Nuclear receptors

Pathway network for the Nuclear receptors SuperPath

Sources:

WikiPathways
Reactome

Pathways in the Nuclear receptors SuperPath

#	Name	Source	Genes
1	Nuclear receptors	WikiPathways	AR ESR1 ESR2 ESRRA ESRRB HNF4A NR0B1 NR1D2 NR1H2 NR1H3 NR1I2 NR1I3 NR2C2 NR2E1 NR2F1 NR2F2 NR2F6 NR3C1 NR4A1 NR4A2 NR5A1 NR5A2 PGR PPARA PPARD PPARG RARA RARB RARG ROR1 RORA RORC RXRA RXRB RXRG THRA THRB VDR (see all 38) (see less)
2	Nuclear Receptor transcription pathway	Reactome	AR ESR1 ESR2 ESRRA ESRRB ESRRG HNF4A HNF4G MED1 NCOR1 NCOR2 NR0B1 NR0B2 NR1D1 NR1D2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2C1 NR2C2 NR2C2AP NR2E1 NR2E3 NR2F1 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NR5A1 NR5A2 NR6A1 NRBF2 NRBP1 PGR PPARA PPARD PPARG RARA RARB RARG RORA RORB RORC RXRA RXRB RXRG THRA THRB VDR (see all 53) (see less)
3	SUMOylation of intracellular receptors	Reactome	AR ESR1 HDAC4 NR1H2 NR1H3 NR1H4 NR1I2 NR2C1 NR3C1 NR3C2 NR4A2 NR5A1 NR5A2 PGR PIAS1 PIAS2 PIAS3 PIAS4 PPARA PPARG RARA RORA RXRA SUMO1 SUMO2 SUMO3 THRA THRB UBE2I VDR (see all 30) (see less)

Gene overlap in member pathways for Nuclear receptors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	3
2	VDR	Vitamin D Receptor	Protein Coding	3
3	NR1H2	Nuclear Receptor Subfamily 1 Group H Member 2	Protein Coding	3
4	THRB	Thyroid Hormone Receptor Beta	Protein Coding	3
5	THRA	Thyroid Hormone Receptor Alpha	Protein Coding	3
6	RXRA	Retinoid X Receptor Alpha	Protein Coding	3
7	RORA	RAR Related Orphan Receptor A	Protein Coding	3
8	RARA	Retinoic Acid Receptor Alpha	Protein Coding	3
9	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	3
10	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	3
11	PGR	Progesterone Receptor	Protein Coding	3
12	NR4A2	Nuclear Receptor Subfamily 4 Group A Member 2	Protein Coding	3
13	AR	Androgen Receptor	Protein Coding	3
14	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	3
15	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	3
16	NR5A2	Nuclear Receptor Subfamily 5 Group A Member 2	Protein Coding	3
17	ESR1	Estrogen Receptor 1	Protein Coding	3
18	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	3
19	NR1D2	Nuclear Receptor Subfamily 1 Group D Member 2	Protein Coding	2
20	NR1I3	Nuclear Receptor Subfamily 1 Group I Member 3	Protein Coding	2
21	NR2C2	Nuclear Receptor Subfamily 2 Group C Member 2	Protein Coding	2
22	NR2F1	Nuclear Receptor Subfamily 2 Group F Member 1	Protein Coding	2
23	RXRG	Retinoid X Receptor Gamma	Protein Coding	2
