA3	1.45
52	Orthostatic intolerance	Enrichment	RPS6KA3	1.45
53	Ventricular septal defect	Enrichment	RPS6KA3	1.40
54	Polydactyly, postaxial, type a1	Enrichment	EP300	1.37
55	Wilms tumor 1	Enrichment	REST	1.37
56	Rare genetic intellectual disability	Enrichment	EP300	1.37
57	Charcot-marie-tooth disease type 4	Enrichment	EGR2	1.30
58	Craniosynostosis	Enrichment	TCF12	1.25
59	Centronuclear myopathy	Enrichment	DNM2	1.23
60	Heart, malformation of	Enrichment	MAPK1	1.11
61	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	1.11
62	Autism spectrum disorder	Enrichment	MEF2C, TCF12	1.06
63	Kallmann syndrome	Enrichment	DUSP6	1.01
64	Microcephaly	Enrichment	EP300, MAPK1	0.98
65	Myopathy	Enrichment	DNM2	0.96
66	Charcot-marie-tooth disease	Enrichment	DNM2	0.95
67	Lung cancer	Enrichment	PPP2R1B	0.87
68	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.86
69	Myeloma, multiple	Enrichment	SGK1	0.83
70	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.82
71	Hypertelorism	Enrichment	RPS6KA3	0.68
72	Colorectal cancer	Enrichment	EP300	0.65
73	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.64
74	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.37

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nuclear Events (kinase and transcription factor activation)

Pathway Network for Nuclear Events (kinase and transcription factor activation)

Member Pathways for Nuclear Events (kinase and transcription factor activation)

Pathways in the Nuclear Events (kinase and transcription factor activation) SuperPath

Associated Genes for Nuclear Events (kinase and transcription factor activation)

Associated Disorders for Nuclear Events (kinase and transcription factor activation)

Disorders associated with Nuclear Events (kinase and transcription factor activation) SuperPath

STRING Interaction Network for Nuclear Events (kinase and transcription factor activation)

Sources for Nuclear Events (kinase and transcription factor activation)