24	RXRB	Retinoid X Receptor Beta	Protein Coding	2
25	RORC	RAR Related Orphan Receptor C	Protein Coding	2
26	RARG	Retinoic Acid Receptor Gamma	Protein Coding	2
27	RARB	Retinoic Acid Receptor Beta	Protein Coding	2
28	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	2
29	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	2
30	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	2
31	ESRRB	Estrogen Related Receptor Beta	Protein Coding	2
32	ESRRA	Estrogen Related Receptor Alpha	Protein Coding	2
33	ESR2	Estrogen Receptor 2	Protein Coding	2
34	NR2F6	Nuclear Receptor Subfamily 2 Group F Member 6	Protein Coding	2
35	NR0B1	Nuclear Receptor Subfamily 0 Group B Member 1	Protein Coding	2
36	NR2E1	Nuclear Receptor Subfamily 2 Group E Member 1	Protein Coding	2
37	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	2
38	NR2C1	Nuclear Receptor Subfamily 2 Group C Member 1	Protein Coding	2
39	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	2
40	NR2F2	Nuclear Receptor Subfamily 2 Group F Member 2	Protein Coding	1
41	ROR1	Receptor Tyrosine Kinase Like Orphan Receptor 1	Protein Coding	1
42	NR2E3	Nuclear Receptor Subfamily 2 Group E Member 3	Protein Coding	1
43	NR2C2AP	Nuclear Receptor 2C2 Associated Protein	Protein Coding	1
44	ESRRG	Estrogen Related Receptor Gamma	Protein Coding	1
45	NR6A1	Nuclear Receptor Subfamily 6 Group A Member 1	Protein Coding	1
46	NRBP1	Nuclear Receptor Binding Protein 1	Protein Coding	1
47	NRBF2	Nuclear Receptor Binding Factor 2	Protein Coding	1
48	HNF4G	Hepatocyte Nuclear Factor 4 Gamma	Protein Coding	1
49	MED1	Mediator Complex Subunit 1	Protein Coding	1
50	RORB	RAR Related Orphan Receptor B	Protein Coding	1
51	NR4A3	Nuclear Receptor Subfamily 4 Group A Member 3	Protein Coding	1
52	NR0B2	Nuclear Receptor Subfamily 0 Group B Member 2	Protein Coding	1
53	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	1
54	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
55	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
56	PIAS3	Protein Inhibitor Of Activated STAT 3	Protein Coding	1
57	PIAS4	Protein Inhibitor Of Activated STAT 4	Protein Coding	1
58	SUMO3	Small Ubiquitin Like Modifier 3	Protein Coding	1
59	SUMO2	Small Ubiquitin Like Modifier 2	Protein Coding	1
60	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
61	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	1
62	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	1
63	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	1
64	HDAC4	Histone Deacetylase 4	Protein Coding	1

Disorders associated with Nuclear receptors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	46,xy complete gonadal dysgenesis	Enrichment	AR, NR0B1, NR5A1	5.48
2	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1, THRA	4.82
3	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	NR0B1, NR5A1	4.12
4	46,xy disorder of sex development	Enrichment	NR2F2, NR5A1	3.94
5	Difference of sex development	Enrichment	AR, NR5A1	3.88
6	46,xy partial gonadal dysgenesis	Enrichment	NR0B1, NR5A1	3.17
7	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.66
8	Androgen insensitivity, partial	Enrichment	AR	2.66
9	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.66
10	46,xx sex reversal 4	Enrichment	NR5A1	2.66
11	Spermatogenic failure 8	Enrichment	NR5A1	2.66
12	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.66
13	Orofacial cleft 10	Enrichment	SUMO1	2.66
14	Progesterone resistance	Enrichment	PGR	2.66
15	Hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy	Enrichment	NR3C2	2.66
16	Premature ovarian failure 7	Enrichment	NR5A1	2.66
17	Cholestasis, progressive familial intrahepatic, 5	Enrichment	NR1H4	2.66
18	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.66
19	Intellectual developmental disorder with language impairment and early-onset dopa-responsive dystonia-parkinsonism	Enrichment	NR4A2	2.66
20	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.66
21	Rickets	Enrichment	VDR	2.66
22	Pseudohyperaldosteronism type 2	Enrichment	NR3C2	2.66
23	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor alpha	Enrichment	THRA	2.66
24	Complete androgen insensitivity syndrome	Enrichment	AR	2.66
25	Resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta	Enrichment	THRB	2.66
26	Generalized resistance to thyroid hormone	Enrichment	THRB	2.66
27	Male infertility	Enrichment	AR, NR5A1	2.60
28	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.55
29	Deafness, autosomal recessive 108	Enrichment	ROR1	2.55
30	46,xy sex reversal 2	Enrichment	NR0B1	2.55
31	Adrenal hypoplasia, congenital	Enrichment	NR0B1	2.55
32	46,xx sex reversal 5	Enrichment	NR2F2	2.55
33	Immunodeficiency 42	Enrichment	RORC	2.55
34	Ovarian dysgenesis 8	Enrichment	ESR2	2.55
35	Deafness, autosomal recessive 35	Enrichment	ESRRB	2.55
36	Microphthalmia, syndromic 12	Enrichment	RARB	2.55
37	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.55
38	Epilepsy, idiopathic generalized 15	Enrichment	RORB	2.41
39	Retinitis pigmentosa 37	Enrichment	NR2E3	2.41
40	Oculovertebral syndrome	Enrichment	NR6A1	2.41
41	Thyroid hormone resistance, selective pituitary	Enrichment	THRB	2.35
42	Galactosemia ii	Enrichment	NR3C1	2.35
43	Thyroid hormone resistance, generalized, autosomal dominant	Enrichment	THRB	2.35
44	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	2.35
45	Carotid intimal medial thickness 1	Enrichment	PPARG	2.35
46	Thyroid hormone resistance, generalized, autosomal recessive	Enrichment	THRB	2.35
47	Pseudohypoaldosteronism, type i, autosomal dominant	Enrichment	NR3C2	2.35
48	46,xy sex reversal 1	Enrichment	AR	2.35
49	Androgen insensitivity syndrome	Enrichment	AR	2.35
50	Thyroid hormone resistance syndrome	Enrichment	THRB	2.35
51	Hypospadias 1, x-linked	Enrichment	AR	2.35
52	46,xy sex reversal 3	Enrichment	NR5A1	2.35
53	Intellectual developmental disorder with or without epilepsy or cerebellar ataxia	Enrichment	RORA	2.35
54	Familial partial lipodystrophy	Enrichment	PPARG	2.35
55	Posterior hypospadias	Enrichment	AR	2.35
56	Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion	Enrichment	NR4A2	2.35
57	Pseudohypoaldosteronism	Enrichment	NR3C2	2.35
58	Maturity-onset diabetes of the young, type 1	Enrichment	HNF4A	2.25
59	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.25
60	Bosch-boonstra-schaaf optic atrophy syndrome	Enrichment	NR2F1	2.25
61	Hyperinsulinism	Enrichment	HNF4A	2.25
62	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF4A	2.25
63	Type 2 diabetes mellitus	Enrichment	HNF4A, PPARG	2.21
64	46,xx sex reversal 1	Enrichment	NR5A1	2.18
65	Estrogen resistance	Enrichment	ESR1	2.18
66	Migraine without aura	Enrichment	ESR1	2.18
67	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	NR4A2	2.18
68	Myeloma, multiple	Enrichment	HDAC4, RXRA	2.17
69	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR, NR5A1	2.17
70	Enhanced s-cone syndrome 1	Enrichment	NR2E3	2.11
71	Enhanced s-cone syndrome	Enrichment	NR2E3	2.11
72	Thyroid carcinoma, familial medullary	Enrichment	ESR2	2.08
73	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	2.05
74	Spermatogenic failure 1	Enrichment	NR5A1	2.05
75	Leptin deficiency or dysfunction	Enrichment	PPARG	2.05
76	Congenital generalized lipodystrophy	Enrichment	PPARG	2.05
77	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.05
78	Intrahepatic cholestasis of pregnancy	Enrichment	NR1H4	2.05
79	Autism spectrum disorder	Enrichment	NR2F1, NR3C2, NR4A2	2.05
80	Epilepsy	Enrichment	NR4A2, RORB	1.97
81	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.96
82	Maturity-onset diabetes of the young, type 3	Enrichment	HNF4A	1.95
83	Cholestasis, progressive familial intrahepatic, 1	Enrichment	NR1H4	1.88
84	Atrioventricular septal defect	Enrichment	NR1D2	1.86
85	Congenital heart defects, multiple types, 4	Enrichment	NR2F2	1.86
86	Color blindness	Enrichment	NR2E3	1.81
87	Body mass index quantitative trait locus 11	Enrichment	NR0B2, PPARG	1.79
88	Chondrosarcoma, extraskeletal myxoid	Enrichment	NR4A3	1.71
89	Primary hyperaldosteronism	Enrichment	NR3C1	1.70
90	Epilepsy, childhood absence 1	Enrichment	RORB	1.63
91	Albinism, ocular, type i	Enrichment	NR2E3	1.63
92	Migraine with or without aura 1	Enrichment	ESR1	1.62
93	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ESRRB, ROR1	1.59
94	46 xx gonadal dysgenesis	Enrichment	NR5A1	1.58
95	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.55
96	Acute promyelocytic leukemia	Enrichment	RARA	1.55
97	Complex neurodevelopmental disorder	Enrichment	NR4A2, RORA	1.52
98	Multiple sclerosis	Enrichment	NR1H3	1.52
99	Mhc class ii deficiency	Enrichment	NR2C2AP	1.46
100	Gliosarcoma	Enrichment	PPARG	1.46
101	Microphthalmia/coloboma 12	Enrichment	RARB	1.45
102	Giant cell glioblastoma	Enrichment	PPARG	1.43
103	Heart disease	Enrichment	NR2F2	1.41
104	Parkinson's disease	Enrichment	NR4A2	1.38
105	Coloboma of macula	Enrichment	RARB	1.38
106	Mhc class ii deficiency 1	Enrichment	NR2C2AP	1.38
107	Epilepsy, idiopathic generalized	Enrichment	RORB	1.38
108	Polycystic liver disease	Enrichment	HNF4A	1.33
109	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	1.33
110	Hepatocellular carcinoma	Enrichment	VDR	1.32
111	Myocardial infarction	Enrichment	ESR1	1.32
112	Tooth agenesis	Enrichment	SUMO1	1.32
113	Parkinson disease, late-onset	Enrichment	NR4A2	1.29
114	Maturity-onset diabetes of the young	Enrichment	HNF4A	1.26
115	Microphthalmia	Enrichment	RARB	1.22
116	Prostate cancer	Enrichment	AR	1.21
117	Differentiated thyroid carcinoma	Enrichment	PPARG	1.21
118	Nephronophthisis	Enrichment	PIAS1	1.15
119	Hereditary breast carcinoma	Enrichment	ESR1	1.03
120	Optic atrophy plus syndrome	Enrichment	NR2F1	0.93
121	Primary ovarian insufficiency	Enrichment	NR5A2	0.91
122	Eye disease	Enrichment	NR2E3	0.89
123	Breast cancer	Enrichment	ESR1	0.81
124	Deafness, autosomal recessive	Enrichment	ESRRB	0.79
125	Autosomal recessive nonsyndromic deafness	Enrichment	ESRRB	0.78
126	Colorectal cancer	Enrichment	PPARG	0.76
127	Rare genetic deafness	Enrichment	ESRRB	0.70
128	Ovarian cancer	Enrichment	AR	0.70
129	Cone-rod dystrophy 2	Enrichment	NR2E3	0.63
130	Leber plus disease	Enrichment	NR2E3	0.51
131	Retinitis pigmentosa	Enrichment	NR2E3	0.25
132	Hereditary retinal dystrophy	Enrichment	NR2E3	0.17
133	Fundus dystrophy	Enrichment	NR2E3	0.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Nuclear receptors

Pathway Network for Nuclear receptors

Pathway network for the Nuclear receptors SuperPath

Member Pathways for Nuclear receptors

Pathways in the Nuclear receptors SuperPath

Gene overlap in member pathways for Nuclear receptors SuperPath

Associated Genes for Nuclear receptors

Associated Disorders for Nuclear receptors

Disorders associated with Nuclear receptors SuperPath

STRING Interaction Network for Nuclear receptors

Sources for Nuclear receptors